Insr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Insr
Entrez Gene ID	24954
Full Name	insulin receptor
General protein information	Preferred Names insulin receptor Names insulin receptor IR insulin receptor preproprotein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 12 Map Location: 12p12
Summary	receptor for insulin; involved in intracellular signalling; mutations in gene are associated with type 2 diabetes mellitus [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017071.2	NP_058767.2	insulin receptor preproprotein

Pathways from BioSystems

Homologies

Bos taurus (cattle)	INSR	XP_002688878.3
Danio rerio (zebrafish)	insra	NP_001136144.1
Homo sapiens (human)	INSR	NP_000199.2
Danio rerio (zebrafish)	insrb	NP_001116701.1
Macaca mulatta (Rhesus monkey)	INSR	XP_001094337.2
Canis lupus familiaris (dog)	INSR	XP_005633279.1
Gallus gallus (chicken)	INSR	XP_001233399.3
Mus musculus (house mouse)	Insr	NP_034698.2
Pan troglodytes (chimpanzee)	INSR	XP_512324.2
Rattus norvegicus (Norway rat)	Insr	NP_058767.2
Xenopus tropicalis (tropical clawed frog)	LOC100492718	XP_002934425.2

Gene Ontology
Bibliography

Related articles in PubMed

Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity.
Lopez-Pastor AR, Gomez-Hernandez A, Diaz-Castroverde S, Gonzalez-Aseguinolaza G, Gonzalez-Rodriguez A, Garcia G, Fernandez S, Escribano O, Benito M
Disease models & mechanisms12(2)(2019 02)

Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways.
Mazibuko-Mbeje SE, Dludla PV, Roux C, Johnson R, Ghoor S, Joubert E, Louw J, Opoku AR, Muller CJF
International journal of molecular sciences20(3)(2019 Feb)

The insulin receptor is differentially expressed in somatic and visceral primary sensory neurons.
Lázár BA, Jancsó G, Nagy I, Horváth V, Sántha P
Cell and tissue research374(2)243-249(2018 Nov)

Dendrobium mixture regulates hepatic gluconeogenesis in diabetic rats via the phosphoinositide-3-kinase/protein kinase B signaling pathway.
Lin X, Shi H, Cui Y, Wang X, Zhang J, Yu W, Wei M
Experimental and therapeutic medicine16(1)204-212(2018 Jul)

Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction.
Seino S, Seino M, Bell GI
Diabetes39(1)123-8(1990 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Insr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Insr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13303	NM_017071.2 Latest version!	Rattus norvegicus insulin receptor (Insr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Insr ( NM_017071.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058767.2 Rattus norvegicus insulin receptor (Insr), mRNA.

Price & Availability↑

CloneID	ORa13303
Clone ID Related Accession (Same CDS sequence)	NM_017071.2
Accession Version	NM_017071.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4155bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Rattus norvegicus(Norway rat)
Product	insulin receptor preproprotein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07034946.1, AABR07034945.1 and AABR07034944.1. On Jun 13, 2010 this sequence version replaced NM_017071.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29014.1, KF112847.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGCTCCG GGAGAGGATG TGAGACGACG GCGGTGCCGT TGCTGATGGC CGTGGCCGCG 
TTGCTGGTGG GCACAGCCGG CCACCTGTAC CCTGGAGAGG TGTGCCCGGG AATGGACATC 
CGGAACAACC TGACCAGGTT GCATGAGCTG GAGAACTGCT CGGTCATTGA GGGCCATCTG 
CAGATCCTCT TGATGTTCAA GACCAGACCC GAAGATTTCC GAGACCTCAG TTTCCCCAAA 
CTCATCATGA TCACAGACTA CCTGCTTCTT TTCCGTGTCT ATGGCCTAGA AAGTCTAAAA 
GACCTCTTCC CAAACCTCAC AGTCATCCGA GGCTCCCGTC TCTTCTTCAA CTATGCCCTG 
GTCATCTTCG AGATGGTCCA CCTGAAGGAG CTGGGTCTTT ACAACCTCAT GAACATCACC 
CGGGGCTCTG TCCGCATCGA GAAGAATAAT GAACTCTGCT ACCTGGCCAC TATCGACTGG 
TCCCGCATCC TGGATTCCGT GGAGGACAAC TACATTGTAC TGAACAAAGA TGACAATGAG 
GAATGTGGGG ACGTCTGTCC AGGCACAGCC AAGGGCAAGA CCAACTGCCC TGCCACCGTC 
ATCAATGGGC AGTTTGTGGA ACGGTGCTGG ACACACAGTC ATTGTCAGAA AGTTTGCCCA 
ACCATCTGTA AGTCACATGG CTGCACAGCT GAAGGCCTGT GCTGTCACAA GGAGTGCCTG 
GGCAACTGTT CAGAACCCGA TGACCCTACC AAGTGTGTGG CCTGTCGAAA CTTCTACCTG 
GATGGTCAGT GTGTGGAGAC CTGCCCACCA CCCTACTATC ACTTCCAGGA TTGGCGCTGT 
GTAAACTTCA GCTTCTGCCA AGACCTTCAC TACAAATGCA GGAACTCTCG GAAGCCTGGC 
TGTCACCAAT ACGTCATTCA CAACAACAAG TGCATCCCCG AGTGCCCGTC TGGCTATACC 
ATGAATTCCA GCAACTTGAT GTGCACCCCG TGTCTGGGAC CCTGTCCTAA GGTCTGCCAA 
ATCCTCGAAG GCGAGAAGAC CATTGATTCC GTGACATCTG CCCAGGAGCT CCGAGGCTGC 
ACTGTGATCA ATGGCAGCCT GATTATCAAC ATCCGAGGGG GCAACAACCT GGCAGCTGAA 
CTAGAGGCTA ACCTTGGCCT CATTGAAGAA ATCTCAGGGT TCCTAAAGAT CCGTCGCTCC 
TATGCTCTGG TGTCACTTTC TTTCTTCAGG AAGCTACATC TGATTCGAGG AGAGACCTTG 
GAAATTGGGA ACTATTCTTT CTACGCCTTG GACAACCAGA ACCTGAGGCA GCTGTGGGAC 
TGGAACAAGC ACAACCTCAC GATCACTCAG GGCAAGCTCT TCTTCCACTA CAACCCCAAA 
CTCTGCCTGT CTGAGATCCA CAAGATGGAG GAAGTGTCCG GAACCAAGGG CCGCCAGGAG 
AGGAACGACA TTGCCCTGAA GACCAACGGG GACCAGGCAT CCTGTGAAAA TGAATTACTT 
AAATTCTCTT TCATCCGGAC GTCTTTTGAC AAGATCTTGC TGAGGTGGGA GCCCTACTGG 
CCCCCCGACT TCCGAGATCT CCTGGGATTC ATGCTGTTCT ACAAAGAGGC CCCTTATCAG 
AACGTGACAG AGTTTGACGG GCAGGATGCG TGTGGCTCCA ACAGCTGGAC TGTGGTGGAT 
ATTGACCCGC CCCAGAGGTC CAACGACCCT AAGTCTCAGA CCCCAAGCCA CCCTGGGTGG 
CTGATGCGGG GCCTCAAACC CTGGACCCAG TATGCCATCT TTGTCAAGAC CTTGGTTACC 
TTCTCTGATG AACGCCGGAC CTATGGAGCC AAAAGTGATA TCATCTATGT GCAAACAGAT 
GCCACCAATC CTTCCGTTCC CCTGGATCCC ATATCAGTTT CCAACTCCTC ATCTCAGATT 
ATCTTAAAGT GGAAGCCCCC CTCGGACCCC AATGGCAACA TCACACACTA CCTGGTCTAC 
TGGGAGAGGC AGGCGGAGGA CAGCGAGCTG TTCGAGTTGG ATTATTGTCT CAAAGGGCTG 
AAGCTCCCCT CACGCACCTG GTCCCCACCT TTTGAGTCTG ACGATTCTCA AAAGCACAAT 
CAGAGTGAGT ATGACGACTC GGCCAGCGAG TGCTGCTCAT GTCCTAAGAC TGACTCTCAG 
ATCCTGAAGG AGCTGGAGGA GTCTTCATTC AGGAAGACCT TCGAGGATTA CCTGCACAAC 
GTGGTTTTTG TTCCCAGAAA AACCTCTTCA GGCAATGGTG CTGAGGACAC TAGGCCATCC 
CGAAAGCGAA GATCCCTTGA AGAGGTGGGC AATGTGACAG CCACTACACC CACACTTCCA 
GATTTTCCCA ACATCTCCTC CACCATCGCG CCCACAAGCC ACGAAGAGCA CAGACCATTT 
GAGAAAGTAG TAAACAAGGA GTCACTTGTC ATCTCTGGCC TGAGACACTT CACTGGGTAC 
CGCATTGAGC TGCAGGCATG CAATCAGGAC TCCCCAGAAG AGAGGTGCAG CGTGGCTGCC 
TACGTCAGTG CCCGGACCAT GCCTGAAGCT AAGGCAGATG ACATCGTTGG CCCTGTGACC 
CATGAAATCT TTGAGAACAA TGTTGTACAC TTAATGTGGC AAGAGCCAAA GGAACCTAAT 
GGTCTGATTG TGCTATATGA AGTGAGCTAT CGGCGATATG GTGATGAGGA GCTGCACCTC 
TGTGTCTCCC GGAAGCATTT TGCCCTGGAG CGGGGCTGCA GGCTTCGAGG GCTCTCTCCA 
GGAAACTACA GTGTTCGAGT CCGGGCTACC TCTCTGGCAG GAAATGGCTC CTGGACAGAA 
CCCACCTATT TTTATGTGAC TGATTATTTA GATGTCCCAT CAAATATTGC CAAAATTATC 
ATCGGGCCCC TCATCTTCGT CTTCCTCTTC AGTGTCGTGA TCGGAAGTAT TTATCTATTC 
TTGAGGAAGA GGCAGCCAGA TGGGCCAATG GGACCACTGT ACGCTTCTTC AAACCCAGAG 
TACCTCAGTG CCAGTGATGT CTTTCCATCT TCCGTATACG TTCCGGATGA GTGGGAGGTA 
CCTCGAGAGA AGATCACCCT CCTCCGAGAG CTGGGGCAGG GATCCTTCGG TATGGTGTAC 
GAAGGCAATG CCAAGGATAT CATCAAGGGT GAGGTAGAGA CCCGTGTTGC GGTGAAGACG 
GTCAATGAGT CAGCCAGTCT TCGAGAACGG ATCGAGTTCC TCAATGAGGC ATCAGTCATG 
AAGGGCTTCA CCTGTCATCA CGTGGTCCGC CTTCTTGGGG TGGTGTCCAA AGGCCAGCCC 
ACATTGGTAG TGATGGAACT GATGGCTCAT GGAGACCTGA AAAGTCACCT CCGTTCTCTG 
CGGCCCGATG CTGAGAACAA CCCAGGCCGT CCTCCCCCTA CCTTGCAAGA AATGATTCAG 
ATGACAGCAG AAATTGCCGA TGGCATGGCA TACTTGAACG CCAAGAAGTT TGTGCACCGG 
GACCTGGCAG CTCGGAACTG CATGGTTGCC CATGATTTTA CTGTCAAAAT CGGAGACTTT 
GGAATGACGA GAGACATCTA CGAGACAGAT TACTATCGGA AAGGGGGCAA GGGGTTGCTG 
CCCGTGAGGT GGATGTCACC CGAGTCCCTG AAGGACGGAG TCTTCACTGC TTCTTCCGAC 
ATGTGGTCCT TTGGGGTGGT CCTTTGGGAA ATCACCAGCC TGGCTGAGCA ACCTTACCAA 
GGCCTGTCTA ATGAACAGGT GTTGAAATTT GTCATGGATG GAGGCTATCT GGATCCCCCT 
GATAACTGTC CAGAGAGACT CACTGACCTG ATGCGCATGT GCTGGCAGTT CAACCCCAAG 
ATGAGGCCGA CCTTCCTGGA AATCGTCAAC CTGCTCAAGG ACGACCTCCA CCCCAGCTTT 
CCGGAAGTTT CCTTCTTCTA CAGCGAGGAG AACAAGGCTC CCGAGAGTGA AGAGCTGGAG 
ATGGAGTTCG AGGACATGGA GAATGTCCCC TTGGATCGTT CCTCTCACTG TCAGAGAGAA 
GAGGCTGGAT GCCGGGAGGG AGGGTCCTCT CTGAGCATCA AACGGACCTA TGATGAACAC 
ATCCCCTACA CCCACATGAA CGGGGGCAAG AAGAATGGGC GGGTCCTCAC CCTGCCGAGG 
TCGAACCCTT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058767.2
CDS	349..4503
Translation	MGSGRGCETTAVPLLMAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHYKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPSRKRRSLEEVGNVTATTPTLPDFPNISSTIAPTSHEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGCREGGSSLSIKRTYDEHIPYTHMNGGKKNGRVLTLPRSNPS

Target ORF information:

RefSeq Version	NM_017071.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin receptor (Insr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017071.2

ORF Insert Sequence:

ATGGGCTCCG GGAGAGGATG TGAGACGACG GCGGTGCCGT TGCTGATGGC CGTGGCCGCG 
TTGCTGGTGG GCACAGCCGG CCACCTGTAC CCTGGAGAGG TGTGCCCGGG AATGGACATC 
CGGAACAACC TGACCAGGTT GCATGAGCTG GAGAACTGCT CGGTCATTGA GGGCCATCTG 
CAGATCCTCT TGATGTTCAA GACCAGACCC GAAGATTTCC GAGACCTCAG TTTCCCCAAA 
CTCATCATGA TCACAGACTA CCTGCTTCTT TTCCGTGTCT ATGGCCTAGA AAGTCTAAAA 
GACCTCTTCC CAAACCTCAC AGTCATCCGA GGCTCCCGTC TCTTCTTCAA CTATGCCCTG 
GTCATCTTCG AGATGGTCCA CCTGAAGGAG CTGGGTCTTT ACAACCTCAT GAACATCACC 
CGGGGCTCTG TCCGCATCGA GAAGAATAAT GAACTCTGCT ACCTGGCCAC TATCGACTGG 
TCCCGCATCC TGGATTCCGT GGAGGACAAC TACATTGTAC TGAACAAAGA TGACAATGAG 
GAATGTGGGG ACGTCTGTCC AGGCACAGCC AAGGGCAAGA CCAACTGCCC TGCCACCGTC 
ATCAATGGGC AGTTTGTGGA ACGGTGCTGG ACACACAGTC ATTGTCAGAA AGTTTGCCCA 
ACCATCTGTA AGTCACATGG CTGCACAGCT GAAGGCCTGT GCTGTCACAA GGAGTGCCTG 
GGCAACTGTT CAGAACCCGA TGACCCTACC AAGTGTGTGG CCTGTCGAAA CTTCTACCTG 
GATGGTCAGT GTGTGGAGAC CTGCCCACCA CCCTACTATC ACTTCCAGGA TTGGCGCTGT 
GTAAACTTCA GCTTCTGCCA AGACCTTCAC TACAAATGCA GGAACTCTCG GAAGCCTGGC 
TGTCACCAAT ACGTCATTCA CAACAACAAG TGCATCCCCG AGTGCCCGTC TGGCTATACC 
ATGAATTCCA GCAACTTGAT GTGCACCCCG TGTCTGGGAC CCTGTCCTAA GGTCTGCCAA 
ATCCTCGAAG GCGAGAAGAC CATTGATTCC GTGACATCTG CCCAGGAGCT CCGAGGCTGC 
ACTGTGATCA ATGGCAGCCT GATTATCAAC ATCCGAGGGG GCAACAACCT GGCAGCTGAA 
CTAGAGGCTA ACCTTGGCCT CATTGAAGAA ATCTCAGGGT TCCTAAAGAT CCGTCGCTCC 
TATGCTCTGG TGTCACTTTC TTTCTTCAGG AAGCTACATC TGATTCGAGG AGAGACCTTG 
GAAATTGGGA ACTATTCTTT CTACGCCTTG GACAACCAGA ACCTGAGGCA GCTGTGGGAC 
TGGAACAAGC ACAACCTCAC GATCACTCAG GGCAAGCTCT TCTTCCACTA CAACCCCAAA 
CTCTGCCTGT CTGAGATCCA CAAGATGGAG GAAGTGTCCG GAACCAAGGG CCGCCAGGAG 
AGGAACGACA TTGCCCTGAA GACCAACGGG GACCAGGCAT CCTGTGAAAA TGAATTACTT 
AAATTCTCTT TCATCCGGAC GTCTTTTGAC AAGATCTTGC TGAGGTGGGA GCCCTACTGG 
CCCCCCGACT TCCGAGATCT CCTGGGATTC ATGCTGTTCT ACAAAGAGGC CCCTTATCAG 
AACGTGACAG AGTTTGACGG GCAGGATGCG TGTGGCTCCA ACAGCTGGAC TGTGGTGGAT 
ATTGACCCGC CCCAGAGGTC CAACGACCCT AAGTCTCAGA CCCCAAGCCA CCCTGGGTGG 
CTGATGCGGG GCCTCAAACC CTGGACCCAG TATGCCATCT TTGTCAAGAC CTTGGTTACC 
TTCTCTGATG AACGCCGGAC CTATGGAGCC AAAAGTGATA TCATCTATGT GCAAACAGAT 
GCCACCAATC CTTCCGTTCC CCTGGATCCC ATATCAGTTT CCAACTCCTC ATCTCAGATT 
ATCTTAAAGT GGAAGCCCCC CTCGGACCCC AATGGCAACA TCACACACTA CCTGGTCTAC 
TGGGAGAGGC AGGCGGAGGA CAGCGAGCTG TTCGAGTTGG ATTATTGTCT CAAAGGGCTG 
AAGCTCCCCT CACGCACCTG GTCCCCACCT TTTGAGTCTG ACGATTCTCA AAAGCACAAT 
CAGAGTGAGT ATGACGACTC GGCCAGCGAG TGCTGCTCAT GTCCTAAGAC TGACTCTCAG 
ATCCTGAAGG AGCTGGAGGA GTCTTCATTC AGGAAGACCT TCGAGGATTA CCTGCACAAC 
GTGGTTTTTG TTCCCAGAAA AACCTCTTCA GGCAATGGTG CTGAGGACAC TAGGCCATCC 
CGAAAGCGAA GATCCCTTGA AGAGGTGGGC AATGTGACAG CCACTACACC CACACTTCCA 
GATTTTCCCA ACATCTCCTC CACCATCGCG CCCACAAGCC ACGAAGAGCA CAGACCATTT 
GAGAAAGTAG TAAACAAGGA GTCACTTGTC ATCTCTGGCC TGAGACACTT CACTGGGTAC 
CGCATTGAGC TGCAGGCATG CAATCAGGAC TCCCCAGAAG AGAGGTGCAG CGTGGCTGCC 
TACGTCAGTG CCCGGACCAT GCCTGAAGCT AAGGCAGATG ACATCGTTGG CCCTGTGACC 
CATGAAATCT TTGAGAACAA TGTTGTACAC TTAATGTGGC AAGAGCCAAA GGAACCTAAT 
GGTCTGATTG TGCTATATGA AGTGAGCTAT CGGCGATATG GTGATGAGGA GCTGCACCTC 
TGTGTCTCCC GGAAGCATTT TGCCCTGGAG CGGGGCTGCA GGCTTCGAGG GCTCTCTCCA 
GGAAACTACA GTGTTCGAGT CCGGGCTACC TCTCTGGCAG GAAATGGCTC CTGGACAGAA 
CCCACCTATT TTTATGTGAC TGATTATTTA GATGTCCCAT CAAATATTGC CAAAATTATC 
ATCGGGCCCC TCATCTTCGT CTTCCTCTTC AGTGTCGTGA TCGGAAGTAT TTATCTATTC 
TTGAGGAAGA GGCAGCCAGA TGGGCCAATG GGACCACTGT ACGCTTCTTC AAACCCAGAG 
TACCTCAGTG CCAGTGATGT CTTTCCATCT TCCGTATACG TTCCGGATGA GTGGGAGGTA 
CCTCGAGAGA AGATCACCCT CCTCCGAGAG CTGGGGCAGG GATCCTTCGG TATGGTGTAC 
GAAGGCAATG CCAAGGATAT CATCAAGGGT GAGGTAGAGA CCCGTGTTGC GGTGAAGACG 
GTCAATGAGT CAGCCAGTCT TCGAGAACGG ATCGAGTTCC TCAATGAGGC ATCAGTCATG 
AAGGGCTTCA CCTGTCATCA CGTGGTCCGC CTTCTTGGGG TGGTGTCCAA AGGCCAGCCC 
ACATTGGTAG TGATGGAACT GATGGCTCAT GGAGACCTGA AAAGTCACCT CCGTTCTCTG 
CGGCCCGATG CTGAGAACAA CCCAGGCCGT CCTCCCCCTA CCTTGCAAGA AATGATTCAG 
ATGACAGCAG AAATTGCCGA TGGCATGGCA TACTTGAACG CCAAGAAGTT TGTGCACCGG 
GACCTGGCAG CTCGGAACTG CATGGTTGCC CATGATTTTA CTGTCAAAAT CGGAGACTTT 
GGAATGACGA GAGACATCTA CGAGACAGAT TACTATCGGA AAGGGGGCAA GGGGTTGCTG 
CCCGTGAGGT GGATGTCACC CGAGTCCCTG AAGGACGGAG TCTTCACTGC TTCTTCCGAC 
ATGTGGTCCT TTGGGGTGGT CCTTTGGGAA ATCACCAGCC TGGCTGAGCA ACCTTACCAA 
GGCCTGTCTA ATGAACAGGT GTTGAAATTT GTCATGGATG GAGGCTATCT GGATCCCCCT 
GATAACTGTC CAGAGAGACT CACTGACCTG ATGCGCATGT GCTGGCAGTT CAACCCCAAG 
ATGAGGCCGA CCTTCCTGGA AATCGTCAAC CTGCTCAAGG ACGACCTCCA CCCCAGCTTT 
CCGGAAGTTT CCTTCTTCTA CAGCGAGGAG AACAAGGCTC CCGAGAGTGA AGAGCTGGAG 
ATGGAGTTCG AGGACATGGA GAATGTCCCC TTGGATCGTT CCTCTCACTG TCAGAGAGAA 
GAGGCTGGAT GCCGGGAGGG AGGGTCCTCT CTGAGCATCA AACGGACCTA TGATGAACAC 
ATCCCCTACA CCCACATGAA CGGGGGCAAG AAGAATGGGC GGGTCCTCAC CCTGCCGAGG 
TCGAACCCTT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity.
Disease models & mechanisms12(2)(2019 02)
Lopez-Pastor AR,Gomez-Hernandez A,Diaz-Castroverde S,Gonzalez-Aseguinolaza G,Gonzalez-Rodriguez A,Garcia G,Fernandez S,Escribano O,Benito M

Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways.
International journal of molecular sciences20(3)(2019 Feb)
Mazibuko-Mbeje SE,Dludla PV,Roux C,Johnson R,Ghoor S,Joubert E,Louw J,Opoku AR,Muller CJF

The insulin receptor is differentially expressed in somatic and visceral primary sensory neurons.
Cell and tissue research374(2)243-249(2018 Nov)
Lázár BA,Jancsó G,Nagy I,Horváth V,Sántha P

Dendrobium mixture regulates hepatic gluconeogenesis in diabetic rats via the phosphoinositide-3-kinase/protein kinase B signaling pathway.
Experimental and therapeutic medicine16(1)204-212(2018 Jul)
Lin X,Shi H,Cui Y,Wang X,Zhang J,Yu W,Wei M

Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction.
Diabetes39(1)123-8(1990 Jan)
Seino S,Seino M,Bell GI

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Insr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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