Sst cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sst
Entrez Gene ID	24797
Full Name	somatostatin
Synonyms	SS-14,SS-28,Smst
General protein information	Preferred Names somatostatin Names somatostatin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q23
Summary	inhibits the secretion of several pituitary, pancreatic, and gastrointestinal hormones [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012659.2	NP_036791.1	somatostatin precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SST	NP_001003307.1
Mus musculus (house mouse)	Sst	NP_033241.1
Danio rerio (zebrafish)	sst1.1	NP_898893.1
Macaca mulatta (Rhesus monkey)	SST	XP_001103516.1
Gallus gallus (chicken)	SST	NP_990667.1
Bos taurus (cattle)	SST	NP_776385.1
Xenopus tropicalis (tropical clawed frog)	LOC100486511	XP_002944417.2
Xenopus tropicalis (tropical clawed frog)	sst	NP_001090807.1
Homo sapiens (human)	SST	NP_001039.1
Pan troglodytes (chimpanzee)	SST	XP_003310215.1
Rattus norvegicus (Norway rat)	Sst	NP_036791.1

Gene Ontology
Bibliography

Related articles in PubMed

Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.
Elrick MM, Samson WK, Corbett JA, Salvatori AS, Stein LM, Kolar GR, Naatz A, Yosten GL
American journal of physiology. Regulatory, integrative and comparative physiology310(2)R143-55(2016 Jan)

Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus.
Zou S, Kumar U
Brain research1622114-26(2015 Oct)

Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells.
Chen W, Ke JB, Wu HJ, Miao Y, Li F, Yang XL, Wang Z
Neuroscience273118-27(2014 Jul)

Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons.
Takahashi M, Takeda M, Matsumoto S
Brain research bulletin10076-83(2014 Jan)

The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia.
Jovanović AA, Babović SS, Damjanović A, Puskas L, Lazić D, Cvetić T, Jasović-Gasić M
Collegium antropologicum37(3)847-52(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sst gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sst cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42959	NM_012659.2 Latest version!	Rattus norvegicus somatostatin (Sst), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sst ( NM_012659.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036791.1 Rattus norvegicus somatostatin (Sst), mRNA.

Price & Availability↑

CloneID	ORa42959
Clone ID Related Accession (Same CDS sequence)	NM_012659.2
Accession Version	NM_012659.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569168000000
Organism	Rattus norvegicus(Norway rat)
Product	somatostatin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07034592.1. On Jun 13, 2015 this sequence version replaced NM_012659.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DV718445.1, M25890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGTCCT GCCGTCTCCA GTGCGCGCTG GCCGCGCTCT GCATCGTCCT GGCTTTGGGC 
GGTGTCACCG GGGCGCCCTC GGACCCCAGA CTCCGTCAGT TTCTGCAGAA GTCTCTGGCG 
GCTGCCACCG GGAAACAGGA ACTGGCCAAG TACTTCTTGG CAGAACTGCT GTCCGAGCCC 
AACCAGACAG AGAACGATGC CCTGGAGCCT GAGGATTTGC CCCAGGCAGC TGAGCAGGAC 
GAGATGAGGC TGGAGCTGCA GAGGTCTGCC AACTCGAACC CAGCCATGGC ACCCCGGGAA 
CGCAAAGCTG GCTGCAAGAA CTTCTTCTGG AAGACATTCA CATCCTGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036791.1
CDS	151..501
Translation	MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC

Target ORF information:

RefSeq Version	NM_012659.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus somatostatin (Sst), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012659.2

ORF Insert Sequence:

ATGCTGTCCT GCCGTCTCCA GTGCGCGCTG GCCGCGCTCT GCATCGTCCT GGCTTTGGGC 
GGTGTCACCG GGGCGCCCTC GGACCCCAGA CTCCGTCAGT TTCTGCAGAA GTCTCTGGCG 
GCTGCCACCG GGAAACAGGA ACTGGCCAAG TACTTCTTGG CAGAACTGCT GTCCGAGCCC 
AACCAGACAG AGAACGATGC CCTGGAGCCT GAGGATTTGC CCCAGGCAGC TGAGCAGGAC 
GAGATGAGGC TGGAGCTGCA GAGGTCTGCC AACTCGAACC CAGCCATGGC ACCCCGGGAA 
CGCAAAGCTG GCTGCAAGAA CTTCTTCTGG AAGACATTCA CATCCTGTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.
American journal of physiology. Regulatory, integrative and comparative physiology310(2)R143-55(2016 Jan)
Elrick MM,Samson WK,Corbett JA,Salvatori AS,Stein LM,Kolar GR,Naatz A,Yosten GL

Colocalization of cannabinoid receptor 1 with somatostatin and neuronal nitric oxide synthase in rat brain hippocampus.
Brain research1622114-26(2015 Oct)
Zou S,Kumar U

Somatostatin receptor-mediated suppression of gabaergic synaptic transmission in cultured rat retinal amacrine cells.
Neuroscience273118-27(2014 Jul)
Chen W,Ke JB,Wu HJ,Miao Y,Li F,Yang XL,Wang Z

Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons.
Brain research bulletin10076-83(2014 Jan)
Takahashi M,Takeda M,Matsumoto S

The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia.
Collegium antropologicum37(3)847-52(2013 Sep)
Jovanović AA,Babović SS,Damjanović A,Puskas L,Lazić D,Cvetić T,Jasović-Gasić M