Prlr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prlr
Entrez Gene ID	24684
Full Name	prolactin receptor
Synonyms	RATPRLR
General protein information	Preferred Names prolactin receptor Names prolactin receptor PRL-R lactogen receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q16

mRNA and Protein(s)

mRNA	Protein	Name
NM_001034111.1	NP_001029283.1	prolactin receptor isoform a precursor
NM_012630.2	NP_036762.1	prolactin receptor isoform b precursor
XM_017590635.1	XP_017446124.1	prolactin receptor isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PRLR	XP_005619456.1
Macaca mulatta (Rhesus monkey)	PRLR	XP_001092241.1
Mus musculus (house mouse)	Prlr	NP_035299.4
Danio rerio (zebrafish)	prlra	NP_001122149.1
Bos taurus (cattle)	PRLR	NP_001034815.1
Rattus norvegicus (Norway rat)	Prlr	NP_001029283.1
Gallus gallus (chicken)	PRLR	NP_990185.1
Xenopus tropicalis (tropical clawed frog)	prlr	XP_002940001.1
Homo sapiens (human)	PRLR	NP_000940.1
Pan troglodytes (chimpanzee)	PRLR	XP_001150064.2

Gene Ontology
Bibliography

Related articles in PubMed

Prolactin prevents the kainic acid-induced neuronal loss in the rat hippocampus by inducing prolactin receptor and putatively increasing the VGLUT1 overexpression.
Ortiz-Pérez A, Limón-Morales O, Rojas-Castañeda JC, Cerbón M, Picazo O
Neuroscience letters694116-123(2019 02)

Prolactin mediates neuroprotection against excitotoxicity in primary cell cultures of hippocampal neurons via its receptor.
Vergara-Castañeda E, Grattan DR, Pasantes-Morales H, Pérez-Domínguez M, Cabrera-Reyes EA, Morales T, Cerbón M
Brain research1636193-199(2016 Apr)

Correlation of prolactin levels and PRL-receptor expression with Stat and Mapk cell signaling in the prostate of long-term sexually active rats.
Rojas-Durán F, Pascual-Mathey LI, Serrano K, Aranda-Abreu GE, Manzo J, Soto-Cid AH, Hernandez ME
Physiology & behavior138188-92(2015 Jan)

Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression.
Arumugam R, Fleenor D, Freemark M
Endocrine46(3)568-76(2014 Aug)

Impact of lactobacilli on orally acquired listeriosis.
Archambaud C, Nahori MA, Soubigou G, Bécavin C, Laval L, Lechat P, Smokvina T, Langella P, Lecuit M, Cossart P
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Prlr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prlr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00499	NM_012630.2 Latest version!	Rattus norvegicus prolactin receptor (Prlr), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa08871	NM_001034111.1 Latest version!	Rattus norvegicus prolactin receptor (Prlr), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa42946	XM_017590635.1 Latest version!	Rattus norvegicus prolactin receptor (Prlr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prlr ( NM_012630.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036762.1 Rattus norvegicus prolactin receptor (Prlr), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa00499
Clone ID Related Accession (Same CDS sequence)	NM_012630.2
Accession Version	NM_012630.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569254400000
Organism	Rattus norvegicus(Norway rat)
Product	prolactin receptor isoform b precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M19304.1. On Aug 30, 2012 this sequence version replaced NM_012630.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M19304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGCCATCTG CACTTGCTTT CGTCCTACTT GTTCTCAACA TCAGCCTCCT GAAGGGACAG 
TCACCACCAG GGAAACCTGA GATCCACAAA TGTCGCTCTC CTGACAAGGA AACATTCACC 
TGCTGGTGGA ATCCTGGGAC AGATGGAGGA CTTCCTACCA ATTATTCACT GACTTACAGC 
AAAGAAGGAG AGAAAACCAC CTACGAATGT CCAGACTACA AAACCAGTGG CCCCAACTCC 
TGCTTCTTTA GCAAGCAGTA CACTTCCATC TGGAAAATAT ATATCATCAC AGTAAATGCC 
ACGAACCAAA TGGGAAGCAG TTCCTCGGAT CCACTTTATG TGGATGTGAC TTACATCGTT 
GAGCCAGAGC CTCCTCGGAA CCTGACATTA GAAGTAAAAC AGCTAAAAGA CAAAAAAACA 
TATCTGTGGG TAAAATGGTC CCCACCCACC ATAACTGATG TGAAAACTGG TTGGTTTACA 
ATGGAATATG AAATTCGATT AAAGCCTGAA GAAGCAGAAG AGTGGGAGAT CCATTTTACA 
GGTCATCAAA CACAGTTTAA AGTTTTTGAC CTATATCCAG GGCAAAAGTA TCTTGTCCAG 
ACTCGCTGCA AGCCAGACCA TGGATACTGG AGTAGATGGA GCCAGGAGAG TTCCGTTGAA 
ATGCCAAATG ACTTCACCTT GAAGGACACA ACCGTGTGGA TCATTGTGGC CATTCTCTCT 
GCTGTCATCT GTTTGATTAT GGTCTGGGCA GTGGCTTTGA AGGGCTATAG CATGATGACC 
TGCATCTTTC CACCAGTTCC TGGGCCAAAA ATAAAAGGAT TTGATACCCA TCTGCTGGAG 
ACTGGTTCTC CAAGCAAATA CAAGGTGGAT CTGTACCTGG CCCTTCCTGG AGGATTCCAG 
AAACTGGACA ATGCAGGGGA ACTTGACTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036762.1
CDS	207..1139
Translation	MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWNPGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATNQMGSSSSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFTMEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESSVEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDTHLLETGSPSKYKVDLYLALPGGFQKLDNAGELDY

Target ORF information:

RefSeq Version	NM_012630.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prolactin receptor (Prlr), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012630.2

ORF Insert Sequence:

ATGCCATCTG CACTTGCTTT CGTCCTACTT GTTCTCAACA TCAGCCTCCT GAAGGGACAG 
TCACCACCAG GGAAACCTGA GATCCACAAA TGTCGCTCTC CTGACAAGGA AACATTCACC 
TGCTGGTGGA ATCCTGGGAC AGATGGAGGA CTTCCTACCA ATTATTCACT GACTTACAGC 
AAAGAAGGAG AGAAAACCAC CTACGAATGT CCAGACTACA AAACCAGTGG CCCCAACTCC 
TGCTTCTTTA GCAAGCAGTA CACTTCCATC TGGAAAATAT ATATCATCAC AGTAAATGCC 
ACGAACCAAA TGGGAAGCAG TTCCTCGGAT CCACTTTATG TGGATGTGAC TTACATCGTT 
GAGCCAGAGC CTCCTCGGAA CCTGACATTA GAAGTAAAAC AGCTAAAAGA CAAAAAAACA 
TATCTGTGGG TAAAATGGTC CCCACCCACC ATAACTGATG TGAAAACTGG TTGGTTTACA 
ATGGAATATG AAATTCGATT AAAGCCTGAA GAAGCAGAAG AGTGGGAGAT CCATTTTACA 
GGTCATCAAA CACAGTTTAA AGTTTTTGAC CTATATCCAG GGCAAAAGTA TCTTGTCCAG 
ACTCGCTGCA AGCCAGACCA TGGATACTGG AGTAGATGGA GCCAGGAGAG TTCCGTTGAA 
ATGCCAAATG ACTTCACCTT GAAGGACACA ACCGTGTGGA TCATTGTGGC CATTCTCTCT 
GCTGTCATCT GTTTGATTAT GGTCTGGGCA GTGGCTTTGA AGGGCTATAG CATGATGACC 
TGCATCTTTC CACCAGTTCC TGGGCCAAAA ATAAAAGGAT TTGATACCCA TCTGCTGGAG 
ACTGGTTCTC CAAGCAAATA CAAGGTGGAT CTGTACCTGG CCCTTCCTGG AGGATTCCAG 
AAACTGGACA ATGCAGGGGA ACTTGACTAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prlr ( NM_001034111.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001029283.1 Rattus norvegicus prolactin receptor (Prlr), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa08871
Clone ID Related Accession (Same CDS sequence)	NM_001034111.1
Accession Version	NM_001034111.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1833bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577030400000
Organism	Rattus norvegicus(Norway rat)
Product	prolactin receptor isoform a precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M57668.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M57668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689601 [ECO:0000348] ##Evidence-Data-END##

ATGCCATCTG CACTTGCTTT CGTCCTACTT GTTCTCAACA TCAGCCTCCT GAAGGGACAG 
TCACCACCAG GGAAACCTGA GATCCACAAA TGTCGCTCTC CTGACAAGGA AACATTCACC 
TGCTGGTGGA ATCCTGGGAC AGATGGAGGA CTTCCTACCA ATTATTCACT GACTTACAGC 
AAAGAAGGAG AGAAAACCAC CTACGAATGT CCAGACTACA AAACCAGTGG CCCCAACTCC 
TGCTTCTTTA GCAAGCAGTA CACTTCCATC TGGAAAATAT ATATCATCAC AGTAAATGCC 
ACGAACCAAA TGGGAAGCAG TTCCTCGGAT CCACTTTATG TGGATGTGAC TTACATCGTT 
GAGCCAGAGC CTCCTCGGAA CCTGACATTA GAAGTAAAAC AGCTAAAAGA CAAAAAAACA 
TATCTGTGGG TAAAATGGTC CCCACCCACC ATAACTGATG TGAAAACTGG TTGGTTTACA 
ATGGAATATG AAATTCGATT AAAGCCTGAA GAAGCAGAAG AGTGGGAGAT CCATTTTACA 
GGTCATCAAA CACAGTTTAA AGTTTTTGAC CTATATCCAG GGCAAAAGTA TCTTGTCCAG 
ACTCGCTGCA AGCCAGACCA TGGATACTGG AGTAGATGGA GCCAGGAGAG TTCCGTTGAA 
ATGCCAAATG ACTTCACCTT GAAGGACACA ACCGTGTGGA TCATTGTGGC CATTCTCTCT 
GCTGTCATCT GTTTGATTAT GGTCTGGGCA GTGGCTTTGA AGGGCTATAG CATGATGACC 
TGCATCTTTC CACCAGTTCC TGGGCCAAAA ATAAAAGGAT TTGATACCCA TCTGCTGGAG 
AAGGGCAAGT CTGAAGAGCT GCTGAGTGCC TTGGGGTGCC AAGACTTTCC CCCTACTTCT 
GACTGTGAGG ACTTGCTGGT GGAGTTCTTA GAAGTTGATG ACAATGAGGA CGAGCGGCTA 
ATGCCATCCC ATTCCAAAGA GTATCCAGGT CAAGGTGTTA AGCCCACACA CCTAGATCCC 
GACAGTGACT CTGGTCACGG AAGCTATGAC AGCCATTCTC TTTTATCTGA AAAGTGTGAG 
GAACCCCAGG CCTACCCCCC TACTTTGCAC ATCCCTGAGA TCACTGAGAA GCCAGAGAAT 
CCTGAAGCAA ATATTCCTCC CACCGTGGAC CCCCAAAGCA CCAACCCCAA TTTTCATGTA 
GATGCACCCA AATCTTCAAC ATGGCCATTA CTGCCTGGCC AACACATGCC CAGATCTCCT 
TACCACAGTG TTGCTGATGT GTGCAAGCTA GCCGGAAGTC CTGTGAATAC ACTGGACTCT 
TTCTTGGACA AAGCAGAGGA AAATGTTCTA AAGTTGTCTA AAGCCCTTGA GACTGGAGAG 
GAAGAAGTGG CTAAGCAAAA AGGGGCAAAA AGCTTCCCTT CTGACAAACA AAACACACCT 
TGGCCGCTGC TCCAGGAGAA AAGCCCCACT GTCTATGTTA AACCCCCAGA TTATGTGGAG 
ATTCACAAAG TCAACAAAGA TGGAGTGCTA TCATTATTCC CCAAGCAGAG AGAAAACAAC 
CAGACAGAGA AGCCTGGGGT TCCTGAAACC AGTAAGGAGT ATGCCAAGGT GTCTGGCATT 
ATGGATAACA ATATCCTCGT ATTAGTGCCA GACTCACGAG CCCAGAACAC AGCGTTGCTC 
GAGGAATCAG CCAAGAAGGC TCCACCATCG TTTGAAGCTG ACCAATCTGA GAAAGATCTG 
GCCAGCTTCA CTGCAACCTC AAGCAACCGC AGACTCCAAC TGGGTAGGCT GGATTACCTG 
GATCCTACGT GCTTCATGCA CTCCTTTCAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001029283.1
CDS	197..2029
Translation	MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWNPGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATNQMGSSSSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFTMEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESSVEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDTHLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVKPTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPTLHIPEITEKPENPEANIPPTVDPQSTNPNFHVDAPKSSTWPLLPGQHMPRSPYHSVADVCKLAGSPVNTLDSFLDKAEENVLKLSKALETGEEEVAKQKGAKSFPSDKQNTPWPLLQEKSPTVYVKPPDYVEIHKVNKDGVLSLFPKQRENNQTEKPGVPETSKEYAKVSGIMDNNILVLVPDSRAQNTALLEESAKKAPPSFEADQSEKDLASFTATSSNRRLQLGRLDYLDPTCFMHSFH

Target ORF information:

RefSeq Version	NM_001034111.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prolactin receptor (Prlr), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001034111.1

ORF Insert Sequence:

ATGCCATCTG CACTTGCTTT CGTCCTACTT GTTCTCAACA TCAGCCTCCT GAAGGGACAG 
TCACCACCAG GGAAACCTGA GATCCACAAA TGTCGCTCTC CTGACAAGGA AACATTCACC 
TGCTGGTGGA ATCCTGGGAC AGATGGAGGA CTTCCTACCA ATTATTCACT GACTTACAGC 
AAAGAAGGAG AGAAAACCAC CTACGAATGT CCAGACTACA AAACCAGTGG CCCCAACTCC 
TGCTTCTTTA GCAAGCAGTA CACTTCCATC TGGAAAATAT ATATCATCAC AGTAAATGCC 
ACGAACCAAA TGGGAAGCAG TTCCTCGGAT CCACTTTATG TGGATGTGAC TTACATCGTT 
GAGCCAGAGC CTCCTCGGAA CCTGACATTA GAAGTAAAAC AGCTAAAAGA CAAAAAAACA 
TATCTGTGGG TAAAATGGTC CCCACCCACC ATAACTGATG TGAAAACTGG TTGGTTTACA 
ATGGAATATG AAATTCGATT AAAGCCTGAA GAAGCAGAAG AGTGGGAGAT CCATTTTACA 
GGTCATCAAA CACAGTTTAA AGTTTTTGAC CTATATCCAG GGCAAAAGTA TCTTGTCCAG 
ACTCGCTGCA AGCCAGACCA TGGATACTGG AGTAGATGGA GCCAGGAGAG TTCCGTTGAA 
ATGCCAAATG ACTTCACCTT GAAGGACACA ACCGTGTGGA TCATTGTGGC CATTCTCTCT 
GCTGTCATCT GTTTGATTAT GGTCTGGGCA GTGGCTTTGA AGGGCTATAG CATGATGACC 
TGCATCTTTC CACCAGTTCC TGGGCCAAAA ATAAAAGGAT TTGATACCCA TCTGCTGGAG 
AAGGGCAAGT CTGAAGAGCT GCTGAGTGCC TTGGGGTGCC AAGACTTTCC CCCTACTTCT 
GACTGTGAGG ACTTGCTGGT GGAGTTCTTA GAAGTTGATG ACAATGAGGA CGAGCGGCTA 
ATGCCATCCC ATTCCAAAGA GTATCCAGGT CAAGGTGTTA AGCCCACACA CCTAGATCCC 
GACAGTGACT CTGGTCACGG AAGCTATGAC AGCCATTCTC TTTTATCTGA AAAGTGTGAG 
GAACCCCAGG CCTACCCCCC TACTTTGCAC ATCCCTGAGA TCACTGAGAA GCCAGAGAAT 
CCTGAAGCAA ATATTCCTCC CACCGTGGAC CCCCAAAGCA CCAACCCCAA TTTTCATGTA 
GATGCACCCA AATCTTCAAC ATGGCCATTA CTGCCTGGCC AACACATGCC CAGATCTCCT 
TACCACAGTG TTGCTGATGT GTGCAAGCTA GCCGGAAGTC CTGTGAATAC ACTGGACTCT 
TTCTTGGACA AAGCAGAGGA AAATGTTCTA AAGTTGTCTA AAGCCCTTGA GACTGGAGAG 
GAAGAAGTGG CTAAGCAAAA AGGGGCAAAA AGCTTCCCTT CTGACAAACA AAACACACCT 
TGGCCGCTGC TCCAGGAGAA AAGCCCCACT GTCTATGTTA AACCCCCAGA TTATGTGGAG 
ATTCACAAAG TCAACAAAGA TGGAGTGCTA TCATTATTCC CCAAGCAGAG AGAAAACAAC 
CAGACAGAGA AGCCTGGGGT TCCTGAAACC AGTAAGGAGT ATGCCAAGGT GTCTGGCATT 
ATGGATAACA ATATCCTCGT ATTAGTGCCA GACTCACGAG CCCAGAACAC AGCGTTGCTC 
GAGGAATCAG CCAAGAAGGC TCCACCATCG TTTGAAGCTG ACCAATCTGA GAAAGATCTG 
GCCAGCTTCA CTGCAACCTC AAGCAACCGC AGACTCCAAC TGGGTAGGCT GGATTACCTG 
GATCCTACGT GCTTCATGCA CTCCTTTCAC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prlr ( XM_017590635.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446124.1 Rattus norvegicus prolactin receptor (Prlr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa42946
Clone ID Related Accession (Same CDS sequence)	XM_017590635.1
Accession Version	XM_017590635.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2841bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	prolactin receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 3% of CDS bases ##RefSeq-Attributes-END##

ATGCCATCTG CACTTGCTTT CGTCCTACTT GTTCTCAACA TCAGCCTCCT GAAGGGACAG 
TCACCACCAG GGAAACCTGA GATCCACAAA TGTCGCTCTC CTGACAAGGA AACATTCACC 
TGCTGGTGGA ATCCTGGGAC AGATGGAGGA CTTCCTACCA ATTATTCACT GACTTACAGC 
AAAGAAGGAG AGAAAACCAC CTACGAATGT CCAGACTACA AAACCAGCGG CCCCAACTCC 
TGCTTCTTTA GCAAGCAGTA CACTTCCATC TGGAAAATAT ATATCATCAC AGTAAATGCC 
ACGAACCAAA TGGGAAGCAG TTCCTCGGAT CCACTTTATG TGGATGTGAC TTACATCGGG 
ATTTTAAATA GTTTATCCTT CCTTCTGCTG AGTGCCTTGG GGTGCCAAGA CTTTCCCCCT 
ACTTCTGACT GTGAGGACTT GCTGGTGGAG TTCTTAGAAG TTGATGACAA TGAGGACGAG 
CGGCTAATGC CATCCCATTC CAAAGAGTAT CCAGGTCAGG GTGTTAAGCC CACACACCTA 
GATCCCGACA GTGACTCTGG TCACGGAAGC TATGACAGCC ATTCTCTTTT ATCTGAAAAG 
TGTGAGGAAC CCCAGGCCTA CCCCCCTACT TTGCACATCC CTGAGATCAC TGAGAAGCCA 
GAGAATCCTG AAGCAAATAT TCCTCCCACC GTGGACCCCC AAAGCACCAA CCCCAATTTT 
CATGTAGATG CACCCAAATC TTCAACATGG CCATTACTGC CTGGCCAACA CATGCCCAGA 
TCTCCTTACC ACAGTGTTGC TGATGTGTGC AAGCTAGCCG GAAGTCCTGT GAATACACTG 
GACTCTTTCT TGGACAAAGC AGAGGAAAAT GTTCTAAAGT TGTCTAAAGC CCTTGAGACT 
GGAGAGGAAG AAGTGGCTGA GCAAAAAGGG GCAAAAAGCT TCCCTTCTGA CAAACAAAAC 
ACACCTTGGC CGCTGCTCCA GGAGAAAAGC CCCACTGTCT ATGTTAAACC CCCAGATTAT 
GTGGAGATTC ACAAAGTCAA CAAAGATGGA GTGCTATCAT TATTCCCCAA GCAGAGAGAA 
AACAACCAGA CAGAGAAGCC TGGGGTTCCT GAAACCAGTA AGGAGTATGC CAAGGTGTCT 
GGCATTACGG ATAACAATAT CCTCGTATTA GTGCCAGACT CACGAGCCCA GAACACAGCG 
TTGCTCGAGG AATCAGCCAA GAAGGCTCCA CCATCGTTTG AAGCTGACCA ATCTGAGAAA 
GATCTGGCCA GCTTCACTGC AACCTCAAGC AACCGCAGAC TCCAACTGGG CGCTCCTGCC 
CCCACGTTGA GTGGAAGTCT CAGCAACACG CACATGGAAC AAGGAATATT GAGCCAGAGC 
TCTCGGAACC TGACATTAGA AGTAAAACAG CTAAAAGACA AAAAAACATA TCTGTGGGTA 
AAATGGTCCC CACCCACCAT AACTGATGTG AAAACTGGTT GGTTTACAAT GGAATATGAA 
ATTCGATTAA AGCCTGAAGA AGCAGAAGAG TGGGAGATCC ATTTTACAGG TCATCAAACA 
CAGTTTAAAG TTTTTGACCT ATATCCAGGG CAAAAGTATC TTGTCCAGAC TCGCTGCAAG 
CCAGACCATG GATACTGGAG TAGATGGAGC CAGGAGAGTT CCGTTGAAAT GCCAAATGAC 
TTCACCTTGA AGGACACAAC CGTGTGGATC ATTGTGGCCA TTCTCTCTGC TGTCATCTGT 
TTGATTATGG TCTGGGCAGT GGCTTTGAAG GGCTATAGCA TGATGACCTG CATCTTTCCA 
CCAGTTCCTG GGCCAAAAAT AAAAGGATTT GATACCCATC TGCTGGAGAA GGGCAAGTCT 
GAAGAGCTGC TGAGTGCCTT GGGGTGCCAA GACTTTCCCC CTACTTCTGA CTGTGAGGAC 
TTGCTGGTGG AGTTCTTAGA AGTTGATGAC AATGAGGACG AGCGGCTAAT GCCATCCCAT 
TCCAAAGAGT ATCCAGGTCA GGGTGTTAAG CCCACACACC TAGATCCCGA CAGTGACTCT 
GGTCACGGAA GCTATGACAG CCATTCTCTT TTATCTGAAA AGTGTGAGGA ACCCCAGGCC 
TACCCCCCTA CTTTGCACAT CCCTGAGATC ACTGAGAAGC CAGAGAATCC TGAAGCAAAT 
ATTCCTCCCA CCGTGGACCC CCAAAGCACC AACCCCAATT TTCATGTAGA TGCACCCAAA 
TCTTCAACAT GGCCATTACT GCCTGGCCAA CACATGCCCA GATCTCCTTA CCACAGTGTT 
GCTGATGTGT GCAAGCTAGC CGGAAGTCCT GTGAATACAC TGGACTCTTT CTTGGACAAA 
GCAGAGGAAA ATGTTCTAAA GTTGTCTAAA GCCCTTGAGA CTGGAGAGGA AGAAGTGGCT 
GAGCAAAAAG GGGCAAAAAG CTTCCCTTCT GACAAACAAA ACACACCTTG GCCGCTGCTC 
CAGGAGAAAA GCCCCACTGT CTATGTTAAA CCCCCAGATT ATGTGGAGAT TCACAAAGTC 
AACAAAGATG GAGTGCTATC ATTATTCCCC AAGCAGAGAG AAAACAACCA GACAGAGAAG 
CCTGGGGTTC CTGAAACCAG TAAGGAGTAT GCCAAGGTGT CTGGCATTAC GGATAACAAT 
ATCCTCGTAT TAGTGCCAGA CTCACGAGCC CAGAACACAG CGTTGCTCGA GGAATCAGCC 
AAGAAGGCTC CACCATCGTT TGAAGCTGAC CAATCTGAGA AAGATCTGGC CAGCTTCACT 
GCAACCTCAA GCAACCGCAG ACTCCAACTG GGTAGGCTGG ATTACCTGGA TCCTACGTGC 
TTCATGCACT CCTTTCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446124.1
CDS	600..3440
Translation	MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWNPGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATNQMGSSSSDPLYVDVTYIGILNSLSFLLLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVKPTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPTLHIPEITEKPENPEANIPPTVDPQSTNPNFHVDAPKSSTWPLLPGQHMPRSPYHSVADVCKLAGSPVNTLDSFLDKAEENVLKLSKALETGEEEVAEQKGAKSFPSDKQNTPWPLLQEKSPTVYVKPPDYVEIHKVNKDGVLSLFPKQRENNQTEKPGVPETSKEYAKVSGITDNNILVLVPDSRAQNTALLEESAKKAPPSFEADQSEKDLASFTATSSNRRLQLGAPAPTLSGSLSNTHMEQGILSQSSRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFTMEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESSVEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDTHLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVKPTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPTLHIPEITEKPENPEANIPPTVDPQSTNPNFHVDAPKSSTWPLLPGQHMPRSPYHSVADVCKLAGSPVNTLDSFLDKAEENVLKLSKALETGEEEVAEQKGAKSFPSDKQNTPWPLLQEKSPTVYVKPPDYVEIHKVNKDGVLSLFPKQRENNQTEKPGVPETSKEYAKVSGITDNNILVLVPDSRAQNTALLEESAKKAPPSFEADQSEKDLASFTATSSNRRLQLGRLDYLDPTCFMHSFH

Target ORF information:

RefSeq Version	XM_017590635.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prolactin receptor (Prlr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590635.1

ORF Insert Sequence:

ATGCCATCTG CACTTGCTTT CGTCCTACTT GTTCTCAACA TCAGCCTCCT GAAGGGACAG 
TCACCACCAG GGAAACCTGA GATCCACAAA TGTCGCTCTC CTGACAAGGA AACATTCACC 
TGCTGGTGGA ATCCTGGGAC AGATGGAGGA CTTCCTACCA ATTATTCACT GACTTACAGC 
AAAGAAGGAG AGAAAACCAC CTACGAATGT CCAGACTACA AAACCAGCGG CCCCAACTCC 
TGCTTCTTTA GCAAGCAGTA CACTTCCATC TGGAAAATAT ATATCATCAC AGTAAATGCC 
ACGAACCAAA TGGGAAGCAG TTCCTCGGAT CCACTTTATG TGGATGTGAC TTACATCGGG 
ATTTTAAATA GTTTATCCTT CCTTCTGCTG AGTGCCTTGG GGTGCCAAGA CTTTCCCCCT 
ACTTCTGACT GTGAGGACTT GCTGGTGGAG TTCTTAGAAG TTGATGACAA TGAGGACGAG 
CGGCTAATGC CATCCCATTC CAAAGAGTAT CCAGGTCAGG GTGTTAAGCC CACACACCTA 
GATCCCGACA GTGACTCTGG TCACGGAAGC TATGACAGCC ATTCTCTTTT ATCTGAAAAG 
TGTGAGGAAC CCCAGGCCTA CCCCCCTACT TTGCACATCC CTGAGATCAC TGAGAAGCCA 
GAGAATCCTG AAGCAAATAT TCCTCCCACC GTGGACCCCC AAAGCACCAA CCCCAATTTT 
CATGTAGATG CACCCAAATC TTCAACATGG CCATTACTGC CTGGCCAACA CATGCCCAGA 
TCTCCTTACC ACAGTGTTGC TGATGTGTGC AAGCTAGCCG GAAGTCCTGT GAATACACTG 
GACTCTTTCT TGGACAAAGC AGAGGAAAAT GTTCTAAAGT TGTCTAAAGC CCTTGAGACT 
GGAGAGGAAG AAGTGGCTGA GCAAAAAGGG GCAAAAAGCT TCCCTTCTGA CAAACAAAAC 
ACACCTTGGC CGCTGCTCCA GGAGAAAAGC CCCACTGTCT ATGTTAAACC CCCAGATTAT 
GTGGAGATTC ACAAAGTCAA CAAAGATGGA GTGCTATCAT TATTCCCCAA GCAGAGAGAA 
AACAACCAGA CAGAGAAGCC TGGGGTTCCT GAAACCAGTA AGGAGTATGC CAAGGTGTCT 
GGCATTACGG ATAACAATAT CCTCGTATTA GTGCCAGACT CACGAGCCCA GAACACAGCG 
TTGCTCGAGG AATCAGCCAA GAAGGCTCCA CCATCGTTTG AAGCTGACCA ATCTGAGAAA 
GATCTGGCCA GCTTCACTGC AACCTCAAGC AACCGCAGAC TCCAACTGGG CGCTCCTGCC 
CCCACGTTGA GTGGAAGTCT CAGCAACACG CACATGGAAC AAGGAATATT GAGCCAGAGC 
TCTCGGAACC TGACATTAGA AGTAAAACAG CTAAAAGACA AAAAAACATA TCTGTGGGTA 
AAATGGTCCC CACCCACCAT AACTGATGTG AAAACTGGTT GGTTTACAAT GGAATATGAA 
ATTCGATTAA AGCCTGAAGA AGCAGAAGAG TGGGAGATCC ATTTTACAGG TCATCAAACA 
CAGTTTAAAG TTTTTGACCT ATATCCAGGG CAAAAGTATC TTGTCCAGAC TCGCTGCAAG 
CCAGACCATG GATACTGGAG TAGATGGAGC CAGGAGAGTT CCGTTGAAAT GCCAAATGAC 
TTCACCTTGA AGGACACAAC CGTGTGGATC ATTGTGGCCA TTCTCTCTGC TGTCATCTGT 
TTGATTATGG TCTGGGCAGT GGCTTTGAAG GGCTATAGCA TGATGACCTG CATCTTTCCA 
CCAGTTCCTG GGCCAAAAAT AAAAGGATTT GATACCCATC TGCTGGAGAA GGGCAAGTCT 
GAAGAGCTGC TGAGTGCCTT GGGGTGCCAA GACTTTCCCC CTACTTCTGA CTGTGAGGAC 
TTGCTGGTGG AGTTCTTAGA AGTTGATGAC AATGAGGACG AGCGGCTAAT GCCATCCCAT 
TCCAAAGAGT ATCCAGGTCA GGGTGTTAAG CCCACACACC TAGATCCCGA CAGTGACTCT 
GGTCACGGAA GCTATGACAG CCATTCTCTT TTATCTGAAA AGTGTGAGGA ACCCCAGGCC 
TACCCCCCTA CTTTGCACAT CCCTGAGATC ACTGAGAAGC CAGAGAATCC TGAAGCAAAT 
ATTCCTCCCA CCGTGGACCC CCAAAGCACC AACCCCAATT TTCATGTAGA TGCACCCAAA 
TCTTCAACAT GGCCATTACT GCCTGGCCAA CACATGCCCA GATCTCCTTA CCACAGTGTT 
GCTGATGTGT GCAAGCTAGC CGGAAGTCCT GTGAATACAC TGGACTCTTT CTTGGACAAA 
GCAGAGGAAA ATGTTCTAAA GTTGTCTAAA GCCCTTGAGA CTGGAGAGGA AGAAGTGGCT 
GAGCAAAAAG GGGCAAAAAG CTTCCCTTCT GACAAACAAA ACACACCTTG GCCGCTGCTC 
CAGGAGAAAA GCCCCACTGT CTATGTTAAA CCCCCAGATT ATGTGGAGAT TCACAAAGTC 
AACAAAGATG GAGTGCTATC ATTATTCCCC AAGCAGAGAG AAAACAACCA GACAGAGAAG 
CCTGGGGTTC CTGAAACCAG TAAGGAGTAT GCCAAGGTGT CTGGCATTAC GGATAACAAT 
ATCCTCGTAT TAGTGCCAGA CTCACGAGCC CAGAACACAG CGTTGCTCGA GGAATCAGCC 
AAGAAGGCTC CACCATCGTT TGAAGCTGAC CAATCTGAGA AAGATCTGGC CAGCTTCACT 
GCAACCTCAA GCAACCGCAG ACTCCAACTG GGTAGGCTGG ATTACCTGGA TCCTACGTGC 
TTCATGCACT CCTTTCACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prolactin prevents the kainic acid-induced neuronal loss in the rat hippocampus by inducing prolactin receptor and putatively increasing the VGLUT1 overexpression.
Neuroscience letters694116-123(2019 02)
Ortiz-Pérez A,Limón-Morales O,Rojas-Castañeda JC,Cerbón M,Picazo O

Prolactin mediates neuroprotection against excitotoxicity in primary cell cultures of hippocampal neurons via its receptor.
Brain research1636193-199(2016 Apr)
Vergara-Castañeda E,Grattan DR,Pasantes-Morales H,Pérez-Domínguez M,Cabrera-Reyes EA,Morales T,Cerbón M

Correlation of prolactin levels and PRL-receptor expression with Stat and Mapk cell signaling in the prostate of long-term sexually active rats.
Physiology & behavior138188-92(2015 Jan)
Rojas-Durán F,Pascual-Mathey LI,Serrano K,Aranda-Abreu GE,Manzo J,Soto-Cid AH,Hernandez ME

Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression.
Endocrine46(3)568-76(2014 Aug)
Arumugam R,Fleenor D,Freemark M

Impact of lactobacilli on orally acquired listeriosis.
Proceedings of the National Academy of Sciences of the United States of America109(41)16684-9(2012 Oct)
Archambaud C,Nahori MA,Soubigou G,Bécavin C,Laval L,Lechat P,Smokvina T,Langella P,Lecuit M,Cossart P

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Prlr cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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