Unc13d cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Unc13d
Entrez Gene ID	192177
Full Name	unc-13 homolog D
Synonyms	Munc13-4,Unc13h4
General protein information	Preferred Names unc-13 homolog D Names protein unc-13 homolog D
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q32.1
Summary	may mediate synaptic vesicle exocytosis from glutamatergic synapses [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006247702.2	XP_006247764.1	protein unc-13 homolog D isoform X1
NM_138844.1	NP_620199.1	protein unc-13 homolog D

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UNC13D	NP_001179012.1
Pan troglodytes (chimpanzee)	UNC13D	XP_511686.3
Canis lupus familiaris (dog)	UNC13D	XP_540438.2
Macaca mulatta (Rhesus monkey)	UNC13D	XP_001100477.2
Mus musculus (house mouse)	Unc13d	NP_001009573.2
Danio rerio (zebrafish)	unc13d	XP_005156451.1
Homo sapiens (human)	UNC13D	NP_954712.1
Rattus norvegicus (Norway rat)	Unc13d	NP_620199.1
Gallus gallus (chicken)	UNC13D	XP_004946185.1
Xenopus tropicalis (tropical clawed frog)	unc13d	NP_001120507.1

Gene Ontology
Bibliography

Related articles in PubMed

Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37.
Higashio H, Satoh Y, Saino T
Scientific reports622539(2016 Mar)

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.
Man KN, Imig C, Walter AM, Pinheiro PS, Stevens DR, Rettig J, Sørensen JB, Cooper BH, Brose N, Wojcik SM
eLife4(2015 Nov)

A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis.
Zografou S, Basagiannis D, Papafotika A, Shirakawa R, Horiuchi H, Auerbach D, Fukuda M, Christoforidis S
Journal of cell science125(Pt 20)4780-90(2012 Oct)

Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7.
Peters CG, Michelson AD, Flaumenhaft R
Blood120(1)199-206(2012 Jul)

A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 function.
Elstak ED, te Loo M, Tesselaar K, van Kerkhof P, Loeffen J, Grivas D, Hennekam E, Boelens JJ, Hoogerbrugge PM, van der Sluijs P, van Gijn ME, van de Corput L
Pediatric blood & cancer58(4)598-605(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Unc13d gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Unc13d cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01709	NM_138844.1 Latest version!	Rattus norvegicus unc-13 homolog D (Unc13d), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00
ORa33911	XM_006247702.2 Latest version!	Rattus norvegicus unc-13 homolog D (C. elegans) (Unc13d), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$559.30 $799.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Unc13d ( NM_138844.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620199.1 Rattus norvegicus unc-13 homolog D (Unc13d), mRNA.

Price & Availability↑

CloneID	ORa01709
Clone ID Related Accession (Same CDS sequence)	NM_138844.1
Accession Version	NM_138844.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3267bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550160000000
Organism	Rattus norvegicus(Norway rat)
Product	protein unc-13 homolog D
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF159356.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF159356.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGACAC ACCTCTCCCA CCCCCAGCGG CGCCCTCCAC TCTTGCGCCA GGCCGTCAAG 
ATAAGGCGCC GCAGGGTCAG AGACCTGCAG GATCCACCGC CCCAAGCCAC CCCGGAGGTC 
CAGGTTCAAT CCCACCACTT CTCCCCGGAG GAGCGGGACC TGCTGTATGA GGAAGCCCTC 
TATACCGTCC TGCACCGCCT GGGTCAGCCA GAGCCCAACC ATGTGAAGGA GGCCTCGGAA 
CTGCTGTGCT ATCTGCAGGA GGCTTTCCAG GTGCAGCCCG AGGAGCACCA GCAGATGCTA 
CAGCGTGTCA GGGAGCTTGA GAAGCCAATA TTTTGTCTGA AGGCAACAGT GAAACAGGCC 
AAGGGCATTC TGGGCAAGGA TGTCAGCGGG TTCAGCGACC CCTATTGCCT GCTGGGCATC 
GAGCAGAAGG TTGGTGTGCC GGAGGGCAGC CCTGTGTCCC GGCGTCGGCA GAAGGCCGTG 
GTGAGGCACA CCATCCCTGA AGAGGAGACC CATCGCACCC AAGTCAAGAC CCAGACACTT 
AATCCCGTCT GGGACGAGAC CTTTATCTTG GAGTTTGAGG ATATAACTAA CGCAAGCTTT 
CACCTGGACA TGTGGGACCT GGACACTGTG GAGTCTGTCA GGCACAAGCT CGGGGAGCTC 
ACAGACCTGC ATGGGCTCAG GAGGATCTTT AAAGAAGCTC GGAAGGATAA AGGCCAGGAC 
GACTTTCTGG GGAATGTGAT GCTAAGATTG CAGGACCTGC GCTGCCGAGA GGATCAGTGG 
TTCCCGCTAG AGCCCTGCAC AGAGACCTAC CCAGACCGCG GCCAGTGTCA CCTGCAGTTC 
CAATTCATTC ACAAGCGGAG AGCCACGGTG GCCAGCCGCT CCCAGCCCAG CTACACTGTA 
CACTTTCACC TACTGCAGCA GCTGGTGTCC CATGAAGTCA CACAGCACCA GGCCGGCGGT 
ACCTCCTGGG GACGCATCGC TGAGTCCCAG GCCGTCACCA TCCTCTTTCT CCACGCCACC 
CAGAAGGACC TGTCAGACTT CCACCAGTCC ATGGCGCAGT GGTTGGCCTA CAGCCGCCTC 
TACCAGAGCC TGGAGTTCCC TAGCAGCTGC CTCCTGCACC CCATCACCAG CATAGAGTAC 
CAGTGGATCC AGGGCCGACT CAAAGCGGAA CAGCGGGAGG AGTTGGCCAC CTCCTTCACA 
TCCCTGTTGG CCTATGGCCT CTCCCTCATC CGGAAGTTCC GCTCCGTCTT TCCCCTGTCT 
GTCTCTGACT CCCCGTCCAG GCTGCAGTCC CTCCTCAGAG TCTTGGTCCA GATGTGCAAG 
ATGAAGGCCT TTGGAGAACT GTGCCCAGAC AGTGCCCCAC TGCCCCAGCT GGTTTCCGAA 
GCCCTGCGGA TGGGCACAGT TGAATGGTTT CACCTGATGC AGCAACACCA CCAGCCGATG 
GTACAGGGCA TCTTGGAGGC TGGCAAGGCC TTGCTGAGCC TGGTACAGGA CGTTATGGGT 
GATCTGTACC AGTGCCGTCG CACATGGAAC AAGATTTTTC ACAATGTCCT CAAGATAGAC 
CTGTTCACCA TGGCCTTCCT GGAGCTGCAA TGGCTGGTGG CCAAGAGGGT ACAGGACCAC 
ACGGCGGCGG TCGGCGACCT TGTTTCTCCA GATGTTGGAG AGAGTCTGTT TCAGCTCTAT 
GTCAGCCTGA GGGAGTTCTG CCAGCTGGGC CCCTCAGACA GCCATGAAGT CCTGGCCCTG 
GATGGTTTCC ACCGCTGGTT TCAGTCAGCC ATCCCTTCCT GGCTGCAGAG GACCTATAGC 
GTTGCCCTGG AGCGGGTGCA GCGAGCCGTA CAGATGGACT CGCTGGTACC CCTGGGTGAA 
CTGACCAAGC ATAGCACTTC TGCTGTGGAT CTGTCTACCT GCTTTGCCCA AATTAGCCAC 
ACTGCCCGGC AGCTGGACTG GCCAGACCCA GAGGAGGCCT TCATGATCAC GGTCAAGTTC 
GTGGAGGACA CCTGCCGGCT GGCCCTGGTC TACTGCAGCC TTATAAAGGC CCGGGCCCGA 
GAGCTGTCTG CGGTTCAGAA GGACCAGAGC CAGGCAGCTG ACATGCTGTG CGTGGTGGTA 
AATAATGTGG AGCGACTACG GTTGATCATC GACAAGCTGC CCACCCAACT GGCATGGGAG 
GCATTGGAGC AGCGGGTCGG GGCTGTGCTG GAGCAGGGGC AGCTGCAGAA CACGCTACAC 
ACTCAGCTGC AGGGCGCCTT GGCCGGGCTG GGCCACGAGA TCCGTACCGG TGTCCGTACT 
CTGGCAGAGC AGTTGGAAGT GGGCATTGCC ACACACATCC AGAAGCTCAT CGATGCCAAG 
GGGTCGATTC TGCCTGAGGA TGCCATTCTG CCCCTGATGA AATTCCTGGA GGTGAAGCTT 
TGTTACATGA ACACCAACCT GGTCCAGGAG AACTTCAGCA GCCTCCTGAC TCTACTGTGG 
ACCCACACAC TTACCGTGCT GGTGGAGGCG GCGGCTTCCC ATCGTAACTC GTCACTGGCT 
TCTAGCAGGC TGAAGGTCGC CCTCCAGAAC CTGGAGATCT GCTTCCATGC TGAGGGCTGT 
GGTCTACCAC CAGAGGCCCT GCACACAGAC ACCTTCCTGG CTCTGCAGAG CGACCTGGAG 
CTGCAGGCAG CCTCCAGCCG GGAGCTCATC CAGAAGTACT TCCGTAGCCG GATCCAACAG 
CAGGCGGAAA CCACTTCTGA GAGGCTGGGT GCAGTCACGG TCAAGGCGTC CTATCGAGCC 
TCTGAGCAGA AGCTGCACGT GGAGCTGCTC AGTGCCTCCA GCCTGCTGCC CCTTGACTCC 
AATGGTTCCA GTGACCCCTT TGTTCAGCTG ACACTGGAAC CCAGACATGA ATTCCCTGAG 
CTGGCTCCCC GGGAGACCCA GAAGCACAAG AAGGAACTTC ACCCGCTCTT TGATGAGACC 
TTTGAATTCC TGGTGCCTGC TGAGCCGTGC CAAAAAGACG GGGCGTGCCT CCTGCTCACT 
GTGCTGGACC ACGACAGGCT GGGAGCTGAT GACCTGGAGG GAGAGGCCTT CTTACCGCTC 
TGCAGGGTAC CTGGACTGAC AGGCTGTGTG GAGCCTGGCG AAGCACCTCA GATGCGCCTG 
CCTCTCACAT ACCCTGCACC CAATGGGGAT CCGATTTTAC GGCTGCTGGA GAGCCGGAAG 
GGTGATCGCG AGGCCCAGGC CTTTGTGAAG CTGAGGAGGC AGCGGGCCAA GCAGGCCTCC 
CAGCATGCCC CCGCAACAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620199.1
CDS	186..3452
Translation	MATHLSHPQRRPPLLRQAVKIRRRRVRDLQDPPPQATPEVQVQSHHFSPEERDLLYEEALYTVLHRLGQPEPNHVKEASELLCYLQEAFQVQPEEHQQMLQRVRELEKPIFCLKATVKQAKGILGKDVSGFSDPYCLLGIEQKVGVPEGSPVSRRRQKAVVRHTIPEEETHRTQVKTQTLNPVWDETFILEFEDITNASFHLDMWDLDTVESVRHKLGELTDLHGLRRIFKEARKDKGQDDFLGNVMLRLQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRRATVASRSQPSYTVHFHLLQQLVSHEVTQHQAGGTSWGRIAESQAVTILFLHATQKDLSDFHQSMAQWLAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFRSVFPLSVSDSPSRLQSLLRVLVQMCKMKAFGELCPDSAPLPQLVSEALRMGTVEWFHLMQQHHQPMVQGILEAGKALLSLVQDVMGDLYQCRRTWNKIFHNVLKIDLFTMAFLELQWLVAKRVQDHTAAVGDLVSPDVGESLFQLYVSLREFCQLGPSDSHEVLALDGFHRWFQSAIPSWLQRTYSVALERVQRAVQMDSLVPLGELTKHSTSAVDLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAVQKDQSQAADMLCVVVNNVERLRLIIDKLPTQLAWEALEQRVGAVLEQGQLQNTLHTQLQGALAGLGHEIRTGVRTLAEQLEVGIATHIQKLIDAKGSILPEDAILPLMKFLEVKLCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASHRNSSLASSRLKVALQNLEICFHAEGCGLPPEALHTDTFLALQSDLELQAASSRELIQKYFRSRIQQQAETTSERLGAVTVKASYRASEQKLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELHPLFDETFEFLVPAEPCQKDGACLLLTVLDHDRLGADDLEGEAFLPLCRVPGLTGCVEPGEAPQMRLPLTYPAPNGDPILRLLESRKGDREAQAFVKLRRQRAKQASQHAPATEP

Target ORF information:

RefSeq Version	NM_138844.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus unc-13 homolog D (Unc13d), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138844.1

ORF Insert Sequence:

ATGGCGACAC ACCTCTCCCA CCCCCAGCGG CGCCCTCCAC TCTTGCGCCA GGCCGTCAAG 
ATAAGGCGCC GCAGGGTCAG AGACCTGCAG GATCCACCGC CCCAAGCCAC CCCGGAGGTC 
CAGGTTCAAT CCCACCACTT CTCCCCGGAG GAGCGGGACC TGCTGTATGA GGAAGCCCTC 
TATACCGTCC TGCACCGCCT GGGTCAGCCA GAGCCCAACC ATGTGAAGGA GGCCTCGGAA 
CTGCTGTGCT ATCTGCAGGA GGCTTTCCAG GTGCAGCCCG AGGAGCACCA GCAGATGCTA 
CAGCGTGTCA GGGAGCTTGA GAAGCCAATA TTTTGTCTGA AGGCAACAGT GAAACAGGCC 
AAGGGCATTC TGGGCAAGGA TGTCAGCGGG TTCAGCGACC CCTATTGCCT GCTGGGCATC 
GAGCAGAAGG TTGGTGTGCC GGAGGGCAGC CCTGTGTCCC GGCGTCGGCA GAAGGCCGTG 
GTGAGGCACA CCATCCCTGA AGAGGAGACC CATCGCACCC AAGTCAAGAC CCAGACACTT 
AATCCCGTCT GGGACGAGAC CTTTATCTTG GAGTTTGAGG ATATAACTAA CGCAAGCTTT 
CACCTGGACA TGTGGGACCT GGACACTGTG GAGTCTGTCA GGCACAAGCT CGGGGAGCTC 
ACAGACCTGC ATGGGCTCAG GAGGATCTTT AAAGAAGCTC GGAAGGATAA AGGCCAGGAC 
GACTTTCTGG GGAATGTGAT GCTAAGATTG CAGGACCTGC GCTGCCGAGA GGATCAGTGG 
TTCCCGCTAG AGCCCTGCAC AGAGACCTAC CCAGACCGCG GCCAGTGTCA CCTGCAGTTC 
CAATTCATTC ACAAGCGGAG AGCCACGGTG GCCAGCCGCT CCCAGCCCAG CTACACTGTA 
CACTTTCACC TACTGCAGCA GCTGGTGTCC CATGAAGTCA CACAGCACCA GGCCGGCGGT 
ACCTCCTGGG GACGCATCGC TGAGTCCCAG GCCGTCACCA TCCTCTTTCT CCACGCCACC 
CAGAAGGACC TGTCAGACTT CCACCAGTCC ATGGCGCAGT GGTTGGCCTA CAGCCGCCTC 
TACCAGAGCC TGGAGTTCCC TAGCAGCTGC CTCCTGCACC CCATCACCAG CATAGAGTAC 
CAGTGGATCC AGGGCCGACT CAAAGCGGAA CAGCGGGAGG AGTTGGCCAC CTCCTTCACA 
TCCCTGTTGG CCTATGGCCT CTCCCTCATC CGGAAGTTCC GCTCCGTCTT TCCCCTGTCT 
GTCTCTGACT CCCCGTCCAG GCTGCAGTCC CTCCTCAGAG TCTTGGTCCA GATGTGCAAG 
ATGAAGGCCT TTGGAGAACT GTGCCCAGAC AGTGCCCCAC TGCCCCAGCT GGTTTCCGAA 
GCCCTGCGGA TGGGCACAGT TGAATGGTTT CACCTGATGC AGCAACACCA CCAGCCGATG 
GTACAGGGCA TCTTGGAGGC TGGCAAGGCC TTGCTGAGCC TGGTACAGGA CGTTATGGGT 
GATCTGTACC AGTGCCGTCG CACATGGAAC AAGATTTTTC ACAATGTCCT CAAGATAGAC 
CTGTTCACCA TGGCCTTCCT GGAGCTGCAA TGGCTGGTGG CCAAGAGGGT ACAGGACCAC 
ACGGCGGCGG TCGGCGACCT TGTTTCTCCA GATGTTGGAG AGAGTCTGTT TCAGCTCTAT 
GTCAGCCTGA GGGAGTTCTG CCAGCTGGGC CCCTCAGACA GCCATGAAGT CCTGGCCCTG 
GATGGTTTCC ACCGCTGGTT TCAGTCAGCC ATCCCTTCCT GGCTGCAGAG GACCTATAGC 
GTTGCCCTGG AGCGGGTGCA GCGAGCCGTA CAGATGGACT CGCTGGTACC CCTGGGTGAA 
CTGACCAAGC ATAGCACTTC TGCTGTGGAT CTGTCTACCT GCTTTGCCCA AATTAGCCAC 
ACTGCCCGGC AGCTGGACTG GCCAGACCCA GAGGAGGCCT TCATGATCAC GGTCAAGTTC 
GTGGAGGACA CCTGCCGGCT GGCCCTGGTC TACTGCAGCC TTATAAAGGC CCGGGCCCGA 
GAGCTGTCTG CGGTTCAGAA GGACCAGAGC CAGGCAGCTG ACATGCTGTG CGTGGTGGTA 
AATAATGTGG AGCGACTACG GTTGATCATC GACAAGCTGC CCACCCAACT GGCATGGGAG 
GCATTGGAGC AGCGGGTCGG GGCTGTGCTG GAGCAGGGGC AGCTGCAGAA CACGCTACAC 
ACTCAGCTGC AGGGCGCCTT GGCCGGGCTG GGCCACGAGA TCCGTACCGG TGTCCGTACT 
CTGGCAGAGC AGTTGGAAGT GGGCATTGCC ACACACATCC AGAAGCTCAT CGATGCCAAG 
GGGTCGATTC TGCCTGAGGA TGCCATTCTG CCCCTGATGA AATTCCTGGA GGTGAAGCTT 
TGTTACATGA ACACCAACCT GGTCCAGGAG AACTTCAGCA GCCTCCTGAC TCTACTGTGG 
ACCCACACAC TTACCGTGCT GGTGGAGGCG GCGGCTTCCC ATCGTAACTC GTCACTGGCT 
TCTAGCAGGC TGAAGGTCGC CCTCCAGAAC CTGGAGATCT GCTTCCATGC TGAGGGCTGT 
GGTCTACCAC CAGAGGCCCT GCACACAGAC ACCTTCCTGG CTCTGCAGAG CGACCTGGAG 
CTGCAGGCAG CCTCCAGCCG GGAGCTCATC CAGAAGTACT TCCGTAGCCG GATCCAACAG 
CAGGCGGAAA CCACTTCTGA GAGGCTGGGT GCAGTCACGG TCAAGGCGTC CTATCGAGCC 
TCTGAGCAGA AGCTGCACGT GGAGCTGCTC AGTGCCTCCA GCCTGCTGCC CCTTGACTCC 
AATGGTTCCA GTGACCCCTT TGTTCAGCTG ACACTGGAAC CCAGACATGA ATTCCCTGAG 
CTGGCTCCCC GGGAGACCCA GAAGCACAAG AAGGAACTTC ACCCGCTCTT TGATGAGACC 
TTTGAATTCC TGGTGCCTGC TGAGCCGTGC CAAAAAGACG GGGCGTGCCT CCTGCTCACT 
GTGCTGGACC ACGACAGGCT GGGAGCTGAT GACCTGGAGG GAGAGGCCTT CTTACCGCTC 
TGCAGGGTAC CTGGACTGAC AGGCTGTGTG GAGCCTGGCG AAGCACCTCA GATGCGCCTG 
CCTCTCACAT ACCCTGCACC CAATGGGGAT CCGATTTTAC GGCTGCTGGA GAGCCGGAAG 
GGTGATCGCG AGGCCCAGGC CTTTGTGAAG CTGAGGAGGC AGCGGGCCAA GCAGGCCTCC 
CAGCATGCCC CCGCAACAGA GCCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Unc13d ( XM_006247702.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006247764.1 Rattus norvegicus unc-13 homolog D (C. elegans) (Unc13d), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa33911
Clone ID Related Accession (Same CDS sequence)	XM_006247702.2
Accession Version	XM_006247702.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3231bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	protein unc-13 homolog D isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006247702.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACCTCA GGCATGGCAG TACAGGGGAT GAGCAAGATG GCCCAGGGGT TTGCCCTTCA 
GGGAGCCTCA TGTTGGAACA GGTCCAGGTT CAATCCCACC ACTTCTCCCC GGAGGAGCGG 
GACCTGCTGT ATGAGGAAGC CCTCTATACC ATCCTGCACC GCCTGGGTCA GCCAGAGCCC 
AACCATGTGA AGGAGGCCTC GGAACTGCTG TGCTATCTGC AGGAGGCTTT CCAGGTGCAG 
CCCGAGGAGC ACCAGCAGAT GCTACAGCGT GTCAGGGAGC TTGAGAAGCC AATATTTTGT 
CTGAAGGCAA CAGTGAAACA GGCCAAGGGC ATTCTGGGCA AGGATGTCAG CGGGTTCAGC 
GACCCCTATT GCCTGCTGGG CATCGAGCAG AAGGTTGGTG TGCCGGAGGG CAGCCCTGTG 
TCCCGGCGTC GGCAGAAGGC CGTGGTGAGG CACACCATCC CTGAAGAGGA GACCCATCGC 
ACCCAAGTCA AGACCCAGAC ACTTAATCCC GTCTGGGACG AGACCTTTAT CTTGGAGTTT 
GAGGATATAA CTAACGCAAG CTTTCACCTG GACATGTGGG ACCTGGACAC TGTGGAGTCT 
GTCAGGCACA AGCTCGGGGA GCTCACAGAC CTGCATGGGC TCAGGAGGAT CTTTAAAGAA 
GCTCGGAAGG ATAAAGGCCA GGACGACTTT CTGGGGAATG TGATGCTAAG ATTGCAGGAC 
CTGCGCTGCC GAGAGGATCA GTGGTTCCCG CTAGAGCCCT GCACAGAGAC CTACCCAGAC 
CGCGGCCAGT GTCACCTGCA GTTCCAATTC ATTCACAAGC GGAGAGCCAC GGTGGCCAGC 
CGCTCCCAGC CCAGCTACAC TGTACACTTT CACCTACTGC AGCAGCTGGT GTCCCATGAA 
GTCACACAGC ACCAGGCCGG CGGTACCTCC TGGGACGCAT CGCTGAGTCC CCAGGCCGTC 
ACCATCCTCT TTCTCCACGC CACCCAGAAG GACCTGTCAG ACTTCCACCA GTCCATGGCG 
CAGTGGTTGG CCTACAGCCG CCTCTACCAG AGCCTGGAGT TCCCTAGCAG CTGCCTCCTG 
CACCCCATCA CCAGCATAGA GTACCAGTGG ATCCAGGGCC GACTCAAAGC GGAACAGCGG 
GAGGAGTTGG CCACCTCCTT CACATCCCTG TTGGCCTATG GCCTCTCCCT CATCCGGAAG 
TTCCGCTCCG TCTTTCCCCT GTCTGTCTCT GACTCCCCGT CCAGGCTGCA GTCCCTCCTC 
AGAGTCTTGG TCCAGATGTG CAAGATGAAG GCCTTTGGAG AACTGTGCCC AGACAGTGCC 
CCACTGCCCC AGCTGGTTTC CGAAGCCCTG CGGATGGGCA CAGTTGAATG GTTTCACCTG 
ATGCAGCAAC ACCACCAGCC GATGGTACAG GGCATCTTGG AGGCTGGCAA GGCCTTGCTG 
AGCCTGGTAC AGGACGTTAT GGGTGATCTG TACCAGTGCC GTCGCACATG GAACAAGATT 
TTTCACAATG TCCTCAAGAT AGACCTGTTC ACCATGGCCT TCCTGGAGCT GCAATGGCTG 
GTGGCCAAGA GGGTACAGGA CCACACGGCG GCGGTCGGCG ACCTTGTTTC TCCAGATGTT 
GGAGAGAGTC TGTTTCAGCT CTATGTCAGC CTGAGGGAGT TCTGCCAGCT GGGCCCCTCA 
GACAGCCATG AAGTCCTGGC CCTGGATGGT TTCCACCGCT GGTTTCAGTC AGCCATCCCT 
TCCTGGCTGC AGAGGACCTA TAGCGTTGCC CTGGAGCGGG TGCAGCGAGC CGTACAGATG 
GACTCGCTGG TACCCCTGGG TGAACTGACC AAGCATAGCA CTTCTGCTGT GGATCTGTCT 
ACCTGCTTTG CCCAAATTAG CCACACTGCC CGGCAGCTGG ACTGGCCAGA CCCAGAGGAG 
GCCTTCATGA TCACGGTCAA GTTCGTGGAG GACACCTGCC GGCTGGCCCT GGTCTACTGC 
AGCCTTATAA AGGCCCGGGC CCGAGAGCTG TCTGCGGTTC AGAAGGACCA GAGCCAGGCA 
GCTGACATGC TGTGCGTGGT GGTAAATAAT GTGGAGCGAC TACGGTTGAT CATCGACAAG 
CTGCCCACCC AACTGGCATG GGAGGCATTG GAGCAGCGGG TCGGGGCTGT GCTGGAGCAG 
GGGCAGCTGC AGAACACGCT ACACACTCAG CTGCAGGGCG CCTTGGCCGG GCTGGGCCAC 
GAGATCCGTA CCGGTGTCCG TACTCTGGCA GAGCAGTTGG AAGTGGGCAT TGCCACACAC 
ATCCAGAAGC TCATCGATGC CAAGGGGTCG ATTCTGCCTG AGGATGCCAT TCTGCCCCTG 
ATGAAATTCC TGGAGGTGAA GCTTTGTTAC ATGAACACCA ACCTGGTCCA GGAGAACTTC 
AGCAGCCTCC TGACTCTACT GTGGACCCAC ACACTTACCG TGCTGGTGGA GGCGGCGGCT 
TCCCATCGTA ACTCGTCACT GGCTTCTAGC AGGCTGAAGG TCGCCCTCCA GAACCTGGAG 
ATCTGCTTCC ATGCTGAGGG CTGTGGTCTA CCACCAGAGG CCCTGCACAC AGACACCTTC 
CTGGCTCTGC AGAGCGACCT GGAGCTGCAG GCAGCCTCCA GCCGGGAGCT CATCCAGAAG 
TACTTCCGTA GCCGGATCCA ACAGCAGGCG GAAACCACTT CTGAGAGGCT GGGTGCAGTC 
ACGGTCAAGG CGTCCTATCG AGCCTCTGAG CAGAAGCTGC ACGTGGAGCT GCTCAGTGCC 
TCCAGCCTGC TGCCCCTTGA CTCCAATGGT TCCAGTGACC CCTTTGTTCA GCTGACACTG 
GAACCCAGAC ATGAATTCCC TGAGCTGGCT CCCCGGGAGA CCCAGAAGCA CAAGAAGGAA 
CTTCACCCGC TCTTTGATGA GACCTTTGAA TTCCTGGTGC CTGCTGAGCC GTGCCAAAAA 
GACGGGGCGT GCCTCCTGCT CACTGTGCTG GACCACGACA GGCTGGGAGC TGATGACCTG 
GAGGGAGAGG CCTTCTTACC GCTCTGCAGG GTACCTGGAC TGACAGGCTG TGTGGAGCCT 
GGCGAAGCAC CTCAGATGCG CCTGCCTCTC ACATACCCTG CACCCAATGG GGATCCGATT 
TTACGGCTGC TGGAGAGCCG GAAGGGTGAT CGCGAGGCCC AGGCCTTTGT GAAGCTGAGG 
AGGCAGCGGG CCAAGCAGGC CTCCCAGCAT GCCCCCGCAA CAGAGCCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006247764.1
CDS	407..3637
Translation	MDLRHGSTGDEQDGPGVCPSGSLMLEQVQVQSHHFSPEERDLLYEEALYTILHRLGQPEPNHVKEASELLCYLQEAFQVQPEEHQQMLQRVRELEKPIFCLKATVKQAKGILGKDVSGFSDPYCLLGIEQKVGVPEGSPVSRRRQKAVVRHTIPEEETHRTQVKTQTLNPVWDETFILEFEDITNASFHLDMWDLDTVESVRHKLGELTDLHGLRRIFKEARKDKGQDDFLGNVMLRLQDLRCREDQWFPLEPCTETYPDRGQCHLQFQFIHKRRATVASRSQPSYTVHFHLLQQLVSHEVTQHQAGGTSWDASLSPQAVTILFLHATQKDLSDFHQSMAQWLAYSRLYQSLEFPSSCLLHPITSIEYQWIQGRLKAEQREELATSFTSLLAYGLSLIRKFRSVFPLSVSDSPSRLQSLLRVLVQMCKMKAFGELCPDSAPLPQLVSEALRMGTVEWFHLMQQHHQPMVQGILEAGKALLSLVQDVMGDLYQCRRTWNKIFHNVLKIDLFTMAFLELQWLVAKRVQDHTAAVGDLVSPDVGESLFQLYVSLREFCQLGPSDSHEVLALDGFHRWFQSAIPSWLQRTYSVALERVQRAVQMDSLVPLGELTKHSTSAVDLSTCFAQISHTARQLDWPDPEEAFMITVKFVEDTCRLALVYCSLIKARARELSAVQKDQSQAADMLCVVVNNVERLRLIIDKLPTQLAWEALEQRVGAVLEQGQLQNTLHTQLQGALAGLGHEIRTGVRTLAEQLEVGIATHIQKLIDAKGSILPEDAILPLMKFLEVKLCYMNTNLVQENFSSLLTLLWTHTLTVLVEAAASHRNSSLASSRLKVALQNLEICFHAEGCGLPPEALHTDTFLALQSDLELQAASSRELIQKYFRSRIQQQAETTSERLGAVTVKASYRASEQKLHVELLSASSLLPLDSNGSSDPFVQLTLEPRHEFPELAPRETQKHKKELHPLFDETFEFLVPAEPCQKDGACLLLTVLDHDRLGADDLEGEAFLPLCRVPGLTGCVEPGEAPQMRLPLTYPAPNGDPILRLLESRKGDREAQAFVKLRRQRAKQASQHAPATEP

Target ORF information:

RefSeq Version	XM_006247702.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus unc-13 homolog D (C. elegans) (Unc13d), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006247702.2

ORF Insert Sequence:

ATGGACCTCA GGCATGGCAG TACAGGGGAT GAGCAAGATG GCCCAGGGGT TTGCCCTTCA 
GGGAGCCTCA TGTTGGAACA GGTCCAGGTT CAATCCCACC ACTTCTCCCC GGAGGAGCGG 
GACCTGCTGT ATGAGGAAGC CCTCTATACC ATCCTGCACC GCCTGGGTCA GCCAGAGCCC 
AACCATGTGA AGGAGGCCTC GGAACTGCTG TGCTATCTGC AGGAGGCTTT CCAGGTGCAG 
CCCGAGGAGC ACCAGCAGAT GCTACAGCGT GTCAGGGAGC TTGAGAAGCC AATATTTTGT 
CTGAAGGCAA CAGTGAAACA GGCCAAGGGC ATTCTGGGCA AGGATGTCAG CGGGTTCAGC 
GACCCCTATT GCCTGCTGGG CATCGAGCAG AAGGTTGGTG TGCCGGAGGG CAGCCCTGTG 
TCCCGGCGTC GGCAGAAGGC CGTGGTGAGG CACACCATCC CTGAAGAGGA GACCCATCGC 
ACCCAAGTCA AGACCCAGAC ACTTAATCCC GTCTGGGACG AGACCTTTAT CTTGGAGTTT 
GAGGATATAA CTAACGCAAG CTTTCACCTG GACATGTGGG ACCTGGACAC TGTGGAGTCT 
GTCAGGCACA AGCTCGGGGA GCTCACAGAC CTGCATGGGC TCAGGAGGAT CTTTAAAGAA 
GCTCGGAAGG ATAAAGGCCA GGACGACTTT CTGGGGAATG TGATGCTAAG ATTGCAGGAC 
CTGCGCTGCC GAGAGGATCA GTGGTTCCCG CTAGAGCCCT GCACAGAGAC CTACCCAGAC 
CGCGGCCAGT GTCACCTGCA GTTCCAATTC ATTCACAAGC GGAGAGCCAC GGTGGCCAGC 
CGCTCCCAGC CCAGCTACAC TGTACACTTT CACCTACTGC AGCAGCTGGT GTCCCATGAA 
GTCACACAGC ACCAGGCCGG CGGTACCTCC TGGGACGCAT CGCTGAGTCC CCAGGCCGTC 
ACCATCCTCT TTCTCCACGC CACCCAGAAG GACCTGTCAG ACTTCCACCA GTCCATGGCG 
CAGTGGTTGG CCTACAGCCG CCTCTACCAG AGCCTGGAGT TCCCTAGCAG CTGCCTCCTG 
CACCCCATCA CCAGCATAGA GTACCAGTGG ATCCAGGGCC GACTCAAAGC GGAACAGCGG 
GAGGAGTTGG CCACCTCCTT CACATCCCTG TTGGCCTATG GCCTCTCCCT CATCCGGAAG 
TTCCGCTCCG TCTTTCCCCT GTCTGTCTCT GACTCCCCGT CCAGGCTGCA GTCCCTCCTC 
AGAGTCTTGG TCCAGATGTG CAAGATGAAG GCCTTTGGAG AACTGTGCCC AGACAGTGCC 
CCACTGCCCC AGCTGGTTTC CGAAGCCCTG CGGATGGGCA CAGTTGAATG GTTTCACCTG 
ATGCAGCAAC ACCACCAGCC GATGGTACAG GGCATCTTGG AGGCTGGCAA GGCCTTGCTG 
AGCCTGGTAC AGGACGTTAT GGGTGATCTG TACCAGTGCC GTCGCACATG GAACAAGATT 
TTTCACAATG TCCTCAAGAT AGACCTGTTC ACCATGGCCT TCCTGGAGCT GCAATGGCTG 
GTGGCCAAGA GGGTACAGGA CCACACGGCG GCGGTCGGCG ACCTTGTTTC TCCAGATGTT 
GGAGAGAGTC TGTTTCAGCT CTATGTCAGC CTGAGGGAGT TCTGCCAGCT GGGCCCCTCA 
GACAGCCATG AAGTCCTGGC CCTGGATGGT TTCCACCGCT GGTTTCAGTC AGCCATCCCT 
TCCTGGCTGC AGAGGACCTA TAGCGTTGCC CTGGAGCGGG TGCAGCGAGC CGTACAGATG 
GACTCGCTGG TACCCCTGGG TGAACTGACC AAGCATAGCA CTTCTGCTGT GGATCTGTCT 
ACCTGCTTTG CCCAAATTAG CCACACTGCC CGGCAGCTGG ACTGGCCAGA CCCAGAGGAG 
GCCTTCATGA TCACGGTCAA GTTCGTGGAG GACACCTGCC GGCTGGCCCT GGTCTACTGC 
AGCCTTATAA AGGCCCGGGC CCGAGAGCTG TCTGCGGTTC AGAAGGACCA GAGCCAGGCA 
GCTGACATGC TGTGCGTGGT GGTAAATAAT GTGGAGCGAC TACGGTTGAT CATCGACAAG 
CTGCCCACCC AACTGGCATG GGAGGCATTG GAGCAGCGGG TCGGGGCTGT GCTGGAGCAG 
GGGCAGCTGC AGAACACGCT ACACACTCAG CTGCAGGGCG CCTTGGCCGG GCTGGGCCAC 
GAGATCCGTA CCGGTGTCCG TACTCTGGCA GAGCAGTTGG AAGTGGGCAT TGCCACACAC 
ATCCAGAAGC TCATCGATGC CAAGGGGTCG ATTCTGCCTG AGGATGCCAT TCTGCCCCTG 
ATGAAATTCC TGGAGGTGAA GCTTTGTTAC ATGAACACCA ACCTGGTCCA GGAGAACTTC 
AGCAGCCTCC TGACTCTACT GTGGACCCAC ACACTTACCG TGCTGGTGGA GGCGGCGGCT 
TCCCATCGTA ACTCGTCACT GGCTTCTAGC AGGCTGAAGG TCGCCCTCCA GAACCTGGAG 
ATCTGCTTCC ATGCTGAGGG CTGTGGTCTA CCACCAGAGG CCCTGCACAC AGACACCTTC 
CTGGCTCTGC AGAGCGACCT GGAGCTGCAG GCAGCCTCCA GCCGGGAGCT CATCCAGAAG 
TACTTCCGTA GCCGGATCCA ACAGCAGGCG GAAACCACTT CTGAGAGGCT GGGTGCAGTC 
ACGGTCAAGG CGTCCTATCG AGCCTCTGAG CAGAAGCTGC ACGTGGAGCT GCTCAGTGCC 
TCCAGCCTGC TGCCCCTTGA CTCCAATGGT TCCAGTGACC CCTTTGTTCA GCTGACACTG 
GAACCCAGAC ATGAATTCCC TGAGCTGGCT CCCCGGGAGA CCCAGAAGCA CAAGAAGGAA 
CTTCACCCGC TCTTTGATGA GACCTTTGAA TTCCTGGTGC CTGCTGAGCC GTGCCAAAAA 
GACGGGGCGT GCCTCCTGCT CACTGTGCTG GACCACGACA GGCTGGGAGC TGATGACCTG 
GAGGGAGAGG CCTTCTTACC GCTCTGCAGG GTACCTGGAC TGACAGGCTG TGTGGAGCCT 
GGCGAAGCAC CTCAGATGCG CCTGCCTCTC ACATACCCTG CACCCAATGG GGATCCGATT 
TTACGGCTGC TGGAGAGCCG GAAGGGTGAT CGCGAGGCCC AGGCCTTTGT GAAGCTGAGG 
AGGCAGCGGG CCAAGCAGGC CTCCCAGCAT GCCCCCGCAA CAGAGCCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab37.
Scientific reports622539(2016 Mar)
Higashio H,Satoh Y,Saino T

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.
eLife4(2015 Nov)
Man KN,Imig C,Walter AM,Pinheiro PS,Stevens DR,Rettig J,Sørensen JB,Cooper BH,Brose N,Wojcik SM

A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis.
Journal of cell science125(Pt 20)4780-90(2012 Oct)
Zografou S,Basagiannis D,Papafotika A,Shirakawa R,Horiuchi H,Auerbach D,Fukuda M,Christoforidis S

Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7.
Blood120(1)199-206(2012 Jul)
Peters CG,Michelson AD,Flaumenhaft R

A novel Dutch mutation in UNC13D reveals an essential role of the C2B domain in munc13-4 function.
Pediatric blood & cancer58(4)598-605(2012 Apr)
Elstak ED,te Loo M,Tesselaar K,van Kerkhof P,Loeffen J,Grivas D,Hennekam E,Boelens JJ,Hoogerbrugge PM,van der Sluijs P,van Gijn ME,van de Corput L

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Unc13d cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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