Acmsd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acmsd
Entrez Gene ID	171385
Full Name	aminocarboxymuconate semialdehyde decarboxylase
General protein information	Preferred Names aminocarboxymuconate semialdehyde decarboxylase Names 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase picolinate carboxylase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_134372.1	NP_599199.1	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Pathways from BioSystems

Homologies

Neurospora crassa	NCU06417	XP_957308.1
Homo sapiens (human)	ACMSD	NP_612199.2
Mus musculus (house mouse)	Acmsd	NP_001028213.1
Magnaporthe oryzae (rice blast fungus)	MGG_06488	XP_003717072.1
Pan troglodytes (chimpanzee)	ACMSD	XP_515804.1
Macaca mulatta (Rhesus monkey)	ACMSD	XP_001097996.1
Rattus norvegicus (Norway rat)	Acmsd	NP_599199.1
Caenorhabditis elegans (roundworm)	Y71D11A.3	NP_497336.3
Canis lupus familiaris (dog)	ACMSD	XP_533332.3
Bos taurus (cattle)	ACMSD	NP_001069162.1
Gallus gallus (chicken)	ACMSD	XP_422133.2
Danio rerio (zebrafish)	acmsd	NP_001082963.1
Xenopus tropicalis (tropical clawed frog)	acmsd	XP_002941468.2

Gene Ontology
Bibliography

Related articles in PubMed

The kynurenine pathway and neurodegenerative disease.
Maddison DC, Giorgini F
Seminars in cell & developmental biology40134-41(2015 Apr)

Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD): a structural and mechanistic unveiling.
Huo L, Liu F, Iwaki H, Li T, Hasegawa Y, Liu A
Proteins83(1)178-87(2015 Jan)

Regulation of rat hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase, a key enzyme in the tryptophan- NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2.
Matsuda H, Sato M, Yakushiji M, Koshiguchi M, Hirai S, Egashira Y
European journal of nutrition53(2)469-77(2014)

The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis.
Garavaglia S, Perozzi S, Galeazzi L, Raffaelli N, Rizzi M
The FEBS journal276(22)6615-23(2009 Nov)

Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats.
Sasaki N, Egashira Y, Sanada H
European journal of nutrition48(3)145-53(2009 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Acmsd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acmsd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01221	NM_134372.1 Latest version!	Rattus norvegicus aminocarboxymuconate semialdehyde decarboxylase (Acmsd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acmsd ( NM_134372.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_599199.1 Rattus norvegicus aminocarboxymuconate semialdehyde decarboxylase (Acmsd), mRNA.

Price & Availability↑

CloneID	ORa01221
Clone ID Related Accession (Same CDS sequence)	NM_134372.1
Accession Version	NM_134372.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1011bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1576857600000
Organism	Rattus norvegicus(Norway rat)
Product	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB069781.1. On Dec 17, 2003 this sequence version replaced XM_346445.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB069781.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689597, SAMEA2689598 [ECO:0000350] ##Evidence-Data-END##

ATGAAAATTG ACATCCACAC TCACATTCTA CCAAAGGAAT GGCCTGATCT AGAAAAGAGG 
TTTGGCTATG GAGGCTGGGT GCAGCTCCAA CAGCAAGGCA AGGGAGAAGC AAAGATGATG 
AAAGACGGGA AGGTCTTCAG AGTGATCCAA CAGAACTGCT GGGACCCAGA AGTCCGCATC 
AGAGAAATGA ACCAGAAAGG AGTGACAGTG CAAGCTCTTT CCACAGTTCC CGTCATGTTT 
AGTTACTGGG CCAAACCTAA GGACACTTTG GAACTGTGCC AGTTTTTAAA CAATGACCTC 
GCTGCCACGG TGGCCAGATA CCCTCGAAGG TTTGTGGGTT TGGGGACATT GCCTATGCAA 
GCCCCGGGGC TGGCTGTCGA GGAGATGGAG CGTTGTGTAA AGGAGCTAGG ATTTCCAGGA 
ATCCAGATTG GATCCCACAT CAACATGTGG GACCTGAATG ACCCGGAACT CTTCCCCATC 
TACACGGCGG CTGAGAGGCT GAATTGTTCT CTGTTCGTGC ATCCCTGGGA TATGCAGATG 
GATGGACGGA TGGCCAAATA CTGGCTGCCT TGGCTCGTAG GAATGCCATC GGAGACCACC 
ACGGCCATTT GCTCCATGAT CATGGGTGGG GTGTTCGAGA AGTTTCCCAA ACTCAAAGTG 
TGTTTTGCAC ATGGAGGTGG TGCTTTCCCC TTCACCATAG GAAGAATTGC TCATGGATTT 
AACATGCGCC CAGATCTCTG TGCCCGGGAC AATTCATCTG ACCCCAGAAA ATACCTTGGC 
TCCTTCTACA CGGACTCCCT GGTTCATGAT CCTCTGTCTC TCAAGCTATT GACAGATGTT 
ATAGGGAAGG ATAGAGTTAT TCTGGGAACT GATTACCCCT TTCCACTAGG TGAGCAGGAG 
CCTGGGAAGT TGATAGAGTC TATGGCAGAC TTTGATGAAG AAACAAAGGA TAAACTTACA 
GCTGGCAATG CCTTGACTTT TTTGGGTCTT GAGAGAAAAC TATTTGAATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_599199.1
CDS	1..1011
Translation	MKIDIHTHILPKEWPDLEKRFGYGGWVQLQQQGKGEAKMMKDGKVFRVIQQNCWDPEVRIREMNQKGVTVQALSTVPVMFSYWAKPKDTLELCQFLNNDLAATVARYPRRFVGLGTLPMQAPGLAVEEMERCVKELGFPGIQIGSHINMWDLNDPELFPIYTAAERLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPSETTTAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTIGRIAHGFNMRPDLCARDNSSDPRKYLGSFYTDSLVHDPLSLKLLTDVIGKDRVILGTDYPFPLGEQEPGKLIESMADFDEETKDKLTAGNALTFLGLERKLFE

Target ORF information:

RefSeq Version	NM_134372.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus aminocarboxymuconate semialdehyde decarboxylase (Acmsd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134372.1

ORF Insert Sequence:

ATGAAAATTG ACATCCACAC TCACATTCTA CCAAAGGAAT GGCCTGATCT AGAAAAGAGG 
TTTGGCTATG GAGGCTGGGT GCAGCTCCAA CAGCAAGGCA AGGGAGAAGC AAAGATGATG 
AAAGACGGGA AGGTCTTCAG AGTGATCCAA CAGAACTGCT GGGACCCAGA AGTCCGCATC 
AGAGAAATGA ACCAGAAAGG AGTGACAGTG CAAGCTCTTT CCACAGTTCC CGTCATGTTT 
AGTTACTGGG CCAAACCTAA GGACACTTTG GAACTGTGCC AGTTTTTAAA CAATGACCTC 
GCTGCCACGG TGGCCAGATA CCCTCGAAGG TTTGTGGGTT TGGGGACATT GCCTATGCAA 
GCCCCGGGGC TGGCTGTCGA GGAGATGGAG CGTTGTGTAA AGGAGCTAGG ATTTCCAGGA 
ATCCAGATTG GATCCCACAT CAACATGTGG GACCTGAATG ACCCGGAACT CTTCCCCATC 
TACACGGCGG CTGAGAGGCT GAATTGTTCT CTGTTCGTGC ATCCCTGGGA TATGCAGATG 
GATGGACGGA TGGCCAAATA CTGGCTGCCT TGGCTCGTAG GAATGCCATC GGAGACCACC 
ACGGCCATTT GCTCCATGAT CATGGGTGGG GTGTTCGAGA AGTTTCCCAA ACTCAAAGTG 
TGTTTTGCAC ATGGAGGTGG TGCTTTCCCC TTCACCATAG GAAGAATTGC TCATGGATTT 
AACATGCGCC CAGATCTCTG TGCCCGGGAC AATTCATCTG ACCCCAGAAA ATACCTTGGC 
TCCTTCTACA CGGACTCCCT GGTTCATGAT CCTCTGTCTC TCAAGCTATT GACAGATGTT 
ATAGGGAAGG ATAGAGTTAT TCTGGGAACT GATTACCCCT TTCCACTAGG TGAGCAGGAG 
CCTGGGAAGT TGATAGAGTC TATGGCAGAC TTTGATGAAG AAACAAAGGA TAAACTTACA 
GCTGGCAATG CCTTGACTTT TTTGGGTCTT GAGAGAAAAC TATTTGAATG A