Il12rb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il12rb1
Entrez Gene ID	171333
Full Name	interleukin 12 receptor subunit beta 1
Synonyms	Il12rb
General protein information	Preferred Names interleukin 12 receptor subunit beta 1 Names interleukin-12 receptor subunit beta-1 interleukin 12 receptor, beta 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14
Summary	transmembrane protein that belongs to the hemopoietin receptor superfamily; human homolg binds interleukin (IL)12 with a low affinity and may be a part of the IL12 receptor complex [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001170604.1	NP_001164075.1	interleukin-12 receptor subunit beta-1 precursor
XM_006252821.3	XP_006252883.1	interleukin-12 receptor subunit beta-1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL12RB1	NP_005526.1
Pan troglodytes (chimpanzee)	IL12RB1	XP_003316249.1
Rattus norvegicus (Norway rat)	Il12rb1	NP_001164075.1
Macaca mulatta (Rhesus monkey)	IL12RB1	XP_001115186.2
Canis lupus familiaris (dog)	IL12RB1	XP_005632766.1
Mus musculus (house mouse)	Il12rb1	NP_032379.2
Bos taurus (cattle)	IL12RB1	XP_002688616.1
Gallus gallus (chicken)	IL12RB1	XP_004948972.1

Gene Ontology
Bibliography

Related articles in PubMed

Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis.
Qian C, Jiang T, Zhang W, Ren C, Wang Q, Qin Q, Chen J, Deng A, Zhong R
Cytokine64(1)172-80(2013 Oct)

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses.
Watanabe T, Kitani A, Murray PJ, Strober W
Nature immunology5(8)800-8(2004 Aug)

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development.
Smits HH, van Beelen AJ, Hessle C, Westland R, de Jong E, Soeteman E, Wold A, Wierenga EA, Kapsenberg ML
European journal of immunology34(5)1371-80(2004 May)

IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency.
Hoeve MA, de Boer T, Langenberg DM, Sanal O, Verreck FA, Ottenhoff TH
European journal of immunology33(12)3393-7(2003 Dec)

Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.
Pirhonen J, Matikainen S, Julkunen I
Journal of immunology (Baltimore, Md. : 1950)169(10)5673-8(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Il12rb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il12rb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06377	NM_001170604.1 Latest version!	Rattus norvegicus interleukin 12 receptor subunit beta 1 (Il12rb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa06377	XM_006252821.3 Latest version!	Rattus norvegicus interleukin 12 receptor subunit beta 1 (Il12rb1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il12rb1 ( NM_001170604.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001164075.1 Rattus norvegicus interleukin 12 receptor subunit beta 1 (Il12rb1), mRNA.

Price & Availability↑

CloneID	ORa06377
Clone ID Related Accession (Same CDS sequence)	NM_001170604.1 , XM_006252821.3
Accession Version	NM_001170604.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566748800000
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-12 receptor subunit beta-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07024875.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGACATGA CGGGGCTGCC AGGGACCAGC AAGCACATCA TCTTCCTCCT GCTTTGCCAG 
CTAAGCGCCT CCAGCCGAGG TGACAGCTGC TGCGTTGAGA AGATATCATA CCCAGATGAA 
GCCTCAGGCC CCTCCTTAGG ACCCAGGGAC TTGAGCTGCT ACAGGGTTTC CGGGACAGAC 
TATGAGTGCT CCTGGCAGTA TGATGGCCCT GAGGACAATG TTGCTCACTT CCTGTGGTGC 
TGCTTTGCTC ATCCAAACCC TACCCACACC AGCTTTGGCC AAGAATGCTG CTGCTACTTC 
TCTTCGGGCC GGTCTCGGAC TGTGCAGTTC TGGGAACAGG ATGGTATCTC TACGTTGTCC 
AAGGTCAACT TCTGGGTCGA GTCTCGGCTT GGGAACAGGA CCTTGAAGTC TCAGGAGATA 
TCGCAGTACC TGTACAACTG GACCAAGCTC ACCCCTCCTC TGGGACACAT CAGAGTGTCA 
CGATCACGCG GGGAGTTGCG AATGGACTGG AATGTGTCGG ATGGGGCCGG TGCTGAGGTA 
CAACTGAGGC GCCGGATGCC CACAACGAAT TGGACCTTGG GTGACTGCGG ACCTCAGGTT 
AGCTCTGGCT TAGGTGTGAT TGGTGACATT CACGGTAGCA GTTCTGAGTC CTGCCTCTGC 
CCTTCTGAGA ACATGGCCCA GGAAATCCAG ATACGGAGAC GGCGGCGCCT CTCCTCAGGA 
GCTCCTGGAG GTCCCTGGAG TAATTGGAGC ATGTCTGTGT GTGTCCCGCC TGAATTCCTC 
CCCCAGGCTG AGATTAAGTT CCTGGTGGAG CCCCTGAACC AAGATGGAAG GAGGCGTCTG 
ACTATGGAAG GGCAGACACC ACAGCTGGCA GTCCCGGAGG GCTGCAGGGA CCGGCCTGGG 
GCGCAGGTGA AGAAGCACTT GGTGCTGGTG CACATGCTGG CCTGCAGGTG CCAGGCTCGG 
ACCTGGAAGA CCGTGCCCCT GGGCAAGACG CTGGACCTCT CCGGTGCCGC CTACGACCTG 
GATGTACTCG CCCAGACTCG CTTCGGCCGC AGCATCATCC AGAAGTGGCC CCTTCCTGCC 
CAAGAGCTCA CAGAGACAAG AACCCTGAAT GTCATCGTGG AAGGCAACGT GACATCCATG 
CAGTGGGCAG CCCAGCCTCC AGGCACTGCC TACTGCCTTG AGTGGCAGCC ATGGGGCCAG 
GACAGGAACC ACACGGACTG TACTCTGATT GCACCAGAAG AAGAGGACCC AGCCAAGATG 
GTGACGCACA CCTGGAGCTC CAAGCCTACC CTGGACCAGG AGGAATGTTA CCGCATCACT 
GTCTTCGCCT CCAAGAACCC CAAGAATCCC ATGATGTGGG CCACGGTCCT GTCCAGTTAC 
TACTTTGGGG GTAACGTCTC AAGGGTCGGA ACTCCACGCC ACGTGTCGGT GAGGAACCAC 
ACCGAGGACT CAGTGTCCGT GGAGTGGACA GCGTCACAGC TGAGCACCTG CCCAGGGGTC 
CTGACGCAAT ACGTCGTGCG CTGCGAGGCT GAAGATGGCA CGTGGGAGTC AGAGTTGCTC 
GTGCCACCCA CGAAGACCCA AGTGACACTA AACAGTCTGC GCAGCCGCGT GGTGTACAAG 
GTTCAGGTGC GAGCTGACAC TGCGATGCTC CCAGGCTCCT GGAGCCGTCC CCAGCGCTTC 
AGCGTTGAGG TGCAGATTTC CCGTTTATCC ATCGTTTTCG CGTCTCTGGG AAGCTTCGCC 
AGCGTCCTCC TCGTGGGCAG TCTCGGATAC ATTGGCTTAA ACAGGGCTGC CTGGCACTTG 
TGCCCACCTC TGCCTACGCC CTGTGGCAGC ACTGCTGTGG AGTTCCCTGG CAGCCAGGAC 
AAGCAGGCTT GGCAATGGCG CAACCCTGAG GACTTCCCCG AGGTGTTGTA CCCACGAGAC 
GCGCTGGTGG TGGAGATGCC CAGGGACAGA GATGATGAGA CAGAGTCGCC CCAGGCCACC 
CCTGAGCGCG CCCTGGACAC AAGGTGGCCC TTGGGAACTG AGGGGCAGGT GCAAGGACTC 
TCAGAGGCCA GGCTCCCGGA CCTGGCTAGA GAGGACTGTC CCCGTGGTGA CCTGGCCCAC 
GTGACACTCC CGCTGCTCCT GGGAGATGTG ACCCAGGGAG CCTCGGTACT TGGTGATCTT 
TGGTGGATCC ATAAGACCGT GGAGCCAGGA CCACCCACTT TGGGTCAAGA GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001164075.1
CDS	1..2217
Translation	MDMTGLPGTSKHIIFLLLCQLSASSRGDSCCVEKISYPDEASGPSLGPRDLSCYRVSGTDYECSWQYDGPEDNVAHFLWCCFAHPNPTHTSFGQECCCYFSSGRSRTVQFWEQDGISTLSKVNFWVESRLGNRTLKSQEISQYLYNWTKLTPPLGHIRVSRSRGELRMDWNVSDGAGAEVQLRRRMPTTNWTLGDCGPQVSSGLGVIGDIHGSSSESCLCPSENMAQEIQIRRRRRLSSGAPGGPWSNWSMSVCVPPEFLPQAEIKFLVEPLNQDGRRRLTMEGQTPQLAVPEGCRDRPGAQVKKHLVLVHMLACRCQARTWKTVPLGKTLDLSGAAYDLDVLAQTRFGRSIIQKWPLPAQELTETRTLNVIVEGNVTSMQWAAQPPGTAYCLEWQPWGQDRNHTDCTLIAPEEEDPAKMVTHTWSSKPTLDQEECYRITVFASKNPKNPMMWATVLSSYYFGGNVSRVGTPRHVSVRNHTEDSVSVEWTASQLSTCPGVLTQYVVRCEAEDGTWESELLVPPTKTQVTLNSLRSRVVYKVQVRADTAMLPGSWSRPQRFSVEVQISRLSIVFASLGSFASVLLVGSLGYIGLNRAAWHLCPPLPTPCGSTAVEFPGSQDKQAWQWRNPEDFPEVLYPRDALVVEMPRDRDDETESPQATPERALDTRWPLGTEGQVQGLSEARLPDLAREDCPRGDLAHVTLPLLLGDVTQGASVLGDLWWIHKTVEPGPPTLGQEA

Target ORF information:

RefSeq Version	NM_001170604.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 12 receptor subunit beta 1 (Il12rb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001170604.1

ORF Insert Sequence:

ATGGACATGA CGGGGCTGCC AGGGACCAGC AAGCACATCA TCTTCCTCCT GCTTTGCCAG 
CTAAGCGCCT CCAGCCGAGG TGACAGCTGC TGCGTTGAGA AGATATCATA CCCAGATGAA 
GCCTCAGGCC CCTCCTTAGG ACCCAGGGAC TTGAGCTGCT ACAGGGTTTC CGGGACAGAC 
TATGAGTGCT CCTGGCAGTA TGATGGCCCT GAGGACAATG TTGCTCACTT CCTGTGGTGC 
TGCTTTGCTC ATCCAAACCC TACCCACACC AGCTTTGGCC AAGAATGCTG CTGCTACTTC 
TCTTCGGGCC GGTCTCGGAC TGTGCAGTTC TGGGAACAGG ATGGTATCTC TACGTTGTCC 
AAGGTCAACT TCTGGGTCGA GTCTCGGCTT GGGAACAGGA CCTTGAAGTC TCAGGAGATA 
TCGCAGTACC TGTACAACTG GACCAAGCTC ACCCCTCCTC TGGGACACAT CAGAGTGTCA 
CGATCACGCG GGGAGTTGCG AATGGACTGG AATGTGTCGG ATGGGGCCGG TGCTGAGGTA 
CAACTGAGGC GCCGGATGCC CACAACGAAT TGGACCTTGG GTGACTGCGG ACCTCAGGTT 
AGCTCTGGCT TAGGTGTGAT TGGTGACATT CACGGTAGCA GTTCTGAGTC CTGCCTCTGC 
CCTTCTGAGA ACATGGCCCA GGAAATCCAG ATACGGAGAC GGCGGCGCCT CTCCTCAGGA 
GCTCCTGGAG GTCCCTGGAG TAATTGGAGC ATGTCTGTGT GTGTCCCGCC TGAATTCCTC 
CCCCAGGCTG AGATTAAGTT CCTGGTGGAG CCCCTGAACC AAGATGGAAG GAGGCGTCTG 
ACTATGGAAG GGCAGACACC ACAGCTGGCA GTCCCGGAGG GCTGCAGGGA CCGGCCTGGG 
GCGCAGGTGA AGAAGCACTT GGTGCTGGTG CACATGCTGG CCTGCAGGTG CCAGGCTCGG 
ACCTGGAAGA CCGTGCCCCT GGGCAAGACG CTGGACCTCT CCGGTGCCGC CTACGACCTG 
GATGTACTCG CCCAGACTCG CTTCGGCCGC AGCATCATCC AGAAGTGGCC CCTTCCTGCC 
CAAGAGCTCA CAGAGACAAG AACCCTGAAT GTCATCGTGG AAGGCAACGT GACATCCATG 
CAGTGGGCAG CCCAGCCTCC AGGCACTGCC TACTGCCTTG AGTGGCAGCC ATGGGGCCAG 
GACAGGAACC ACACGGACTG TACTCTGATT GCACCAGAAG AAGAGGACCC AGCCAAGATG 
GTGACGCACA CCTGGAGCTC CAAGCCTACC CTGGACCAGG AGGAATGTTA CCGCATCACT 
GTCTTCGCCT CCAAGAACCC CAAGAATCCC ATGATGTGGG CCACGGTCCT GTCCAGTTAC 
TACTTTGGGG GTAACGTCTC AAGGGTCGGA ACTCCACGCC ACGTGTCGGT GAGGAACCAC 
ACCGAGGACT CAGTGTCCGT GGAGTGGACA GCGTCACAGC TGAGCACCTG CCCAGGGGTC 
CTGACGCAAT ACGTCGTGCG CTGCGAGGCT GAAGATGGCA CGTGGGAGTC AGAGTTGCTC 
GTGCCACCCA CGAAGACCCA AGTGACACTA AACAGTCTGC GCAGCCGCGT GGTGTACAAG 
GTTCAGGTGC GAGCTGACAC TGCGATGCTC CCAGGCTCCT GGAGCCGTCC CCAGCGCTTC 
AGCGTTGAGG TGCAGATTTC CCGTTTATCC ATCGTTTTCG CGTCTCTGGG AAGCTTCGCC 
AGCGTCCTCC TCGTGGGCAG TCTCGGATAC ATTGGCTTAA ACAGGGCTGC CTGGCACTTG 
TGCCCACCTC TGCCTACGCC CTGTGGCAGC ACTGCTGTGG AGTTCCCTGG CAGCCAGGAC 
AAGCAGGCTT GGCAATGGCG CAACCCTGAG GACTTCCCCG AGGTGTTGTA CCCACGAGAC 
GCGCTGGTGG TGGAGATGCC CAGGGACAGA GATGATGAGA CAGAGTCGCC CCAGGCCACC 
CCTGAGCGCG CCCTGGACAC AAGGTGGCCC TTGGGAACTG AGGGGCAGGT GCAAGGACTC 
TCAGAGGCCA GGCTCCCGGA CCTGGCTAGA GAGGACTGTC CCCGTGGTGA CCTGGCCCAC 
GTGACACTCC CGCTGCTCCT GGGAGATGTG ACCCAGGGAG CCTCGGTACT TGGTGATCTT 
TGGTGGATCC ATAAGACCGT GGAGCCAGGA CCACCCACTT TGGGTCAAGA GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Il12rb1 ( XM_006252821.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252883.1 Rattus norvegicus interleukin 12 receptor subunit beta 1 (Il12rb1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa06377
Clone ID Related Accession (Same CDS sequence)	NM_001170604.1 , XM_006252821.3
Accession Version	XM_006252821.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	interleukin-12 receptor subunit beta-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252821.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACATGA CGGGGCTGCC AGGGACCAGC AAGCACATCA TCTTCCTCCT GCTTTGCCAG 
CTAAGCGCCT CCAGCCGAGG TGACAGCTGC TGCGTTGAGA AGATATCATA CCCAGATGAA 
GCCTCAGGCC CCTCCTTAGG ACCCAGGGAC TTGAGCTGCT ACAGGGTTTC CGGGACAGAC 
TATGAGTGCT CCTGGCAGTA TGATGGCCCT GAGGACAATG TTGCTCACTT CCTGTGGTGC 
TGCTTTGCTC ATCCAAACCC TACCCACACC AGCTTTGGCC AAGAATGCTG CTGCTACTTC 
TCTTCGGGCC GGTCTCGGAC TGTGCAGTTC TGGGAACAGG ATGGTATCTC TACGTTGTCC 
AAGGTCAACT TCTGGGTCGA GTCTCGGCTT GGGAACAGGA CCTTGAAGTC TCAGGAGATA 
TCGCAGTACC TGTACAACTG GACCAAGCTC ACCCCTCCTC TGGGACACAT CAGAGTGTCA 
CGATCACGCG GGGAGTTGCG AATGGACTGG AATGTGTCGG ATGGGGCCGG TGCTGAGGTA 
CAACTGAGGC GCCGGATGCC CACAACGAAT TGGACCTTGG GTGACTGCGG ACCTCAGGTT 
AGCTCTGGCT TAGGTGTGAT TGGTGACATT CACGGTAGCA GTTCTGAGTC CTGCCTCTGC 
CCTTCTGAGA ACATGGCCCA GGAAATCCAG ATACGGAGAC GGCGGCGCCT CTCCTCAGGA 
GCTCCTGGAG GTCCCTGGAG TAATTGGAGC ATGTCTGTGT GTGTCCCGCC TGAATTCCTC 
CCCCAGGCTG AGATTAAGTT CCTGGTGGAG CCCCTGAACC AAGATGGAAG GAGGCGTCTG 
ACTATGGAAG GGCAGACACC ACAGCTGGCA GTCCCGGAGG GCTGCAGGGA CCGGCCTGGG 
GCGCAGGTGA AGAAGCACTT GGTGCTGGTG CACATGCTGG CCTGCAGGTG CCAGGCTCGG 
ACCTGGAAGA CCGTGCCCCT GGGCAAGACG CTGGACCTCT CCGGTGCCGC CTACGACCTG 
GATGTACTCG CCCAGACTCG CTTCGGCCGC AGCATCATCC AGAAGTGGCC CCTTCCTGCC 
CAAGAGCTCA CAGAGACAAG AACCCTGAAT GTCATCGTGG AAGGCAACGT GACATCCATG 
CAGTGGGCAG CCCAGCCTCC AGGCACTGCC TACTGCCTTG AGTGGCAGCC ATGGGGCCAG 
GACAGGAACC ACACGGACTG TACTCTGATT GCACCAGAAG AAGAGGACCC AGCCAAGATG 
GTGACGCACA CCTGGAGCTC CAAGCCTACC CTGGACCAGG AGGAATGTTA CCGCATCACT 
GTCTTCGCCT CCAAGAACCC CAAGAATCCC ATGATGTGGG CCACGGTCCT GTCCAGTTAC 
TACTTTGGGG GTAACGTCTC AAGGGTCGGA ACTCCACGCC ACGTGTCGGT GAGGAACCAC 
ACCGAGGACT CAGTGTCCGT GGAGTGGACA GCGTCACAGC TGAGCACCTG CCCAGGGGTC 
CTGACGCAAT ACGTCGTGCG CTGCGAGGCT GAAGATGGCA CGTGGGAGTC AGAGTTGCTC 
GTGCCACCCA CGAAGACCCA AGTGACACTA AACAGTCTGC GCAGCCGCGT GGTGTACAAG 
GTTCAGGTGC GAGCTGACAC TGCGATGCTC CCAGGCTCCT GGAGCCGTCC CCAGCGCTTC 
AGCGTTGAGG TGCAGATTTC CCGTTTATCC ATCGTTTTCG CGTCTCTGGG AAGCTTCGCC 
AGCGTCCTCC TCGTGGGCAG TCTCGGATAC ATTGGCTTAA ACAGGGCTGC CTGGCACTTG 
TGCCCACCTC TGCCTACGCC CTGTGGCAGC ACTGCTGTGG AGTTCCCTGG CAGCCAGGAC 
AAGCAGGCTT GGCAATGGCG CAACCCTGAG GACTTCCCCG AGGTGTTGTA CCCACGAGAC 
GCGCTGGTGG TGGAGATGCC CAGGGACAGA GATGATGAGA CAGAGTCGCC CCAGGCCACC 
CCTGAGCGCG CCCTGGACAC AAGGTGGCCC TTGGGAACTG AGGGGCAGGT GCAAGGACTC 
TCAGAGGCCA GGCTCCCGGA CCTGGCTAGA GAGGACTGTC CCCGTGGTGA CCTGGCCCAC 
GTGACACTCC CGCTGCTCCT GGGAGATGTG ACCCAGGGAG CCTCGGTACT TGGTGATCTT 
TGGTGGATCC ATAAGACCGT GGAGCCAGGA CCACCCACTT TGGGTCAAGA GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252883.1
CDS	101..2317
Translation	MDMTGLPGTSKHIIFLLLCQLSASSRGDSCCVEKISYPDEASGPSLGPRDLSCYRVSGTDYECSWQYDGPEDNVAHFLWCCFAHPNPTHTSFGQECCCYFSSGRSRTVQFWEQDGISTLSKVNFWVESRLGNRTLKSQEISQYLYNWTKLTPPLGHIRVSRSRGELRMDWNVSDGAGAEVQLRRRMPTTNWTLGDCGPQVSSGLGVIGDIHGSSSESCLCPSENMAQEIQIRRRRRLSSGAPGGPWSNWSMSVCVPPEFLPQAEIKFLVEPLNQDGRRRLTMEGQTPQLAVPEGCRDRPGAQVKKHLVLVHMLACRCQARTWKTVPLGKTLDLSGAAYDLDVLAQTRFGRSIIQKWPLPAQELTETRTLNVIVEGNVTSMQWAAQPPGTAYCLEWQPWGQDRNHTDCTLIAPEEEDPAKMVTHTWSSKPTLDQEECYRITVFASKNPKNPMMWATVLSSYYFGGNVSRVGTPRHVSVRNHTEDSVSVEWTASQLSTCPGVLTQYVVRCEAEDGTWESELLVPPTKTQVTLNSLRSRVVYKVQVRADTAMLPGSWSRPQRFSVEVQISRLSIVFASLGSFASVLLVGSLGYIGLNRAAWHLCPPLPTPCGSTAVEFPGSQDKQAWQWRNPEDFPEVLYPRDALVVEMPRDRDDETESPQATPERALDTRWPLGTEGQVQGLSEARLPDLAREDCPRGDLAHVTLPLLLGDVTQGASVLGDLWWIHKTVEPGPPTLGQEA

Target ORF information:

RefSeq Version	XM_006252821.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus interleukin 12 receptor subunit beta 1 (Il12rb1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252821.3

ORF Insert Sequence:

ATGGACATGA CGGGGCTGCC AGGGACCAGC AAGCACATCA TCTTCCTCCT GCTTTGCCAG 
CTAAGCGCCT CCAGCCGAGG TGACAGCTGC TGCGTTGAGA AGATATCATA CCCAGATGAA 
GCCTCAGGCC CCTCCTTAGG ACCCAGGGAC TTGAGCTGCT ACAGGGTTTC CGGGACAGAC 
TATGAGTGCT CCTGGCAGTA TGATGGCCCT GAGGACAATG TTGCTCACTT CCTGTGGTGC 
TGCTTTGCTC ATCCAAACCC TACCCACACC AGCTTTGGCC AAGAATGCTG CTGCTACTTC 
TCTTCGGGCC GGTCTCGGAC TGTGCAGTTC TGGGAACAGG ATGGTATCTC TACGTTGTCC 
AAGGTCAACT TCTGGGTCGA GTCTCGGCTT GGGAACAGGA CCTTGAAGTC TCAGGAGATA 
TCGCAGTACC TGTACAACTG GACCAAGCTC ACCCCTCCTC TGGGACACAT CAGAGTGTCA 
CGATCACGCG GGGAGTTGCG AATGGACTGG AATGTGTCGG ATGGGGCCGG TGCTGAGGTA 
CAACTGAGGC GCCGGATGCC CACAACGAAT TGGACCTTGG GTGACTGCGG ACCTCAGGTT 
AGCTCTGGCT TAGGTGTGAT TGGTGACATT CACGGTAGCA GTTCTGAGTC CTGCCTCTGC 
CCTTCTGAGA ACATGGCCCA GGAAATCCAG ATACGGAGAC GGCGGCGCCT CTCCTCAGGA 
GCTCCTGGAG GTCCCTGGAG TAATTGGAGC ATGTCTGTGT GTGTCCCGCC TGAATTCCTC 
CCCCAGGCTG AGATTAAGTT CCTGGTGGAG CCCCTGAACC AAGATGGAAG GAGGCGTCTG 
ACTATGGAAG GGCAGACACC ACAGCTGGCA GTCCCGGAGG GCTGCAGGGA CCGGCCTGGG 
GCGCAGGTGA AGAAGCACTT GGTGCTGGTG CACATGCTGG CCTGCAGGTG CCAGGCTCGG 
ACCTGGAAGA CCGTGCCCCT GGGCAAGACG CTGGACCTCT CCGGTGCCGC CTACGACCTG 
GATGTACTCG CCCAGACTCG CTTCGGCCGC AGCATCATCC AGAAGTGGCC CCTTCCTGCC 
CAAGAGCTCA CAGAGACAAG AACCCTGAAT GTCATCGTGG AAGGCAACGT GACATCCATG 
CAGTGGGCAG CCCAGCCTCC AGGCACTGCC TACTGCCTTG AGTGGCAGCC ATGGGGCCAG 
GACAGGAACC ACACGGACTG TACTCTGATT GCACCAGAAG AAGAGGACCC AGCCAAGATG 
GTGACGCACA CCTGGAGCTC CAAGCCTACC CTGGACCAGG AGGAATGTTA CCGCATCACT 
GTCTTCGCCT CCAAGAACCC CAAGAATCCC ATGATGTGGG CCACGGTCCT GTCCAGTTAC 
TACTTTGGGG GTAACGTCTC AAGGGTCGGA ACTCCACGCC ACGTGTCGGT GAGGAACCAC 
ACCGAGGACT CAGTGTCCGT GGAGTGGACA GCGTCACAGC TGAGCACCTG CCCAGGGGTC 
CTGACGCAAT ACGTCGTGCG CTGCGAGGCT GAAGATGGCA CGTGGGAGTC AGAGTTGCTC 
GTGCCACCCA CGAAGACCCA AGTGACACTA AACAGTCTGC GCAGCCGCGT GGTGTACAAG 
GTTCAGGTGC GAGCTGACAC TGCGATGCTC CCAGGCTCCT GGAGCCGTCC CCAGCGCTTC 
AGCGTTGAGG TGCAGATTTC CCGTTTATCC ATCGTTTTCG CGTCTCTGGG AAGCTTCGCC 
AGCGTCCTCC TCGTGGGCAG TCTCGGATAC ATTGGCTTAA ACAGGGCTGC CTGGCACTTG 
TGCCCACCTC TGCCTACGCC CTGTGGCAGC ACTGCTGTGG AGTTCCCTGG CAGCCAGGAC 
AAGCAGGCTT GGCAATGGCG CAACCCTGAG GACTTCCCCG AGGTGTTGTA CCCACGAGAC 
GCGCTGGTGG TGGAGATGCC CAGGGACAGA GATGATGAGA CAGAGTCGCC CCAGGCCACC 
CCTGAGCGCG CCCTGGACAC AAGGTGGCCC TTGGGAACTG AGGGGCAGGT GCAAGGACTC 
TCAGAGGCCA GGCTCCCGGA CCTGGCTAGA GAGGACTGTC CCCGTGGTGA CCTGGCCCAC 
GTGACACTCC CGCTGCTCCT GGGAGATGTG ACCCAGGGAG CCTCGGTACT TGGTGATCTT 
TGGTGGATCC ATAAGACCGT GGAGCCAGGA CCACCCACTT TGGGTCAAGA GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Increased IL-23 and IL-17 expression by peripheral blood cells of patients with primary biliary cirrhosis.
Cytokine64(1)172-80(2013 Oct)
Qian C,Jiang T,Zhang W,Ren C,Wang Q,Qin Q,Chen J,Deng A,Zhong R

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses.
Nature immunology5(8)800-8(2004 Aug)
Watanabe T,Kitani A,Murray PJ,Strober W

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development.
European journal of immunology34(5)1371-80(2004 May)
Smits HH,van Beelen AJ,Hessle C,Westland R,de Jong E,Soeteman E,Wold A,Wierenga EA,Kapsenberg ML

IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency.
European journal of immunology33(12)3393-7(2003 Dec)
Hoeve MA,de Boer T,Langenberg DM,Sanal O,Verreck FA,Ottenhoff TH

Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.
Journal of immunology (Baltimore, Md. : 1950)169(10)5673-8(2002 Nov)
Pirhonen J,Matikainen S,Julkunen I

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