Fgf19 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf19
Entrez Gene ID	170582
Full Name	fibroblast growth factor 19
Synonyms	Fgf15
General protein information	Preferred Names fibroblast growth factor 19 Names fibroblast growth factor 19 fibroblast growth factor 15
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q42
Summary	member of the fibroblast growth factor (FGF) family; implicated in activities including embryonic development, cell growth, morphogenesis, tissue growth, and tumor growth and invasion [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_130753.1	NP_570109.1	fibroblast growth factor 19 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	FGF19	NP_990005.1
Homo sapiens (human)	FGF19	NP_005108.1
Pan troglodytes (chimpanzee)	FGF19	XP_003952007.1
Bos taurus (cattle)	FGF19	XP_002699484.1
Rattus norvegicus (Norway rat)	Fgf19	NP_570109.1
Xenopus tropicalis (tropical clawed frog)	fgf19	NP_001136297.1
Macaca mulatta (Rhesus monkey)	FGF19	XP_001100825.1
Canis lupus familiaris (dog)	FGF19	XP_540802.3
Mus musculus (house mouse)	Fgf15	NP_032029.1
Danio rerio (zebrafish)	fgf19	NP_001012246.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatic cholesterol accumulation ascribed to the activation of ileum Fxr-Fgf15 pathway inhibiting hepatic Cyp7a1 in high-fat diet-induced obesity rats.
Duan Y, Zhang F, Yuan W, Wei Y, Wei M, Zhou Y, Yang Y, Chang Y, Wu X
Life sciences232116638(2019 Sep)

Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine.
Wang F, Lu Z, Wang X, Zhang Y
Biochemical and biophysical research communications495(1)1490-1496(2018 01)

The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance.
Yan X, Li P, Tang Z, Feng B
BMC endocrine disorders17(1)60(2017 Sep)

FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels.
Shang Q, Guo GL, Honda A, Saumoy M, Salen G, Xu G
Journal of lipid research54(10)2606-14(2013 Oct)

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K
Cell metabolism17(6)916-28(2013 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fgf19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12611	NM_130753.1 Latest version!	Rattus norvegicus fibroblast growth factor 19 (Fgf19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf19 ( NM_130753.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_570109.1 Rattus norvegicus fibroblast growth factor 19 (Fgf19), mRNA.

Price & Availability↑

CloneID	ORa12611
Clone ID Related Accession (Same CDS sequence)	NM_130753.1
Accession Version	NM_130753.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569772800000
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 19 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB078900.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB078900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689604, SAMN02642715 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAGAA AGTGGAGTGG GCGTATTGTG GCCCGAGCTC TGGTCCTGGC CACTCTGTGG 
CTGGCCGTGT CTGGGCGTCC CCTGGTCCAG CAATCCCAGT CTGTGTCGGA TGAAGGTCCA 
CTCTTTCTCT ATGGCTGGGG CAAGATTACC CGCCTGCAGT ACCTGTACTC TGCTGGTCCC 
TACGTCTCCA ACTGCTTCCT GCGTATCCGG AGTGACGGCT CTGTGGACTG CGAGGAGGAC 
CAGAACGAAC GAAATCTGTT GGAGTTCCGC GCGGTTGCTC TGAAGACAAT TGCCATCAAG 
GACGTCAGCA GCGTGCGGTA CCTCTGCATG AGCGCCGACG GCAAGATATA CGGGCTGATT 
CGCTACTCGG AGGAAGACTG TACCTTCAGG GAGGAAATGG ACTGTTTGGG CTACAACCAG 
TACAGGTCCA TGAAGCACCA CCTCCACATC ATCTTCATCA AGGCCAAGCC CAGAGAGCAG 
CTCCAGGGCC AGAAACCTTC AAACTTTATC CCCATATTTC ACCGGTCTTT CTTTGAATCC 
ACGGACCAGC TGAGGTCTAA AATGTTCTCT CTGCCCCTGG AGAGCGACAG CATGGATCCG 
TTCAGAATGG TGGAGGATGT GGACCACCTA GTGAAGAGTC CCAGCTTCCA GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570109.1
CDS	1..657
Translation	MARKWSGRIVARALVLATLWLAVSGRPLVQQSQSVSDEGPLFLYGWGKITRLQYLYSAGPYVSNCFLRIRSDGSVDCEEDQNERNLLEFRAVALKTIAIKDVSSVRYLCMSADGKIYGLIRYSEEDCTFREEMDCLGYNQYRSMKHHLHIIFIKAKPREQLQGQKPSNFIPIFHRSFFESTDQLRSKMFSLPLESDSMDPFRMVEDVDHLVKSPSFQK

Target ORF information:

RefSeq Version	NM_130753.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 19 (Fgf19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130753.1

ORF Insert Sequence:

ATGGCGAGAA AGTGGAGTGG GCGTATTGTG GCCCGAGCTC TGGTCCTGGC CACTCTGTGG 
CTGGCCGTGT CTGGGCGTCC CCTGGTCCAG CAATCCCAGT CTGTGTCGGA TGAAGGTCCA 
CTCTTTCTCT ATGGCTGGGG CAAGATTACC CGCCTGCAGT ACCTGTACTC TGCTGGTCCC 
TACGTCTCCA ACTGCTTCCT GCGTATCCGG AGTGACGGCT CTGTGGACTG CGAGGAGGAC 
CAGAACGAAC GAAATCTGTT GGAGTTCCGC GCGGTTGCTC TGAAGACAAT TGCCATCAAG 
GACGTCAGCA GCGTGCGGTA CCTCTGCATG AGCGCCGACG GCAAGATATA CGGGCTGATT 
CGCTACTCGG AGGAAGACTG TACCTTCAGG GAGGAAATGG ACTGTTTGGG CTACAACCAG 
TACAGGTCCA TGAAGCACCA CCTCCACATC ATCTTCATCA AGGCCAAGCC CAGAGAGCAG 
CTCCAGGGCC AGAAACCTTC AAACTTTATC CCCATATTTC ACCGGTCTTT CTTTGAATCC 
ACGGACCAGC TGAGGTCTAA AATGTTCTCT CTGCCCCTGG AGAGCGACAG CATGGATCCG 
TTCAGAATGG TGGAGGATGT GGACCACCTA GTGAAGAGTC CCAGCTTCCA GAAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatic cholesterol accumulation ascribed to the activation of ileum Fxr-Fgf15 pathway inhibiting hepatic Cyp7a1 in high-fat diet-induced obesity rats.
Life sciences232116638(2019 Sep)
Duan Y,Zhang F,Yuan W,Wei Y,Wei M,Zhou Y,Yang Y,Chang Y,Wu X

Impaired vagus function in rats suppresses bile acid synthesis in the liver by disrupting tight junctions and activating Fxr-Fgf15 signaling in the intestine.
Biochemical and biophysical research communications495(1)1490-1496(2018 01)
Wang F,Lu Z,Wang X,Zhang Y

The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance.
BMC endocrine disorders17(1)60(2017 Sep)
Yan X,Li P,Tang Z,Feng B

FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels.
Journal of lipid research54(10)2606-14(2013 Oct)
Shang Q,Guo GL,Honda A,Saumoy M,Salen G,Xu G

Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.
Cell metabolism17(6)916-28(2013 Jun)
Vergnes L,Lee JM,Chin RG,Auwerx J,Reue K