| Gene Symbol | OAZ3 |
| Entrez Gene ID | 100985778 |
| Full Name | ornithine decarboxylase antizyme 3 |
| Gene Type | protein-coding |
| Organism | Pan paniscus(pygmy chimpanzee) |
| Summary | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been noted for this gene. [provided by RefSeq, Aug 2014]. |
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OAZ3 cDNA ORF clone, Pan paniscus(pygmy chimpanzee)
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Gene
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Clones
gRNAs
The following OAZ3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OPa259777 Clone ID Related Accession (Same CDS sequence) NM_001290340.1 Accession Version NM_001290340.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 573bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1556899200000 Organism Pan paniscus(pygmy chimpanzee) Product ornithine decarboxylase antizyme 3 isoform 2 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJFE02058366.1 and AJFE02058365.1. On Mar 12, 2014 this sequence version replaced XM_003817238.1. Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation from an AUG start codon, compared to variant 1. The resulting isoform (2) is shorter with a distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00632220, SAMN02189950 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541ATGACCGTGC CCTGGCGGCC AGGAAAGCGA CGCATCACTT ATAAGGAAGA GGAGGACTTG
ACACTCCAGC CCCGTTCCTG CCTCCAGTGC TCCGAGTCCC TAGTAGGCCT CCAGGAGGGC
AAAAGCACCG AGCAGGGTAA CCACGACCAG CTTAAAGAAC TGTATTCGGC TGGGAACTTG
ACGGTGCTGG CTACTGACCC CCTGCTCCAC CAGGACCCAG TACAGTTAGA CTTTCACTTC
CGCCTTACCT CCCAGACCTC TGCCCATTGG CACGGCCTTC TCTGTGACCA TCGACTCTTC
CTGGATATCC CATATCAGGC CTTGGATCAA GGCAACCGGG AAAGTTTGAC CGCAACCCTG
GAGTACGTGG AAGAGAAGAC AAATGTGGAC TCTGTGTTTG TGAACTTCCA GAATGATCGG
AATGACAGAG GTGCCCTGCT GCGGGCCTTC AGCTACATGG GCTTTGAGGT GGTCAGACCA
GGTCACCCTG CCCTCCCTCC CTTGGACAAT GTCATCTTTA TGGTGTATCC CCTTGAAAGG
GATGTTGGCC ACCTGCCCAG TGAGCCTCCT TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001277269.1 CDS join(288..380,382..861) Translation 
Target ORF information:
RefSeq Version NM_001290340.1 Organism Pan paniscus(pygmy chimpanzee) Definition Pan paniscus ornithine decarboxylase antizyme 3 (OAZ3), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001290340.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGACCGTGC CCTGGCGGCC AGGAAAGCGA CGCATCACTT ATAAGGAAGA GGAGGACTTG
ACACTCCAGC CCCGTTCCTG CCTCCAGTGC TCCGAGTCCC TAGTAGGCCT CCAGGAGGGC
AAAAGCACCG AGCAGGGTAA CCACGACCAG CTTAAAGAAC TGTATTCGGC TGGGAACTTG
ACGGTGCTGG CTACTGACCC CCTGCTCCAC CAGGACCCAG TACAGTTAGA CTTTCACTTC
CGCCTTACCT CCCAGACCTC TGCCCATTGG CACGGCCTTC TCTGTGACCA TCGACTCTTC
CTGGATATCC CATATCAGGC CTTGGATCAA GGCAACCGGG AAAGTTTGAC CGCAACCCTG
GAGTACGTGG AAGAGAAGAC AAATGTGGAC TCTGTGTTTG TGAACTTCCA GAATGATCGG
AATGACAGAG GTGCCCTGCT GCGGGCCTTC AGCTACATGG GCTTTGAGGT GGTCAGACCA
GGTCACCCTG CCCTCCCTCC CTTGGACAAT GTCATCTTTA TGGTGTATCC CCTTGAAAGG
GATGTTGGCC ACCTGCCCAG TGAGCCTCCT TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OPa259778 Clone ID Related Accession (Same CDS sequence) NM_001301415.1 Accession Version NM_001301415.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 708bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1556899200000 Organism Pan paniscus(pygmy chimpanzee) Product ornithine decarboxylase antizyme 3 isoform 1 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJFE02058366.1 and AJFE02058365.1. Transcript Variant: This variant (1) initiates translation from a non-AUG (CUG) start codon, and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00632231, SAMN02189950 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541
601
661CTGCCTTGTA AGAGGTGTCG CCCCTCTGTC TACTCCCTTT CTTATATCAA GAGGGGAAAA
ACACGTAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA TTGTTACAAG
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTCGCTGTT ATAAAAGCAT CACTTATAAG
GAAGAGGAGG ACTTGACACT CCAGCCCCGT TCCTGCCTCC AGTGCTCCGA GTCCCTAGTA
GGCCTCCAGG AGGGCAAAAG CACCGAGCAG GGTAACCACG ACCAGCTTAA AGAACTGTAT
TCGGCTGGGA ACTTGACGGT GCTGGCTACT GACCCCCTGC TCCACCAGGA CCCAGTACAG
TTAGACTTTC ACTTCCGCCT TACCTCCCAG ACCTCTGCCC ATTGGCACGG CCTTCTCTGT
GACCATCGAC TCTTCCTGGA TATCCCATAT CAGGCCTTGG ATCAAGGCAA CCGGGAAAGT
TTGACCGCAA CCCTGGAGTA CGTGGAAGAG AAGACAAATG TGGACTCTGT GTTTGTGAAC
TTCCAGAATG ATCGGAATGA CAGAGGTGCC CTGCTGCGGG CCTTCAGCTA CATGGGCTTT
GAGGTGGTCA GACCAGGTCA CCCTGCCCTC CCTCCCTTGG ACAATGTCAT CTTTATGGTG
TATCCCCTTG AAAGGGATGT TGGCCACCTG CCCAGTGAGC CTCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001288344.1 CDS join(68..295,297..776) Translation
Target ORF information:
RefSeq Version NM_001301415.1 Organism Pan paniscus(pygmy chimpanzee) Definition Pan paniscus ornithine decarboxylase antizyme 3 (OAZ3), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001301415.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661CTGCCTTGTA AGAGGTGTCG CCCCTCTGTC TACTCCCTTT CTTATATCAA GAGGGGAAAA
ACACGTAACT ACCTCTACCC GATCTGGTCA CCATACGCCT ATTACCTTTA TTGTTACAAG
TACCGGATCA CCCTCCGGGA GAAGATGCTG CCTCGCTGTT ATAAAAGCAT CACTTATAAG
GAAGAGGAGG ACTTGACACT CCAGCCCCGT TCCTGCCTCC AGTGCTCCGA GTCCCTAGTA
GGCCTCCAGG AGGGCAAAAG CACCGAGCAG GGTAACCACG ACCAGCTTAA AGAACTGTAT
TCGGCTGGGA ACTTGACGGT GCTGGCTACT GACCCCCTGC TCCACCAGGA CCCAGTACAG
TTAGACTTTC ACTTCCGCCT TACCTCCCAG ACCTCTGCCC ATTGGCACGG CCTTCTCTGT
GACCATCGAC TCTTCCTGGA TATCCCATAT CAGGCCTTGG ATCAAGGCAA CCGGGAAAGT
TTGACCGCAA CCCTGGAGTA CGTGGAAGAG AAGACAAATG TGGACTCTGT GTTTGTGAAC
TTCCAGAATG ATCGGAATGA CAGAGGTGCC CTGCTGCGGG CCTTCAGCTA CATGGGCTTT
GAGGTGGTCA GACCAGGTCA CCCTGCCCTC CCTCCCTTGG ACAATGTCAT CTTTATGGTG
TATCCCCTTG AAAGGGATGT TGGCCACCTG CCCAGTGAGC CTCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF
Polyamines in spermiogenesis: not now, darling.
Proceedings of the National Academy of Sciences of the United States of America97(9)4421-3(2000 Apr)
Coffino P
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