SLC9A3 cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene
Clones
gRNAs

Summary

Gene Symbol	SLC9A3
Entrez Gene ID	100009430
Full Name	solute carrier family 9 member A3
Synonyms	NHE-3
Gene Type	protein-coding
Organism	Oryctolagus cuniculus(rabbit)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001082697.1	NP_001076166.1	sodium/hydrogen exchanger 3 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.
Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M
American journal of physiology. Cell physiology307(1)C55-65(2014 Jul)

AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.
Singh V, Lin R, Yang J, Cha B, Sarker R, Tse CM, Donowitz M
The Journal of biological chemistry289(9)5449-61(2014 Feb)

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M
The Journal of biological chemistry287(16)13442-56(2012 Apr)

Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.
Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology22(5-6)693-704(2008)

cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.
Yun CH, Oh S, Zizak M, Steplock D, Tsao S, Tse CM, Weinman EJ, Donowitz M
Proceedings of the National Academy of Sciences of the United States of America94(7)3010-5(1997 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SLC9A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLC9A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OOb30253	NM_001082697.1 Latest version!	Oryctolagus cuniculus solute carrier family 9 member A3 (SLC9A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SLC9A3 ( NM_001082697.1 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> NP_001076166.1 Oryctolagus cuniculus solute carrier family 9 member A3 (SLC9A3), mRNA.

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CloneID	OOb30253
Clone ID Related Accession (Same CDS sequence)	NM_001082697.1
Accession Version	NM_001082697.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2499bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569081600000
Organism	Oryctolagus cuniculus(rabbit)
Product	sodium/hydrogen exchanger 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M87007.1. ##Evidence-Data-START## Transcript exon combination :: M87007.1 [ECO:0000332] ##Evidence-Data-END##

ATGTCAGGGC GCGGGGGCTG CGGCCCTTGC TGGGGGTTGC TGCTGGCGCT GGTGCTGGCG 
CTGGGCGCGC TGCCCTGGAC GCAGGGCGCC GAGCAGGAGC ATCACGATGA GATCCAGGGC 
TTCCAGATAG TCACGTTCAA ATGGCACCAC GTCCAGGACC CCTACATCAT CGCGCTCTGG 
GTCCTCGTGG CCAGCTTGGC TAAGATCGTC TTCCACCTGT CCCACAAAGT CACCAGTGTC 
GTCCCCGAGA GCGCGCTGCT CATCGTGCTA GGCCTGGTGC TAGGCGGCAT CGTCCTGGCC 
GCTGACCACA TCGCCTCCTT CACGCTCACG CCCACCGTCT TCTTCTTCTA CCTGCTGCCG 
CCCATCGTGC TGGACGCCGG CTACTTCATG CCCAACCGGC TCTTCTTCAG CAACCTGGGC 
AGCATCCTGC TCTACGCCGT CGTGGGCACC GTGTGGAACG CGGCCACCAC CGGGCTGTCG 
CTCTACGGAG TCTTCCTCAG CGGCATCATG GGCGAACTGA AGATCGGCCT CCTGGACTTC 
CTGCTGTTCG GCAGCCTCAT TGCTGCCGTG GACCCCGTGG CCGTGCTGGC CGTGTTCGAG 
GAGGTCCACG TCAACGAGGT TCTGTTCATC ATCGTTTTCG GGGAGTCGCT GCTAAACGAC 
GCCGTCACGG TGGTGCTGTA CAACGTGTTC CAATCTTTCG TGACACTGGG TGGTGACAAG 
GTGACAGGCG TGGACTGTGT GAAGGGCATA GTGTCCTTCT TCGTGGTGAG CCTGGGGGGC 
ACGCTGGTGG GGGTGGTCTT CGCCTTCCTG CTGTCGCTGG TGACGCGCTT CACCAAGCAC 
GTGCGCGTCA TCGAGCCCGG CTTCGTCTTC ATCATCTCCT ACCTGAGCTA CCTGACGTCC 
GAGATGCTGT CCCTGTCGTC CATCCTGGCT ATCACCTTCT GCGGCATCTG CTGTCAGAAG 
TATGTGAAAG CCAACATCTC GGAGCAGTCG GCCACCACGG TGCGCTACAC CATGAAGATG 
CTGGCCAGCG GGGCTGAGAC CATCATCTTC ATGTTCCTGG GCATCTCGGC CGTGGACCCG 
CTCATCTGGA CCTGGAACAC GGCCTTCGTG CTGCTCACGC TGCTCTTCGT GTCCGTGTTC 
CGGGCCATCG GTGTCGTGCT GCAGACCTGG CTGCTGAACC GGTACCGCAT GGTGCAGCTG 
GAGCTGATCG ACCAGGTGGT CATGTCCTAC GGCGGCCTGC GCGGGGCCGT GGCCTTCGCC 
CTGGTCGCGC TGCTGGACGG GAACAAGGTC AAGGAGAAGA ACTTGTTCGT CAGCACCACC 
ATCATCGTCG TCTTCTTCAC CGTCATCTTC CAGGGCCTGA CCATCAAGCC GCTGGTGCAG 
TGGCTGAAGG TGAAGCGCAG CGAGCACCGG GAGCCCAAGC TGAACGAGAA GCTGCACGGC 
CGGGCTTTCG ACCACATCCT CTCGGCCATC GAGGACATAT CCGGGCAGAT TGGGCACAAT 
TATCTCAGGG ACAAGTGGGC CAACTTCGAC CGGAGGTTCC TCAGCAAACT GCTCATGAGG 
CAGTCGGCCC AGAAGTCTCG GGACCGGATT CTGAACGTGT TCCACGAGCT GAACCTGAAG 
GATGCCATCA GCTACGTGAC CGAGGGAGAG CGCCGAGGCT CCCTGGCCTT CATCCGCTCC 
CCGAGCACTG ACAACATGGT CAATGTGGAC TTCAGCACGC CGCGCCCGTC CACCGTGGAG 
GCCTCCGTCT CCTACCTCCT GAGGGAGAGT GCCAGCGCCG TGTGCCTGGA CATGCAGTCG 
CTGGAGCAGC GGCGGCGCAG CGTGCGCGAC GCAGAGGACG TCATCACGCA CCACACGCTG 
CAGCAGTACC TGTACAAGCC TCGGCAGGAG TACAAACACC TGTACAGCCG GCACGTGCTC 
AGCCCCAGCG AGGACGAGAA GCAGGACAAG GAGATCTTCC ACCGCACCAT GCGCAAGCGG 
CTGGAGTCCT TCAAGTCGGC CAAGCTGGGC CTCGGCCAGA GCAAGAAGGC GACCAAGCAC 
AAGCGGGAGC GGGAGCGGGC GCAGAAGCGG AGAAACAGCA GTGTCCCCAA CGGGAAGCTG 
CCCCTGGACA GCCCTGCCTA CGGCCTCACC CTTAAGGAGA GAGAGCTGGA ACTTTCAGAC 
CCCGAGGAGG CCCCCGACTA CTACGAGGCT GAGAAGATGA GTGGGGGGAT CGAGTTCCTG 
GCCAGCGTCA CCAAGGACAC GACCTCCGAC TCCCCTGCAG GAATTGACAA CCCTGTGTTC 
TCCCCGGACG AGGACCTGGC CCCCAGCCTC CTGGCCAGGG TGCCACCCTG GCTGTCTCCC 
GGGGAGGCCG TGGTGCCCTC CCAGAGGGCC CGCGTGCAGA TCCCCTACTC CCCGGGCAAC 
TTCCGCCGCC TGGCGCCCTT CCGGCTCAGC AACAAGTCGG TGGACTCGTT CCTGCTGGCG 
GAGGACGGCG CTGAACACCC CGAGTCCACA CACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001076166.1
CDS	212..2710
Translation	MSGRGGCGPCWGLLLALVLALGALPWTQGAEQEHHDEIQGFQIVTFKWHHVQDPYIIALWVLVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVLAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFSNLGSILLYAVVGTVWNAATTGLSLYGVFLSGIMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFQSFVTLGGDKVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRVIEPGFVFIISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPLIWTWNTAFVLLTLLFVSVFRAIGVVLQTWLLNRYRMVQLELIDQVVMSYGGLRGAVAFALVALLDGNKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWANFDRRFLSKLLMRQSAQKSRDRILNVFHELNLKDAISYVTEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYLLRESASAVCLDMQSLEQRRRSVRDAEDVITHHTLQQYLYKPRQEYKHLYSRHVLSPSEDEKQDKEIFHRTMRKRLESFKSAKLGLGQSKKATKHKRERERAQKRRNSSVPNGKLPLDSPAYGLTLKERELELSDPEEAPDYYEAEKMSGGIEFLASVTKDTTSDSPAGIDNPVFSPDEDLAPSLLARVPPWLSPGEAVVPSQRARVQIPYSPGNFRRLAPFRLSNKSVDSFLLAEDGAEHPESTHM

Target ORF information:

RefSeq Version	NM_001082697.1
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus solute carrier family 9 member A3 (SLC9A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001082697.1

ORF Insert Sequence:

ATGTCAGGGC GCGGGGGCTG CGGCCCTTGC TGGGGGTTGC TGCTGGCGCT GGTGCTGGCG 
CTGGGCGCGC TGCCCTGGAC GCAGGGCGCC GAGCAGGAGC ATCACGATGA GATCCAGGGC 
TTCCAGATAG TCACGTTCAA ATGGCACCAC GTCCAGGACC CCTACATCAT CGCGCTCTGG 
GTCCTCGTGG CCAGCTTGGC TAAGATCGTC TTCCACCTGT CCCACAAAGT CACCAGTGTC 
GTCCCCGAGA GCGCGCTGCT CATCGTGCTA GGCCTGGTGC TAGGCGGCAT CGTCCTGGCC 
GCTGACCACA TCGCCTCCTT CACGCTCACG CCCACCGTCT TCTTCTTCTA CCTGCTGCCG 
CCCATCGTGC TGGACGCCGG CTACTTCATG CCCAACCGGC TCTTCTTCAG CAACCTGGGC 
AGCATCCTGC TCTACGCCGT CGTGGGCACC GTGTGGAACG CGGCCACCAC CGGGCTGTCG 
CTCTACGGAG TCTTCCTCAG CGGCATCATG GGCGAACTGA AGATCGGCCT CCTGGACTTC 
CTGCTGTTCG GCAGCCTCAT TGCTGCCGTG GACCCCGTGG CCGTGCTGGC CGTGTTCGAG 
GAGGTCCACG TCAACGAGGT TCTGTTCATC ATCGTTTTCG GGGAGTCGCT GCTAAACGAC 
GCCGTCACGG TGGTGCTGTA CAACGTGTTC CAATCTTTCG TGACACTGGG TGGTGACAAG 
GTGACAGGCG TGGACTGTGT GAAGGGCATA GTGTCCTTCT TCGTGGTGAG CCTGGGGGGC 
ACGCTGGTGG GGGTGGTCTT CGCCTTCCTG CTGTCGCTGG TGACGCGCTT CACCAAGCAC 
GTGCGCGTCA TCGAGCCCGG CTTCGTCTTC ATCATCTCCT ACCTGAGCTA CCTGACGTCC 
GAGATGCTGT CCCTGTCGTC CATCCTGGCT ATCACCTTCT GCGGCATCTG CTGTCAGAAG 
TATGTGAAAG CCAACATCTC GGAGCAGTCG GCCACCACGG TGCGCTACAC CATGAAGATG 
CTGGCCAGCG GGGCTGAGAC CATCATCTTC ATGTTCCTGG GCATCTCGGC CGTGGACCCG 
CTCATCTGGA CCTGGAACAC GGCCTTCGTG CTGCTCACGC TGCTCTTCGT GTCCGTGTTC 
CGGGCCATCG GTGTCGTGCT GCAGACCTGG CTGCTGAACC GGTACCGCAT GGTGCAGCTG 
GAGCTGATCG ACCAGGTGGT CATGTCCTAC GGCGGCCTGC GCGGGGCCGT GGCCTTCGCC 
CTGGTCGCGC TGCTGGACGG GAACAAGGTC AAGGAGAAGA ACTTGTTCGT CAGCACCACC 
ATCATCGTCG TCTTCTTCAC CGTCATCTTC CAGGGCCTGA CCATCAAGCC GCTGGTGCAG 
TGGCTGAAGG TGAAGCGCAG CGAGCACCGG GAGCCCAAGC TGAACGAGAA GCTGCACGGC 
CGGGCTTTCG ACCACATCCT CTCGGCCATC GAGGACATAT CCGGGCAGAT TGGGCACAAT 
TATCTCAGGG ACAAGTGGGC CAACTTCGAC CGGAGGTTCC TCAGCAAACT GCTCATGAGG 
CAGTCGGCCC AGAAGTCTCG GGACCGGATT CTGAACGTGT TCCACGAGCT GAACCTGAAG 
GATGCCATCA GCTACGTGAC CGAGGGAGAG CGCCGAGGCT CCCTGGCCTT CATCCGCTCC 
CCGAGCACTG ACAACATGGT CAATGTGGAC TTCAGCACGC CGCGCCCGTC CACCGTGGAG 
GCCTCCGTCT CCTACCTCCT GAGGGAGAGT GCCAGCGCCG TGTGCCTGGA CATGCAGTCG 
CTGGAGCAGC GGCGGCGCAG CGTGCGCGAC GCAGAGGACG TCATCACGCA CCACACGCTG 
CAGCAGTACC TGTACAAGCC TCGGCAGGAG TACAAACACC TGTACAGCCG GCACGTGCTC 
AGCCCCAGCG AGGACGAGAA GCAGGACAAG GAGATCTTCC ACCGCACCAT GCGCAAGCGG 
CTGGAGTCCT TCAAGTCGGC CAAGCTGGGC CTCGGCCAGA GCAAGAAGGC GACCAAGCAC 
AAGCGGGAGC GGGAGCGGGC GCAGAAGCGG AGAAACAGCA GTGTCCCCAA CGGGAAGCTG 
CCCCTGGACA GCCCTGCCTA CGGCCTCACC CTTAAGGAGA GAGAGCTGGA ACTTTCAGAC 
CCCGAGGAGG CCCCCGACTA CTACGAGGCT GAGAAGATGA GTGGGGGGAT CGAGTTCCTG 
GCCAGCGTCA CCAAGGACAC GACCTCCGAC TCCCCTGCAG GAATTGACAA CCCTGTGTTC 
TCCCCGGACG AGGACCTGGC CCCCAGCCTC CTGGCCAGGG TGCCACCCTG GCTGTCTCCC 
GGGGAGGCCG TGGTGCCCTC CCAGAGGGCC CGCGTGCAGA TCCCCTACTC CCCGGGCAAC 
TTCCGCCGCC TGGCGCCCTT CCGGCTCAGC AACAAGTCGG TGGACTCGTT CCTGCTGGCG 
GAGGACGGCG CTGAACACCC CGAGTCCACA CACATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling.
American journal of physiology. Cell physiology307(1)C55-65(2014 Jul)
Cha B,Chen T,Sarker R,Yang J,Raben D,Tse CM,Kovbasnjuk O,Donowitz M

AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking.
The Journal of biological chemistry289(9)5449-61(2014 Feb)
Singh V,Lin R,Yang J,Cha B,Sarker R,Tse CM,Donowitz M

Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
The Journal of biological chemistry287(16)13442-56(2012 Apr)
Zizak M,Chen T,Bartonicek D,Sarker R,Zachos NC,Cha B,Kovbasnjuk O,Korac J,Mohan S,Cole R,Chen Y,Tse CM,Donowitz M

Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology22(5-6)693-704(2008)
Zachos NC,Hodson C,Kovbasnjuk O,Li X,Thelin WR,Cha B,Milgram S,Donowitz M

cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein.
Proceedings of the National Academy of Sciences of the United States of America94(7)3010-5(1997 Apr)
Yun CH,Oh S,Zizak M,Steplock D,Tsao S,Tse CM,Weinman EJ,Donowitz M

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SLC9A3 cDNA ORF clone, Oryctolagus cuniculus(rabbit)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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