MMP2 cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP2
Entrez Gene ID	100009000
Full Name	matrix metallopeptidase 2
Gene Type	protein-coding
Organism	Oryctolagus cuniculus(rabbit)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001082209.1	NP_001075678.1	72 kDa type IV collagenase precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction.
Prado AF, Pernomian L, Azevedo A, Costa RAP, Rizzi E, Ramos J, Paes Leme AF, Bendhack LM, Tanus-Santos JE, Gerlach RF
Redox biology18181-190(2018 09)

TIMP‑3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP‑2 and MMP‑9 activity, and reduced TNF‑α expression.
Zhai H, Qi X, Li Z, Zhang W, Li C, Ji L, Xu K, Zhong H
Molecular medicine reports18(2)2061-2067(2018 Aug)

Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments.
Xie J, Wang CL, Yang W, Wang J, Chen C, Zheng L, Sung KLP, Zhou X
Journal of tissue engineering and regenerative medicine12(1)e550-e565(2018 01)

Selenium modulates MMP2 expression through the TGFβ1/Smad signalling pathway in human umbilical vein endothelial cells and rabbits following lipid disturbance.
Xu C, Lu G, Li Q, Zhang J, Huang Z, Gao X
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)4259-67(2017 Jul)

Influence of repetitive mechanical loading on MMP2 activity in tendon fibroblasts.
Huisman E, Lu A, Jamil S, Mousavizadeh R, McCormack R, Roberts C, Scott A
Journal of orthopaedic research : official publication of the Orthopaedic Research Society34(11)1991-2000(2016 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OOb00034	NM_001082209.1 Latest version!	Oryctolagus cuniculus matrix metallopeptidase 2 (MMP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP2 ( NM_001082209.1 ) cDNA ORF clone, Oryctolagus cuniculus(rabbit) -> NP_001075678.1 Oryctolagus cuniculus matrix metallopeptidase 2 (MMP2), mRNA.

Price & Availability↑

CloneID	OOb00034
Clone ID Related Accession (Same CDS sequence)	NM_001082209.1
Accession Version	NM_001082209.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1989bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Oryctolagus cuniculus(rabbit)
Product	72 kDa type IV collagenase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D63579.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D63579.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1876850, SAMEA3321799 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCGC TAGGGGCCCG GGGCGCGCTC GCCGGCTTCC TGCGGGCGCT CTGCGTCCTG 
GGCTGCCTGC TGGGCCGCGC CACCGCCCCG CCGTCTCCCG TCATCAAATT CCCCGGCGAT 
GTCGCCCCCA AAACGGACAA AGAGCTGGCG GTGCAATACC TGAACACCTT CTACGGCTGC 
CCCAAGGACA GTTGCAACCT GTTCGTGCTG AAGGACACCC TCAAGAAGAT GCAGAAGTTC 
TTCGGGCTGC CCCAGACAGG TGAACTGGAC CAGAGCACCA TCGAGACCAT GCGGAAGCCG 
CGCTGCGGCA ACCCGGATGT GGCCAACTAT AACTTCTTCC CCCGCAAGCC CAAGTGGGAC 
AAGAATCAGA TCACATACAG GATCATCGGC TACACGCCTG ACCTCGACCC GGAAACAGTG 
GATGATGCCT TCGCGCGCGC CTTCCAAGTC TGGAGTAACG TGACCCCGCT GCGGTTTTCT 
CGAATCCACG ATGGAGAAGC TGACATCATG ATCAACTTTG GCCGCTGGGA GCATGGAGAC 
GGATACCCGT TTGACGGCAA GGACGGGCTC CTGGCTCATG CCTTTGCTCC GGGCACTGGT 
GTTGGGGGAG ATTCCCACTT TGATGATGAT GAGCTGTGGA CCCTGGGAGA AGGTCAAGTG 
GTCCGTGTGA AGTATGGCAA TGCCGATGGG GAGTACTGCA AGTTCCCCTT CCTGTTCAAT 
GGCAAGGAGT ACACCAGCTG CACAGACACC GGTCGCAGCG ATGGCTTCCT CTGGTGCTCC 
ACCACCTACA ACTTTGAGAA GGATGGCAAG TACGGCTTCT GCCCCCATGA AGCCCTGTTC 
ACCATGGGTG GCAACGCCGA TGGGCAGCCC TGCAAGTTCC CGTTCCGCTT CCAAGGCACA 
TCCTACAGCA GCTGCACCAC GGAAGGCCGC ACCGACGGCT ACCGCTGGTG CGGCACCACC 
GAGGACTACG ACCGCGACAA GAAGTATGGC TTCTGCCCCG AGACTGCCAT GTCTACTATT 
GGCGGGAACT CGGAAGGCGC CCCCTGTGTC TTCCCCTTCA CCTTCCTGGG CAACAAGTAT 
GAGAGCTGTA CCAGCGCCGG CCGCAGTGAT GGCAAGATGT GGTGCGCGAC CTCAACCAAC 
TACGACGATG ACCGCAAGTG GGGCTTCTGC CCTGACCAAG GTTACAGCCT GTTCCTCGTG 
GCAGCCCATG AGTTTGGCCA CGCCATGGGG CTGGAGCACT CCCAGGACCC CGGGGCCCTG 
ATGGCGCCCA TTTACACCTA CACGAAGAAC TTCCGCCTGT CACAGGATGA CATCAAGGGC 
ATTCAAGAGC TCTACGGGGC CTCTCCCGAC GCTGGCACGG ACGCTGGCAC CGGCCCCACG 
CCTACGCTGG GACCTGTCAC TCCTGAGATC TGCACACAGG ACATCGTCTT CGATGGCATC 
GCTCAGATCC GTGGGGAGAT CTTCTTCTTC AAGGACCGGT TCATTTGGCG GACGGTGACA 
CCGGGTGACA AGCCCATGGG ACCCCTGCTG GTGGCCACCT TCTGGCCTGA GCTCCCGGAG 
AAGATCGACG CTGTGTACGA GGCCCCCCAG GAGGAGAAGG CCGTGTTCTT TGCAGGCAAT 
GAATACTGGG TGTATTCAGC CAGCACCCTG GAGCGAGGGT ACCCCAAGCC TCTGACCAGC 
CTCGGGCTGC CCCCCGATGT CCAGCGAGTA GACGCGGCCT TCAACTGGAG CAAGAACAAG 
AAGACGTACA TCTTTGCTGG AGACAAGTTC TGGAGATACA ATGAGGTGAA GAAGAAGATG 
GACCCTGGCT TCCCTCGGCT CATCGCGGAT GCCTGGAACG CCATCCCCGA TCACCTGGAT 
GCTGTGGTGG ACCTGCAGGG CAGCGGTCAC AGCTACTTCT TCAAGGGCAC TTATTACCTG 
AAGCTCGAGA ACCAAAGTCT GAAGAGCGTG AAGGTTGGAA GCATCAAGAC GGACTGGCTG 
GGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001075678.1
CDS	1..1989
Translation	MEALGARGALAGFLRALCVLGCLLGRATAPPSPVIKFPGDVAPKTDKELAVQYLNTFYGCPKDSCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSNVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYSSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATSTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDAGTDAGTGPTPTLGPVTPEICTQDIVFDGIAQIRGEIFFFKDRFIWRTVTPGDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPRLIADAWNAIPDHLDAVVDLQGSGHSYFFKGTYYLKLENQSLKSVKVGSIKTDWLGC

Target ORF information:

RefSeq Version	NM_001082209.1
Organism	Oryctolagus cuniculus(rabbit)
Definition	Oryctolagus cuniculus matrix metallopeptidase 2 (MMP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001082209.1

ORF Insert Sequence:

ATGGAGGCGC TAGGGGCCCG GGGCGCGCTC GCCGGCTTCC TGCGGGCGCT CTGCGTCCTG 
GGCTGCCTGC TGGGCCGCGC CACCGCCCCG CCGTCTCCCG TCATCAAATT CCCCGGCGAT 
GTCGCCCCCA AAACGGACAA AGAGCTGGCG GTGCAATACC TGAACACCTT CTACGGCTGC 
CCCAAGGACA GTTGCAACCT GTTCGTGCTG AAGGACACCC TCAAGAAGAT GCAGAAGTTC 
TTCGGGCTGC CCCAGACAGG TGAACTGGAC CAGAGCACCA TCGAGACCAT GCGGAAGCCG 
CGCTGCGGCA ACCCGGATGT GGCCAACTAT AACTTCTTCC CCCGCAAGCC CAAGTGGGAC 
AAGAATCAGA TCACATACAG GATCATCGGC TACACGCCTG ACCTCGACCC GGAAACAGTG 
GATGATGCCT TCGCGCGCGC CTTCCAAGTC TGGAGTAACG TGACCCCGCT GCGGTTTTCT 
CGAATCCACG ATGGAGAAGC TGACATCATG ATCAACTTTG GCCGCTGGGA GCATGGAGAC 
GGATACCCGT TTGACGGCAA GGACGGGCTC CTGGCTCATG CCTTTGCTCC GGGCACTGGT 
GTTGGGGGAG ATTCCCACTT TGATGATGAT GAGCTGTGGA CCCTGGGAGA AGGTCAAGTG 
GTCCGTGTGA AGTATGGCAA TGCCGATGGG GAGTACTGCA AGTTCCCCTT CCTGTTCAAT 
GGCAAGGAGT ACACCAGCTG CACAGACACC GGTCGCAGCG ATGGCTTCCT CTGGTGCTCC 
ACCACCTACA ACTTTGAGAA GGATGGCAAG TACGGCTTCT GCCCCCATGA AGCCCTGTTC 
ACCATGGGTG GCAACGCCGA TGGGCAGCCC TGCAAGTTCC CGTTCCGCTT CCAAGGCACA 
TCCTACAGCA GCTGCACCAC GGAAGGCCGC ACCGACGGCT ACCGCTGGTG CGGCACCACC 
GAGGACTACG ACCGCGACAA GAAGTATGGC TTCTGCCCCG AGACTGCCAT GTCTACTATT 
GGCGGGAACT CGGAAGGCGC CCCCTGTGTC TTCCCCTTCA CCTTCCTGGG CAACAAGTAT 
GAGAGCTGTA CCAGCGCCGG CCGCAGTGAT GGCAAGATGT GGTGCGCGAC CTCAACCAAC 
TACGACGATG ACCGCAAGTG GGGCTTCTGC CCTGACCAAG GTTACAGCCT GTTCCTCGTG 
GCAGCCCATG AGTTTGGCCA CGCCATGGGG CTGGAGCACT CCCAGGACCC CGGGGCCCTG 
ATGGCGCCCA TTTACACCTA CACGAAGAAC TTCCGCCTGT CACAGGATGA CATCAAGGGC 
ATTCAAGAGC TCTACGGGGC CTCTCCCGAC GCTGGCACGG ACGCTGGCAC CGGCCCCACG 
CCTACGCTGG GACCTGTCAC TCCTGAGATC TGCACACAGG ACATCGTCTT CGATGGCATC 
GCTCAGATCC GTGGGGAGAT CTTCTTCTTC AAGGACCGGT TCATTTGGCG GACGGTGACA 
CCGGGTGACA AGCCCATGGG ACCCCTGCTG GTGGCCACCT TCTGGCCTGA GCTCCCGGAG 
AAGATCGACG CTGTGTACGA GGCCCCCCAG GAGGAGAAGG CCGTGTTCTT TGCAGGCAAT 
GAATACTGGG TGTATTCAGC CAGCACCCTG GAGCGAGGGT ACCCCAAGCC TCTGACCAGC 
CTCGGGCTGC CCCCCGATGT CCAGCGAGTA GACGCGGCCT TCAACTGGAG CAAGAACAAG 
AAGACGTACA TCTTTGCTGG AGACAAGTTC TGGAGATACA ATGAGGTGAA GAAGAAGATG 
GACCCTGGCT TCCCTCGGCT CATCGCGGAT GCCTGGAACG CCATCCCCGA TCACCTGGAT 
GCTGTGGTGG ACCTGCAGGG CAGCGGTCAC AGCTACTTCT TCAAGGGCAC TTATTACCTG 
AAGCTCGAGA ACCAAAGTCT GAAGAGCGTG AAGGTTGGAA GCATCAAGAC GGACTGGCTG 
GGCTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction.
Redox biology18181-190(2018 09)
Prado AF,Pernomian L,Azevedo A,Costa RAP,Rizzi E,Ramos J,Paes Leme AF,Bendhack LM,Tanus-Santos JE,Gerlach RF

TIMP‑3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP‑2 and MMP‑9 activity, and reduced TNF‑α expression.
Molecular medicine reports18(2)2061-2067(2018 Aug)
Zhai H,Qi X,Li Z,Zhang W,Li C,Ji L,Xu K,Zhong H

Modulation of MMP-2 and MMP-9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments.
Journal of tissue engineering and regenerative medicine12(1)e550-e565(2018 01)
Xie J,Wang CL,Yang W,Wang J,Chen C,Zheng L,Sung KLP,Zhou X

Selenium modulates MMP2 expression through the TGFβ1/Smad signalling pathway in human umbilical vein endothelial cells and rabbits following lipid disturbance.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)4259-67(2017 Jul)
Xu C,Lu G,Li Q,Zhang J,Huang Z,Gao X

Influence of repetitive mechanical loading on MMP2 activity in tendon fibroblasts.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society34(11)1991-2000(2016 11)
Huisman E,Lu A,Jamil S,Mousavizadeh R,McCormack R,Roberts C,Scott A

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MMP2 cDNA ORF clone, Oryctolagus cuniculus(rabbit)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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