Qars cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Qars
Entrez Gene ID	97541
Full Name	glutaminyl-tRNA synthetase
Synonyms	1110018N24Rik,1200016L19Rik,C80286,GLNRS
General protein information	Preferred Names glutaminyl-tRNA synthetase Names glutamine--tRNA ligase glutamine-tRNA ligase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 F2

mRNA and Protein(s)

mRNA	Protein	Name
NM_133794.2	NP_598555.2	glutamine--tRNA ligase

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Qars	NP_598555.2
Rattus norvegicus (Norway rat)	Qars	NP_001007625.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.
Zhang X, Ling J, Barcia G, Jing L, Wu J, Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q, Poduri A, Partlow JN, Ville D, Dulac O, Yu TW, Lam AT, Servattalab S, Rodriguez J, Boddaert N, Munnich A, Colleaux L, Zon LI, Söll D, Walsh CA, Nabbout R
American journal of human genetics94(4)547-58(2014 Apr)

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M
Genes & development25(7)755-66(2011 Apr)

p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.
Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG, Kim S
Proceedings of the National Academy of Sciences of the United States of America99(12)7912-6(2002 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Qars gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Qars cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12916	NM_133794.2 Latest version!	Mus musculus glutaminyl-tRNA synthetase (Qars), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Qars ( NM_133794.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_598555.2 Mus musculus glutaminyl-tRNA synthetase (Qars), mRNA.

Price & Availability↑

CloneID	OMu12916
Clone ID Related Accession (Same CDS sequence)	NM_133794.2
Accession Version	NM_133794.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2328bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550678400000
Organism	Mus musculus(house mouse)
Product	glutamine--tRNA ligase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY131964.1, AK155759.1 and CT010508.10. On Nov 26, 2009 this sequence version replaced NM_133794.1. ##Evidence-Data-START## Transcript exon combination :: AK145632.1, AK088049.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTACTC CAGATTCGCT AGCGCTGTTC ACCGGCCTTG GCCTTAGCGA GAACAAGGCC 
CGCGAGACGC TCAAGAACGA GGCTCTGAGC ACTCAGCTGC GCGAGGCGGC GACCCAGGCA 
CACCAGATTC TGGGTTCTAC CATCGACAAG GCTACTGGGG TCCTCCTATA TGACTTGGTC 
TCCCGACTCA GGGATACTCG GCGTCGTTCT TTCCTTGTGA GCTATATAGC CAATAAGAAG 
ATTCACACGG GACTCCAGCT GAGCGCTGCT CTTGAATATG TTCGGAGTCA TCCCCAGGAT 
CCCATTGATA CCAAGGACTT CGAGCAGGAG TGTGGCGTCG GTGTGGTGGT GACACCGGAG 
CAGATTGAGG AAGCTGTGGA GTCCACCATA AATAAGCATC AGTTGCAGCT CCTAGCGGAA 
CGGTACCGTT TCAACATGGG GCTGCTAATG GGAGAGGCTC GGGCTGCGCT CAGATGGGCA 
GACGGCAAAA TGATCAAGAA CGAGGTGGAT ATGCAGGTGC TTCACCTTTT GGGGCCCAAG 
ATGGAAGCTG ATCTGGTGAA GAAGCCCAAG GTGGCAAAGG CACGGCTGGA AGAAACAGAC 
CGGAAGACAG CAAAAGATGT GGTGGAGAAA GGTGAAGTGG CTGGCCAGAC CCTGTCTCTG 
ATGGAGCAGC TCCGGGGGGA GGCACTTAAG TTTCATAAGC CAGGTGAGAA CTACAAGACG 
CCAGGCTATG TGATCACTCC ATATACCATG GATCTGCTGA AGCAGCACCT GGAGATCACT 
GGGGGACAGG TACGTACGCG GTTCCCTCCA GAGCCCAATG GAATCCTGCA TATTGGACAC 
GCCAAAGCCA TCAATTTCAA CTTTGGTTAT GCCAAGGCCA ACAATGGTAT CTGTTTTCTG 
CGCTTTGATG ACACCAACCC TGAGAAAGAA GAAGCAAAAT TCTTCACTGC TATTTATGAC 
ATGGTGACCT GGCTGGGTTA TACACCTTAC AAAGTGACAT ATGCTTCTGA CTATTTTGAC 
CAGCTGTATG CCTGGGCCGT GGAACTCATC CATGGGGGTC TTGCTTATGT GTGTCACCAG 
AGAGTGGAAG AGCTCAAAGG CCATAACCCT TTACCTTCTC CATGGAGGGA CAGGCCTAAG 
GAAGAATCAT TGCTGCTCTT TGAGGCAATG CGCAAGGGCA AATTTGCAGA AGGAGAGGCC 
ACACTTCGAA TGAAGTTGGT GATGGAAGAT GGCAAGATGG ACCCCGTGGC CTATCGAGTC 
AAGTACACGC CACACCATCG CACAGGGGAC AAATGGTGCA TCTACCCCAC CTATGACTAC 
ACACATTGTC TGTGTGACTC CATTGAGCAC ATTACCCACT CGTTGTGTAC CAAGGAGTTC 
CAGGCTCGAC GGTCTTCCTA CTTTTGGTTA TGTAACGCTC TGAAAGTCTA TTGTCCTGTT 
CAGTGGGAAT ATGGTCGCCT CAATTTGCAC TATGCTGTTG TCTCAAAGCG CAAGATTCTC 
CAGCTTGTAG CAGCTGGTGC TGTTCGGGAC TGGGACGATC CACGGCTCTT CACACTCACT 
GCCCTACGAC GACGGGGTTT TCCACCAGAG GCTATCAACA ACTTCTGTGC TCGGGTTGGG 
GTCACAGTGG CACAGACCAC AATGGAACCT CATCTTCTGG AAGCCTGTGT GCGTGATGTG 
CTGAATGATG CAGCCCCACG TGCCATGGCT GTTCTAGAGC CACTACAAGT TGTCATCACC 
AACTTTCCTG CTCCCAAGCC CTTGGACATC CGAGTGCCAA ATTTCCCAGC TGATGAGACC 
AAGGGTTTCC ACCAGGTTCC TTTTGCTTCC ACTGTCTTCA TTGAGAGAAG CGACTTTAAG 
GAGGAGTCAG AACCAGGCTA TAAGCGCCTA GCTTCGGGCC AGCCTGTGGG CCTGAGACAC 
ACTGGTTATG TCATTGAACT GCAGAATATT GTCAGGGGCT CCAGTGGCTG TGTGGAACGC 
TTGGAGGTGA CCTGTAGACG AGCTGATGCT GGAGAGAAGC CCAAGGCCTT TATTCACTGG 
GTATCACAGC CTTTGGTGTG TGAGATTCGC CTCTATGAGT GCCTATTCCA GCACAAGAAC 
CCCGAAGACC CTGTTGAAGT GCCTGGTGGA TTCCTAAGTG ACCTGAACCC GGCGTCACTA 
CAAGTGGTAG AAGGAGCATT AGTGGACTGC TCTGTGGCTT TGGCAAAGCC CTTTGACAAG 
TTCCAGTTTG AGCGCCTTGG GTACTTCTCT GTGGATCCAG ACAGCCATCA AGGACAGATT 
GTCTTCAACC GAACTGTCAC ACTAAAAGAA GACCCAGGCA AAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598555.2
CDS	79..2406
Translation	MATPDSLALFTGLGLSENKARETLKNEALSTQLREAATQAHQILGSTIDKATGVLLYDLVSRLRDTRRRSFLVSYIANKKIHTGLQLSAALEYVRSHPQDPIDTKDFEQECGVGVVVTPEQIEEAVESTINKHQLQLLAERYRFNMGLLMGEARAALRWADGKMIKNEVDMQVLHLLGPKMEADLVKKPKVAKARLEETDRKTAKDVVEKGEVAGQTLSLMEQLRGEALKFHKPGENYKTPGYVITPYTMDLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAIYDMVTWLGYTPYKVTYASDYFDQLYAWAVELIHGGLAYVCHQRVEELKGHNPLPSPWRDRPKEESLLLFEAMRKGKFAEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALKVYCPVQWEYGRLNLHYAVVSKRKILQLVAAGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDAAPRAMAVLEPLQVVITNFPAPKPLDIRVPNFPADETKGFHQVPFASTVFIERSDFKEESEPGYKRLASGQPVGLRHTGYVIELQNIVRGSSGCVERLEVTCRRADAGEKPKAFIHWVSQPLVCEIRLYECLFQHKNPEDPVEVPGGFLSDLNPASLQVVEGALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGQIVFNRTVTLKEDPGKI

Target ORF information:

RefSeq Version	NM_133794.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaminyl-tRNA synthetase (Qars), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133794.2

ORF Insert Sequence:

ATGGCTACTC CAGATTCGCT AGCGCTGTTC ACCGGCCTTG GCCTTAGCGA GAACAAGGCC 
CGCGAGACGC TCAAGAACGA GGCTCTGAGC ACTCAGCTGC GCGAGGCGGC GACCCAGGCA 
CACCAGATTC TGGGTTCTAC CATCGACAAG GCTACTGGGG TCCTCCTATA TGACTTGGTC 
TCCCGACTCA GGGATACTCG GCGTCGTTCT TTCCTTGTGA GCTATATAGC CAATAAGAAG 
ATTCACACGG GACTCCAGCT GAGCGCTGCT CTTGAATATG TTCGGAGTCA TCCCCAGGAT 
CCCATTGATA CCAAGGACTT CGAGCAGGAG TGTGGCGTCG GTGTGGTGGT GACACCGGAG 
CAGATTGAGG AAGCTGTGGA GTCCACCATA AATAAGCATC AGTTGCAGCT CCTAGCGGAA 
CGGTACCGTT TCAACATGGG GCTGCTAATG GGAGAGGCTC GGGCTGCGCT CAGATGGGCA 
GACGGCAAAA TGATCAAGAA CGAGGTGGAT ATGCAGGTGC TTCACCTTTT GGGGCCCAAG 
ATGGAAGCTG ATCTGGTGAA GAAGCCCAAG GTGGCAAAGG CACGGCTGGA AGAAACAGAC 
CGGAAGACAG CAAAAGATGT GGTGGAGAAA GGTGAAGTGG CTGGCCAGAC CCTGTCTCTG 
ATGGAGCAGC TCCGGGGGGA GGCACTTAAG TTTCATAAGC CAGGTGAGAA CTACAAGACG 
CCAGGCTATG TGATCACTCC ATATACCATG GATCTGCTGA AGCAGCACCT GGAGATCACT 
GGGGGACAGG TACGTACGCG GTTCCCTCCA GAGCCCAATG GAATCCTGCA TATTGGACAC 
GCCAAAGCCA TCAATTTCAA CTTTGGTTAT GCCAAGGCCA ACAATGGTAT CTGTTTTCTG 
CGCTTTGATG ACACCAACCC TGAGAAAGAA GAAGCAAAAT TCTTCACTGC TATTTATGAC 
ATGGTGACCT GGCTGGGTTA TACACCTTAC AAAGTGACAT ATGCTTCTGA CTATTTTGAC 
CAGCTGTATG CCTGGGCCGT GGAACTCATC CATGGGGGTC TTGCTTATGT GTGTCACCAG 
AGAGTGGAAG AGCTCAAAGG CCATAACCCT TTACCTTCTC CATGGAGGGA CAGGCCTAAG 
GAAGAATCAT TGCTGCTCTT TGAGGCAATG CGCAAGGGCA AATTTGCAGA AGGAGAGGCC 
ACACTTCGAA TGAAGTTGGT GATGGAAGAT GGCAAGATGG ACCCCGTGGC CTATCGAGTC 
AAGTACACGC CACACCATCG CACAGGGGAC AAATGGTGCA TCTACCCCAC CTATGACTAC 
ACACATTGTC TGTGTGACTC CATTGAGCAC ATTACCCACT CGTTGTGTAC CAAGGAGTTC 
CAGGCTCGAC GGTCTTCCTA CTTTTGGTTA TGTAACGCTC TGAAAGTCTA TTGTCCTGTT 
CAGTGGGAAT ATGGTCGCCT CAATTTGCAC TATGCTGTTG TCTCAAAGCG CAAGATTCTC 
CAGCTTGTAG CAGCTGGTGC TGTTCGGGAC TGGGACGATC CACGGCTCTT CACACTCACT 
GCCCTACGAC GACGGGGTTT TCCACCAGAG GCTATCAACA ACTTCTGTGC TCGGGTTGGG 
GTCACAGTGG CACAGACCAC AATGGAACCT CATCTTCTGG AAGCCTGTGT GCGTGATGTG 
CTGAATGATG CAGCCCCACG TGCCATGGCT GTTCTAGAGC CACTACAAGT TGTCATCACC 
AACTTTCCTG CTCCCAAGCC CTTGGACATC CGAGTGCCAA ATTTCCCAGC TGATGAGACC 
AAGGGTTTCC ACCAGGTTCC TTTTGCTTCC ACTGTCTTCA TTGAGAGAAG CGACTTTAAG 
GAGGAGTCAG AACCAGGCTA TAAGCGCCTA GCTTCGGGCC AGCCTGTGGG CCTGAGACAC 
ACTGGTTATG TCATTGAACT GCAGAATATT GTCAGGGGCT CCAGTGGCTG TGTGGAACGC 
TTGGAGGTGA CCTGTAGACG AGCTGATGCT GGAGAGAAGC CCAAGGCCTT TATTCACTGG 
GTATCACAGC CTTTGGTGTG TGAGATTCGC CTCTATGAGT GCCTATTCCA GCACAAGAAC 
CCCGAAGACC CTGTTGAAGT GCCTGGTGGA TTCCTAAGTG ACCTGAACCC GGCGTCACTA 
CAAGTGGTAG AAGGAGCATT AGTGGACTGC TCTGTGGCTT TGGCAAAGCC CTTTGACAAG 
TTCCAGTTTG AGCGCCTTGG GTACTTCTCT GTGGATCCAG ACAGCCATCA AGGACAGATT 
GTCTTCAACC GAACTGTCAC ACTAAAAGAA GACCCAGGCA AAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures.
American journal of human genetics94(4)547-58(2014 Apr)
Zhang X,Ling J,Barcia G,Jing L,Wu J,Barry BJ,Mochida GH,Hill RS,Weimer JM,Stein Q,Poduri A,Partlow JN,Ville D,Dulac O,Yu TW,Lam AT,Servattalab S,Rodriguez J,Boddaert N,Munnich A,Colleaux L,Zon LI,Söll D,Walsh CA,Nabbout R

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Genes & development25(7)755-66(2011 Apr)
Chen J,Melton C,Suh N,Oh JS,Horner K,Xie F,Sette C,Blelloch R,Conti M

p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.
Proceedings of the National Academy of Sciences of the United States of America99(12)7912-6(2002 Jun)
Kim JY,Kang YS,Lee JW,Kim HJ,Ahn YH,Park H,Ko YG,Kim S

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Qars cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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