Cxcr6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcr6
Entrez Gene ID	80901
Full Name	chemokine (C-X-C motif) receptor 6
Synonyms	BB217514,BONZO,STRL33
General protein information	Preferred Names chemokine (C-X-C motif) receptor 6 Names C-X-C chemokine receptor type 6 CXC-R6 CXCR-6
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 F4\|9 74.57 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_030712.4	NP_109637.3	C-X-C chemokine receptor type 6

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CXCR6	NP_001014859.1
Rattus norvegicus (Norway rat)	Cxcr6	NP_001096057.1
Homo sapiens (human)	CXCR6	NP_006555.1
Mus musculus (house mouse)	Cxcr6	NP_109637.3
Xenopus tropicalis (tropical clawed frog)	cxcr6	XP_002933456.1
Pan troglodytes (chimpanzee)	CXCR6	NP_001009051.1
Macaca mulatta (Rhesus monkey)	CXCR6	NP_001040606.1
Canis lupus familiaris (dog)	CXCR6	XP_851891.1

Gene Ontology
Bibliography

Related articles in PubMed

Fungal dissemination is limited by liver macrophage filtration of the blood.
Sun D, Sun P, Li H, Zhang M, Liu G, Strickland AB, Chen Y, Fu Y, Xu J, Yosri M, Nan Y, Zhou H, Zhang X, Shi M
Nature communications10(1)4566(2019 10)

CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.
Zhu H, Zhang Q, Chen G
International immunopharmacology72224-234(2019 Jul)

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4
Mossanen JC, Kohlhepp M, Wehr A, Krenkel O, Liepelt A, Roeth AA, Möckel D, Heymann F, Lammers T, Gassler N, Hermann J, Jankowski J, Neumann UP, Luedde T, Trautwein C, Tacke F
Gastroenterology156(6)1877-1889.e4(2019 05)

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB
Nature communications9(1)5340(2018 12)

CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma.
Lepore F, D'Alessandro G, Antonangeli F, Santoro A, Esposito V, Limatola C, Trettel F
Frontiers in immunology92750(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cxcr6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcr6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08407	NM_030712.4 Latest version!	Mus musculus chemokine (C-X-C motif) receptor 6 (Cxcr6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcr6 ( NM_030712.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_109637.3 Mus musculus chemokine (C-X-C motif) receptor 6 (Cxcr6), mRNA.

Price & Availability↑

CloneID	OMu08407
Clone ID Related Accession (Same CDS sequence)	NM_030712.4
Accession Version	NM_030712.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Mus musculus(house mouse)
Product	C-X-C chemokine receptor type 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF305709.1, AF301018.1, BQ562712.1 and AK137703.1. On Sep 14, 2007 this sequence version replaced NM_030712.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BB660928.1, AK153914.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATGATG GGCATCAAGA GTCAGCTCTG TACGATGGGC ACTACGAGGG AGATTTCTGG 
CTCTTCAACA ATTCCAGTGA TAACAGCCAG GAGAACAAAC GCTTCCTAAA GTTCAAGGAG 
GTCTTTTTGC CCTGTGTGTA CCTGGTAGTG TTTGTCTTTG GACTGCTAGG AAACTCCCTG 
GTTCTGATTA TATACATTTT CTACCAGAAG CTGAGGACTC TGACAGATGT GTTTCTGCTG 
AACTTGCCCC TGGCTGACCT GGTGTTTGTC TGTACTCTGC CCTTTTGGGC CTATGCAGGC 
ACCTATGAGT GGGTCTTTGG CACAGTCATG TGCAAAACTC TTCGAGGCAT GTATACAATG 
AACTTCTACG TGTCCATGCT CACTCTCACC TGCATCACAG TGGATCGTTT CATTGTAGTG 
GTCCAGGCTA CCAAGGCCTT CAACCGGCAG GCTAAGTGGA AGATCTGGGG CCAAGTCATT 
TGCTTGCTCA TTTGGGTGGT CTCCCTGTTG GTTTCTTTGC CACAGATCAT CTATGGCCAT 
GTTCAAGATA TTGACAAGCT TATCTGTCAG TACCACAGTG AGGAGATATC CACTATGGTT 
CTTGTTATAC AGATGACTCT GGGGTTCTTC CTGCCATTGC TCACTATGAT TCTGTGCTAC 
TCAGGCATTA TCAAGACCTT GCTTCATGCT CGAAACTTCC AGAAGCACAA ATCTCTAAAG 
ATCATCTTCC TTGTAGTGGC TGTGTTCCTG CTGACCCAGA CACCCTTCAA CCTTGCCATG 
TTAATCCAAA GTACAAGCTG GGAGTACTAT ACCATAACCA GCTTTAAGTA TGCCATCGTA 
GTGACAGAGG CTATAGCATA CTTTCGGGCT TGCCTTAACC CTGTACTTTA TGCCTTTGTT 
GGCTTAAAGT TCCGGAAGAA CGTCTGGAAA CTTATGAAGG ATATCGGCTG CCTCTCTCAC 
CTGGGAGTCT CAAGTCAATG GAAGTCTTCT GAGGACAGTT CCAAGACTTG TTCTGCCTCC 
CACAATGTAG AGACCACCAG TATGTTCCAA TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_109637.3
CDS	75..1130
Translation	MDDGHQESALYDGHYEGDFWLFNNSSDNSQENKRFLKFKEVFLPCVYLVVFVFGLLGNSLVLIIYIFYQKLRTLTDVFLLNLPLADLVFVCTLPFWAYAGTYEWVFGTVMCKTLRGMYTMNFYVSMLTLTCITVDRFIVVVQATKAFNRQAKWKIWGQVICLLIWVVSLLVSLPQIIYGHVQDIDKLICQYHSEEISTMVLVIQMTLGFFLPLLTMILCYSGIIKTLLHARNFQKHKSLKIIFLVVAVFLLTQTPFNLAMLIQSTSWEYYTITSFKYAIVVTEAIAYFRACLNPVLYAFVGLKFRKNVWKLMKDIGCLSHLGVSSQWKSSEDSSKTCSASHNVETTSMFQL

Target ORF information:

RefSeq Version	NM_030712.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus chemokine (C-X-C motif) receptor 6 (Cxcr6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030712.4

ORF Insert Sequence:

ATGGATGATG GGCATCAAGA GTCAGCTCTG TACGATGGGC ACTACGAGGG AGATTTCTGG 
CTCTTCAACA ATTCCAGTGA TAACAGCCAG GAGAACAAAC GCTTCCTAAA GTTCAAGGAG 
GTCTTTTTGC CCTGTGTGTA CCTGGTAGTG TTTGTCTTTG GACTGCTAGG AAACTCCCTG 
GTTCTGATTA TATACATTTT CTACCAGAAG CTGAGGACTC TGACAGATGT GTTTCTGCTG 
AACTTGCCCC TGGCTGACCT GGTGTTTGTC TGTACTCTGC CCTTTTGGGC CTATGCAGGC 
ACCTATGAGT GGGTCTTTGG CACAGTCATG TGCAAAACTC TTCGAGGCAT GTATACAATG 
AACTTCTACG TGTCCATGCT CACTCTCACC TGCATCACAG TGGATCGTTT CATTGTAGTG 
GTCCAGGCTA CCAAGGCCTT CAACCGGCAG GCTAAGTGGA AGATCTGGGG CCAAGTCATT 
TGCTTGCTCA TTTGGGTGGT CTCCCTGTTG GTTTCTTTGC CACAGATCAT CTATGGCCAT 
GTTCAAGATA TTGACAAGCT TATCTGTCAG TACCACAGTG AGGAGATATC CACTATGGTT 
CTTGTTATAC AGATGACTCT GGGGTTCTTC CTGCCATTGC TCACTATGAT TCTGTGCTAC 
TCAGGCATTA TCAAGACCTT GCTTCATGCT CGAAACTTCC AGAAGCACAA ATCTCTAAAG 
ATCATCTTCC TTGTAGTGGC TGTGTTCCTG CTGACCCAGA CACCCTTCAA CCTTGCCATG 
TTAATCCAAA GTACAAGCTG GGAGTACTAT ACCATAACCA GCTTTAAGTA TGCCATCGTA 
GTGACAGAGG CTATAGCATA CTTTCGGGCT TGCCTTAACC CTGTACTTTA TGCCTTTGTT 
GGCTTAAAGT TCCGGAAGAA CGTCTGGAAA CTTATGAAGG ATATCGGCTG CCTCTCTCAC 
CTGGGAGTCT CAAGTCAATG GAAGTCTTCT GAGGACAGTT CCAAGACTTG TTCTGCCTCC 
CACAATGTAG AGACCACCAG TATGTTCCAA TTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fungal dissemination is limited by liver macrophage filtration of the blood.
Nature communications10(1)4566(2019 10)
Sun D,Sun P,Li H,Zhang M,Liu G,Strickland AB,Chen Y,Fu Y,Xu J,Yosri M,Nan Y,Zhou H,Zhang X,Shi M

CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.
International immunopharmacology72224-234(2019 Jul)
Zhu H,Zhang Q,Chen G

CXCR6 Inhibits Hepatocarcinogenesis by Promoting Natural Killer T- and CD4
Gastroenterology156(6)1877-1889.e4(2019 05)
Mossanen JC,Kohlhepp M,Wehr A,Krenkel O,Liepelt A,Roeth AA,Möckel D,Heymann F,Lammers T,Gassler N,Hermann J,Jankowski J,Neumann UP,Luedde T,Trautwein C,Tacke F

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications9(1)5340(2018 12)
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB

CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma.
Frontiers in immunology92750(2018)
Lepore F,D'Alessandro G,Antonangeli F,Santoro A,Esposito V,Limatola C,Trettel F

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Cxcr6 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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