Scn2b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scn2b
Entrez Gene ID	72821
Full Name	sodium channel, voltage-gated, type II, beta
Synonyms	2810451E09Rik,AI840361,Gm183
General protein information	Preferred Names sodium channel, voltage-gated, type II, beta Names sodium channel subunit beta-2 sodium channel, voltage-gated, type II, beta polypeptide
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9 A5.2\|9 24.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006510629.3	XP_006510692.1	sodium channel subunit beta-2 isoform X1
NM_001014761.2	NP_001014761.1	sodium channel subunit beta-2 precursor
XM_006510629.4	XP_006510692.1	sodium channel subunit beta-2 isoform X1

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	SCN2B	XP_001096430.2
Xenopus tropicalis (tropical clawed frog)	scn2b	NP_001116903.2
Homo sapiens (human)	SCN2B	NP_004579.1
Bos taurus (cattle)	SCN2B	NP_001179003.1
Rattus norvegicus (Norway rat)	Scn2b	NP_037009.1
Danio rerio (zebrafish)	scn2b	NP_001071097.1
Canis lupus familiaris (dog)	SCN2B	XP_005619771.1
Mus musculus (house mouse)	Scn2b	NP_001014761.1
Pan troglodytes (chimpanzee)	SCN2B	XP_522196.2
Gallus gallus (chicken)	SCN2B	XP_417914.3

Gene Ontology
Bibliography

Related articles in PubMed

Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation.
Hu T, Li SS, Lu MN, Zhang L, Chen B, Mao R, Mei R, Tan YX, Li S, Xiyang YB
Molecular medicine reports20(2)2002-2011(2019 Aug)

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.
Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K
Communications biology196(2018)

Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.
Bao Y, Willis BC, Frasier CR, Lopez-Santiago LF, Lin X, Ramos-Mondragón R, Auerbach DS, Chen C, Wang Z, Anumonwo J, Valdivia HH, Delmar M, Jalife J, Isom LL
Circulation. Arrhythmia and electrophysiology9(12)(2016 12)

Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
XiYang YB, Wang YC, Zhao Y, Ru J, Lu BT, Zhang YN, Wang NC, Hu WY, Liu J, Yang JW, Wang ZJ, Hao CG, Feng ZT, Xiao ZC, Dong W, Quan XZ, Zhang LF, Wang TH
Molecular neurobiology53(2)955-967(2016 Mar)

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Templin JS, Bang SJ, Soiza-Reilly M, Berde CB, Commons KG
Brain research14571-12(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Scn2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scn2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11751	NM_001014761.2 Latest version!	Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$139.30 $199.00
OMu42415	XM_006510629.4 Latest version!	Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$104.30 $149.00
View Old Accession Versions >>
OMu42415	XM_006510629.3	Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$104.30 $149.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scn2b ( NM_001014761.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001014761.1 Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), mRNA.

Price & Availability↑

CloneID	OMu11751
Clone ID Related Accession (Same CDS sequence)	NM_001014761.2
Accession Version	NM_001014761.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Mus musculus(house mouse)
Product	sodium channel subunit beta-2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF533534.1 and AC122305.4. On Mar 14, 2007 this sequence version replaced NM_001014761.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF533534.1, BC092225.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACAGGG ATGCCTGGCT ACCTCGCCCT GCCTTCAGTC TCACGGGGCT CAGTCTGTTT 
TTCTCTTTGG TGCCCCCGGG GCGGAGCATG GAAGTCACAG CGCCCACCAC TCTTAGTGTC 
CTCAATGGGT CCGATACCCG CCTGCCCTGT ACCTTCAACT CCTGCTACAC CGTGAACCAC 
AAGCAGTTCT CTCTTAACTG GACTTACCAG GAGTGTAACA ATTGCACAGA GGAGATGTTC 
CTCCAGTTCC GAATGAAGAT CATTAACCTG AAGCTGGAGC GGTTTGGAGA CCGCGTGGAG 
TTCTCAGGGA ACCCCAGTAA GTACGACGTG TCAGTGACTC TAAAGAACGT GCAGCTAGAA 
GACGAAGGCA TTTACAACTG CTACATTACC AACCCTCCAG ACCGCCACCG CGGCCACGGC 
AAGATTTACC TGCAGGTCCT TCTAGAAGTA CCCCCAGAGC GGGACTCCAC GGTGGCGGTC 
ATCGTGGGTG CCTCAGTGGG GGGTTTCCTG GCTGTGGTCA TCTTGGTGCT GATGGTGGTC 
AAATGTGTGA GGAGGAAAAA AGAGCAGAAG CTGAGCACGG ATGACCTGAA GACTGAAGAG 
GAAGGCAAGA TGGATGGTGA GGGCAACGCG GAAGATGGCA CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001014761.1
CDS	149..796
Translation	MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTAPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK

Target ORF information:

RefSeq Version	NM_001014761.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001014761.2

ORF Insert Sequence:

ATGCACAGGG ATGCCTGGCT ACCTCGCCCT GCCTTCAGTC TCACGGGGCT CAGTCTGTTT 
TTCTCTTTGG TGCCCCCGGG GCGGAGCATG GAAGTCACAG CGCCCACCAC TCTTAGTGTC 
CTCAATGGGT CCGATACCCG CCTGCCCTGT ACCTTCAACT CCTGCTACAC CGTGAACCAC 
AAGCAGTTCT CTCTTAACTG GACTTACCAG GAGTGTAACA ATTGCACAGA GGAGATGTTC 
CTCCAGTTCC GAATGAAGAT CATTAACCTG AAGCTGGAGC GGTTTGGAGA CCGCGTGGAG 
TTCTCAGGGA ACCCCAGTAA GTACGACGTG TCAGTGACTC TAAAGAACGT GCAGCTAGAA 
GACGAAGGCA TTTACAACTG CTACATTACC AACCCTCCAG ACCGCCACCG CGGCCACGGC 
AAGATTTACC TGCAGGTCCT TCTAGAAGTA CCCCCAGAGC GGGACTCCAC GGTGGCGGTC 
ATCGTGGGTG CCTCAGTGGG GGGTTTCCTG GCTGTGGTCA TCTTGGTGCT GATGGTGGTC 
AAATGTGTGA GGAGGAAAAA AGAGCAGAAG CTGAGCACGG ATGACCTGAA GACTGAAGAG 
GAAGGCAAGA TGGATGGTGA GGGCAACGCG GAAGATGGCA CCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scn2b ( XM_006510629.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510692.1 Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu42415
Clone ID Related Accession (Same CDS sequence)	XM_006510629.3 , XM_006510629.4
Accession Version	XM_006510629.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	sodium channel subunit beta-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006510629.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGTCA CAGCGCCCAC CACTCTTAGT GTCCTCAATG GGTCCGATAC CCGCCTGCCC 
TGTACCTTCA ACTCCTGCTA CACCGTGAAC CACAAGCAGT TCTCTCTTAA CTGGACTTAC 
CAGGAGTGTA ACAATTGCAC AGAGGAGATG TTCCTCCAGT TCCGAATGAA GATCATTAAC 
CTGAAGCTGG AGCGGTTTGG AGACCGCGTG GAGTTCTCAG GGAACCCCAG TAAGTACGAC 
GTGTCAGTGA CTCTAAAGAA CGTGCAGCTA GAAGACGAAG GCATTTACAA CTGCTACATT 
ACCAACCCTC CAGACCGCCA CCGCGGCCAC GGCAAGATTT ACCTGCAGGT CCTTCTAGAA 
GTACCCCCAG AGCGGGACTC CACGGTGGCG GTCATCGTGG GTGCCTCAGT GGGGGGTTTC 
CTGGCTGTGG TCATCTTGGT GCTGATGGTG GTCAAATGTG TGAGGAGGAA AAAAGAGCAG 
AAGCTGAGCA CGGATGACCT GAAGACTGAA GAGGAAGGCA AGATGGATGG TGAGGGCAAC 
GCGGAAGATG GCACCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510692.1
CDS	155..715
Translation	MEVTAPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK

Target ORF information:

RefSeq Version	XM_006510629.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006510629.3

ORF Insert Sequence:

ATGGAAGTCA CAGCGCCCAC CACTCTTAGT GTCCTCAATG GGTCCGATAC CCGCCTGCCC 
TGTACCTTCA ACTCCTGCTA CACCGTGAAC CACAAGCAGT TCTCTCTTAA CTGGACTTAC 
CAGGAGTGTA ACAATTGCAC AGAGGAGATG TTCCTCCAGT TCCGAATGAA GATCATTAAC 
CTGAAGCTGG AGCGGTTTGG AGACCGCGTG GAGTTCTCAG GGAACCCCAG TAAGTACGAC 
GTGTCAGTGA CTCTAAAGAA CGTGCAGCTA GAAGACGAAG GCATTTACAA CTGCTACATT 
ACCAACCCTC CAGACCGCCA CCGCGGCCAC GGCAAGATTT ACCTGCAGGT CCTTCTAGAA 
GTACCCCCAG AGCGGGACTC CACGGTGGCG GTCATCGTGG GTGCCTCAGT GGGGGGTTTC 
CTGGCTGTGG TCATCTTGGT GCTGATGGTG GTCAAATGTG TGAGGAGGAA AAAAGAGCAG 
AAGCTGAGCA CGGATGACCT GAAGACTGAA GAGGAAGGCA AGATGGATGG TGAGGGCAAC 
GCGGAAGATG GCACCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scn2b ( XM_006510629.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006510692.1 Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu42415
Clone ID Related Accession (Same CDS sequence)	XM_006510629.3 , XM_006510629.4
Accession Version	XM_006510629.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	sodium channel subunit beta-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006510629.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGTCA CAGCGCCCAC CACTCTTAGT GTCCTCAATG GGTCCGATAC CCGCCTGCCC 
TGTACCTTCA ACTCCTGCTA CACCGTGAAC CACAAGCAGT TCTCTCTTAA CTGGACTTAC 
CAGGAGTGTA ACAATTGCAC AGAGGAGATG TTCCTCCAGT TCCGAATGAA GATCATTAAC 
CTGAAGCTGG AGCGGTTTGG AGACCGCGTG GAGTTCTCAG GGAACCCCAG TAAGTACGAC 
GTGTCAGTGA CTCTAAAGAA CGTGCAGCTA GAAGACGAAG GCATTTACAA CTGCTACATT 
ACCAACCCTC CAGACCGCCA CCGCGGCCAC GGCAAGATTT ACCTGCAGGT CCTTCTAGAA 
GTACCCCCAG AGCGGGACTC CACGGTGGCG GTCATCGTGG GTGCCTCAGT GGGGGGTTTC 
CTGGCTGTGG TCATCTTGGT GCTGATGGTG GTCAAATGTG TGAGGAGGAA AAAAGAGCAG 
AAGCTGAGCA CGGATGACCT GAAGACTGAA GAGGAAGGCA AGATGGATGG TGAGGGCAAC 
GCGGAAGATG GCACCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006510692.1
CDS	153..713
Translation	MEVTAPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK

Target ORF information:

RefSeq Version	XM_006510629.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006510629.4

ORF Insert Sequence:

ATGGAAGTCA CAGCGCCCAC CACTCTTAGT GTCCTCAATG GGTCCGATAC CCGCCTGCCC 
TGTACCTTCA ACTCCTGCTA CACCGTGAAC CACAAGCAGT TCTCTCTTAA CTGGACTTAC 
CAGGAGTGTA ACAATTGCAC AGAGGAGATG TTCCTCCAGT TCCGAATGAA GATCATTAAC 
CTGAAGCTGG AGCGGTTTGG AGACCGCGTG GAGTTCTCAG GGAACCCCAG TAAGTACGAC 
GTGTCAGTGA CTCTAAAGAA CGTGCAGCTA GAAGACGAAG GCATTTACAA CTGCTACATT 
ACCAACCCTC CAGACCGCCA CCGCGGCCAC GGCAAGATTT ACCTGCAGGT CCTTCTAGAA 
GTACCCCCAG AGCGGGACTC CACGGTGGCG GTCATCGTGG GTGCCTCAGT GGGGGGTTTC 
CTGGCTGTGG TCATCTTGGT GCTGATGGTG GTCAAATGTG TGAGGAGGAA AAAAGAGCAG 
AAGCTGAGCA CGGATGACCT GAAGACTGAA GAGGAAGGCA AGATGGATGG TGAGGGCAAC 
GCGGAAGATG GCACCAAGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulation.
Molecular medicine reports20(2)2002-2011(2019 Aug)
Hu T,Li SS,Lu MN,Zhang L,Chen B,Mao R,Mei R,Tan YX,Li S,Xiyang YB

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.
Communications biology196(2018)
Ogiwara I,Miyamoto H,Tatsukawa T,Yamagata T,Nakayama T,Atapour N,Miura E,Mazaki E,Ernst SJ,Cao D,Ohtani H,Itohara S,Yanagawa Y,Montal M,Yuzaki M,Inoue Y,Hensch TK,Noebels JL,Yamakawa K

Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias.
Circulation. Arrhythmia and electrophysiology9(12)(2016 12)
Bao Y,Willis BC,Frasier CR,Lopez-Santiago LF,Lin X,Ramos-Mondragón R,Auerbach DS,Chen C,Wang Z,Anumonwo J,Valdivia HH,Delmar M,Jalife J,Isom LL

Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
Molecular neurobiology53(2)955-967(2016 Mar)
XiYang YB,Wang YC,Zhao Y,Ru J,Lu BT,Zhang YN,Wang NC,Hu WY,Liu J,Yang JW,Wang ZJ,Hao CG,Feng ZT,Xiao ZC,Dong W,Quan XZ,Zhang LF,Wang TH

Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Brain research14571-12(2012 May)
Templin JS,Bang SJ,Soiza-Reilly M,Berde CB,Commons KG

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Scn2b cDNA ORF clone, Mus musculus(house mouse)

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Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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