| Gene Symbol | Phf6 |
| Entrez Gene ID | 70998 |
| Full Name | PHD finger protein 6 |
| Synonyms | 2700007B13Rik,4931428F02Rik,mKIAA1823 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Phf6 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Phf6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phf6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu13933 Clone ID Related Accession (Same CDS sequence) NM_027642.2 Accession Version NM_027642.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1095bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577808000000 Organism Mus musculus(house mouse) Product PHD finger protein 6 isoform 1 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK016480.1, BC055330.1 and CJ287261.1. On Mar 14, 2014 this sequence version replaced NM_027642.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC043127.1, AK141804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTCAAGCT CAATTGAACA GAAAAAAGGG TCTACGAGAC AGCGTAAATG TGGCTTTTGT
AAGTCAAATA GAGACAAGGA ATGTGGACAG TTACTGATAT CTGAAAACCA GAAGGTGGCA
GCACACCACA AGTGCATGCT GTTTTCGTCT GCTTTGGTGT CCTCACATTC TGATAATGAG
AGTCTTGGTG GATTTTCTAT TGAAGATGTT CAAAAGGAAA TTAAAAGAGG CACAAAGCTG
ATGTGTTCTC TTTGTCATTG TCCTGGAGCA ACCATTGGCT GTGATGTGAA AACCTGCCAC
AGGACATACC ACTACCACTG TGCATTGCAT GATAAAGCTC AGATCCGAGA GAAACCTTCG
CAAGGGATTT ACATGGTTTA TTGTCGAAAA CACAAGAAAA CTGCACATAA CTCGGAAGCT
GATTTAGAAG AAAGTTTTAA TGAGCATGAA CTGGAGCCCT CATCTCCAAA GACTAAGAAG
AAAAGTCGCA AAGGAAGACC GAGAAAAACT AACCTTAAAG GCTTGCCAGA AGACAGCAGG
TCCACATCCT CCCATGGAAC AGATGAAATG GAAAGTAGCT CCTACCGAGA TAGGTCTCCA
CACAGGAGCA GTCCTAATGA TACCAGGCCT AAATGTGGAT TTTGCCATGT AGGGGAGGAA
GAAAATGAAG CAAGAGGGAA ATTGCATATA TTTAATGCCA AGAAGGCAGC CGCACATTAC
AAGTGCATGT TGTTTTCTTC TGGCACTGTT CAGCTCACAA CAACATCAAG AGCAGAATTT
GGAGATTTCG ATATTAAAAC TGTACTTCAG GAGATTAAGC GAGGAAAAAG GATGAAATGT
ACACTTTGCA GTCAGCCTGG TGCTACTATT GGATGCGAAA TAAAAGCCTG TGTTAAAACC
TACCATTACC ACTGTGGTGT ACAAGACAAG GCAAAATACA TTGAAAATAT GTCACGAGGA
ATTTACAAAC TCTATTGTAA AAACCATAGT GGAAATGATG AGCGAGATGA AGAAGATGAG
GAGCGAGAGA GTAAAAGCCG TGGAAGAGTA GCGATTGATC AGCAGCTAAC CCAGCAGCAG
CTTAATGGAA ACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_081918.1 CDS 270..1364 Translation 
Target ORF information:
RefSeq Version NM_027642.2 Organism Mus musculus(house mouse) Definition Mus musculus PHD finger protein 6 (Phf6), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_027642.2
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTCAAGCT CAATTGAACA GAAAAAAGGG TCTACGAGAC AGCGTAAATG TGGCTTTTGT
AAGTCAAATA GAGACAAGGA ATGTGGACAG TTACTGATAT CTGAAAACCA GAAGGTGGCA
GCACACCACA AGTGCATGCT GTTTTCGTCT GCTTTGGTGT CCTCACATTC TGATAATGAG
AGTCTTGGTG GATTTTCTAT TGAAGATGTT CAAAAGGAAA TTAAAAGAGG CACAAAGCTG
ATGTGTTCTC TTTGTCATTG TCCTGGAGCA ACCATTGGCT GTGATGTGAA AACCTGCCAC
AGGACATACC ACTACCACTG TGCATTGCAT GATAAAGCTC AGATCCGAGA GAAACCTTCG
CAAGGGATTT ACATGGTTTA TTGTCGAAAA CACAAGAAAA CTGCACATAA CTCGGAAGCT
GATTTAGAAG AAAGTTTTAA TGAGCATGAA CTGGAGCCCT CATCTCCAAA GACTAAGAAG
AAAAGTCGCA AAGGAAGACC GAGAAAAACT AACCTTAAAG GCTTGCCAGA AGACAGCAGG
TCCACATCCT CCCATGGAAC AGATGAAATG GAAAGTAGCT CCTACCGAGA TAGGTCTCCA
CACAGGAGCA GTCCTAATGA TACCAGGCCT AAATGTGGAT TTTGCCATGT AGGGGAGGAA
GAAAATGAAG CAAGAGGGAA ATTGCATATA TTTAATGCCA AGAAGGCAGC CGCACATTAC
AAGTGCATGT TGTTTTCTTC TGGCACTGTT CAGCTCACAA CAACATCAAG AGCAGAATTT
GGAGATTTCG ATATTAAAAC TGTACTTCAG GAGATTAAGC GAGGAAAAAG GATGAAATGT
ACACTTTGCA GTCAGCCTGG TGCTACTATT GGATGCGAAA TAAAAGCCTG TGTTAAAACC
TACCATTACC ACTGTGGTGT ACAAGACAAG GCAAAATACA TTGAAAATAT GTCACGAGGA
ATTTACAAAC TCTATTGTAA AAACCATAGT GGAAATGATG AGCGAGATGA AGAAGATGAG
GAGCGAGAGA GTAAAAGCCG TGGAAGAGTA GCGATTGATC AGCAGCTAAC CCAGCAGCAG
CTTAATGGAA ACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu17094 Clone ID Related Accession (Same CDS sequence) NM_001290546.1 Accession Version NM_001290546.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 855bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577808000000 Organism Mus musculus(house mouse) Product PHD finger protein 6 isoform 2 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK016480.1, AK028498.1, BC055330.1 and CJ287261.1. On Mar 14, 2014 this sequence version replaced XM_006541544.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028498.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGTGTTCTC TTTGTCATTG TCCTGGAGCA ACCATTGGCT GTGATGTGAA AACCTGCCAC
AGGACATACC ACTACCACTG TGCATTGCAT GATAAAGCTC AGATCCGAGA GAAACCTTCG
CAAGGGATTT ACATGGTTTA TTGTCGAAAA CACAAGAAAA CTGCACATAA CTCGGAAGCT
GATTTAGAAG AAAGTTTTAA TGAGCATGAA CTGGAGCCCT CATCTCCAAA GACTAAGAAG
AAAAGTCGCA AAGGAAGACC GAGAAAAACT AACCTTAAAG GCTTGCCAGA AGACAGCAGG
TCCACATCCT CCCATGGAAC AGATGAAATG GAAAGTAGCT CCTACCGAGA TAGGTCTCCA
CACAGGAGCA GTCCTAATGA TACCAGGCCT AAATGTGGAT TTTGCCATGT AGGGGAGGAA
GAAAATGAAG CAAGAGGGAA ATTGCATATA TTTAATGCCA AGAAGGCAGC CGCACATTAC
AAGTGCATGT TGTTTTCTTC TGGCACTGTT CAGCTCACAA CAACATCAAG AGCAGAATTT
GGAGATTTCG ATATTAAAAC TGTACTTCAG GAGATTAAGC GAGGAAAAAG GATGAAATGT
ACACTTTGCA GTCAGCCTGG TGCTACTATT GGATGCGAAA TAAAAGCCTG TGTTAAAACC
TACCATTACC ACTGTGGTGT ACAAGACAAG GCAAAATACA TTGAAAATAT GTCACGAGGA
ATTTACAAAC TCTATTGTAA AAACCATAGT GGAAATGATG AGCGAGATGA AGAAGATGAG
GAGCGAGAGA GTAAAAGCCG TGGAAGAGTA GCGATTGATC AGCAGCTAAC CCAGCAGCAG
CTTAATGGAA ACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001277475.1 CDS 224..1078 Translation
Target ORF information:
RefSeq Version NM_001290546.1 Organism Mus musculus(house mouse) Definition Mus musculus PHD finger protein 6 (Phf6), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001290546.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGTGTTCTC TTTGTCATTG TCCTGGAGCA ACCATTGGCT GTGATGTGAA AACCTGCCAC
AGGACATACC ACTACCACTG TGCATTGCAT GATAAAGCTC AGATCCGAGA GAAACCTTCG
CAAGGGATTT ACATGGTTTA TTGTCGAAAA CACAAGAAAA CTGCACATAA CTCGGAAGCT
GATTTAGAAG AAAGTTTTAA TGAGCATGAA CTGGAGCCCT CATCTCCAAA GACTAAGAAG
AAAAGTCGCA AAGGAAGACC GAGAAAAACT AACCTTAAAG GCTTGCCAGA AGACAGCAGG
TCCACATCCT CCCATGGAAC AGATGAAATG GAAAGTAGCT CCTACCGAGA TAGGTCTCCA
CACAGGAGCA GTCCTAATGA TACCAGGCCT AAATGTGGAT TTTGCCATGT AGGGGAGGAA
GAAAATGAAG CAAGAGGGAA ATTGCATATA TTTAATGCCA AGAAGGCAGC CGCACATTAC
AAGTGCATGT TGTTTTCTTC TGGCACTGTT CAGCTCACAA CAACATCAAG AGCAGAATTT
GGAGATTTCG ATATTAAAAC TGTACTTCAG GAGATTAAGC GAGGAAAAAG GATGAAATGT
ACACTTTGCA GTCAGCCTGG TGCTACTATT GGATGCGAAA TAAAAGCCTG TGTTAAAACC
TACCATTACC ACTGTGGTGT ACAAGACAAG GCAAAATACA TTGAAAATAT GTCACGAGGA
ATTTACAAAC TCTATTGTAA AAACCATAGT GGAAATGATG AGCGAGATGA AGAAGATGAG
GAGCGAGAGA GTAAAAGCCG TGGAAGAGTA GCGATTGATC AGCAGCTAAC CCAGCAGCAG
CTTAATGGAA ACTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
Blood133(16)1729-1741(2019 04)
McRae HM,Garnham AL,Hu Y,Witkowski MT,Corbett MA,Dixon MP,May RE,Sheikh BN,Chiang W,Kueh AJ,Nguyen TA,Man K,Gloury R,Aubrey BJ,Policheni A,Di Rago L,Alexander WS,Gray DHD,Strasser A,Hawkins ED,Wilcox S,Gécz J,Kallies A,McCormack MP,Smyth GK,Voss AK,Thomas T
Characterization of a Mouse Model of Börjeson-Forssman-Lehmann Syndrome.
Cell reports25(6)1404-1414.e6(2018 11)
Cheng C,Deng PY,Ikeuchi Y,Yuede C,Li D,Rensing N,Huang J,Baldridge D,Maloney SE,Dougherty JD,Constantino J,Jahani-Asl A,Wong M,Wozniak DF,Wang T,Klyachko VA,Bonni A
PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.
Genes & development31(10)973-989(2017 05)
Soto-Feliciano YM,Bartlebaugh JME,Liu Y,Sánchez-Rivera FJ,Bhutkar A,Weintraub AS,Buenrostro JD,Cheng CS,Regev A,Jacks TE,Young RA,Hemann MT
Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos.
Scientific reports637396(2016 11)
Cui W,Dai X,Marcho C,Han Z,Zhang K,Tremblay KD,Mager J
High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA
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