Pkp2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pkp2
Entrez Gene ID	67451
Full Name	plakophilin 2
Synonyms	1200008D14Rik,1200012P04Rik,AA516617,Pkp2l
General protein information	Preferred Names plakophilin 2 Names plakophilin-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 A2

mRNA and Protein(s)

mRNA	Protein	Name
NM_026163.2	NP_080439.1	plakophilin-2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	PKP2	XP_416362.4
Homo sapiens (human)	PKP2	NP_001005242.2
Canis lupus familiaris (dog)	PKP2	XP_543739.2
Danio rerio (zebrafish)	pkp2	NP_001106904.1
Rattus norvegicus (Norway rat)	Pkp2	NP_001093969.1
Pan troglodytes (chimpanzee)	PKP2	XP_003954415.1
Bos taurus (cattle)	PKP2	NP_001077198.1
Mus musculus (house mouse)	Pkp2	NP_080439.1
Xenopus tropicalis (tropical clawed frog)	pkp2	NP_001096312.1

Gene Ontology
Bibliography

Related articles in PubMed

Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex.
de Paiva Lima C, da Silva E Silva DA, Damasceno S, Ribeiro AF, Rocha CS, Berenguer de Matos AH, Correia D, Boerngen-Lacerda R, Brunialti Godard AL
Journal of neurogenetics31(3)170-177(2017 09)

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Cerrone M, Montnach J, Lin X, Zhao YT, Zhang M, Agullo-Pascual E, Leo-Macias A, Alvarado FJ, Dolgalev I, Karathanos TV, Malkani K, Van Opbergen CJM, van Bavel JJA, Yang HQ, Vasquez C, Tester D, Fowler S, Liang F, Rothenberg E, Heguy A, Morley GE, Coetzee WA, Trayanova NA, Ackerman MJ, van Veen TAB, Valdivia HH, Delmar M
Nature communications8(1)106(2017 07)

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.
Ragni CV, Diguet N, Le Garrec JF, Novotova M, Resende TP, Pop S, Charon N, Guillemot L, Kitasato L, Badouel C, Dufour A, Olivo-Marin JC, Trouvé A, McNeill H, Meilhac SM
Nature communications814582(2017 02)

Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro.
Gurha P, Chen X, Lombardi R, Willerson JT, Marian AJ
Circulation research119(6)731-50(2016 Sep)

Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model.
Moncayo-Arlandi J, Guasch E, Sanz-de la Garza M, Casado M, Garcia NA, Mont L, Sitges M, Knöll R, Buyandelger B, Campuzano O, Diez-Juan A, Brugada R
Human molecular genetics25(17)3676-3688(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pkp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pkp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu01715	NM_026163.2 Latest version!	Mus musculus plakophilin 2 (Pkp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pkp2 ( NM_026163.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080439.1 Mus musculus plakophilin 2 (Pkp2), mRNA.

Price & Availability↑

CloneID	OMu01715
Clone ID Related Accession (Same CDS sequence)	NM_026163.2
Accession Version	NM_026163.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2388bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1533830400000
Organism	Mus musculus(house mouse)
Product	plakophilin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK004650.1. On Apr 6, 2007 this sequence version replaced NM_026163.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004650.1, AK049481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCGTCC CCGGCTCACT GGCCGAGTGT GGCTACATCC GGACTGTGCT GGGCCAGCAG 
ATCCTGGGTC ACCTGGACAG CTCCAGCCTG GCCTTGCCCT CCGAGGCCAG ACTGAGGCTG 
GCCGGCAGCA GCGGCCGCGG CGACCCGGCG GCCCGGAGCC AGCGGATCCA GGAGCAGGTG 
CAGCAGACCC TGGCCCGCCG GGGCCGGAGC TCTGCGGTCA GCGGGAACCT TCACCGAACC 
AGCAGTGTCC CTGAGTATGT CTACAAGCTA CACGTGGTTG AGAATGACTT TGTTGGACGG 
CAGTCACCTG TCACTAGGGA CTATGACATG CTTAAGGCTG GAATGACTGC CACTTATGGA 
AGTCGCTGGG GGAGAGCAGC AGCACAGTAC AGTTCCCAGA AGTCAGTGGA GGAGAGATCC 
TGGAGGCAGC CTCTGAGGAG ACTTGAGATT TCCCCAGATA GCAGCCCGGA GAGAGCCCAC 
TATGGGCACA GCGAATACCA GTATGCCTGG CGGAGCCACG TGGTGCCTGG TGGGCGCCTC 
ACCCTGCCAC GCTATGCTCG CTCAGAGATC CTGGGCCTAC GCCAGGCTGG CACAGCCCGC 
AGGCCACCTG GGTGCGGGTC ATTCAGCGAT GCTGTCTTCG ACAATGGCCC ACTCAAGCCC 
ACAATGCCCA CCCACCCTCC TGGCACCAGC CACAGTGCGG GCAGCTTGTT GGAAGAGACC 
ACTGTGCGCG TGAGCCAGGC TCGGCTTCAA AGCACGCAGA GCAGAACCGC CCGCTCCTCC 
TGGCCCAGGA GCTCAGTCCG CAGTAGCCTG CGGGAGCCAG GAAGAATGCT GACCACCGCA 
GGCCAGGCTG CCGTGGGCAG CGGGGATGCA CATGGGGACA GGAGTGTCTT CGCTGACGCC 
CAGCTGGGGA ATGCAGACAT CGAAATGACC TTGGAGAGAG CTGTGAATAT GCTGGATGCA 
GACCATGTAC CAGTATCCAA GATCTCTGCC GCAGCTACCT TCATACAGCA TGAGAGCTTC 
CAAAAATCTG AAGCACGGAA AAGGGTCAAT CAACTTCGAG GCATCCCTAA GCTTCTACAA 
CTGCTCAAAC TTCAGAACGA AGATGTTCAA CGGGCTGCTT GTGGGGCCTT GAGAAACTTG 
GTATTTGAAG ACAATGATAA CAAGTTGGAG GTAGCTGAAC TGAATGGAGT GCCTCGGCTA 
CTGCAGGTGC TGAAGCAAAC CAGAGACTTG GAGACAAAAA AGCAAATAAC AGGTTTGCTC 
TGGAACCTGT CCTCTAGTGA TAAACTCAAG CATCTCATGA TAACAGAAGC CTTGCTCACC 
TTGACAGAGA GTGTCATCAT CCCCTTCTCC GGGTGGCCTG AAGGCGACTA CCCCAAAGCC 
AATGGCTTGC TTGATTTTGA TATATTCTAC AATGTCACTG GATGCCTAAG GAACATGAGC 
TCTGCTGGCC CCGATGGGAG GAAGATGATG AGAAGGTGTG ATGGTCTCAT TGACTCATTG 
GTCCACTATG TCAGAGGAAC TATTGCAGAC TACCAGCCAG ATGATAAGGC CACAGAGAAC 
TGTGTGTGCA TTCTTCATAA CCTCTCCTAC CAGCTGGAGG CAGAGCTCCC AGAGAAATAT 
TCCCAGAGTA TCTACATGCA AAACCGGAAT ATCCAGACTA ACAGTAACAA AAGTATTGGG 
TGTTTTGGCA GCCGAAGTAG GAAACTAAAA GAGCAATACC AAGACTTGCA GATGCCAGAG 
GAAAGGAGCA ATCCACATGG CATTGAGTGG CTGTGGCATT CCATTGTGAT AAGGATGTAT 
TTGTCCTTAA TTGCCAAGAG TACCCGAAAC TATACCCAAG AGGCATCACT TGGGGCTCTC 
CAGAACCTCA CAGCAGGAGG CGGCCCGATA CCCACATTGG TGGCTCGAAT GGTTGTCCAA 
AAGGAAAATG GTCTTCAGCA TACACGGAAG ATGCTGCACG TGGGTGATCC CAGTGTGAAA 
AAGACTGCGG TCTCCCTGCT GAGGAATTTG TCACGGAATC TTTCCCTGCA GAATGAAATT 
GCTAAAGAAA CTCTACCAGA TTTGGTTTCT ATAATTCCTG ACACAGTCCC AAGTACTGAC 
CTTCTCATTG AAACCACAGC CTCTGCTTGC TATACGTTGA ACAATTTAAT GCAAAATAGT 
TACCAGAATG CACGAGACCT TCTGAACACC GGAGGTCTGC AGAAAATTAT GACCATCAGC 
ATAGGGGAAG GCTATGCCCC CAACAAGGCC AGCAAAGCAG CCTCTGTCCT CCTTTACTCT 
CTGTGGGCAC ATACAGAGCT GCATCACGCC TATAAGAAGG CTCAGTTTAA GAAAACAGAC 
TTTGTCAACA GCCGGACTGC CAAAGCCTAC CACTCTCTTA AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080439.1
CDS	29..2416
Translation	MAVPGSLAECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPAARSQRIQEQVQQTLARRGRSSAVSGNLHRTSSVPEYVYKLHVVENDFVGRQSPVTRDYDMLKAGMTATYGSRWGRAAAQYSSQKSVEERSWRQPLRRLEISPDSSPERAHYGHSEYQYAWRSHVVPGGRLTLPRYARSEILGLRQAGTARRPPGCGSFSDAVFDNGPLKPTMPTHPPGTSHSAGSLLEETTVRVSQARLQSTQSRTARSSWPRSSVRSSLREPGRMLTTAGQAAVGSGDAHGDRSVFADAQLGNADIEMTLERAVNMLDADHVPVSKISAAATFIQHESFQKSEARKRVNQLRGIPKLLQLLKLQNEDVQRAACGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSSDKLKHLMITEALLTLTESVIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKMMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKLKEQYQDLQMPEERSNPHGIEWLWHSIVIRMYLSLIAKSTRNYTQEASLGALQNLTAGGGPIPTLVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELHHAYKKAQFKKTDFVNSRTAKAYHSLKD

Target ORF information:

RefSeq Version	NM_026163.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus plakophilin 2 (Pkp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026163.2

ORF Insert Sequence:

ATGGCCGTCC CCGGCTCACT GGCCGAGTGT GGCTACATCC GGACTGTGCT GGGCCAGCAG 
ATCCTGGGTC ACCTGGACAG CTCCAGCCTG GCCTTGCCCT CCGAGGCCAG ACTGAGGCTG 
GCCGGCAGCA GCGGCCGCGG CGACCCGGCG GCCCGGAGCC AGCGGATCCA GGAGCAGGTG 
CAGCAGACCC TGGCCCGCCG GGGCCGGAGC TCTGCGGTCA GCGGGAACCT TCACCGAACC 
AGCAGTGTCC CTGAGTATGT CTACAAGCTA CACGTGGTTG AGAATGACTT TGTTGGACGG 
CAGTCACCTG TCACTAGGGA CTATGACATG CTTAAGGCTG GAATGACTGC CACTTATGGA 
AGTCGCTGGG GGAGAGCAGC AGCACAGTAC AGTTCCCAGA AGTCAGTGGA GGAGAGATCC 
TGGAGGCAGC CTCTGAGGAG ACTTGAGATT TCCCCAGATA GCAGCCCGGA GAGAGCCCAC 
TATGGGCACA GCGAATACCA GTATGCCTGG CGGAGCCACG TGGTGCCTGG TGGGCGCCTC 
ACCCTGCCAC GCTATGCTCG CTCAGAGATC CTGGGCCTAC GCCAGGCTGG CACAGCCCGC 
AGGCCACCTG GGTGCGGGTC ATTCAGCGAT GCTGTCTTCG ACAATGGCCC ACTCAAGCCC 
ACAATGCCCA CCCACCCTCC TGGCACCAGC CACAGTGCGG GCAGCTTGTT GGAAGAGACC 
ACTGTGCGCG TGAGCCAGGC TCGGCTTCAA AGCACGCAGA GCAGAACCGC CCGCTCCTCC 
TGGCCCAGGA GCTCAGTCCG CAGTAGCCTG CGGGAGCCAG GAAGAATGCT GACCACCGCA 
GGCCAGGCTG CCGTGGGCAG CGGGGATGCA CATGGGGACA GGAGTGTCTT CGCTGACGCC 
CAGCTGGGGA ATGCAGACAT CGAAATGACC TTGGAGAGAG CTGTGAATAT GCTGGATGCA 
GACCATGTAC CAGTATCCAA GATCTCTGCC GCAGCTACCT TCATACAGCA TGAGAGCTTC 
CAAAAATCTG AAGCACGGAA AAGGGTCAAT CAACTTCGAG GCATCCCTAA GCTTCTACAA 
CTGCTCAAAC TTCAGAACGA AGATGTTCAA CGGGCTGCTT GTGGGGCCTT GAGAAACTTG 
GTATTTGAAG ACAATGATAA CAAGTTGGAG GTAGCTGAAC TGAATGGAGT GCCTCGGCTA 
CTGCAGGTGC TGAAGCAAAC CAGAGACTTG GAGACAAAAA AGCAAATAAC AGGTTTGCTC 
TGGAACCTGT CCTCTAGTGA TAAACTCAAG CATCTCATGA TAACAGAAGC CTTGCTCACC 
TTGACAGAGA GTGTCATCAT CCCCTTCTCC GGGTGGCCTG AAGGCGACTA CCCCAAAGCC 
AATGGCTTGC TTGATTTTGA TATATTCTAC AATGTCACTG GATGCCTAAG GAACATGAGC 
TCTGCTGGCC CCGATGGGAG GAAGATGATG AGAAGGTGTG ATGGTCTCAT TGACTCATTG 
GTCCACTATG TCAGAGGAAC TATTGCAGAC TACCAGCCAG ATGATAAGGC CACAGAGAAC 
TGTGTGTGCA TTCTTCATAA CCTCTCCTAC CAGCTGGAGG CAGAGCTCCC AGAGAAATAT 
TCCCAGAGTA TCTACATGCA AAACCGGAAT ATCCAGACTA ACAGTAACAA AAGTATTGGG 
TGTTTTGGCA GCCGAAGTAG GAAACTAAAA GAGCAATACC AAGACTTGCA GATGCCAGAG 
GAAAGGAGCA ATCCACATGG CATTGAGTGG CTGTGGCATT CCATTGTGAT AAGGATGTAT 
TTGTCCTTAA TTGCCAAGAG TACCCGAAAC TATACCCAAG AGGCATCACT TGGGGCTCTC 
CAGAACCTCA CAGCAGGAGG CGGCCCGATA CCCACATTGG TGGCTCGAAT GGTTGTCCAA 
AAGGAAAATG GTCTTCAGCA TACACGGAAG ATGCTGCACG TGGGTGATCC CAGTGTGAAA 
AAGACTGCGG TCTCCCTGCT GAGGAATTTG TCACGGAATC TTTCCCTGCA GAATGAAATT 
GCTAAAGAAA CTCTACCAGA TTTGGTTTCT ATAATTCCTG ACACAGTCCC AAGTACTGAC 
CTTCTCATTG AAACCACAGC CTCTGCTTGC TATACGTTGA ACAATTTAAT GCAAAATAGT 
TACCAGAATG CACGAGACCT TCTGAACACC GGAGGTCTGC AGAAAATTAT GACCATCAGC 
ATAGGGGAAG GCTATGCCCC CAACAAGGCC AGCAAAGCAG CCTCTGTCCT CCTTTACTCT 
CTGTGGGCAC ATACAGAGCT GCATCACGCC TATAAGAAGG CTCAGTTTAA GAAAACAGAC 
TTTGTCAACA GCCGGACTGC CAAAGCCTAC CACTCTCTTA AAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex.
Journal of neurogenetics31(3)170-177(2017 09)
de Paiva Lima C,da Silva E Silva DA,Damasceno S,Ribeiro AF,Rocha CS,Berenguer de Matos AH,Correia D,Boerngen-Lacerda R,Brunialti Godard AL

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Nature communications8(1)106(2017 07)
Cerrone M,Montnach J,Lin X,Zhao YT,Zhang M,Agullo-Pascual E,Leo-Macias A,Alvarado FJ,Dolgalev I,Karathanos TV,Malkani K,Van Opbergen CJM,van Bavel JJA,Yang HQ,Vasquez C,Tester D,Fowler S,Liang F,Rothenberg E,Heguy A,Morley GE,Coetzee WA,Trayanova NA,Ackerman MJ,van Veen TAB,Valdivia HH,Delmar M

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.
Nature communications814582(2017 02)
Ragni CV,Diguet N,Le Garrec JF,Novotova M,Resende TP,Pop S,Charon N,Guillemot L,Kitasato L,Badouel C,Dufour A,Olivo-Marin JC,Trouvé A,McNeill H,Meilhac SM

Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro.
Circulation research119(6)731-50(2016 Sep)
Gurha P,Chen X,Lombardi R,Willerson JT,Marian AJ

Molecular disturbance underlies to arrhythmogenic cardiomyopathy induced by transgene content, age and exercise in a truncated PKP2 mouse model.
Human molecular genetics25(17)3676-3688(2016 09)
Moncayo-Arlandi J,Guasch E,Sanz-de la Garza M,Casado M,Garcia NA,Mont L,Sitges M,Knöll R,Buyandelger B,Campuzano O,Diez-Juan A,Brugada R

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Pkp2 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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