Ddah2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ddah2
Entrez Gene ID	51793
Full Name	dimethylarginine dimethylaminohydrolase 2
Synonyms	1110003M04Rik,AU019324,AW413173,DDAH-2,DDAHII,Ddah,G6a,NG30
General protein information	Preferred Names dimethylarginine dimethylaminohydrolase 2 Names N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Clone 7u dimethylargininase-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 B1

mRNA and Protein(s)

mRNA	Protein	Name
XM_006524612.4	XP_006524675.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X1
NM_001190449.1	NP_001177378.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform 1
XM_006524612.3	XP_006524675.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X1
NM_016765.3	NP_058045.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform 2
XM_030249896.1	XP_030105756.1	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DDAH2	XP_001159196.1
Canis lupus familiaris (dog)	DDAH2	XP_005627218.1
Macaca mulatta (Rhesus monkey)	DDAH2	XP_001113141.1
Homo sapiens (human)	DDAH2	NP_039268.1
Danio rerio (zebrafish)	ddah2	NP_001093535.1
Xenopus tropicalis (tropical clawed frog)	ddah2	NP_001004924.1
Bos taurus (cattle)	DDAH2	NP_001029876.1
Mus musculus (house mouse)	Ddah2	NP_001177378.1
Rattus norvegicus (Norway rat)	Ddah2	NP_001159408.1

Gene Ontology
Bibliography

Related articles in PubMed

DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.
Zhu ZD, Ye JM, Fu XM, Wang XC, Ye JY, Wu XR, Hua P, Liao YQ, Xuan W, Duan JL, Li WY, Fu H, Xia ZH, Zhang X
International journal of molecular medicine43(2)749-760(2019 Feb)

Hyper-activation of pp60
Kumar S, Sun X, Noonepalle SK, Lu Q, Zemskov E, Wang T, Aggarwal S, Gross C, Sharma S, Desai AA, Hou Y, Dasarathy S, Qu N, Reddy V, Lee SG, Cherian-Shaw M, Yuan JX, Catravas JD, Rafikov R, Garcia JGN, Black SM
Free radical biology & medicine102217-228(2017 01)

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
Minakuchi H, Wakino S, Hosoya K, Sueyasu K, Hasegawa K, Shinozuka K, Yoshifuji A, Futatsugi K, Komatsu M, Kanda T, Tokuyama H, Hayashi K, Itoh H
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association31(3)413-23(2016 Mar)

The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
Hasegawa K, Wakino S, Kimoto M, Minakuchi H, Fujimura K, Hosoya K, Komatsu M, Kaneko Y, Kanda T, Tokuyama H, Hayashi K, Itoh H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2301-15(2013 Jun)

The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Pullamsetti SS, Savai R, Dumitrascu R, Dahal BK, Wilhelm J, Konigshoff M, Zakrzewicz D, Ghofrani HA, Weissmann N, Eickelberg O, Guenther A, Leiper J, Seeger W, Grimminger F, Schermuly RT
Science translational medicine3(87)87ra53(2011 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ddah2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ddah2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu01330	NM_001190449.1 Latest version!	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu10624	NM_016765.3 Latest version!	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu01330	XM_006524612.4 Latest version!	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu10624	XM_030249896.1 Latest version!	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu01330	XM_006524612.3	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ddah2 ( NM_001190449.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001177378.1 Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu01330
Clone ID Related Accession (Same CDS sequence)	XM_006524612.4 , NM_001190449.1 , XM_006524612.3
Accession Version	NM_001190449.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572796800000
Organism	Mus musculus(house mouse)
Product	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087117.9. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003328.1, SRR1660817.344793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGTGGG 
GACCTGCCCA ACAGCCAGGA GGCTCTGCAG AAGCTCTCTG ATGTCACCCT GGTACCTGTG 
TCCTGCTCAG AACTGGAGAA GGCTGGAGCT GGCCTCAGCT CCCTCTGCCT GGTGCTCAGC 
ACACGCCCCC ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177378.1
CDS	301..1158
Translation	MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHC

Target ORF information:

RefSeq Version	NM_001190449.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190449.1

ORF Insert Sequence:

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGTGGG 
GACCTGCCCA ACAGCCAGGA GGCTCTGCAG AAGCTCTCTG ATGTCACCCT GGTACCTGTG 
TCCTGCTCAG AACTGGAGAA GGCTGGAGCT GGCCTCAGCT CCCTCTGCCT GGTGCTCAGC 
ACACGCCCCC ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ddah2 ( NM_016765.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058045.1 Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu10624
Clone ID Related Accession (Same CDS sequence)	NM_016765.3 , XM_030249896.1
Accession Version	NM_016765.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572796800000
Organism	Mus musculus(house mouse)
Product	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC087117.9. On Jun 25, 2010 this sequence version replaced NM_016765.2. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF004106.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGCTCT 
GCAGAAGCTC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058045.1
CDS	301..1035
Translation	MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGSAEAL

Target ORF information:

RefSeq Version	NM_016765.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016765.3

ORF Insert Sequence:

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGCTCT 
GCAGAAGCTC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ddah2 ( XM_006524612.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524675.1 Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01330
Clone ID Related Accession (Same CDS sequence)	XM_006524612.4 , NM_001190449.1 , XM_006524612.3
Accession Version	XM_006524612.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006524612.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGTGGG 
GACCTGCCCA ACAGCCAGGA GGCTCTGCAG AAGCTCTCTG ATGTCACCCT GGTACCTGTG 
TCCTGCTCAG AACTGGAGAA GGCTGGAGCT GGCCTCAGCT CCCTCTGCCT GGTGCTCAGC 
ACACGCCCCC ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524675.1
CDS	723..1580
Translation	MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHC

Target ORF information:

RefSeq Version	XM_006524612.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524612.4

ORF Insert Sequence:

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGTGGG 
GACCTGCCCA ACAGCCAGGA GGCTCTGCAG AAGCTCTCTG ATGTCACCCT GGTACCTGTG 
TCCTGCTCAG AACTGGAGAA GGCTGGAGCT GGCCTCAGCT CCCTCTGCCT GGTGCTCAGC 
ACACGCCCCC ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ddah2 ( XM_006524612.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006524675.1 Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01330
Clone ID Related Accession (Same CDS sequence)	XM_006524612.4 , NM_001190449.1 , XM_006524612.3
Accession Version	XM_006524612.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006524612.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGTGGG 
GACCTGCCCA ACAGCCAGGA GGCTCTGCAG AAGCTCTCTG ATGTCACCCT GGTACCTGTG 
TCCTGCTCAG AACTGGAGAA GGCTGGAGCT GGCCTCAGCT CCCTCTGCCT GGTGCTCAGC 
ACACGCCCCC ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006524675.1
CDS	706..1563
Translation	MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHC

Target ORF information:

RefSeq Version	XM_006524612.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006524612.3

ORF Insert Sequence:

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGTGGG 
GACCTGCCCA ACAGCCAGGA GGCTCTGCAG AAGCTCTCTG ATGTCACCCT GGTACCTGTG 
TCCTGCTCAG AACTGGAGAA GGCTGGAGCT GGCCTCAGCT CCCTCTGCCT GGTGCTCAGC 
ACACGCCCCC ACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ddah2 ( XM_030249896.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030105756.1 Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X2, mRNA.

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CloneID	OMu10624
Clone ID Related Accession (Same CDS sequence)	NM_016765.3 , XM_030249896.1
Accession Version	XM_030249896.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGCTCT 
GCAGAAGCTC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030105756.1
CDS	726..1460
Translation	MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGSAEAL

Target ORF information:

RefSeq Version	XM_030249896.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus dimethylarginine dimethylaminohydrolase 2 (Ddah2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030249896.1

ORF Insert Sequence:

ATGGGGACGC CGGGGGAGGG GCTGGGTCGT TGTTCCCATG CCCTGATCCG GGGTGTCCCC 
GAGAGCTTGG CATCCGGGGA AGGTGCTGGC GCTGGTCTTC CGGCTCTGGA CCTGGCTAAA 
GCTCAAAGGG AGCATGGAGT ACTAGGAGGT AAACTGAGGC AACGACTAGG GCTGCAGCTG 
CTTGAACTGC CTCCTGAGGA GTCACTGCCG CTGGGACCAC TGCTTGGTGA CACGGCTGTG 
ATCCAAGGAG ACACGGCCCT AATCACAAGG CCCTGGAGCC CAGCACGTAG GCCTGAGGTT 
GATGGAGTGC GTAAAGCCCT CCAGGACTTG GGACTCCGAA TTGTGGAGAT GGGGGATGAG 
AATGCGACGC TGGACGGCAC CGACGTCCTC TTCACCGGCC GGGAGTTTTT CGTAGGCCTC 
TCCAAGTGGA CCAATCATCG AGGAGCTGAG ATCGTGGCAG ACACGTTCCG GGACTTCGCT 
GTCTCAACGG TACCGGTCTC AGGCTCCTCG CACCTGCGCG GCCTCTGTGG CATGGGGGGA 
CCTCGCACCG TGGTGGCTGG AAGCAGCGAG GCTGCCCAAA AAGCAGTCAG GGCAATGGCA 
GCGCTGACTG ATCACCCCTA CGCCTCTCTG ACCCTCCCAG ATGATGCAGC TAGTGACTGT 
CTCTTTCTGC GTCCTGGGTT GCCTGGTGCC ACACCTTTCC TCCTGCACCG CGGAGGCTCT 
GCAGAAGCTC TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats.
International journal of molecular medicine43(2)749-760(2019 Feb)
Zhu ZD,Ye JM,Fu XM,Wang XC,Ye JY,Wu XR,Hua P,Liao YQ,Xuan W,Duan JL,Li WY,Fu H,Xia ZH,Zhang X

Hyper-activation of pp60
Free radical biology & medicine102217-228(2017 01)
Kumar S,Sun X,Noonepalle SK,Lu Q,Zemskov E,Wang T,Aggarwal S,Gross C,Sharma S,Desai AA,Hou Y,Dasarathy S,Qu N,Reddy V,Lee SG,Cherian-Shaw M,Yuan JX,Catravas JD,Rafikov R,Garcia JGN,Black SM

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association31(3)413-23(2016 Mar)
Minakuchi H,Wakino S,Hosoya K,Sueyasu K,Hasegawa K,Shinozuka K,Yoshifuji A,Futatsugi K,Komatsu M,Kanda T,Tokuyama H,Hayashi K,Itoh H

The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2301-15(2013 Jun)
Hasegawa K,Wakino S,Kimoto M,Minakuchi H,Fujimura K,Hosoya K,Komatsu M,Kaneko Y,Kanda T,Tokuyama H,Hayashi K,Itoh H

The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
Science translational medicine3(87)87ra53(2011 Jun)
Pullamsetti SS,Savai R,Dumitrascu R,Dahal BK,Wilhelm J,Konigshoff M,Zakrzewicz D,Ghofrani HA,Weissmann N,Eickelberg O,Guenther A,Leiper J,Seeger W,Grimminger F,Schermuly RT

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Ddah2 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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