Gcdh cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gcdh
Entrez Gene ID	270076
Full Name	glutaryl-Coenzyme A dehydrogenase
Synonyms	9030411L18,AI266902,D17825,GCD
General protein information	Preferred Names glutaryl-Coenzyme A dehydrogenase Names glutaryl-CoA dehydrogenase, mitochondrial
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 C3\|8 41.28 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001044744.1	NP_001038209.2	glutaryl-CoA dehydrogenase, mitochondrial
NM_008097.2	NP_032123.3	glutaryl-CoA dehydrogenase, mitochondrial

Pathways from BioSystems

Homologies

Homo sapiens (human)	GCDH	NP_000150.1
Macaca mulatta (Rhesus monkey)	GCDH	XP_001110430.1
Mus musculus (house mouse)	Gcdh	NP_032123.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008501	XP_316942.3
Canis lupus familiaris (dog)	GCDH	XP_533901.2
Danio rerio (zebrafish)	gcdhl	NP_001006024.1
Drosophila melanogaster (fruit fly)	CG9547	NP_609040.1
Bos taurus (cattle)	GCDH	NP_001039404.1
Rattus norvegicus (Norway rat)	Gcdh	NP_001102366.1
Magnaporthe oryzae (rice blast fungus)	MGG_06561	XP_003716979.1
Oryza sativa (rice)	Os01g0159400	NP_001042084.1
Danio rerio (zebrafish)	gcdh	NP_957180.1
Caenorhabditis elegans (roundworm)	CELE_F54D5.7	NP_496469.1
Arabidopsis thaliana (thale cress)	ACX4	NP_190752.1
Xenopus tropicalis (tropical clawed frog)	gcdh	NP_001016289.1
Oryza sativa (rice)	Os05g0163700	NP_001054738.1
Neurospora crassa	NCU02291	XP_959935.1
Pan troglodytes (chimpanzee)	GCDH	XP_001170352.2
Gallus gallus (chicken)	GCDH	XP_001231726.3

Gene Ontology
Bibliography

Related articles in PubMed

l-Carnitine prevents oxidative stress in striatum of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload.
Guerreiro G, Amaral AU, Ribeiro RT, Faverzani J, Groehs AC, Sitta A, Deon M, Wajner M, Vargas CR
Biochimica et biophysica acta. Molecular basis of disease1865(9)2420-2427(2019 Sep)

Long Lasting High Lysine Diet Aggravates White Matter Injury in Glutaryl-CoA Dehydrogenase Deficient (Gcdh-/-) Mice.
Olivera-Bravo S, Seminotti B, Isasi E, Ribeiro CA, Leipnitz G, Woontner M, Goodman SI, Souza D, Barbeito L, Wajner M
Molecular neurobiology56(1)648-657(2019 Jan)

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity.
Schmiesing J, Storch S, Dörfler AC, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly WS, Braulke T
Cell reports24(11)2946-2956(2018 09)

Induction of Neuroinflammatory Response and Histopathological Alterations Caused by Quinolinic Acid Administration in the Striatum of Glutaryl-CoA Dehydrogenase Deficient Mice.
Amaral AU, Seminotti B, da Silva JC, de Oliveira FH, Ribeiro RT, Vargas CR, Leipnitz G, Santamaría A, Souza DO, Wajner M
Neurotoxicity research33(3)593-606(2018 04)

Impairment of GABAergic system contributes to epileptogenesis in glutaric acidemia type I.
Vendramin Pasquetti M, Meier L, Loureiro S, Ganzella M, Junges B, Barbieri Caus L, Umpierrez Amaral A, Koeller DM, Goodman S, Woontner M, Gomes de Souza DO, Wajner M, Calcagnotto ME
Epilepsia58(10)1771-1781(2017 10)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gcdh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gcdh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13460	NM_001044744.1 Latest version!	Mus musculus glutaryl-Coenzyme A dehydrogenase (Gcdh), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00
OMu13460	NM_008097.2 Latest version!	Mus musculus glutaryl-Coenzyme A dehydrogenase (Gcdh), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gcdh ( NM_001044744.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001038209.2 Mus musculus glutaryl-Coenzyme A dehydrogenase (Gcdh), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu13460
Clone ID Related Accession (Same CDS sequence)	NM_001044744.1 , NM_008097.2
Accession Version	NM_001044744.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	glutaryl-CoA dehydrogenase, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5, AU080952.1, AK078866.1 and AI181022.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.254625.1, SRR1660821.9939.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTCCTG CAATGCTCAC CGGCTACATG TCCCTGAGAG GAGTCTCCGC GCGGTTGCTG 
AGCCGCAGGT CCGGCCTGCG CTTCCCGCGT TTTCCACGTA CCTGGAGCTC GGCGGCCGCC 
CACACCGAGA AGACACAGAT CCGACCGGCC AAATCCTCTC GCCCCGTGTT TGACTGGAAG 
GACCCACTCA TACTGGAGGA GCAGCTGACT GCCGATGAGA AACTGATCAG GGACACCTTC 
CGTAACTACT GCCAGGAGCG GCTTATGTCT CGAATTCTGC TGGCTAATCG AAATGAAGTT 
TTTCACAGGG ACATTGTGTA TGAGATGGGG GAGCTGGGCG TGTTGGGACC CACCATTAAA 
GGGTATGGCT GTGCTGGTGT GTCGTCGGTG GCCTATGGGC TCCTGACCCG AGAGCTTGAG 
AGGGTGGACA GTGGCTACAG GTCGATGATG AGTGTTCAGT CCTCCCTTGT CATGCACCCC 
ATCTATACCT ATGGGAGCGA GGAACAGCGA CAGAAATATC TGCCCGGACT GGCCAAGGGT 
GAACTTCTGG GCTGCTTTGG ACTTACAGAG CCCAACCATG GGAGTGACCC AGGTGGCATG 
GAGACCAGAG CTCGCCACAA TCCATCAAAC CAGAGCTACA CTCTCAGTGG GACCAAGACC 
TGGATCACCA ACTCCCCTGT GGCTGACCTA TTTATAGTGT GGGCTCGGTG TGAGGATAAC 
TGTATTCGGG GCTTCATACT GGAGAAGGGT ATGCGGGGCC TCTCAGCCCC TAGGATTGAA 
GGAAAGTTCT CCTTGCGGGC CTCGGCTACC GGTATGATCA TCATGGACAG TGTGGAAGTG 
CCTGAGGAGA ATGTGCTGCC TAATGTATCC AGCCTGGCGG GCCCTTTTGG CTGCCTTAAC 
ACTGCCCGCT ATGGCATCAC ATGGGGTGTG TTGGGAGCTG CTGAGTTCTG TTTGCACACA 
GCCCGGCAGT ATGCCCTAGA CAGGATCCAG TTTGGAGTCC CCTTGGCCAG GAACCAGCTG 
GTTCAGAAGA AGTTGGCAGA CATGCTCACT GAGATCACAC TGGGACTCCA TGCTTGTTTG 
CAACTTGGCC GTTTAAAGGA TCAGGACAAG GCTACCCCAG AGATGGTCTC CATGTTGAAG 
AGAAACAACT GTGGAAAAGC CCTGGATATT GCCCGCCAGG CACGAGACAT CCTGGGAGGA 
AATGGGATTT CTGATGAGTA CCATGTCATC CGGCATGCTA TGAATCTGGA GGCAGTGAAC 
ACTTATGAAG GTACACATGA CATTCATGCT CTGATCCTTG GGAGAGCAAT TACTGGGATT 
CAGGCATTCA CGGTTGGCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001038209.2
CDS	184..1527
Translation	MVPAMLTGYMSLRGVSARLLSRRSGLRFPRFPRTWSSAAAHTEKTQIRPAKSSRPVFDWKDPLILEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYGSEEQRQKYLPGLAKGELLGCFGLTEPNHGSDPGGMETRARHNPSNQSYTLSGTKTWITNSPVADLFIVWARCEDNCIRGFILEKGMRGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVPLARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSMLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVGK

Target ORF information:

RefSeq Version	NM_001044744.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaryl-Coenzyme A dehydrogenase (Gcdh), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001044744.1

ORF Insert Sequence:

ATGGTTCCTG CAATGCTCAC CGGCTACATG TCCCTGAGAG GAGTCTCCGC GCGGTTGCTG 
AGCCGCAGGT CCGGCCTGCG CTTCCCGCGT TTTCCACGTA CCTGGAGCTC GGCGGCCGCC 
CACACCGAGA AGACACAGAT CCGACCGGCC AAATCCTCTC GCCCCGTGTT TGACTGGAAG 
GACCCACTCA TACTGGAGGA GCAGCTGACT GCCGATGAGA AACTGATCAG GGACACCTTC 
CGTAACTACT GCCAGGAGCG GCTTATGTCT CGAATTCTGC TGGCTAATCG AAATGAAGTT 
TTTCACAGGG ACATTGTGTA TGAGATGGGG GAGCTGGGCG TGTTGGGACC CACCATTAAA 
GGGTATGGCT GTGCTGGTGT GTCGTCGGTG GCCTATGGGC TCCTGACCCG AGAGCTTGAG 
AGGGTGGACA GTGGCTACAG GTCGATGATG AGTGTTCAGT CCTCCCTTGT CATGCACCCC 
ATCTATACCT ATGGGAGCGA GGAACAGCGA CAGAAATATC TGCCCGGACT GGCCAAGGGT 
GAACTTCTGG GCTGCTTTGG ACTTACAGAG CCCAACCATG GGAGTGACCC AGGTGGCATG 
GAGACCAGAG CTCGCCACAA TCCATCAAAC CAGAGCTACA CTCTCAGTGG GACCAAGACC 
TGGATCACCA ACTCCCCTGT GGCTGACCTA TTTATAGTGT GGGCTCGGTG TGAGGATAAC 
TGTATTCGGG GCTTCATACT GGAGAAGGGT ATGCGGGGCC TCTCAGCCCC TAGGATTGAA 
GGAAAGTTCT CCTTGCGGGC CTCGGCTACC GGTATGATCA TCATGGACAG TGTGGAAGTG 
CCTGAGGAGA ATGTGCTGCC TAATGTATCC AGCCTGGCGG GCCCTTTTGG CTGCCTTAAC 
ACTGCCCGCT ATGGCATCAC ATGGGGTGTG TTGGGAGCTG CTGAGTTCTG TTTGCACACA 
GCCCGGCAGT ATGCCCTAGA CAGGATCCAG TTTGGAGTCC CCTTGGCCAG GAACCAGCTG 
GTTCAGAAGA AGTTGGCAGA CATGCTCACT GAGATCACAC TGGGACTCCA TGCTTGTTTG 
CAACTTGGCC GTTTAAAGGA TCAGGACAAG GCTACCCCAG AGATGGTCTC CATGTTGAAG 
AGAAACAACT GTGGAAAAGC CCTGGATATT GCCCGCCAGG CACGAGACAT CCTGGGAGGA 
AATGGGATTT CTGATGAGTA CCATGTCATC CGGCATGCTA TGAATCTGGA GGCAGTGAAC 
ACTTATGAAG GTACACATGA CATTCATGCT CTGATCCTTG GGAGAGCAAT TACTGGGATT 
CAGGCATTCA CGGTTGGCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gcdh ( NM_008097.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032123.3 Mus musculus glutaryl-Coenzyme A dehydrogenase (Gcdh), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13460
Clone ID Related Accession (Same CDS sequence)	NM_001044744.1 , NM_008097.2
Accession Version	NM_008097.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1344bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Mus musculus(house mouse)
Product	glutaryl-CoA dehydrogenase, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161765.5, AK165406.1, AK078866.1 and AI181022.1. On Aug 31, 2006 this sequence version replaced NM_008097.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.100556.1, SRR1660821.150443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTCCTG CAATGCTCAC CGGCTACATG TCCCTGAGAG GAGTCTCCGC GCGGTTGCTG 
AGCCGCAGGT CCGGCCTGCG CTTCCCGCGT TTTCCACGTA CCTGGAGCTC GGCGGCCGCC 
CACACCGAGA AGACACAGAT CCGACCGGCC AAATCCTCTC GCCCCGTGTT TGACTGGAAG 
GACCCACTCA TACTGGAGGA GCAGCTGACT GCCGATGAGA AACTGATCAG GGACACCTTC 
CGTAACTACT GCCAGGAGCG GCTTATGTCT CGAATTCTGC TGGCTAATCG AAATGAAGTT 
TTTCACAGGG ACATTGTGTA TGAGATGGGG GAGCTGGGCG TGTTGGGACC CACCATTAAA 
GGGTATGGCT GTGCTGGTGT GTCGTCGGTG GCCTATGGGC TCCTGACCCG AGAGCTTGAG 
AGGGTGGACA GTGGCTACAG GTCGATGATG AGTGTTCAGT CCTCCCTTGT CATGCACCCC 
ATCTATACCT ATGGGAGCGA GGAACAGCGA CAGAAATATC TGCCCGGACT GGCCAAGGGT 
GAACTTCTGG GCTGCTTTGG ACTTACAGAG CCCAACCATG GGAGTGACCC AGGTGGCATG 
GAGACCAGAG CTCGCCACAA TCCATCAAAC CAGAGCTACA CTCTCAGTGG GACCAAGACC 
TGGATCACCA ACTCCCCTGT GGCTGACCTA TTTATAGTGT GGGCTCGGTG TGAGGATAAC 
TGTATTCGGG GCTTCATACT GGAGAAGGGT ATGCGGGGCC TCTCAGCCCC TAGGATTGAA 
GGAAAGTTCT CCTTGCGGGC CTCGGCTACC GGTATGATCA TCATGGACAG TGTGGAAGTG 
CCTGAGGAGA ATGTGCTGCC TAATGTATCC AGCCTGGCGG GCCCTTTTGG CTGCCTTAAC 
ACTGCCCGCT ATGGCATCAC ATGGGGTGTG TTGGGAGCTG CTGAGTTCTG TTTGCACACA 
GCCCGGCAGT ATGCCCTAGA CAGGATCCAG TTTGGAGTCC CCTTGGCCAG GAACCAGCTG 
GTTCAGAAGA AGTTGGCAGA CATGCTCACT GAGATCACAC TGGGACTCCA TGCTTGTTTG 
CAACTTGGCC GTTTAAAGGA TCAGGACAAG GCTACCCCAG AGATGGTCTC CATGTTGAAG 
AGAAACAACT GTGGAAAAGC CCTGGATATT GCCCGCCAGG CACGAGACAT CCTGGGAGGA 
AATGGGATTT CTGATGAGTA CCATGTCATC CGGCATGCTA TGAATCTGGA GGCAGTGAAC 
ACTTATGAAG GTACACATGA CATTCATGCT CTGATCCTTG GGAGAGCAAT TACTGGGATT 
CAGGCATTCA CGGTTGGCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032123.3
CDS	241..1584
Translation	MVPAMLTGYMSLRGVSARLLSRRSGLRFPRFPRTWSSAAAHTEKTQIRPAKSSRPVFDWKDPLILEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYGSEEQRQKYLPGLAKGELLGCFGLTEPNHGSDPGGMETRARHNPSNQSYTLSGTKTWITNSPVADLFIVWARCEDNCIRGFILEKGMRGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVPLARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSMLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVGK

Target ORF information:

RefSeq Version	NM_008097.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutaryl-Coenzyme A dehydrogenase (Gcdh), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008097.2

ORF Insert Sequence:

ATGGTTCCTG CAATGCTCAC CGGCTACATG TCCCTGAGAG GAGTCTCCGC GCGGTTGCTG 
AGCCGCAGGT CCGGCCTGCG CTTCCCGCGT TTTCCACGTA CCTGGAGCTC GGCGGCCGCC 
CACACCGAGA AGACACAGAT CCGACCGGCC AAATCCTCTC GCCCCGTGTT TGACTGGAAG 
GACCCACTCA TACTGGAGGA GCAGCTGACT GCCGATGAGA AACTGATCAG GGACACCTTC 
CGTAACTACT GCCAGGAGCG GCTTATGTCT CGAATTCTGC TGGCTAATCG AAATGAAGTT 
TTTCACAGGG ACATTGTGTA TGAGATGGGG GAGCTGGGCG TGTTGGGACC CACCATTAAA 
GGGTATGGCT GTGCTGGTGT GTCGTCGGTG GCCTATGGGC TCCTGACCCG AGAGCTTGAG 
AGGGTGGACA GTGGCTACAG GTCGATGATG AGTGTTCAGT CCTCCCTTGT CATGCACCCC 
ATCTATACCT ATGGGAGCGA GGAACAGCGA CAGAAATATC TGCCCGGACT GGCCAAGGGT 
GAACTTCTGG GCTGCTTTGG ACTTACAGAG CCCAACCATG GGAGTGACCC AGGTGGCATG 
GAGACCAGAG CTCGCCACAA TCCATCAAAC CAGAGCTACA CTCTCAGTGG GACCAAGACC 
TGGATCACCA ACTCCCCTGT GGCTGACCTA TTTATAGTGT GGGCTCGGTG TGAGGATAAC 
TGTATTCGGG GCTTCATACT GGAGAAGGGT ATGCGGGGCC TCTCAGCCCC TAGGATTGAA 
GGAAAGTTCT CCTTGCGGGC CTCGGCTACC GGTATGATCA TCATGGACAG TGTGGAAGTG 
CCTGAGGAGA ATGTGCTGCC TAATGTATCC AGCCTGGCGG GCCCTTTTGG CTGCCTTAAC 
ACTGCCCGCT ATGGCATCAC ATGGGGTGTG TTGGGAGCTG CTGAGTTCTG TTTGCACACA 
GCCCGGCAGT ATGCCCTAGA CAGGATCCAG TTTGGAGTCC CCTTGGCCAG GAACCAGCTG 
GTTCAGAAGA AGTTGGCAGA CATGCTCACT GAGATCACAC TGGGACTCCA TGCTTGTTTG 
CAACTTGGCC GTTTAAAGGA TCAGGACAAG GCTACCCCAG AGATGGTCTC CATGTTGAAG 
AGAAACAACT GTGGAAAAGC CCTGGATATT GCCCGCCAGG CACGAGACAT CCTGGGAGGA 
AATGGGATTT CTGATGAGTA CCATGTCATC CGGCATGCTA TGAATCTGGA GGCAGTGAAC 
ACTTATGAAG GTACACATGA CATTCATGCT CTGATCCTTG GGAGAGCAAT TACTGGGATT 
CAGGCATTCA CGGTTGGCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

l-Carnitine prevents oxidative stress in striatum of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload.
Biochimica et biophysica acta. Molecular basis of disease1865(9)2420-2427(2019 Sep)
Guerreiro G,Amaral AU,Ribeiro RT,Faverzani J,Groehs AC,Sitta A,Deon M,Wajner M,Vargas CR

Long Lasting High Lysine Diet Aggravates White Matter Injury in Glutaryl-CoA Dehydrogenase Deficient (Gcdh-/-) Mice.
Molecular neurobiology56(1)648-657(2019 Jan)
Olivera-Bravo S,Seminotti B,Isasi E,Ribeiro CA,Leipnitz G,Woontner M,Goodman SI,Souza D,Barbeito L,Wajner M

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity.
Cell reports24(11)2946-2956(2018 09)
Schmiesing J,Storch S,Dörfler AC,Schweizer M,Makrypidi-Fraune G,Thelen M,Sylvester M,Gieselmann V,Meyer-Schwesinger C,Koch-Nolte F,Tidow H,Mühlhausen C,Waheed A,Sly WS,Braulke T

Induction of Neuroinflammatory Response and Histopathological Alterations Caused by Quinolinic Acid Administration in the Striatum of Glutaryl-CoA Dehydrogenase Deficient Mice.
Neurotoxicity research33(3)593-606(2018 04)
Amaral AU,Seminotti B,da Silva JC,de Oliveira FH,Ribeiro RT,Vargas CR,Leipnitz G,Santamaría A,Souza DO,Wajner M

Impairment of GABAergic system contributes to epileptogenesis in glutaric acidemia type I.
Epilepsia58(10)1771-1781(2017 10)
Vendramin Pasquetti M,Meier L,Loureiro S,Ganzella M,Junges B,Barbieri Caus L,Umpierrez Amaral A,Koeller DM,Goodman S,Woontner M,Gomes de Souza DO,Wajner M,Calcagnotto ME

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Gcdh cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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