| Gene Symbol | Sh2d1b1 |
| Entrez Gene ID | 26904 |
| Full Name | SH2 domain containing 1B1 |
| Synonyms | EAT-2,EAT-2A,Eat2,Eat2a,Sh2d1b |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Sh2d1b1 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Sh2d1b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sh2d1b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu09327 Clone ID Related Accession (Same CDS sequence) NM_012009.5 , NM_012009.4 Accession Version NM_012009.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 399bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1551024000000 Organism Mus musculus(house mouse) Product SH2 domain-containing protein 1B Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC123650.7 and BC116698.1. On Feb 16, 2018 this sequence version replaced NM_012009.4. Transcript Variant: This variant (1) represents the longer, protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK089191.1, BC116698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC
AAGGGAGGTG TGGATGGCAA CTTTCTGATA AGAGACAGCG AGTCTGTGCC AGGAGCCCTG
TGCCTCTGTG TCTCGTTTAA AAAGCTTGTC TACAGCTACC GAATCTTCAG AGAGAAACAT
GGATATTACA GGATAGAGAC TAATGCTCAT ACTCCAAGAA CGATCTTTCC AAACCTACAG
GAATTGGTCT CCAAATATGG AAAACCGGGT CAAGGATTGG TGGTTCACCT TTCAAACCCA
ATAATGAGAA ACAACCTATG CCAAAGAGGG AGAAGAATGG AGTTAGAGCT GAATGTTTAT
GAGAACACTG ATAAGGAGTA TGTGGACGTC TTGCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_036139.3 CDS 59..457 Translation 
Target ORF information:
RefSeq Version NM_012009.5 Organism Mus musculus(house mouse) Definition Mus musculus SH2 domain containing 1B1 (Sh2d1b1), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_012009.5
ORF Insert Sequence:
1
61
121
181
241
301
361ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC
AAGGGAGGTG TGGATGGCAA CTTTCTGATA AGAGACAGCG AGTCTGTGCC AGGAGCCCTG
TGCCTCTGTG TCTCGTTTAA AAAGCTTGTC TACAGCTACC GAATCTTCAG AGAGAAACAT
GGATATTACA GGATAGAGAC TAATGCTCAT ACTCCAAGAA CGATCTTTCC AAACCTACAG
GAATTGGTCT CCAAATATGG AAAACCGGGT CAAGGATTGG TGGTTCACCT TTCAAACCCA
ATAATGAGAA ACAACCTATG CCAAAGAGGG AGAAGAATGG AGTTAGAGCT GAATGTTTAT
GAGAACACTG ATAAGGAGTA TGTGGACGTC TTGCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu09327 Clone ID Related Accession (Same CDS sequence) NM_012009.5 , NM_012009.4 Accession Version NM_012009.4 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 399bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1506787200000 Organism Mus musculus(house mouse) Product SH2 domain-containing protein 1B Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC117508.1. On Jun 10, 2007 this sequence version replaced NM_012009.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC116698.1, AK089191.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC
AAGGGAGGTG TGGATGGCAA CTTTCTGATA AGAGACAGCG AGTCTGTGCC AGGAGCCCTG
TGCCTCTGTG TCTCGTTTAA AAAGCTTGTC TACAGCTACC GAATCTTCAG AGAGAAACAT
GGATATTACA GGATAGAGAC TAATGCTCAT ACTCCAAGAA CGATCTTTCC AAACCTACAG
GAATTGGTCT CCAAATATGG AAAACCGGGT CAAGGATTGG TGGTTCACCT TTCAAACCCA
ATAATGAGAA ACAACCTATG CCAAAGAGGG AGAAGAATGG AGTTAGAGCT GAATGTTTAT
GAGAACACTG ATAAGGAGTA TGTGGACGTC TTGCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_036139.3 CDS 53..451 Translation
Target ORF information:
RefSeq Version NM_012009.4 Organism Mus musculus(house mouse) Definition Mus musculus SH2 domain containing 1B1 (Sh2d1b1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_012009.4
ORF Insert Sequence:
1
61
121
181
241
301
361ATGGATCTGC CTTACTACCA TGGCTGCCTG ACCAAGCGAG AGTGTGAAGC CCTGCTCCTC
AAGGGAGGTG TGGATGGCAA CTTTCTGATA AGAGACAGCG AGTCTGTGCC AGGAGCCCTG
TGCCTCTGTG TCTCGTTTAA AAAGCTTGTC TACAGCTACC GAATCTTCAG AGAGAAACAT
GGATATTACA GGATAGAGAC TAATGCTCAT ACTCCAAGAA CGATCTTTCC AAACCTACAG
GAATTGGTCT CCAAATATGG AAAACCGGGT CAAGGATTGG TGGTTCACCT TTCAAACCCA
ATAATGAGAA ACAACCTATG CCAAAGAGGG AGAAGAATGG AGTTAGAGCT GAATGTTTAT
GAGAACACTG ATAAGGAGTA TGTGGACGTC TTGCCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.
Nature immunology17(4)387-96(2016 Apr)
Wu N,Zhong MC,Roncagalli R,Pérez-Quintero LA,Guo H,Zhang Z,Lenoir C,Dong Z,Latour S,Veillette A
Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.
Journal of immunology (Baltimore, Md. : 1950)195(10)4623-31(2015 Nov)
Talaei N,Yu T,Manion K,Bremner R,Wither JE
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.
Molecular and cellular biology35(1)41-51(2015 Jan)
Guo H,Cruz-Munoz ME,Wu N,Robbins M,Veillette A
EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.
The Journal of experimental medicine211(4)727-42(2014 Apr)
Pérez-Quintero LA,Roncagalli R,Guo H,Latour S,Davidson D,Veillette A
Signaling lymphocyte activation molecule regulates development of colitis in mice.
Gastroenterology143(6)1544-1554.e7(2012 Dec)
van Driel B,Liao G,Romero X,O'Keeffe MS,Wang G,Faubion WA,Berger SB,Magelky EM,Manocha M,Azcutia V,Grisham M,Luscinskas FW,Mizoguchi E,de Waal Malefyt R,Reinecker HC,Bhan AK,Wang N,Terhorst C
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