Tnfsf18 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfsf18
Entrez Gene ID	240873
Full Name	tumor necrosis factor (ligand) superfamily, member 18
Synonyms	Gitrl,Tnlg2a
General protein information	Preferred Names tumor necrosis factor (ligand) superfamily, member 18 Names tumor necrosis factor ligand superfamily member 18 GITR ligand glucocorticoid-induced TNF-related ligand glucocorticoid-induced-tumor necrosis factor receptor ligand tumor necrosis factor ligand 2a
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H2.1\|1 69.75 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_183391.3	NP_899247.3	tumor necrosis factor ligand superfamily member 18

Pathways from BioSystems

Homologies

Homo sapiens (human)	TNFSF18	NP_005083.2
Bos taurus (cattle)	TNFSF18	NP_001070604.1
Mus musculus (house mouse)	Tnfsf18	NP_899247.3
Macaca mulatta (Rhesus monkey)	TNFSF18	NP_001035281.1
Canis lupus familiaris (dog)	TNFSF18	XP_005623023.1
Rattus norvegicus (Norway rat)	Tnfsf18	XP_344167.6
Pan troglodytes (chimpanzee)	TNFSF18	XP_001147996.2

Gene Ontology
Bibliography

Related articles in PubMed

GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation.
Chu KL, Batista NV, Wang KC, Zhou AC, Watts TH
Mucosal immunology12(2)363-377(2019 03)

Mature IgD
Ray A, Khalil MI, Pulakanti KL, Burns RT, Gurski CJ, Basu S, Wang D, Rao S, Dittel BN
Nature communications10(1)190(2019 01)

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Premzl M
Immunogenetics68(2)125-32(2016 Feb)

Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.
Kobayashi Y, Kiguchi N, Fukazawa Y, Saika F, Maeda T, Kishioka S
The Journal of biological chemistry290(20)12603-13(2015 May)

Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC.
Clouthier DL, Zhou AC, Watts TH
Journal of immunology (Baltimore, Md. : 1950)193(10)5033-43(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tnfsf18 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfsf18 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu08607	NM_183391.3 Latest version!	Mus musculus tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfsf18 ( NM_183391.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_899247.3 Mus musculus tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), mRNA.

Price & Availability↑

CloneID	OMu08607
Clone ID Related Accession (Same CDS sequence)	NM_183391.3
Accession Version	NM_183391.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 522bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1561910400000
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor ligand superfamily member 18
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC137815.1 and AC163268.4. On May 9, 2009 this sequence version replaced NM_183391.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ577579.1, AY234223.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGGAAA TGCCTTTGAG AGAATCAAGT CCTCAAAGGG CAGAGAGGTG CAAGAAGTCA 
TGGCTCTTGT GCATAGTGGC TCTGTTACTG ATGTTGCTCT GTTCTTTGGG TACACTGATC 
TATACTTCAC TCAAGCCAAC TGCCATCGAG TCCTGCATGG TTAAGTTTGA ACTATCATCC 
TCAAAATGGC ACATGACATC TCCCAAACCT CACTGTGTGA ATACGACATC TGATGGGAAG 
CTGAAGATAC TGCAGAGTGG CACATATTTA ATCTACGGCC AAGTGATTCC TGTGGATAAG 
AAATACATAA AAGACAATGC CCCCTTCGTA GTACAGATAT ATAAAAAGAA TGATGTCCTA 
CAAACTCTAA TGAATGATTT TCAAATCTTG CCTATAGGAG GGGTTTATGA ACTGCATGCT 
GGAGATAACA TATATCTGAA GTTCAACTCT AAAGACCATA TTCAGAAAAC TAACACATAC 
TGGGGGATCA TCTTAATGCC TGATCTACCA TTCATCTCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_899247.3
CDS	57..578
Translation	MEEMPLRESSPQRAERCKKSWLLCIVALLLMLLCSLGTLIYTSLKPTAIESCMVKFELSSSKWHMTSPKPHCVNTTSDGKLKILQSGTYLIYGQVIPVDKKYIKDNAPFVVQIYKKNDVLQTLMNDFQILPIGGVYELHAGDNIYLKFNSKDHIQKTNTYWGIILMPDLPFIS

Target ORF information:

RefSeq Version	NM_183391.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tumor necrosis factor (ligand) superfamily, member 18 (Tnfsf18), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_183391.3

ORF Insert Sequence:

ATGGAGGAAA TGCCTTTGAG AGAATCAAGT CCTCAAAGGG CAGAGAGGTG CAAGAAGTCA 
TGGCTCTTGT GCATAGTGGC TCTGTTACTG ATGTTGCTCT GTTCTTTGGG TACACTGATC 
TATACTTCAC TCAAGCCAAC TGCCATCGAG TCCTGCATGG TTAAGTTTGA ACTATCATCC 
TCAAAATGGC ACATGACATC TCCCAAACCT CACTGTGTGA ATACGACATC TGATGGGAAG 
CTGAAGATAC TGCAGAGTGG CACATATTTA ATCTACGGCC AAGTGATTCC TGTGGATAAG 
AAATACATAA AAGACAATGC CCCCTTCGTA GTACAGATAT ATAAAAAGAA TGATGTCCTA 
CAAACTCTAA TGAATGATTT TCAAATCTTG CCTATAGGAG GGGTTTATGA ACTGCATGCT 
GGAGATAACA TATATCTGAA GTTCAACTCT AAAGACCATA TTCAGAAAAC TAACACATAC 
TGGGGGATCA TCTTAATGCC TGATCTACCA TTCATCTCTT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GITRL on inflammatory antigen presenting cells in the lung parenchyma provides signal 4 for T-cell accumulation and tissue-resident memory T-cell formation.
Mucosal immunology12(2)363-377(2019 03)
Chu KL,Batista NV,Wang KC,Zhou AC,Watts TH

Mature IgD
Nature communications10(1)190(2019 01)
Ray A,Khalil MI,Pulakanti KL,Burns RT,Gurski CJ,Basu S,Wang D,Rao S,Dittel BN

Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Immunogenetics68(2)125-32(2016 Feb)
Premzl M

Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system.
The Journal of biological chemistry290(20)12603-13(2015 May)
Kobayashi Y,Kiguchi N,Fukazawa Y,Saika F,Maeda T,Kishioka S

Anti-GITR agonist therapy intrinsically enhances CD8 T cell responses to chronic lymphocytic choriomeningitis virus (LCMV), thereby circumventing LCMV-induced downregulation of costimulatory GITR ligand on APC.
Journal of immunology (Baltimore, Md. : 1950)193(10)5033-43(2014 Nov)
Clouthier DL,Zhou AC,Watts TH