Gba2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gba2
Entrez Gene ID	230101
Full Name	glucosidase beta 2
Synonyms	F630034E04
General protein information	Preferred Names glucosidase beta 2 Names non-lysosomal glucosylceramidase NLGase beta-glucocerebrosidase 2 beta-glucosidase 2 bile acid glucosidase, beta (bile acid) 2 glucosylceramidase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 A5

mRNA and Protein(s)

mRNA	Protein	Name
XM_006537832.3	XP_006537895.1	non-lysosomal glucosylceramidase isoform X1
XM_006537832.4	XP_006537895.1	non-lysosomal glucosylceramidase isoform X1
NM_172692.3	NP_766280.2	non-lysosomal glucosylceramidase

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	GBA2	XP_001084705.1
Homo sapiens (human)	GBA2	NP_065995.1
Mus musculus (house mouse)	Gba2	NP_766280.2
Arabidopsis thaliana (thale cress)	AT3G24180	NP_189060.2
Gallus gallus (chicken)	GBA2	XP_003642968.1
Danio rerio (zebrafish)	gba2	XP_687652.2
Drosophila melanogaster (fruit fly)	CG33090	NP_788055.2
Caenorhabditis elegans (roundworm)	R08F11.1	NP_504047.2
Bos taurus (cattle)	GBA2	XP_002689726.1
Oryza sativa (rice)	Os10g0473400	NP_001064833.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008830	XP_319575.4
Pan troglodytes (chimpanzee)	GBA2	XP_001167923.2
Canis lupus familiaris (dog)	GBA2	XP_005626843.1
Xenopus tropicalis (tropical clawed frog)	gba2	XP_002943495.2
Rattus norvegicus (Norway rat)	Gba2	NP_001013109.2
Caenorhabditis elegans (roundworm)	hpo-13	NP_001021680.1

Gene Ontology
Bibliography

Related articles in PubMed

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.
Woeste MA, Stern S, Raju DN, Grahn E, Dittmann D, Gutbrod K, Dörmann P, Hansen JN, Schonauer S, Marx CE, Hamzeh H, Körschen HG, Aerts JMFG, Bönigk W, Endepols H, Sandhoff R, Geyer M, Berger TK, Bradke F, Wachten D
The Journal of biological chemistry294(11)3853-3871(2019 03)

Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals.
von Gerichten J, Schlosser K, Lamprecht D, Morace I, Eckhardt M, Wachten D, Jennemann R, Gröne HJ, Mack M, Sandhoff R
Journal of lipid research58(6)1247-1258(2017 06)

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.
Schonauer S, Körschen HG, Penno A, Rennhack A, Breiden B, Sandhoff K, Gutbrod K, Dörmann P, Raju DN, Haberkant P, Gerl MJ, Brügger B, Zigdon H, Vardi A, Futerman AH, Thiele C, Wachten D
The Journal of biological chemistry292(15)6177-6189(2017 04)

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases.
Marques AR, Mirzaian M, Akiyama H, Wisse P, Ferraz MJ, Gaspar P, Ghauharali-van der Vlugt K, Meijer R, Giraldo P, Alfonso P, Irún P, Dahl M, Karlsson S, Pavlova EV, Cox TM, Scheij S, Verhoek M, Ottenhoff R, van Roomen CP, Pannu NS, van Eijk M, Dekker N, Boot RG, Overkleeft HS, Blommaart E, Hirabayashi Y, Aerts JM
Journal of lipid research57(3)451-63(2016 Mar)

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice.
Marques AR, Aten J, Ottenhoff R, van Roomen CP, Herrera Moro D, Claessen N, Vinueza Veloz MF, Zhou K, Lin Z, Mirzaian M, Boot RG, De Zeeuw CI, Overkleeft HS, Yildiz Y, Aerts JM
PloS one10(8)e0135889(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Gba2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gba2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu32875	XM_006537832.4 Latest version!	Mus musculus glucosidase beta 2 (Gba2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OMu20190	NM_172692.3 Latest version!	Mus musculus glucosidase beta 2 (Gba2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$538.30 $769.00
View Old Accession Versions >>
OMu32875	XM_006537832.3	Mus musculus glucosidase beta 2 (Gba2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gba2 ( XM_006537832.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006537895.1 Mus musculus glucosidase beta 2 (Gba2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu32875
Clone ID Related Accession (Same CDS sequence)	XM_006537832.3 , XM_006537832.4
Accession Version	XM_006537832.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	non-lysosomal glucosylceramidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006537832.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCGGAC TGTGTACCAG CAAGTTCTGT CCTTGGAGCT TCCAAATGTC CTGCGCAGCT 
GGAACTGGGG CCTGTGTGGT TACTTTGCTT TCTACCACGC CCTCTATCCC CGAGCCTGGA 
CGGTCTATCA GCTTCCTGGC CAGAATGTCA CCCTCACCTG TCGCCAGGTC ACACCTATCT 
TGCCTCATGA CTACCAGCAG TCTCCCTGTA GGAGTCTTTG TGTGGGATGT AGAAAACGAA 
GGAGATGAGA CTCTGGACGT TTCCATCACG TTCTCCATGC GGAATGGACT AGGAGGCGAA 
GATGATGCGG CCGGGAGTTT GTGGAATGAG CCCTTCCGCC TGGAACAGGG CGGGACGACT 
GTTCAGGGGC TCCTCTTGCA TCATCCAACC CCTCCGAACC CCTACACCAT GGCTGTGGCT 
GCACGATGCA CGGCAGATAC CACGGTAACC CACACCACAG CCTTTGACCC CAATGGCACT 
GGACAGCAGG TGTGGCAGGA CCTACTTCAG GATGGACAGC TGGACTCCCC TGCTGGCCAA 
AGCACCCCAA CACAGAAAGG AGAGGGTATC GCTGGGGCTG TATGCGTCTC TAGCAAGCTG 
TTACCTCGAA GCCGGTGCTG CTTGGAGTTC TCACTGGCTT GGGATATGCC TAAGATCATG 
TTTGGAGCTA AAAGCCAAGT CCACTACAGG CGGTATACAC GGTTCTTTGG TTCAGATGGT 
GATGTGGCGC CTGCCCTGAG CCACTATGCA CTGTGCCACT ATGCAGACTG GGAGGACAGA 
ATCTCAGCCT GGCAGAACCC AGTACTGGAT GACAGAACCT TGCCTGCCTG GTACAAATCT 
GCACTGTTCA ATGAACTGTA CTTCCTGGCC GATGGAGGCA CAGTGTGGCT GGAAGTTCCC 
GCAGACTCCC TACCAGAGGG GCTGGGAGGG AGTATGCGTC AGCTTCGCTC TACTCTGCAG 
GACTATGGGC GATTTGGCTA TCTTGAAGGC CAGGAGTACC GCATGTACAA CACATACGAT 
GTCCACTTTT ATGCGTCCTT TGCCCTCGTC ATGCTGTGGC CCAAACTTGA GCTCAGTCTT 
CAGTATGATA TGGCTCTGGC AACTTTGAAG GAGGACCTGA CCCGGCGACG GTACCTGATG 
AGTGGAGTGG TGGCACCTGT GAAAAGGAGG AACGTCATCC CTCATGACAT TGGGGATCCG 
GATGATGAGC CATGGCTCCG GGTCAACGCA TATTTGATTC ATGATACTGC TGACTGGAAG 
GACCTGAACC TGAAGTTTGT ATTGCAAATT TATCGGGACT ATTACCTGAC GGGTGATCAA 
GGCTTCCTGG AGGACATGTG GCCTGTGTGT CTGGCTGTGA TGGAGTCCGA AATGAAGTTT 
GACAAGGACC AAGATGGACT CATTGAGAAT GGAGGCTACG CAGACCAGAC CTATGATGCA 
TGGGTCACCA CAGGCCCCAG TGCTTACTGC GGAGGGCTGT GGCTGGCGGC AGTGGCTGTA 
ATGGTTCAGA TGGCTGTTCT GTGTGGGGCC CAAGATGTCC AGGAGAGGTT TGCTTCCATT 
CTCTGCCGAG GCCGAGAAGC TTATGAGAGA CTGCTGTGGA ACGGACGCTA TTACAACTAC 
GACAGCAGCT CCCATCCTCA GTCTCGGAGC ATCATGTCTG ACCAGTGTGC TGGGCAGTGG 
TTCCTGAGGG CCTGCGGCCT GGGAGAAGGA GACACTGAAG TATTTCCTAC CCTGCATGTG 
GTCCGTGCTC TCCAAACCAT CTTTGAACTC AACGTCCAAG CCTTTGCAGG AGGAGCCATG 
GGGGCCGTGA ACGGGATGCA CCCTCATGGT GTCCCTGATA GATCCAGTGT GCAGTCTGAT 
GAAGTCTGGG TGGGTGTGGT CTATGGGCTG GCAGCCACCA TGATCCAAGA GGGCCTGACT 
TGGGAAGGTT TCCGGACAGC TGAAGGCTGT TACCGCACTG TATGGGAACG CCTGGGCCTG 
GCTTTCCAGA CCCCAGAGGC ATACTGCCAG CAACAAGTGT TCCGCTCCCT GGCCTACATG 
CGGCCACTGA GCATCTGGGC CATGCAGCTG GCCCTGCAAC AGCAGCAGCA TAAAAAGAGC 
CGCAGGCCAT CAGTCACACA AGGCACGGGA CTAAGCACAC AGCCTGAATG TGGACCAAAG 
AGATCGCTGG CAAACCTCAA TTCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006537895.1
CDS	806..2995
Translation	MGGLCTSKFCPWSFQMSCAAGTGACVVTLLSTTPSIPEPGRSISFLARMSPSPVARSHLSCLMTTSSLPVGVFVWDVENEGDETLDVSITFSMRNGLGGEDDAAGSLWNEPFRLEQGGTTVQGLLLHHPTPPNPYTMAVAARCTADTTVTHTTAFDPNGTGQQVWQDLLQDGQLDSPAGQSTPTQKGEGIAGAVCVSSKLLPRSRCCLEFSLAWDMPKIMFGAKSQVHYRRYTRFFGSDGDVAPALSHYALCHYADWEDRISAWQNPVLDDRTLPAWYKSALFNELYFLADGGTVWLEVPADSLPEGLGGSMRQLRSTLQDYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATLKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQIYRDYYLTGDQGFLEDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDAWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQERFASILCRGREAYERLLWNGRYYNYDSSSHPQSRSIMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALQTIFELNVQAFAGGAMGAVNGMHPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQQVFRSLAYMRPLSIWAMQLALQQQQHKKSRRPSVTQGTGLSTQPECGPKRSLANLNSE

Target ORF information:

RefSeq Version	XM_006537832.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glucosidase beta 2 (Gba2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006537832.3

ORF Insert Sequence:

ATGGGCGGAC TGTGTACCAG CAAGTTCTGT CCTTGGAGCT TCCAAATGTC CTGCGCAGCT 
GGAACTGGGG CCTGTGTGGT TACTTTGCTT TCTACCACGC CCTCTATCCC CGAGCCTGGA 
CGGTCTATCA GCTTCCTGGC CAGAATGTCA CCCTCACCTG TCGCCAGGTC ACACCTATCT 
TGCCTCATGA CTACCAGCAG TCTCCCTGTA GGAGTCTTTG TGTGGGATGT AGAAAACGAA 
GGAGATGAGA CTCTGGACGT TTCCATCACG TTCTCCATGC GGAATGGACT AGGAGGCGAA 
GATGATGCGG CCGGGAGTTT GTGGAATGAG CCCTTCCGCC TGGAACAGGG CGGGACGACT 
GTTCAGGGGC TCCTCTTGCA TCATCCAACC CCTCCGAACC CCTACACCAT GGCTGTGGCT 
GCACGATGCA CGGCAGATAC CACGGTAACC CACACCACAG CCTTTGACCC CAATGGCACT 
GGACAGCAGG TGTGGCAGGA CCTACTTCAG GATGGACAGC TGGACTCCCC TGCTGGCCAA 
AGCACCCCAA CACAGAAAGG AGAGGGTATC GCTGGGGCTG TATGCGTCTC TAGCAAGCTG 
TTACCTCGAA GCCGGTGCTG CTTGGAGTTC TCACTGGCTT GGGATATGCC TAAGATCATG 
TTTGGAGCTA AAAGCCAAGT CCACTACAGG CGGTATACAC GGTTCTTTGG TTCAGATGGT 
GATGTGGCGC CTGCCCTGAG CCACTATGCA CTGTGCCACT ATGCAGACTG GGAGGACAGA 
ATCTCAGCCT GGCAGAACCC AGTACTGGAT GACAGAACCT TGCCTGCCTG GTACAAATCT 
GCACTGTTCA ATGAACTGTA CTTCCTGGCC GATGGAGGCA CAGTGTGGCT GGAAGTTCCC 
GCAGACTCCC TACCAGAGGG GCTGGGAGGG AGTATGCGTC AGCTTCGCTC TACTCTGCAG 
GACTATGGGC GATTTGGCTA TCTTGAAGGC CAGGAGTACC GCATGTACAA CACATACGAT 
GTCCACTTTT ATGCGTCCTT TGCCCTCGTC ATGCTGTGGC CCAAACTTGA GCTCAGTCTT 
CAGTATGATA TGGCTCTGGC AACTTTGAAG GAGGACCTGA CCCGGCGACG GTACCTGATG 
AGTGGAGTGG TGGCACCTGT GAAAAGGAGG AACGTCATCC CTCATGACAT TGGGGATCCG 
GATGATGAGC CATGGCTCCG GGTCAACGCA TATTTGATTC ATGATACTGC TGACTGGAAG 
GACCTGAACC TGAAGTTTGT ATTGCAAATT TATCGGGACT ATTACCTGAC GGGTGATCAA 
GGCTTCCTGG AGGACATGTG GCCTGTGTGT CTGGCTGTGA TGGAGTCCGA AATGAAGTTT 
GACAAGGACC AAGATGGACT CATTGAGAAT GGAGGCTACG CAGACCAGAC CTATGATGCA 
TGGGTCACCA CAGGCCCCAG TGCTTACTGC GGAGGGCTGT GGCTGGCGGC AGTGGCTGTA 
ATGGTTCAGA TGGCTGTTCT GTGTGGGGCC CAAGATGTCC AGGAGAGGTT TGCTTCCATT 
CTCTGCCGAG GCCGAGAAGC TTATGAGAGA CTGCTGTGGA ACGGACGCTA TTACAACTAC 
GACAGCAGCT CCCATCCTCA GTCTCGGAGC ATCATGTCTG ACCAGTGTGC TGGGCAGTGG 
TTCCTGAGGG CCTGCGGCCT GGGAGAAGGA GACACTGAAG TATTTCCTAC CCTGCATGTG 
GTCCGTGCTC TCCAAACCAT CTTTGAACTC AACGTCCAAG CCTTTGCAGG AGGAGCCATG 
GGGGCCGTGA ACGGGATGCA CCCTCATGGT GTCCCTGATA GATCCAGTGT GCAGTCTGAT 
GAAGTCTGGG TGGGTGTGGT CTATGGGCTG GCAGCCACCA TGATCCAAGA GGGCCTGACT 
TGGGAAGGTT TCCGGACAGC TGAAGGCTGT TACCGCACTG TATGGGAACG CCTGGGCCTG 
GCTTTCCAGA CCCCAGAGGC ATACTGCCAG CAACAAGTGT TCCGCTCCCT GGCCTACATG 
CGGCCACTGA GCATCTGGGC CATGCAGCTG GCCCTGCAAC AGCAGCAGCA TAAAAAGAGC 
CGCAGGCCAT CAGTCACACA AGGCACGGGA CTAAGCACAC AGCCTGAATG TGGACCAAAG 
AGATCGCTGG CAAACCTCAA TTCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gba2 ( XM_006537832.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006537895.1 Mus musculus glucosidase beta 2 (Gba2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu32875
Clone ID Related Accession (Same CDS sequence)	XM_006537832.3 , XM_006537832.4
Accession Version	XM_006537832.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	non-lysosomal glucosylceramidase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006537832.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCGGAC TGTGTACCAG CAAGTTCTGT CCTTGGAGCT TCCAAATGTC CTGCGCAGCT 
GGAACTGGGG CCTGTGTGGT TACTTTGCTT TCTACCACGC CCTCTATCCC CGAGCCTGGA 
CGGTCTATCA GCTTCCTGGC CAGAATGTCA CCCTCACCTG TCGCCAGGTC ACACCTATCT 
TGCCTCATGA CTACCAGCAG TCTCCCTGTA GGAGTCTTTG TGTGGGATGT AGAAAACGAA 
GGAGATGAGA CTCTGGACGT TTCCATCACG TTCTCCATGC GGAATGGACT AGGAGGCGAA 
GATGATGCGG CCGGGAGTTT GTGGAATGAG CCCTTCCGCC TGGAACAGGG CGGGACGACT 
GTTCAGGGGC TCCTCTTGCA TCATCCAACC CCTCCGAACC CCTACACCAT GGCTGTGGCT 
GCACGATGCA CGGCAGATAC CACGGTAACC CACACCACAG CCTTTGACCC CAATGGCACT 
GGACAGCAGG TGTGGCAGGA CCTACTTCAG GATGGACAGC TGGACTCCCC TGCTGGCCAA 
AGCACCCCAA CACAGAAAGG AGAGGGTATC GCTGGGGCTG TATGCGTCTC TAGCAAGCTG 
TTACCTCGAA GCCGGTGCTG CTTGGAGTTC TCACTGGCTT GGGATATGCC TAAGATCATG 
TTTGGAGCTA AAAGCCAAGT CCACTACAGG CGGTATACAC GGTTCTTTGG TTCAGATGGT 
GATGTGGCGC CTGCCCTGAG CCACTATGCA CTGTGCCACT ATGCAGACTG GGAGGACAGA 
ATCTCAGCCT GGCAGAACCC AGTACTGGAT GACAGAACCT TGCCTGCCTG GTACAAATCT 
GCACTGTTCA ATGAACTGTA CTTCCTGGCC GATGGAGGCA CAGTGTGGCT GGAAGTTCCC 
GCAGACTCCC TACCAGAGGG GCTGGGAGGG AGTATGCGTC AGCTTCGCTC TACTCTGCAG 
GACTATGGGC GATTTGGCTA TCTTGAAGGC CAGGAGTACC GCATGTACAA CACATACGAT 
GTCCACTTTT ATGCGTCCTT TGCCCTCGTC ATGCTGTGGC CCAAACTTGA GCTCAGTCTT 
CAGTATGATA TGGCTCTGGC AACTTTGAAG GAGGACCTGA CCCGGCGACG GTACCTGATG 
AGTGGAGTGG TGGCACCTGT GAAAAGGAGG AACGTCATCC CTCATGACAT TGGGGATCCG 
GATGATGAGC CATGGCTCCG GGTCAACGCA TATTTGATTC ATGATACTGC TGACTGGAAG 
GACCTGAACC TGAAGTTTGT ATTGCAAATT TATCGGGACT ATTACCTGAC GGGTGATCAA 
GGCTTCCTGG AGGACATGTG GCCTGTGTGT CTGGCTGTGA TGGAGTCCGA AATGAAGTTT 
GACAAGGACC AAGATGGACT CATTGAGAAT GGAGGCTACG CAGACCAGAC CTATGATGCA 
TGGGTCACCA CAGGCCCCAG TGCTTACTGC GGAGGGCTGT GGCTGGCGGC AGTGGCTGTA 
ATGGTTCAGA TGGCTGTTCT GTGTGGGGCC CAAGATGTCC AGGAGAGGTT TGCTTCCATT 
CTCTGCCGAG GCCGAGAAGC TTATGAGAGA CTGCTGTGGA ACGGACGCTA TTACAACTAC 
GACAGCAGCT CCCATCCTCA GTCTCGGAGC ATCATGTCTG ACCAGTGTGC TGGGCAGTGG 
TTCCTGAGGG CCTGCGGCCT GGGAGAAGGA GACACTGAAG TATTTCCTAC CCTGCATGTG 
GTCCGTGCTC TCCAAACCAT CTTTGAACTC AACGTCCAAG CCTTTGCAGG AGGAGCCATG 
GGGGCCGTGA ACGGGATGCA CCCTCATGGT GTCCCTGATA GATCCAGTGT GCAGTCTGAT 
GAAGTCTGGG TGGGTGTGGT CTATGGGCTG GCAGCCACCA TGATCCAAGA GGGCCTGACT 
TGGGAAGGTT TCCGGACAGC TGAAGGCTGT TACCGCACTG TATGGGAACG CCTGGGCCTG 
GCTTTCCAGA CCCCAGAGGC ATACTGCCAG CAACAAGTGT TCCGCTCCCT GGCCTACATG 
CGGCCACTGA GCATCTGGGC CATGCAGCTG GCCCTGCAAC AGCAGCAGCA TAAAAAGAGC 
CGCAGGCCAT CAGTCACACA AGGCACGGGA CTAAGCACAC AGCCTGAATG TGGACCAAAG 
AGATCGCTGG CAAACCTCAA TTCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006537895.1
CDS	1102..3291
Translation	MGGLCTSKFCPWSFQMSCAAGTGACVVTLLSTTPSIPEPGRSISFLARMSPSPVARSHLSCLMTTSSLPVGVFVWDVENEGDETLDVSITFSMRNGLGGEDDAAGSLWNEPFRLEQGGTTVQGLLLHHPTPPNPYTMAVAARCTADTTVTHTTAFDPNGTGQQVWQDLLQDGQLDSPAGQSTPTQKGEGIAGAVCVSSKLLPRSRCCLEFSLAWDMPKIMFGAKSQVHYRRYTRFFGSDGDVAPALSHYALCHYADWEDRISAWQNPVLDDRTLPAWYKSALFNELYFLADGGTVWLEVPADSLPEGLGGSMRQLRSTLQDYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATLKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQIYRDYYLTGDQGFLEDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDAWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQERFASILCRGREAYERLLWNGRYYNYDSSSHPQSRSIMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALQTIFELNVQAFAGGAMGAVNGMHPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQQVFRSLAYMRPLSIWAMQLALQQQQHKKSRRPSVTQGTGLSTQPECGPKRSLANLNSE

Target ORF information:

RefSeq Version	XM_006537832.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus glucosidase beta 2 (Gba2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006537832.4

ORF Insert Sequence:

ATGGGCGGAC TGTGTACCAG CAAGTTCTGT CCTTGGAGCT TCCAAATGTC CTGCGCAGCT 
GGAACTGGGG CCTGTGTGGT TACTTTGCTT TCTACCACGC CCTCTATCCC CGAGCCTGGA 
CGGTCTATCA GCTTCCTGGC CAGAATGTCA CCCTCACCTG TCGCCAGGTC ACACCTATCT 
TGCCTCATGA CTACCAGCAG TCTCCCTGTA GGAGTCTTTG TGTGGGATGT AGAAAACGAA 
GGAGATGAGA CTCTGGACGT TTCCATCACG TTCTCCATGC GGAATGGACT AGGAGGCGAA 
GATGATGCGG CCGGGAGTTT GTGGAATGAG CCCTTCCGCC TGGAACAGGG CGGGACGACT 
GTTCAGGGGC TCCTCTTGCA TCATCCAACC CCTCCGAACC CCTACACCAT GGCTGTGGCT 
GCACGATGCA CGGCAGATAC CACGGTAACC CACACCACAG CCTTTGACCC CAATGGCACT 
GGACAGCAGG TGTGGCAGGA CCTACTTCAG GATGGACAGC TGGACTCCCC TGCTGGCCAA 
AGCACCCCAA CACAGAAAGG AGAGGGTATC GCTGGGGCTG TATGCGTCTC TAGCAAGCTG 
TTACCTCGAA GCCGGTGCTG CTTGGAGTTC TCACTGGCTT GGGATATGCC TAAGATCATG 
TTTGGAGCTA AAAGCCAAGT CCACTACAGG CGGTATACAC GGTTCTTTGG TTCAGATGGT 
GATGTGGCGC CTGCCCTGAG CCACTATGCA CTGTGCCACT ATGCAGACTG GGAGGACAGA 
ATCTCAGCCT GGCAGAACCC AGTACTGGAT GACAGAACCT TGCCTGCCTG GTACAAATCT 
GCACTGTTCA ATGAACTGTA CTTCCTGGCC GATGGAGGCA CAGTGTGGCT GGAAGTTCCC 
GCAGACTCCC TACCAGAGGG GCTGGGAGGG AGTATGCGTC AGCTTCGCTC TACTCTGCAG 
GACTATGGGC GATTTGGCTA TCTTGAAGGC CAGGAGTACC GCATGTACAA CACATACGAT 
GTCCACTTTT ATGCGTCCTT TGCCCTCGTC ATGCTGTGGC CCAAACTTGA GCTCAGTCTT 
CAGTATGATA TGGCTCTGGC AACTTTGAAG GAGGACCTGA CCCGGCGACG GTACCTGATG 
AGTGGAGTGG TGGCACCTGT GAAAAGGAGG AACGTCATCC CTCATGACAT TGGGGATCCG 
GATGATGAGC CATGGCTCCG GGTCAACGCA TATTTGATTC ATGATACTGC TGACTGGAAG 
GACCTGAACC TGAAGTTTGT ATTGCAAATT TATCGGGACT ATTACCTGAC GGGTGATCAA 
GGCTTCCTGG AGGACATGTG GCCTGTGTGT CTGGCTGTGA TGGAGTCCGA AATGAAGTTT 
GACAAGGACC AAGATGGACT CATTGAGAAT GGAGGCTACG CAGACCAGAC CTATGATGCA 
TGGGTCACCA CAGGCCCCAG TGCTTACTGC GGAGGGCTGT GGCTGGCGGC AGTGGCTGTA 
ATGGTTCAGA TGGCTGTTCT GTGTGGGGCC CAAGATGTCC AGGAGAGGTT TGCTTCCATT 
CTCTGCCGAG GCCGAGAAGC TTATGAGAGA CTGCTGTGGA ACGGACGCTA TTACAACTAC 
GACAGCAGCT CCCATCCTCA GTCTCGGAGC ATCATGTCTG ACCAGTGTGC TGGGCAGTGG 
TTCCTGAGGG CCTGCGGCCT GGGAGAAGGA GACACTGAAG TATTTCCTAC CCTGCATGTG 
GTCCGTGCTC TCCAAACCAT CTTTGAACTC AACGTCCAAG CCTTTGCAGG AGGAGCCATG 
GGGGCCGTGA ACGGGATGCA CCCTCATGGT GTCCCTGATA GATCCAGTGT GCAGTCTGAT 
GAAGTCTGGG TGGGTGTGGT CTATGGGCTG GCAGCCACCA TGATCCAAGA GGGCCTGACT 
TGGGAAGGTT TCCGGACAGC TGAAGGCTGT TACCGCACTG TATGGGAACG CCTGGGCCTG 
GCTTTCCAGA CCCCAGAGGC ATACTGCCAG CAACAAGTGT TCCGCTCCCT GGCCTACATG 
CGGCCACTGA GCATCTGGGC CATGCAGCTG GCCCTGCAAC AGCAGCAGCA TAAAAAGAGC 
CGCAGGCCAT CAGTCACACA AGGCACGGGA CTAAGCACAC AGCCTGAATG TGGACCAAAG 
AGATCGCTGG CAAACCTCAA TTCAGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gba2 ( NM_172692.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766280.2 Mus musculus glucosidase beta 2 (Gba2), mRNA.

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CloneID	OMu20190
Clone ID Related Accession (Same CDS sequence)	NM_172692.3
Accession Version	NM_172692.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2757bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1559491200000
Organism	Mus musculus(house mouse)
Product	non-lysosomal glucosylceramidase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK158174.1, BB869336.1 and BC056935.1. On Jun 18, 2009 this sequence version replaced NM_172692.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC056935.1, AK173213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTAACCT GCGTCCCGGC CTCAGAGCAG GTCGGCTGTG CCGAAAGAGA TTCCCAAGTT 
TATTGTGAAG ATACTGGCGG CACTGAGGCT GTGCGGGTTA CAGACTGCGG GAGCCCCGAG 
GATAGTGGAC CCCAGGATGA ACCAAGCTAC TGCAATTCAG AGGACTCTGG GCAGCTGATG 
GCCTCCTACG AGGGTAAAGC TAGGGGCTAC CAGGTGCCTC CTTTTGGCTG GCGGATCTGC 
TTGGCTCACG AGTTTGCAGA GAAGAGGAGA CCTTTTCAAG CTAACAACAT CTCTCTCAGT 
AATTTGGTAA AGCACCTCGG TATGGGCTTG AGGTACTTGA AGTGGTGGTA CCGAAAGACC 
CACGTGGAAA AGAAGACCCC TTTCATCGAC ATGCTCAATT CTCTACCCCT GAGACAGATC 
TATGGTTGTC CCCTGGGTGG CATTGGAGGA GGCACTATCA CCCGGGGCTG GAGAGGCCAG 
TTCTGTCGTT GGCAGCTCAA CCCTGGAATG TACCAGCACC AGACAGTCAT TGCAGACCAA 
TTTATAGTAT GCTTGCGTCG AGATGGGCGG ACTGTGTACC AGCAAGTTCT GTCCTTGGAG 
CTTCCAAATG TCCTGCGCAG CTGGAACTGG GGCCTGTGTG GTTACTTTGC TTTCTACCAC 
GCCCTCTATC CCCGAGCCTG GACGGTCTAT CAGCTTCCTG GCCAGAATGT CACCCTCACC 
TGTCGCCAGG TCACACCTAT CTTGCCTCAT GACTACCAGG ACAGCAGTCT CCCTGTAGGA 
GTCTTTGTGT GGGATGTAGA AAACGAAGGA GATGAGACTC TGGACGTTTC CATCACGTTC 
TCCATGCGGA ATGGACTAGG AGGCGAAGAT GATGCGGCCG GGAGTTTGTG GAATGAGCCC 
TTCCGCCTGG AACAGGGCGG GACGACTGTT CAGGGGCTCC TCTTGCATCA TCCAACCCCT 
CCGAACCCCT ACACCATGGC TGTGGCTGCA CGATGCACGG CAGATACCAC GGTAACCCAC 
ACCACAGCCT TTGACCCCAA TGGCACTGGA CAGCAGGTGT GGCAGGACCT ACTTCAGGAT 
GGACAGCTGG ACTCCCCTGC TGGCCAAAGC ACCCCAACAC AGAAAGGAGA GGGTATCGCT 
GGGGCTGTAT GCGTCTCTAG CAAGCTGTTA CCTCGAAGCC GGTGCTGCTT GGAGTTCTCA 
CTGGCTTGGG ATATGCCTAA GATCATGTTT GGAGCTAAAA GCCAAGTCCA CTACAGGCGG 
TATACACGGT TCTTTGGTTC AGATGGTGAT GTGGCGCCTG CCCTGAGCCA CTATGCACTG 
TGCCACTATG CAGACTGGGA GGACAGAATC TCAGCCTGGC AGAACCCAGT ACTGGATGAC 
AGAACCTTGC CTGCCTGGTA CAAATCTGCA CTGTTCAATG AACTGTACTT CCTGGCCGAT 
GGAGGCACAG TGTGGCTGGA AGTTCCCGCA GACTCCCTAC CAGAGGGGCT GGGAGGGAGT 
ATGCGTCAGC TTCGCTCTAC TCTGCAGGAC TATGGGCGAT TTGGCTATCT TGAAGGCCAG 
GAGTACCGCA TGTACAACAC ATACGATGTC CACTTTTATG CGTCCTTTGC CCTCGTCATG 
CTGTGGCCCA AACTTGAGCT CAGTCTTCAG TATGATATGG CTCTGGCAAC TTTGAAGGAG 
GACCTGACCC GGCGACGGTA CCTGATGAGT GGAGTGGTGG CACCTGTGAA AAGGAGGAAC 
GTCATCCCTC ATGACATTGG GGATCCGGAT GATGAGCCAT GGCTCCGGGT CAACGCATAT 
TTGATTCATG ATACTGCTGA CTGGAAGGAC CTGAACCTGA AGTTTGTATT GCAAATTTAT 
CGGGACTATT ACCTGACGGG TGATCAAGGC TTCCTGGAGG ACATGTGGCC TGTGTGTCTG 
GCTGTGATGG AGTCCGAAAT GAAGTTTGAC AAGGACCAAG ATGGACTCAT TGAGAATGGA 
GGCTACGCAG ACCAGACCTA TGATGCATGG GTCACCACAG GCCCCAGTGC TTACTGCGGA 
GGGCTGTGGC TGGCGGCAGT GGCTGTAATG GTTCAGATGG CTGTTCTGTG TGGGGCCCAA 
GATGTCCAGG AGAGGTTTGC TTCCATTCTC TGCCGAGGCC GAGAAGCTTA TGAGAGACTG 
CTGTGGAACG GACGCTATTA CAACTACGAC AGCAGCTCCC ATCCTCAGTC TCGGAGCATC 
ATGTCTGACC AGTGTGCTGG GCAGTGGTTC CTGAGGGCCT GCGGCCTGGG AGAAGGAGAC 
ACTGAAGTAT TTCCTACCCT GCATGTGGTC CGTGCTCTCC AAACCATCTT TGAACTCAAC 
GTCCAAGCCT TTGCAGGAGG AGCCATGGGG GCCGTGAACG GGATGCACCC TCATGGTGTC 
CCTGATAGAT CCAGTGTGCA GTCTGATGAA GTCTGGGTGG GTGTGGTCTA TGGGCTGGCA 
GCCACCATGA TCCAAGAGGG CCTGACTTGG GAAGGTTTCC GGACAGCTGA AGGCTGTTAC 
CGCACTGTAT GGGAACGCCT GGGCCTGGCT TTCCAGACCC CAGAGGCATA CTGCCAGCAA 
CAAGTGTTCC GCTCCCTGGC CTACATGCGG CCACTGAGCA TCTGGGCCAT GCAGCTGGCC 
CTGCAACAGC AGCAGCATAA AAAGAGCCGC AGGCCATCAG TCACACAAGG CACGGGACTA 
AGCACACAGC CTGAATGTGG ACCAAAGAGA TCGCTGGCAA ACCTCAATTC AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766280.2
CDS	518..3274
Translation	MVTCVPASEQVGCAERDSQVYCEDTGGTEAVRVTDCGSPEDSGPQDEPSYCNSEDSGQLMASYEGKARGYQVPPFGWRICLAHEFAEKRRPFQANNISLSNLVKHLGMGLRYLKWWYRKTHVEKKTPFIDMLNSLPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMYQHQTVIADQFIVCLRRDGRTVYQQVLSLELPNVLRSWNWGLCGYFAFYHALYPRAWTVYQLPGQNVTLTCRQVTPILPHDYQDSSLPVGVFVWDVENEGDETLDVSITFSMRNGLGGEDDAAGSLWNEPFRLEQGGTTVQGLLLHHPTPPNPYTMAVAARCTADTTVTHTTAFDPNGTGQQVWQDLLQDGQLDSPAGQSTPTQKGEGIAGAVCVSSKLLPRSRCCLEFSLAWDMPKIMFGAKSQVHYRRYTRFFGSDGDVAPALSHYALCHYADWEDRISAWQNPVLDDRTLPAWYKSALFNELYFLADGGTVWLEVPADSLPEGLGGSMRQLRSTLQDYGRFGYLEGQEYRMYNTYDVHFYASFALVMLWPKLELSLQYDMALATLKEDLTRRRYLMSGVVAPVKRRNVIPHDIGDPDDEPWLRVNAYLIHDTADWKDLNLKFVLQIYRDYYLTGDQGFLEDMWPVCLAVMESEMKFDKDQDGLIENGGYADQTYDAWVTTGPSAYCGGLWLAAVAVMVQMAVLCGAQDVQERFASILCRGREAYERLLWNGRYYNYDSSSHPQSRSIMSDQCAGQWFLRACGLGEGDTEVFPTLHVVRALQTIFELNVQAFAGGAMGAVNGMHPHGVPDRSSVQSDEVWVGVVYGLAATMIQEGLTWEGFRTAEGCYRTVWERLGLAFQTPEAYCQQQVFRSLAYMRPLSIWAMQLALQQQQHKKSRRPSVTQGTGLSTQPECGPKRSLANLNSE

Target ORF information:

RefSeq Version	NM_172692.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glucosidase beta 2 (Gba2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172692.3

ORF Insert Sequence:

ATGGTAACCT GCGTCCCGGC CTCAGAGCAG GTCGGCTGTG CCGAAAGAGA TTCCCAAGTT 
TATTGTGAAG ATACTGGCGG CACTGAGGCT GTGCGGGTTA CAGACTGCGG GAGCCCCGAG 
GATAGTGGAC CCCAGGATGA ACCAAGCTAC TGCAATTCAG AGGACTCTGG GCAGCTGATG 
GCCTCCTACG AGGGTAAAGC TAGGGGCTAC CAGGTGCCTC CTTTTGGCTG GCGGATCTGC 
TTGGCTCACG AGTTTGCAGA GAAGAGGAGA CCTTTTCAAG CTAACAACAT CTCTCTCAGT 
AATTTGGTAA AGCACCTCGG TATGGGCTTG AGGTACTTGA AGTGGTGGTA CCGAAAGACC 
CACGTGGAAA AGAAGACCCC TTTCATCGAC ATGCTCAATT CTCTACCCCT GAGACAGATC 
TATGGTTGTC CCCTGGGTGG CATTGGAGGA GGCACTATCA CCCGGGGCTG GAGAGGCCAG 
TTCTGTCGTT GGCAGCTCAA CCCTGGAATG TACCAGCACC AGACAGTCAT TGCAGACCAA 
TTTATAGTAT GCTTGCGTCG AGATGGGCGG ACTGTGTACC AGCAAGTTCT GTCCTTGGAG 
CTTCCAAATG TCCTGCGCAG CTGGAACTGG GGCCTGTGTG GTTACTTTGC TTTCTACCAC 
GCCCTCTATC CCCGAGCCTG GACGGTCTAT CAGCTTCCTG GCCAGAATGT CACCCTCACC 
TGTCGCCAGG TCACACCTAT CTTGCCTCAT GACTACCAGG ACAGCAGTCT CCCTGTAGGA 
GTCTTTGTGT GGGATGTAGA AAACGAAGGA GATGAGACTC TGGACGTTTC CATCACGTTC 
TCCATGCGGA ATGGACTAGG AGGCGAAGAT GATGCGGCCG GGAGTTTGTG GAATGAGCCC 
TTCCGCCTGG AACAGGGCGG GACGACTGTT CAGGGGCTCC TCTTGCATCA TCCAACCCCT 
CCGAACCCCT ACACCATGGC TGTGGCTGCA CGATGCACGG CAGATACCAC GGTAACCCAC 
ACCACAGCCT TTGACCCCAA TGGCACTGGA CAGCAGGTGT GGCAGGACCT ACTTCAGGAT 
GGACAGCTGG ACTCCCCTGC TGGCCAAAGC ACCCCAACAC AGAAAGGAGA GGGTATCGCT 
GGGGCTGTAT GCGTCTCTAG CAAGCTGTTA CCTCGAAGCC GGTGCTGCTT GGAGTTCTCA 
CTGGCTTGGG ATATGCCTAA GATCATGTTT GGAGCTAAAA GCCAAGTCCA CTACAGGCGG 
TATACACGGT TCTTTGGTTC AGATGGTGAT GTGGCGCCTG CCCTGAGCCA CTATGCACTG 
TGCCACTATG CAGACTGGGA GGACAGAATC TCAGCCTGGC AGAACCCAGT ACTGGATGAC 
AGAACCTTGC CTGCCTGGTA CAAATCTGCA CTGTTCAATG AACTGTACTT CCTGGCCGAT 
GGAGGCACAG TGTGGCTGGA AGTTCCCGCA GACTCCCTAC CAGAGGGGCT GGGAGGGAGT 
ATGCGTCAGC TTCGCTCTAC TCTGCAGGAC TATGGGCGAT TTGGCTATCT TGAAGGCCAG 
GAGTACCGCA TGTACAACAC ATACGATGTC CACTTTTATG CGTCCTTTGC CCTCGTCATG 
CTGTGGCCCA AACTTGAGCT CAGTCTTCAG TATGATATGG CTCTGGCAAC TTTGAAGGAG 
GACCTGACCC GGCGACGGTA CCTGATGAGT GGAGTGGTGG CACCTGTGAA AAGGAGGAAC 
GTCATCCCTC ATGACATTGG GGATCCGGAT GATGAGCCAT GGCTCCGGGT CAACGCATAT 
TTGATTCATG ATACTGCTGA CTGGAAGGAC CTGAACCTGA AGTTTGTATT GCAAATTTAT 
CGGGACTATT ACCTGACGGG TGATCAAGGC TTCCTGGAGG ACATGTGGCC TGTGTGTCTG 
GCTGTGATGG AGTCCGAAAT GAAGTTTGAC AAGGACCAAG ATGGACTCAT TGAGAATGGA 
GGCTACGCAG ACCAGACCTA TGATGCATGG GTCACCACAG GCCCCAGTGC TTACTGCGGA 
GGGCTGTGGC TGGCGGCAGT GGCTGTAATG GTTCAGATGG CTGTTCTGTG TGGGGCCCAA 
GATGTCCAGG AGAGGTTTGC TTCCATTCTC TGCCGAGGCC GAGAAGCTTA TGAGAGACTG 
CTGTGGAACG GACGCTATTA CAACTACGAC AGCAGCTCCC ATCCTCAGTC TCGGAGCATC 
ATGTCTGACC AGTGTGCTGG GCAGTGGTTC CTGAGGGCCT GCGGCCTGGG AGAAGGAGAC 
ACTGAAGTAT TTCCTACCCT GCATGTGGTC CGTGCTCTCC AAACCATCTT TGAACTCAAC 
GTCCAAGCCT TTGCAGGAGG AGCCATGGGG GCCGTGAACG GGATGCACCC TCATGGTGTC 
CCTGATAGAT CCAGTGTGCA GTCTGATGAA GTCTGGGTGG GTGTGGTCTA TGGGCTGGCA 
GCCACCATGA TCCAAGAGGG CCTGACTTGG GAAGGTTTCC GGACAGCTGA AGGCTGTTAC 
CGCACTGTAT GGGAACGCCT GGGCCTGGCT TTCCAGACCC CAGAGGCATA CTGCCAGCAA 
CAAGTGTTCC GCTCCCTGGC CTACATGCGG CCACTGAGCA TCTGGGCCAT GCAGCTGGCC 
CTGCAACAGC AGCAGCATAA AAAGAGCCGC AGGCCATCAG TCACACAAGG CACGGGACTA 
AGCACACAGC CTGAATGTGG ACCAAAGAGA TCGCTGGCAA ACCTCAATTC AGAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.
The Journal of biological chemistry294(11)3853-3871(2019 03)
Woeste MA,Stern S,Raju DN,Grahn E,Dittmann D,Gutbrod K,Dörmann P,Hansen JN,Schonauer S,Marx CE,Hamzeh H,Körschen HG,Aerts JMFG,Bönigk W,Endepols H,Sandhoff R,Geyer M,Berger TK,Bradke F,Wachten D

Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals.
Journal of lipid research58(6)1247-1258(2017 06)
von Gerichten J,Schlosser K,Lamprecht D,Morace I,Eckhardt M,Wachten D,Jennemann R,Gröne HJ,Mack M,Sandhoff R

Identification of a feedback loop involving β-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease.
The Journal of biological chemistry292(15)6177-6189(2017 04)
Schonauer S,Körschen HG,Penno A,Rennhack A,Breiden B,Sandhoff K,Gutbrod K,Dörmann P,Raju DN,Haberkant P,Gerl MJ,Brügger B,Zigdon H,Vardi A,Futerman AH,Thiele C,Wachten D

Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases.
Journal of lipid research57(3)451-63(2016 Mar)
Marques AR,Mirzaian M,Akiyama H,Wisse P,Ferraz MJ,Gaspar P,Ghauharali-van der Vlugt K,Meijer R,Giraldo P,Alfonso P,Irún P,Dahl M,Karlsson S,Pavlova EV,Cox TM,Scheij S,Verhoek M,Ottenhoff R,van Roomen CP,Pannu NS,van Eijk M,Dekker N,Boot RG,Overkleeft HS,Blommaart E,Hirabayashi Y,Aerts JM

Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice.
PloS one10(8)e0135889(2015)
Marques AR,Aten J,Ottenhoff R,van Roomen CP,Herrera Moro D,Claessen N,Vinueza Veloz MF,Zhou K,Lin Z,Mirzaian M,Boot RG,De Zeeuw CI,Overkleeft HS,Yildiz Y,Aerts JM

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Gba2 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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