| Gene Symbol | Ttr |
| Entrez Gene ID | 22139 |
| Full Name | transthyretin |
| Synonyms | AA408768,AI787086,D17860,prealbumin |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a carrier protein responsible for the transport of thyroid hormones and retinol. The protein consists of a tetramer of identical subunits. Due to increased stability of the tetramer form of this encoded protein in mouse, compared to the human protein, this gene product has a reduced tendency to form amyloid fibrils. In humans, this protein binds beta-amyloid preventing its aggregation and providing a neuroprotective role in Alzheimer's disease. [provided by RefSeq, Mar 2010]. |
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Ttr cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Ttr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ttr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu22940 Clone ID Related Accession (Same CDS sequence) XM_030250412.1 , NM_013697.5 Accession Version NM_013697.5 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 444bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577808000000 Organism Mus musculus(house mouse) Product transthyretin precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC129078.6 and CD742426.1. On Mar 24, 2010 this sequence version replaced NM_013697.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014454.1, D89076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421ATGGCTTCCC TTCGACTCTT CCTCCTTTGC CTCGCTGGAC TGGTATTTGT GTCTGAAGCT
GGCCCCGCGG GTGCTGGAGA ATCCAAATGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC
CGAGGCAGCC CTGCTGTAGA CGTGGCTGTA AAAGTGTTCA AAAAGACCTC TGAGGGATCC
TGGGAGCCCT TTGCCTCTGG GAAGACCGCG GAGTCTGGAG AGCTGCACGG GCTCACCACA
GATGAGAAGT TTGTAGAAGG AGTGTACAGA GTAGAACTGG ACACCAAATC GTACTGGAAG
ACACTTGGCA TTTCCCCGTT CCATGAATTC GCGGATGTGG TTTTCACAGC CAACGACTCT
GGCCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCAT ACTCCTACAG CACCACGGCT
GTCGTCAGCA ACCCCCAGAA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_038725.1 CDS 190..633 Translation 
Target ORF information:
RefSeq Version NM_013697.5 Organism Mus musculus(house mouse) Definition Mus musculus transthyretin (Ttr), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_013697.5
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGGCTTCCC TTCGACTCTT CCTCCTTTGC CTCGCTGGAC TGGTATTTGT GTCTGAAGCT
GGCCCCGCGG GTGCTGGAGA ATCCAAATGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC
CGAGGCAGCC CTGCTGTAGA CGTGGCTGTA AAAGTGTTCA AAAAGACCTC TGAGGGATCC
TGGGAGCCCT TTGCCTCTGG GAAGACCGCG GAGTCTGGAG AGCTGCACGG GCTCACCACA
GATGAGAAGT TTGTAGAAGG AGTGTACAGA GTAGAACTGG ACACCAAATC GTACTGGAAG
ACACTTGGCA TTTCCCCGTT CCATGAATTC GCGGATGTGG TTTTCACAGC CAACGACTCT
GGCCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCAT ACTCCTACAG CACCACGGCT
GTCGTCAGCA ACCCCCAGAA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu22940 Clone ID Related Accession (Same CDS sequence) XM_030250412.1 , NM_013697.5 Accession Version XM_030250412.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 444bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1565107200000 Organism Mus musculus(house mouse) Product transthyretin isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421ATGGCTTCCC TTCGACTCTT CCTCCTTTGC CTCGCTGGAC TGGTATTTGT GTCTGAAGCT
GGCCCCGCGG GTGCTGGAGA ATCCAAATGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC
CGAGGCAGCC CTGCTGTAGA CGTGGCTGTA AAAGTGTTCA AAAAGACCTC TGAGGGATCC
TGGGAGCCCT TTGCCTCTGG GAAGACCGCG GAGTCTGGAG AGCTGCACGG GCTCACCACA
GATGAGAAGT TTGTAGAAGG AGTGTACAGA GTAGAACTGG ACACCAAATC GTACTGGAAG
ACACTTGGCA TTTCCCCGTT CCATGAATTC GCGGATGTGG TTTTCACAGC CAACGACTCT
GGCCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCAT ACTCCTACAG CACCACGGCT
GTCGTCAGCA ACCCCCAGAA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_030106272.1 CDS 214..657 Translation
Target ORF information:
RefSeq Version XM_030250412.1 Organism Mus musculus(house mouse) Definition Mus musculus transthyretin (Ttr), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_030250412.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGGCTTCCC TTCGACTCTT CCTCCTTTGC CTCGCTGGAC TGGTATTTGT GTCTGAAGCT
GGCCCCGCGG GTGCTGGAGA ATCCAAATGT CCTCTGATGG TCAAAGTCCT GGATGCTGTC
CGAGGCAGCC CTGCTGTAGA CGTGGCTGTA AAAGTGTTCA AAAAGACCTC TGAGGGATCC
TGGGAGCCCT TTGCCTCTGG GAAGACCGCG GAGTCTGGAG AGCTGCACGG GCTCACCACA
GATGAGAAGT TTGTAGAAGG AGTGTACAGA GTAGAACTGG ACACCAAATC GTACTGGAAG
ACACTTGGCA TTTCCCCGTT CCATGAATTC GCGGATGTGG TTTTCACAGC CAACGACTCT
GGCCATCGCC ACTACACCAT CGCAGCCCTG CTCAGCCCAT ACTCCTACAG CACCACGGCT
GTCGTCAGCA ACCCCCAGAA TTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Early dorsomedial tissue interactions regulate gyrification of distal neocortex.
Nature communications10(1)5192(2019 Nov)
Chizhikov VV,Iskusnykh IY,Steshina EY,Fattakhov N,Lindgren AG,Shetty AS,Roy A,Tole S,Millen KJ
Defining developmental diversification of diencephalon neurons through single cell gene expression profiling.
Development (Cambridge, England)146(12)(2019 Apr)
Guo Q,Li JYH
WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.
Nature communications10(1)1498(2019 04)
Kaiser K,Gyllborg D,Procházka J,Salašová A,Kompaníková P,Molina FL,Laguna-Goya R,Radaszkiewicz T,Harnoš J,Procházková M,Potěšil D,Barker RA,Casado ÁG,Zdráhal Z,Sedláček R,Arenas E,Villaescusa JC,Bryja V
LDB1 Is Required for the Early Development of the Dorsal Telencephalon and the Thalamus.
eNeuro6(1)(2019 Jan-Feb)
Kinare V,Pal S,Tole S
Identification of transthyretin as a novel interacting partner for the δ subunit of GABAA receptors.
PloS one14(1)e0210094(2019)
Zhou L,Tang X,Li X,Bai Y,Buxbaum JN,Chen G
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