Tnfrsf10b cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfrsf10b
Entrez Gene ID	21933
Full Name	tumor necrosis factor receptor superfamily, member 10b
Synonyms	DR5,KILLER,Ly98,MK,TRAILR2,TRICK2A,TRICK2B,TRICKB
General protein information	Preferred Names tumor necrosis factor receptor superfamily, member 10b Names tumor necrosis factor receptor superfamily member 10B KILLER/DR5 TRAIL death-inducing receptor death receptor 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 D2

mRNA and Protein(s)

mRNA	Protein	Name
NM_020275.4	NP_064671.2	tumor necrosis factor receptor superfamily member 10B precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	TNFRSF10A	XP_001107790.1
Bos taurus (cattle)	TNFRSF10D	NP_001095797.1
Rattus norvegicus (Norway rat)	Tnfrsf10b	NP_001102343.1
Pan troglodytes (chimpanzee)	TNFRSF10A	XP_001158464.1
Bos taurus (cattle)	TNFRSF10B	XP_005210322.1
Homo sapiens (human)	TNFRSF10A	NP_003835.3
Mus musculus (house mouse)	Tnfrsf10b	NP_064671.2

Gene Ontology
Bibliography

Related articles in PubMed

Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.
Kon N, Wang D, Gu W
Cell death & disease10(3)237(2019 03)

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma.
Park JS, Oh Y, Park YJ, Park O, Yang H, Slania S, Hummers LK, Shah AA, An HT, Jang J, Horton MR, Shin J, Dietz HC, Song E, Na DH, Park EJ, Kim K, Lee KC, Roschke VV, Hanes J, Pomper MG, Lee S
Nature communications10(1)1128(2019 03)

CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Yang R, Wang H, Kang B, Chen B, Shi Y, Yang S, Sun L, Liu Y, Xiao W, Zhang T, Yang J, Zhang Y, Zhu M, Xu P, Chang Y, Jia Y, Huang Y
Development (Cambridge, England)146(2)(2019 01)

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, Sarr A, Darding M, Draber P, Haas TL, Akarca A, Marafioti T, Pasparakis M, Bertin J, Gough PJ, Bouillet P, Strasser A, Leverkus M, Silke J, Walczak H
Nature communications9(1)3910(2018 09)

Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.
Kotov DI, Kotov JA, Goldberg MF, Jenkins MK
Journal of immunology (Baltimore, Md. : 1950)200(6)2004-2012(2018 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tnfrsf10b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfrsf10b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu11976	NM_020275.4 Latest version!	Mus musculus tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfrsf10b ( NM_020275.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_064671.2 Mus musculus tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b), mRNA.

Price & Availability↑

CloneID	OMu11976
Clone ID Related Accession (Same CDS sequence)	NM_020275.4
Accession Version	NM_020275.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572796800000
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor receptor superfamily member 10B precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK050753.1 and BC065141.1. On Dec 12, 2009 this sequence version replaced NM_020275.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065141.1, AK080069.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCCTC CAGGACCCAG CACGCCCACA GCCTCTGCCG CTGCCCGGGC AGATCACTAC 
ACCCCAGGCC TCCGGCCACT CCCGAAGCGC AGACTTCTAT ATAGCTTTGC GTTGCTGCTT 
GCTGTGCTAC AGGCTGTCTT TGTTCCAGTA ACAGCTAACC CAGCCCATAA TCGTCCAGCT 
GGCCTACAGC GGCCGGAGGA GAGCCCATCA AGAGGACCCT GTCTAGCAGG CCAGTACCTG 
TCAGAAGGGA ACTGCAAGCC TTGCAGAGAG GGTATTGACT ACACCAGCCA TTCCAACCAT 
TCTCTGGATT CATGTATTCT CTGCACAGTC TGTAAGGAAG ATAAAGTCGT AGAAACCCGA 
TGCAACATAA CCACAAATAC GGTGTGTCGA TGCAAACCAG GCACCTTTGA AGATAAAGAC 
TCCCCTGAGA TCTGCCAGTC ATGCTCTAAC TGCACTGACG GGGAAGAGGA ACTGACTTCC 
TGTACCCCCA GAGAAAACCG GAAGTGTGTC TCCAAAACGG CTTGGGCATC TTGGCATAAG 
CTAGGCCTCT GGATAGGACT CCTGGTTCCA GTAGTGCTGC TGATTGGAGC TCTGCTTGTC 
TGGAAGACTG GAGCATGGAG GCAATGGTTG CTCTGTATAA AAAGAGGCTG TGAACGGGAT 
CCCGAAAGTG CGAACTCTGT GCATTCGTCT CTCTTGGACC GACAGACATC TAGCACGACA 
AATGACTCTA ACCACAACAC GGAACCTGGC AAGACTCAGA AAACAGGAAA GAAGTTGCTG 
GTTCCGGTAA ACGGAAACGA CTCAGCTGAC GACCTGAAGT TTATCTTCGA GTATTGTTCG 
GACATAGTGC CCTTTGACTC CTGGAACCGT CTCATGCGGC AGTTGGGCCT CACAGACAAT 
CAAATCCAAA TGGTCAAAGC CGAAACACTG GTCACACGTG AGGCCCTGTA CCAAATGCTG 
CTCAAGTGGC GCCACCAGAC TGGGCGAAGT GCCTCCATCA ACCATCTGCT GGATGCCTTG 
GAAGCCGTGG AAGAGAGAGA TGCCATGGAG AAAATTGAAG ACTACGCAGT GAAATCCGGG 
AGGTTTACTT ATCAGAACGC TGCAGCCCAA CCAGAGACAG GGCCAGGAGG ATCTCAGTGC 
GTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064671.2
CDS	189..1334
Translation	MEPPGPSTPTASAAARADHYTPGLRPLPKRRLLYSFALLLAVLQAVFVPVTANPAHNRPAGLQRPEESPSRGPCLAGQYLSEGNCKPCREGIDYTSHSNHSLDSCILCTVCKEDKVVETRCNITTNTVCRCKPGTFEDKDSPEICQSCSNCTDGEEELTSCTPRENRKCVSKTAWASWHKLGLWIGLLVPVVLLIGALLVWKTGAWRQWLLCIKRGCERDPESANSVHSSLLDRQTSSTTNDSNHNTEPGKTQKTGKKLLVPVNGNDSADDLKFIFEYCSDIVPFDSWNRLMRQLGLTDNQIQMVKAETLVTREALYQMLLKWRHQTGRSASINHLLDALEAVEERDAMEKIEDYAVKSGRFTYQNAAAQPETGPGGSQCV

Target ORF information:

RefSeq Version	NM_020275.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020275.4

ORF Insert Sequence:

ATGGAGCCTC CAGGACCCAG CACGCCCACA GCCTCTGCCG CTGCCCGGGC AGATCACTAC 
ACCCCAGGCC TCCGGCCACT CCCGAAGCGC AGACTTCTAT ATAGCTTTGC GTTGCTGCTT 
GCTGTGCTAC AGGCTGTCTT TGTTCCAGTA ACAGCTAACC CAGCCCATAA TCGTCCAGCT 
GGCCTACAGC GGCCGGAGGA GAGCCCATCA AGAGGACCCT GTCTAGCAGG CCAGTACCTG 
TCAGAAGGGA ACTGCAAGCC TTGCAGAGAG GGTATTGACT ACACCAGCCA TTCCAACCAT 
TCTCTGGATT CATGTATTCT CTGCACAGTC TGTAAGGAAG ATAAAGTCGT AGAAACCCGA 
TGCAACATAA CCACAAATAC GGTGTGTCGA TGCAAACCAG GCACCTTTGA AGATAAAGAC 
TCCCCTGAGA TCTGCCAGTC ATGCTCTAAC TGCACTGACG GGGAAGAGGA ACTGACTTCC 
TGTACCCCCA GAGAAAACCG GAAGTGTGTC TCCAAAACGG CTTGGGCATC TTGGCATAAG 
CTAGGCCTCT GGATAGGACT CCTGGTTCCA GTAGTGCTGC TGATTGGAGC TCTGCTTGTC 
TGGAAGACTG GAGCATGGAG GCAATGGTTG CTCTGTATAA AAAGAGGCTG TGAACGGGAT 
CCCGAAAGTG CGAACTCTGT GCATTCGTCT CTCTTGGACC GACAGACATC TAGCACGACA 
AATGACTCTA ACCACAACAC GGAACCTGGC AAGACTCAGA AAACAGGAAA GAAGTTGCTG 
GTTCCGGTAA ACGGAAACGA CTCAGCTGAC GACCTGAAGT TTATCTTCGA GTATTGTTCG 
GACATAGTGC CCTTTGACTC CTGGAACCGT CTCATGCGGC AGTTGGGCCT CACAGACAAT 
CAAATCCAAA TGGTCAAAGC CGAAACACTG GTCACACGTG AGGCCCTGTA CCAAATGCTG 
CTCAAGTGGC GCCACCAGAC TGGGCGAAGT GCCTCCATCA ACCATCTGCT GGATGCCTTG 
GAAGCCGTGG AAGAGAGAGA TGCCATGGAG AAAATTGAAG ACTACGCAGT GAAATCCGGG 
AGGTTTACTT ATCAGAACGC TGCAGCCCAA CCAGAGACAG GGCCAGGAGG ATCTCAGTGC 
GTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.
Cell death & disease10(3)237(2019 03)
Kon N,Wang D,Gu W

Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma.
Nature communications10(1)1128(2019 03)
Park JS,Oh Y,Park YJ,Park O,Yang H,Slania S,Hummers LK,Shah AA,An HT,Jang J,Horton MR,Shin J,Dietz HC,Song E,Na DH,Park EJ,Kim K,Lee KC,Roschke VV,Hanes J,Pomper MG,Lee S

CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Development (Cambridge, England)146(2)(2019 01)
Yang R,Wang H,Kang B,Chen B,Shi Y,Yang S,Sun L,Liu Y,Xiao W,Zhang T,Yang J,Zhang Y,Zhu M,Xu P,Chang Y,Jia Y,Huang Y

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Nature communications9(1)3910(2018 09)
Taraborrelli L,Peltzer N,Montinaro A,Kupka S,Rieser E,Hartwig T,Sarr A,Darding M,Draber P,Haas TL,Akarca A,Marafioti T,Pasparakis M,Bertin J,Gough PJ,Bouillet P,Strasser A,Leverkus M,Silke J,Walczak H

Many Th Cell Subsets Have Fas Ligand-Dependent Cytotoxic Potential.
Journal of immunology (Baltimore, Md. : 1950)200(6)2004-2012(2018 03)
Kotov DI,Kotov JA,Goldberg MF,Jenkins MK

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Tnfrsf10b cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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