Eif2b1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Eif2b1
Entrez Gene ID	209354
Full Name	eukaryotic translation initiation factor 2B, subunit 1 (alpha)
Synonyms	D5Ertd406e,EIF2BA
General protein information	Preferred Names eukaryotic translation initiation factor 2B, subunit 1 (alpha) Names translation initiation factor eIF-2B subunit alpha eIF-2B GDP-GTP exchange factor subunit alpha eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 F\|5 63.67 cM
Summary	This gene encodes the alpha subunit of the eukaryotic translation initiation factor complex 2B (eIF2B). The eIF2B complex is a heterodecamer comprised of two molecules each of alpha, beta, gamma, delta and epsilon subunits. The eIF2B complex is a critical regulator of protein synthesis acting as the guanine nucleotide exchange factor for eIF2 to enable the formation of ternary complex that is required for the initiation of mRNA translation. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_145371.4	NP_663346.1	translation initiation factor eIF-2B subunit alpha
XM_006530275.3	XP_006530338.1	translation initiation factor eIF-2B subunit alpha isoform X1
XM_006530275.4	XP_006530338.1	translation initiation factor eIF-2B subunit alpha isoform X1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	eIF2B-alpha	NP_651752.1
Kluyveromyces lactis	KLLA0F13970g	XP_455709.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012611	XP_307038.2
Danio rerio (zebrafish)	LOC100151592	XP_005168723.1
Mus musculus (house mouse)	Eif2b1	NP_663346.1
Caenorhabditis elegans (roundworm)	ZK1098.4	NP_499106.1
Saccharomyces cerevisiae (baker's yeast)	GCN3	NP_012951.1
Eremothecium gossypii	AGOS_AFR084C	NP_985631.2
Gallus gallus (chicken)	EIF2B1	XP_003642240.1
Bos taurus (cattle)	EIF2B1	NP_001069211.1
Arabidopsis thaliana (thale cress)	AT1G53900	NP_564646.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003650	XP_313420.3
Macaca mulatta (Rhesus monkey)	EIF2B1	XP_001101480.2
Xenopus tropicalis (tropical clawed frog)	eif2b1	NP_001017286.1
Oryza sativa (rice)	Os12g0497400	NP_001066807.1
Homo sapiens (human)	EIF2B1	NP_001405.1
Pan troglodytes (chimpanzee)	EIF2B1	XP_522583.3
Canis lupus familiaris (dog)	EIF2B1	XP_005636171.1
Rattus norvegicus (Norway rat)	Eif2b1	NP_742026.1
Danio rerio (zebrafish)	eif2b1	NP_001002060.1
Arabidopsis thaliana (thale cress)	AT1G72340	NP_565041.1
Arabidopsis thaliana (thale cress)	AT1G53880	NP_564643.2
Schizosaccharomyces pombe (fission yeast)	SPCC11E10.07c	NP_588203.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012799	XP_307097.4

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
Wortham NC, Martinez M, Gordiyenko Y, Robinson CV, Proud CG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(5)2225-37(2014 May)

A new function and complexity for protein translation initiation factor eIF2B.
Jennings MD, Pavitt GD
Cell cycle (Georgetown, Tex.)13(17)2660-5(2014)

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.
Woo CW, Kutzler L, Kimball SR, Tabas I
Nature cell biology14(2)192-200(2012 Jan)

Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Cabilly Y, Barbi M, Geva M, Marom L, Chetrit D, Ehrlich M, Elroy-Stein O
PloS one7(10)e46715(2012)

A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
Marom L, Ulitsky I, Cabilly Y, Shamir R, Elroy-Stein O
PloS one6(10)e26992(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Eif2b1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif2b1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11465	NM_145371.4 Latest version!	Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OMu35865	XM_006530275.4 Latest version!	Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu35865	XM_006530275.3	Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Eif2b1 ( NM_145371.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_663346.1 Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), mRNA.

Price & Availability↑

CloneID	OMu11465
Clone ID Related Accession (Same CDS sequence)	NM_145371.4
Accession Version	NM_145371.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1559836800000
Organism	Mus musculus(house mouse)
Product	translation initiation factor eIF-2B subunit alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DV649595.1 and AK133695.1. On Aug 19, 2015 this sequence version replaced NM_145371.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133695.1, BC003426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164143 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGACG GTGAGTTAAT TGAATACTTT AAGTCTCAGA TGAAAGGAGA TCCTAAAATG 
GCCTCAGCTG TGGCTGCCAT CCAGACTTTG TTGGAATTCT TGAAGAGAGA TAAAGGAGAA 
ACACTCCAGG GCCTGAGAGC AAATCTCACC TATGCCATAA AAACCCTCTG TGGTGTGGAC 
TCCTCAGTGG CCGTGTCATC TGGCGGGGAG CTCTTCCTTC GCTTCATCAG CCTCACCTCC 
CTGGAATACT CTGACTACTC CAAATGTAAG AAGATCATGA TTGAGAGAGG AGAGCTGTTC 
CTGAGAAGAA TATCCCTGTC GAGAAATAAG ATTGCCAATC TGTGTCATAC ATTCATCAAA 
GACGGGGCGA GAATTTTGAC TCACGCCTAC TCCAGAGTTG TCTTAAGAGT CCTGGAAGAA 
GCCGTGGCAG CCAAGAAACG GTTCAGTGTG TATATCACGG AGTCGCAGCC TGATTTATCT 
GGTAAGAAAA TGGCCAAAGC CCTCTCCCAC CTCAACGTCC CTGTCACTGT GGTGCTGGAT 
GCTGCTGTCG GCTATATCAT GGAGAAAGCA GATCTTGTCA TAGTTGGTGC TGAAGGAGTG 
GTAGAGAACG GAGGCATTAT TAACAAGATT GGAACCAACC AGATGGCCGT GTGTGCCAAA 
GCCCAGAATA AGCCCTTCTA TGTGGTTGCA GAAAGCTTCA AGTTCGTACG CCTCTTTCCA 
CTCAACCAGG AGGACGTCCC AGATAAGTTT AAGTACAAGG CAGACACTCT GAAGTCTGTG 
CAGACTGGGC AGGATCTCAA AGAGGAACAC CCATGGGTGG ACTACACCTC CCCATCCCTC 
ATCACCCTGC TGTTTACGGA CCTGGGTGTG TTGACGCCAT CTGCTGTAAG CGATGAGCTC 
ATCAAGCTGT ACCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_663346.1
CDS	119..1036
Translation	MEDGELIEYFKSQMKGDPKMASAVAAIQTLLEFLKRDKGETLQGLRANLTYAIKTLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLRRISLSRNKIANLCHTFIKDGARILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLSGKKMAKALSHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQEDVPDKFKYKADTLKSVQTGQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL

Target ORF information:

RefSeq Version	NM_145371.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145371.4

ORF Insert Sequence:

ATGGAGGACG GTGAGTTAAT TGAATACTTT AAGTCTCAGA TGAAAGGAGA TCCTAAAATG 
GCCTCAGCTG TGGCTGCCAT CCAGACTTTG TTGGAATTCT TGAAGAGAGA TAAAGGAGAA 
ACACTCCAGG GCCTGAGAGC AAATCTCACC TATGCCATAA AAACCCTCTG TGGTGTGGAC 
TCCTCAGTGG CCGTGTCATC TGGCGGGGAG CTCTTCCTTC GCTTCATCAG CCTCACCTCC 
CTGGAATACT CTGACTACTC CAAATGTAAG AAGATCATGA TTGAGAGAGG AGAGCTGTTC 
CTGAGAAGAA TATCCCTGTC GAGAAATAAG ATTGCCAATC TGTGTCATAC ATTCATCAAA 
GACGGGGCGA GAATTTTGAC TCACGCCTAC TCCAGAGTTG TCTTAAGAGT CCTGGAAGAA 
GCCGTGGCAG CCAAGAAACG GTTCAGTGTG TATATCACGG AGTCGCAGCC TGATTTATCT 
GGTAAGAAAA TGGCCAAAGC CCTCTCCCAC CTCAACGTCC CTGTCACTGT GGTGCTGGAT 
GCTGCTGTCG GCTATATCAT GGAGAAAGCA GATCTTGTCA TAGTTGGTGC TGAAGGAGTG 
GTAGAGAACG GAGGCATTAT TAACAAGATT GGAACCAACC AGATGGCCGT GTGTGCCAAA 
GCCCAGAATA AGCCCTTCTA TGTGGTTGCA GAAAGCTTCA AGTTCGTACG CCTCTTTCCA 
CTCAACCAGG AGGACGTCCC AGATAAGTTT AAGTACAAGG CAGACACTCT GAAGTCTGTG 
CAGACTGGGC AGGATCTCAA AGAGGAACAC CCATGGGTGG ACTACACCTC CCCATCCCTC 
ATCACCCTGC TGTTTACGGA CCTGGGTGTG TTGACGCCAT CTGCTGTAAG CGATGAGCTC 
ATCAAGCTGT ACCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Eif2b1 ( XM_006530275.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530338.1 Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu35865
Clone ID Related Accession (Same CDS sequence)	XM_006530275.3 , XM_006530275.4
Accession Version	XM_006530275.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	translation initiation factor eIF-2B subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530275.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGAACA GCAGGCTCAG CCAGTCTCCA GCTTGTCCAC TCCTCCAGAG AATTTTGACT 
CACGCCTACT CCAGAGTTGT CTTAAGAGTC CTGGAAGAAG CCGTGGCAGC CAAGAAACGG 
TTCAGTGTGT ATATCACGGA GTCGCAGCCT GATTTATCTG GTAAGAAAAT GGCCAAAGCC 
CTCTCCCACC TCAACGTCCC TGTCACTGTG GTGCTGGATG CTGCTGTCGG CTATATCATG 
GAGAAAGCAG ATCTTGTCAT AGTTGGTGCT GAAGGAGTGG TAGAGAACGG AGGCATTATT 
AACAAGATTG GAACCAACCA GATGGCCGTG TGTGCCAAAG CCCAGAATAA GCCCTTCTAT 
GTGGTTGCAG AAAGCTTCAA GTTCGTACGC CTCTTTCCAC TCAACCAGGA GGACGTCCCA 
GATAAGTTTA AGTACAAGGC AGACACTCTG AAGTCTGTGC AGACTGGGCA GGATCTCAAA 
GAGGAACACC CATGGGTGGA CTACACCTCC CCATCCCTCA TCACCCTGCT GTTTACGGAC 
CTGGGTGTGT TGACGCCATC TGCTGTAAGC GATGAGCTCA TCAAGCTGTA CCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530338.1
CDS	379..975
Translation	MRNSRLSQSPACPLLQRILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLSGKKMAKALSHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQEDVPDKFKYKADTLKSVQTGQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL

Target ORF information:

RefSeq Version	XM_006530275.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530275.3

ORF Insert Sequence:

ATGAGGAACA GCAGGCTCAG CCAGTCTCCA GCTTGTCCAC TCCTCCAGAG AATTTTGACT 
CACGCCTACT CCAGAGTTGT CTTAAGAGTC CTGGAAGAAG CCGTGGCAGC CAAGAAACGG 
TTCAGTGTGT ATATCACGGA GTCGCAGCCT GATTTATCTG GTAAGAAAAT GGCCAAAGCC 
CTCTCCCACC TCAACGTCCC TGTCACTGTG GTGCTGGATG CTGCTGTCGG CTATATCATG 
GAGAAAGCAG ATCTTGTCAT AGTTGGTGCT GAAGGAGTGG TAGAGAACGG AGGCATTATT 
AACAAGATTG GAACCAACCA GATGGCCGTG TGTGCCAAAG CCCAGAATAA GCCCTTCTAT 
GTGGTTGCAG AAAGCTTCAA GTTCGTACGC CTCTTTCCAC TCAACCAGGA GGACGTCCCA 
GATAAGTTTA AGTACAAGGC AGACACTCTG AAGTCTGTGC AGACTGGGCA GGATCTCAAA 
GAGGAACACC CATGGGTGGA CTACACCTCC CCATCCCTCA TCACCCTGCT GTTTACGGAC 
CTGGGTGTGT TGACGCCATC TGCTGTAAGC GATGAGCTCA TCAAGCTGTA CCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Eif2b1 ( XM_006530275.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530338.1 Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu35865
Clone ID Related Accession (Same CDS sequence)	XM_006530275.3 , XM_006530275.4
Accession Version	XM_006530275.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	translation initiation factor eIF-2B subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530275.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGAACA GCAGGCTCAG CCAGTCTCCA GCTTGTCCAC TCCTCCAGAG AATTTTGACT 
CACGCCTACT CCAGAGTTGT CTTAAGAGTC CTGGAAGAAG CCGTGGCAGC CAAGAAACGG 
TTCAGTGTGT ATATCACGGA GTCGCAGCCT GATTTATCTG GTAAGAAAAT GGCCAAAGCC 
CTCTCCCACC TCAACGTCCC TGTCACTGTG GTGCTGGATG CTGCTGTCGG CTATATCATG 
GAGAAAGCAG ATCTTGTCAT AGTTGGTGCT GAAGGAGTGG TAGAGAACGG AGGCATTATT 
AACAAGATTG GAACCAACCA GATGGCCGTG TGTGCCAAAG CCCAGAATAA GCCCTTCTAT 
GTGGTTGCAG AAAGCTTCAA GTTCGTACGC CTCTTTCCAC TCAACCAGGA GGACGTCCCA 
GATAAGTTTA AGTACAAGGC AGACACTCTG AAGTCTGTGC AGACTGGGCA GGATCTCAAA 
GAGGAACACC CATGGGTGGA CTACACCTCC CCATCCCTCA TCACCCTGCT GTTTACGGAC 
CTGGGTGTGT TGACGCCATC TGCTGTAAGC GATGAGCTCA TCAAGCTGTA CCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530338.1
CDS	380..976
Translation	MRNSRLSQSPACPLLQRILTHAYSRVVLRVLEEAVAAKKRFSVYITESQPDLSGKKMAKALSHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQEDVPDKFKYKADTLKSVQTGQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL

Target ORF information:

RefSeq Version	XM_006530275.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530275.4

ORF Insert Sequence:

ATGAGGAACA GCAGGCTCAG CCAGTCTCCA GCTTGTCCAC TCCTCCAGAG AATTTTGACT 
CACGCCTACT CCAGAGTTGT CTTAAGAGTC CTGGAAGAAG CCGTGGCAGC CAAGAAACGG 
TTCAGTGTGT ATATCACGGA GTCGCAGCCT GATTTATCTG GTAAGAAAAT GGCCAAAGCC 
CTCTCCCACC TCAACGTCCC TGTCACTGTG GTGCTGGATG CTGCTGTCGG CTATATCATG 
GAGAAAGCAG ATCTTGTCAT AGTTGGTGCT GAAGGAGTGG TAGAGAACGG AGGCATTATT 
AACAAGATTG GAACCAACCA GATGGCCGTG TGTGCCAAAG CCCAGAATAA GCCCTTCTAT 
GTGGTTGCAG AAAGCTTCAA GTTCGTACGC CTCTTTCCAC TCAACCAGGA GGACGTCCCA 
GATAAGTTTA AGTACAAGGC AGACACTCTG AAGTCTGTGC AGACTGGGCA GGATCTCAAA 
GAGGAACACC CATGGGTGGA CTACACCTCC CCATCCCTCA TCACCCTGCT GTTTACGGAC 
CTGGGTGTGT TGACGCCATC TGCTGTAAGC GATGAGCTCA TCAAGCTGTA CCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(5)2225-37(2014 May)
Wortham NC,Martinez M,Gordiyenko Y,Robinson CV,Proud CG

A new function and complexity for protein translation initiation factor eIF2B.
Cell cycle (Georgetown, Tex.)13(17)2660-5(2014)
Jennings MD,Pavitt GD

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.
Nature cell biology14(2)192-200(2012 Jan)
Woo CW,Kutzler L,Kimball SR,Tabas I

Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
PloS one7(10)e46715(2012)
Cabilly Y,Barbi M,Geva M,Marom L,Chetrit D,Ehrlich M,Elroy-Stein O

A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
PloS one6(10)e26992(2011)
Marom L,Ulitsky I,Cabilly Y,Shamir R,Elroy-Stein O