Serpina1c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina1c
Entrez Gene ID	20702
Full Name	serine (or cysteine) peptidase inhibitor, clade A, member 1C
Synonyms	Pi3,Pi6,Skalp,Spi1-3,Spi1-6,Wap3
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade A, member 1C Names alpha-1-antitrypsin 1-3 alpha-1 protease inhibitor 3 alpha-1 protease inhibitor 6 alpha-1-antitrypsin 1-6 apha-1 protease inhibitor 3 pre-elafin serine (or cysteine) proteinase inhibitor, clade A, member 1c serine protease inhibitor 1-3 serine protease inhibitor 1-6 serine protease inhibitor A1c serpin A1c trappin-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 E\|12 52.98 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009245.2	NP_033271.1	alpha-1-antitrypsin 1-3 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Serpina1	NP_071964.2
Gallus gallus (chicken)	SERPINA4	NP_001264421.1
Gallus gallus (chicken)	SERPINA5	XP_004941954.1
Xenopus tropicalis (tropical clawed frog)	serpina1	XP_002936109.1
Pan troglodytes (chimpanzee)	SERPINA1	XP_522938.2
Mus musculus (house mouse)	Serpina1e	NP_033273.1
Gallus gallus (chicken)	SERPINA1	NP_001264422.1
Danio rerio (zebrafish)	serpina1l	NP_001013277.3
Canis lupus familiaris (dog)	SERPINA1	NP_001073578.1
Mus musculus (house mouse)	Serpina1d	NP_033272.1
Xenopus tropicalis (tropical clawed frog)	serpina3k	XP_002936116.2
Mus musculus (house mouse)	Serpina1c	NP_033271.1
Gallus gallus (chicken)	SERPINA9	XP_004941955.1
Xenopus tropicalis (tropical clawed frog)	LOC100488834	XP_002936115.2
Homo sapiens (human)	SERPINA1	NP_001002236.1
Macaca mulatta (Rhesus monkey)	SERPINA1	XP_001099255.1
Bos taurus (cattle)	SERPINA1	NP_776307.1
Mus musculus (house mouse)	Serpina1a	NP_033269.1
Mus musculus (house mouse)	Serpina1b	NP_033270.3
Danio rerio (zebrafish)	serpina1	NP_001071226.1

Gene Ontology
Bibliography

Related articles in PubMed

Update of the human and mouse SERPIN gene superfamily.
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V
Human genomics722(2013 Oct)

Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment.
Wilkinson TS, Dhaliwal K, Hamilton TW, Lipka AF, Farrell L, Davidson DJ, Duffin R, Morris AC, Haslett C, Govan JR, Gregory CD, Sallenave JM, Simpson AJ
The American journal of pathology174(4)1338-46(2009 Apr)

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization.
Winkler IG, Hendy J, Coughlin P, Horvath A, Lévesque JP
The Journal of experimental medicine201(7)1077-88(2005 Apr)

A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.
Forsyth S, Horvath A, Coughlin P
Genomics81(3)336-45(2003 Mar)

The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure.
Barbour KW, Wei F, Brannan C, Flotte TR, Baumann H, Berger FG
Genomics80(5)515-22(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Serpina1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03782	NM_009245.2 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina1c ( NM_009245.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033271.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c), mRNA.

Price & Availability↑

CloneID	OMu03782
Clone ID Related Accession (Same CDS sequence)	NM_009245.2
Accession Version	NM_009245.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1242bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Mus musculus(house mouse)
Product	alpha-1-antitrypsin 1-3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC134902.7 and M75720.1. On Oct 4, 2005 this sequence version replaced NM_009245.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024108.1, BC031707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTCCCT CCATCTCATG GGGTCTACTG CTTCTGGCAG GCCTGTGTTG CCTGGTCCCC 
AGCTTTCTGG CTGAGGATGT TCAGGAGACA GACACCTCCC AGAAGGATCA GTCCCCAGCC 
TCCCATGAGA TCGCTACAAA CCTGGGAGAC TTTGCAATCA GCCTATACCG GGAGCTGGTC 
CATCAGTCCA ACACTTCCAA CATCTTCTTC TCCCCAGTGA GCATTGCCAC AGCCTTTGCT 
ATGCTCTCCC TAGGGAGCAA GGGTGACACT CACACGCAGA TCCTAGAGGG CCTGCAGTTC 
AACCTCACAC AAACATCGGA GGCTGACATC CACAAGTCCT TCCAACACCT CCTCCAAACC 
CTCAACAGAC CAGACAGTGA GCTGCAGCTG AGCACAGGCA ATGGCCTCTT TGTCAACAAT 
GACCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGCCAAGA ACCATTATCA GGCAGAAGTC 
TTCTCTGTCA ACTTTGCAGA GTCAGAGGAG GCCAAGAAAG TGATTAATGA TTTTGTGGAG 
AAGGGAACCC AAGGAAAGAT AGCTGAGGCG GTGAAAAAAC TGGACCAAGA CACAGTTTTC 
GCCCTGGCAA ATTACATTCT CTTTAAAGGC AAATGGAAGA AGCCATTCGA TCCTGAGAAC 
ACTGAGGAAG CTGAGTTCCA CGTGGACGAG TCCACCACGG TGAAGGTGCC CATGATGACC 
CTCTCGGGAA TGCTTGATGT GCACCATTGC AGCACGCTGT CCAGCTGGGT GCTGCTGATG 
GATTATGCAG GCAATGCCAC TGCTGTCTTC CTTCTGCCCG ATGATGGGAA GATGCAGCAT 
CTGGAGCAAA CTCTCAGCAA GGAGCTCATC TCCAAGTTCC TGCTAAAGAG GCCCAGAAGG 
TTAGCCCAGA TCCACTTCCC CAGACTGTCC ATCTCTGGAG AATATAACTT GAAGACACTC 
ATGAGTCCAC TGGGCATCAC CCGGATCTTC AACAATGGGG CTGACCTCTC CGGAATCACA 
GAGGAGAATG CTCCCCTGAA GCTCAGCCAG GCTGTGCATA AGGCTGTGCT GACCATGGAT 
GAGACAGGAA CAGAAGCTGC AGCAGCTACA GTCTTACTAG CCGTTCCTTA TTCTATGCCC 
CCTATCGTGC GCTTCGATCA CCCTTTCCTT TTCATAATAT TTGAAGAACA CACTCAGAGC 
CCCCTCTTTG TGGGAAAAGT GGTAGATCCC ACACATAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033271.1
CDS	97..1338
Translation	MTPSISWGLLLLAGLCCLVPSFLAEDVQETDTSQKDQSPASHEIATNLGDFAISLYRELVHQSNTSNIFFSPVSIATAFAMLSLGSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLSTGNGLFVNNDLKLVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQDTVFALANYILFKGKWKKPFDPENTEEAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDGKMQHLEQTLSKELISKFLLKRPRRLAQIHFPRLSISGEYNLKTLMSPLGITRIFNNGADLSGITEENAPLKLSQAVHKAVLTMDETGTEAAAATVLLAVPYSMPPIVRFDHPFLFIIFEEHTQSPLFVGKVVDPTHK

Target ORF information:

RefSeq Version	NM_009245.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade A, member 1C (Serpina1c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009245.2

ORF Insert Sequence:

ATGACTCCCT CCATCTCATG GGGTCTACTG CTTCTGGCAG GCCTGTGTTG CCTGGTCCCC 
AGCTTTCTGG CTGAGGATGT TCAGGAGACA GACACCTCCC AGAAGGATCA GTCCCCAGCC 
TCCCATGAGA TCGCTACAAA CCTGGGAGAC TTTGCAATCA GCCTATACCG GGAGCTGGTC 
CATCAGTCCA ACACTTCCAA CATCTTCTTC TCCCCAGTGA GCATTGCCAC AGCCTTTGCT 
ATGCTCTCCC TAGGGAGCAA GGGTGACACT CACACGCAGA TCCTAGAGGG CCTGCAGTTC 
AACCTCACAC AAACATCGGA GGCTGACATC CACAAGTCCT TCCAACACCT CCTCCAAACC 
CTCAACAGAC CAGACAGTGA GCTGCAGCTG AGCACAGGCA ATGGCCTCTT TGTCAACAAT 
GACCTGAAGC TGGTGGAGAA GTTTCTGGAA GAGGCCAAGA ACCATTATCA GGCAGAAGTC 
TTCTCTGTCA ACTTTGCAGA GTCAGAGGAG GCCAAGAAAG TGATTAATGA TTTTGTGGAG 
AAGGGAACCC AAGGAAAGAT AGCTGAGGCG GTGAAAAAAC TGGACCAAGA CACAGTTTTC 
GCCCTGGCAA ATTACATTCT CTTTAAAGGC AAATGGAAGA AGCCATTCGA TCCTGAGAAC 
ACTGAGGAAG CTGAGTTCCA CGTGGACGAG TCCACCACGG TGAAGGTGCC CATGATGACC 
CTCTCGGGAA TGCTTGATGT GCACCATTGC AGCACGCTGT CCAGCTGGGT GCTGCTGATG 
GATTATGCAG GCAATGCCAC TGCTGTCTTC CTTCTGCCCG ATGATGGGAA GATGCAGCAT 
CTGGAGCAAA CTCTCAGCAA GGAGCTCATC TCCAAGTTCC TGCTAAAGAG GCCCAGAAGG 
TTAGCCCAGA TCCACTTCCC CAGACTGTCC ATCTCTGGAG AATATAACTT GAAGACACTC 
ATGAGTCCAC TGGGCATCAC CCGGATCTTC AACAATGGGG CTGACCTCTC CGGAATCACA 
GAGGAGAATG CTCCCCTGAA GCTCAGCCAG GCTGTGCATA AGGCTGTGCT GACCATGGAT 
GAGACAGGAA CAGAAGCTGC AGCAGCTACA GTCTTACTAG CCGTTCCTTA TTCTATGCCC 
CCTATCGTGC GCTTCGATCA CCCTTTCCTT TTCATAATAT TTGAAGAACA CACTCAGAGC 
CCCCTCTTTG TGGGAAAAGT GGTAGATCCC ACACATAAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Update of the human and mouse SERPIN gene superfamily.
Human genomics722(2013 Oct)
Heit C,Jackson BC,McAndrews M,Wright MW,Thompson DC,Silverman GA,Nebert DW,Vasiliou V

Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment.
The American journal of pathology174(4)1338-46(2009 Apr)
Wilkinson TS,Dhaliwal K,Hamilton TW,Lipka AF,Farrell L,Davidson DJ,Duffin R,Morris AC,Haslett C,Govan JR,Gregory CD,Sallenave JM,Simpson AJ

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization.
The Journal of experimental medicine201(7)1077-88(2005 Apr)
Winkler IG,Hendy J,Coughlin P,Horvath A,Lévesque JP

A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins.
Genomics81(3)336-45(2003 Mar)
Forsyth S,Horvath A,Coughlin P

The murine alpha(1)-proteinase inhibitor gene family: polymorphism, chromosomal location, and structure.
Genomics80(5)515-22(2002 Nov)
Barbour KW,Wei F,Brannan C,Flotte TR,Baumann H,Berger FG