Sos2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sos2
Entrez Gene ID	20663
Full Name	SOS Ras/Rho guanine nucleotide exchange factor 2
Synonyms	SOS-2,mSOS-2
General protein information	Preferred Names SOS Ras/Rho guanine nucleotide exchange factor 2 Names son of sevenless homolog 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12 C2\|12 28.93 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001135559.1	NP_001129031.1	son of sevenless homolog 2
XM_006515635.1	XP_006515698.1	son of sevenless homolog 2 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SOS2	NP_008870.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009180	XP_319944.4
Canis lupus familiaris (dog)	SOS2	XP_005623436.1
Pan troglodytes (chimpanzee)	SOS2	XP_003314439.2
Macaca mulatta (Rhesus monkey)	SOS2	XP_001099864.1
Danio rerio (zebrafish)	sos2	XP_690171.2
Bos taurus (cattle)	SOS2	XP_002707757.2
Mus musculus (house mouse)	Sos2	NP_001129031.1
Rattus norvegicus (Norway rat)	Sos2	NP_001129033.1
Gallus gallus (chicken)	SOS2	XP_421461.4
Xenopus tropicalis (tropical clawed frog)	sos2	XP_002938172.2

Gene Ontology
Bibliography

Related articles in PubMed

Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.
Sheffels E, Sealover NE, Wang C, Kim DH, Vazirani IA, Lee E, M Terrell E, Morrison DK, Luo J, Kortum RL
Science signaling11(546)(2018 09)

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.
Liceras-Boillos P, Jimeno D, García-Navas R, Lorenzo-Martín LF, Menacho-Marquez M, Segrelles C, Gómez C, Calzada N, Fuentes-Mateos R, Paramio JM, Bustelo XR, Baltanás FC, Santos E
Molecular and cellular biology38(16)(2018 08)

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.
Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE
European journal of immunology45(8)2389-95(2015 Aug)

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.
Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E
Molecular and cellular biology33(22)4562-78(2013 Nov)

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T
Cell152(5)1008-20(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sos2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sos2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21540	NM_001135559.1 Latest version!	Mus musculus SOS Ras/Rho guanine nucleotide exchange factor 2 (Sos2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00
OMu47691	XM_006515635.1 Latest version!	Mus musculus SOS Ras/Rho guanine nucleotide exchange factor 2 (Sos2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sos2 ( NM_001135559.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001129031.1 Mus musculus SOS Ras/Rho guanine nucleotide exchange factor 2 (Sos2), mRNA.

Price & Availability↑

CloneID	OMu21540
Clone ID Related Accession (Same CDS sequence)	NM_001135559.1
Accession Version	NM_001135559.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570896000000
Organism	Mus musculus(house mouse)
Product	son of sevenless homolog 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC141560.4, AC133949.4 and AC153658.4. On or before Oct 3, 2008 this sequence version replaced XM_916574.3, XM_127051.8. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCAGG CGCCGCAGCC CTACGAGTTC TTCAGCGAAG AAAACAGCCC GAAATGGCGG 
GGACTATTGG TCCCGGCCCT GCGGAAGGTT CAGGAGCAAG TACATCCCAC CCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAA CTGATTTTTC AGCTGCTTAA TAAGCTATGC 
ATGGCTCAAC CAAGGACTGT TCAAGATGTT GAGGAACGAG TTCAAAAGAC CTTTCCTCAT 
CCTATTGATA AATGGGCAAT TGCTGATGCA CAATCTGCTA TAGAGAAACG AAAACGAAGA 
AATCCTCTCT TACTACCTGT GGACAAAATC CATCCTTCCT TGAAGGAAGT TTTGGGGTAT 
AAAGTGGACT ACCATGTGTC CCTCTACATT GTGGCTGTAT TGGAGTATAT CTCAGCAGAT 
ATTTTGAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAA 
GACATTAAAG TGTCCATGTG TGCAGATAAG GTTTTGATGG ACATGTTCGA TCAGGATGAT 
GATATAGGCT TGGTTTCTCT CTGTGAAGAT GAGCCTTGTT CTTCTGGTGA GCTAAACTAT 
TATGACCTCG TCAGGACTGA AATTGCAGAA GAAAGACAGT ATCTACGGGA GCTGAATATG 
ATCATTAAAG TGTTCCGGGA AGCCTTTCTC TTGGACAGAA AGTTGTTCAA GCCTTCTGAA 
ATTGAAAAGA TTTTCAGTAA CATTTCAGAT ATACATGAAT TGACTGTGAA ACTTTTAGGT 
TTAATTGAAG ACACAGTAGA AATGACAGAT GAAAGTAGTC CTCATCCATT AGCTGGTAGC 
TGTTTTGAAG ATTTAGCAGA GGAGCAAGCG TTTGATCCCT ATGAAACATT ATCACAGGAC 
ATTCTTGCAC CAGAGTTTAA TGACCACTTC AGCAAGTTGA TGGCCAGACC TGCAGTCGCT 
CTACATTTTC AGTCCATTGC TGACGGCTTT AAGGAGGCTG TTCGTTATGT CCTTCCACGC 
CTCATGCTGG TTCCCGTGTA TCACTGTTGG CATTACTTTG AATTATTAAA GTTGAAGGCA 
TGCAGTGAAG AGCAGGAGGA CAAAGAGTGC TTGAATCAGG CTATAACTGC CCTCATGAAC 
CTCCAAGGCA GCATGGACCG CATTTACAAG CAGCACTCCC CCAGACGCCG GCCTGGGGAT 
CCAGTTTGCC TTTTTTACAA TCGTCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAACAT AGATGGGTGG GAAGGCAAAG ATATCGGACA GTGTTGTAAT 
GAGTTCATAA TGGAGGGGCC ACTGACCAGA ATTGGTGCTA AACACGAAAG GCATATCTTT 
CTCTTTGATG GCTTAATGAT CAGCTGTAAA CCCAATCATG GCCAGACCCG GCTTCCAGGA 
TATAGCAGTG CAGAATACAG ATTAAAGGAG AAGTTTGTCA TGAGGAAAAT TCAAATCTGT 
GATAAGGAAG ACGCCTGTGA GTACAGACAT GCTTTTGAAT TAGTGTCCAA AGATGAAAAC 
AGTGTAATAT TTGCTGCCAA ATCAGCTGAA GAGAAAAACA ACTGGATGGC AGCCCTCATT 
TCCCTGCACT ATCGCAGCAC TCTAGACAGA ATGCTGGACT CTGTGCTGCT GAAAGAAGAG 
AATGAGCAGC CCCTGAGGCT ACCCAGTCCA GATATGTATC GCTTTGTGGT AACAGACTCT 
GAGGAAAACA TTGTGTTTGA AGACAACTTG CAAAGCAGAA GTGGGATCCC CATAATTAAA 
GGAGGCACTG TGGTGAAGTT GATCGAAAGG CTAACATACC ACATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC TACATATCGT TCATTTTGTA AACCACAGGA ATTGCTAAAC 
TTGCTGATAG AACGGTTTGA AATTCCAGAA CCAGAACCTA CTGAGGCAGA CAAGCTGGCG 
TTAGAAAAAG GCGAGCAGCC AATCAGCGCA GATCTGAAAA GATTCCGCAA GGAATACGTC 
CAACCTGTGC AGCTTAGGGT CTTGAATGTC TTTCGCCACT GGGTTGAGCA TCATTATTAT 
GACTTTGAAA GAGACTTGGA ACTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCCA TGAAGAAATG GGTAGAATCC ATTGCTAAAA TAATCAAGAG GAAGAAGCAA 
GCTCAGGCAA ATGGAATAAG CCATAATATC ACCTTTGAAA GTTCCCCCCC ACCAGTGGAA 
TGGCACATCA GTAGAACAGG ACAGTTCGAA ACATTTGACC TTATGACACT TCATCCAATA 
GAGATCGCAC GGCAGCTAAC ACTTTTGGAA TCTGACCTCT ACAGGAAAGT CCAGCCCTCT 
GAACTTGTAG GGAGTGTCTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAACTTATTA 
AAAATGATTC GCCATACAAC AAACCTCACC CTATGGTTTG AGAAATGCAT TGTGGAAGCA 
GAAAACTTTG AAGAACGGGT GGCAGTGCTC AGCAGAATAG TAGAAATTCT GCAAGTATTT 
CAAGACTTGA ATAATTTCAA TGGCGTGTTG GAGATAGTGA GTGCAGTCAA CTCCGTGTCA 
GTGTACAGGC TAGACCACAC GTTTGAGGCA CTGCAGGAAA GGAAGCGGAG AATTTTGGAT 
GACGCTGTGG AACTAAGTCA GGACCACTTT AAAAAGTACC TAGTAAAACT TAAGTCAATC 
AATCCGCCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACTGAAGAA 
GGGAACAGTG ACTTTCTAAA GAGGAAAGGG AAAGATTTGA TCAATTTCAG TAAGAGGAGG 
AAAGTGGCTG AAATAACTGG AGAGATCCAG CAGTATCAGA ACCAACCGTA CTGCTTACGG 
ACAGAACCAG AAATGAGGAG ATTCTTTGAA AACCTCAACC CCATGGGAAT TTTATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAA TCATTAGAAA TCGAACCCCG AAACTGCAAA 
CAACCACCTC GATTTCCTAG GAAGTCAACC TTTTCCTTAA AATCTCCTGG AATAAGGCCC 
AATGCTGGCC GCCATGGCTC TACCTCAGGC ACGCTACGAG GTCACCCAAC GCCTCTGGAA 
AGAGAGCCTT ATAAGATAAG CTTTAGCCGG ATCGCTGAGA CAGAGCTAGA ATCAACAGTG 
TCTGCACCAA CCTCCCCCAA CACTCCATCC ACCCCACCAG TGTCTGCTTC TTCAGACCAC 
AGCGTGTTTC TAGATGTGGA CCTCAATAGC TCCTGTGGCA GCAACACCAT CTTTGCTCCA 
GTCCTCTTGC CACACTCAAA GACTTTCTTC AGCTCATGTG GAAGTTTACA CAAACTGAGT 
GAAGAGCCAC TAATTCCTCC TCCGCTTCCC CCTCGGAAAA AGTTTGATCA TGATGCTCTC 
AATTCCAAGG GAGCTGTGAA ATCTGATGAT GACCCTCCTG CTATTCCACC AAGACAGCCC 
CCTCCTCCGA AGGTAAAGCC AAGAGTTCCT GTCCTCATGG GTACATTTGA TGGGCCTGTG 
CCCAGTCCAC CTCCACCTCC TCCAAGAGAC CCTCTTCCTG ATACCCCTCC ACCAGTTCCT 
CTTCGGCCTC CGGAACACTT TATAAACTGT CCATTTAATC TTCAGCCGCC TCCACTGGGC 
CATCCTCACA GAGACCCAGA CTGGCTCAGA GACGTCAGCA CGTGTCCTAA CTCACCAAGC 
ACTCCTCCCA CTACGCCCTC TCCACGGATT CCACGCAGCT GTCACTTGCT CAGCTCCAGT 
CACAGCAGCC TTGCTCATCT TCCAGCTCCT CCTGTCCCAC CAAGGCAGAA TTCAAGCCCT 
CTCTTACCAA AGCTGCCACC AAAGACTTAC AAACGGGAGC TTTCCCACCC GCCACTGTAT 
AGACTGCCTC TGCTGGAAAA TGCAGAAACT CCTCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001129031.1
CDS	252..4250
Translation	MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEDEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLLDRKLFKPSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKLKACSEEQEDKECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEYRHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADKLALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHYYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNAGRHGSTSGTLRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKTFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDALNSKGAVKSDDDPPAIPPRQPPPPKVKPRVPVLMGTFDGPVPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPSTPPTTPSPRIPRSCHLLSSSHSSLAHLPAPPVPPRQNSSPLLPKLPPKTYKRELSHPPLYRLPLLENAETPQ

Target ORF information:

RefSeq Version	NM_001135559.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SOS Ras/Rho guanine nucleotide exchange factor 2 (Sos2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001135559.1

ORF Insert Sequence:

ATGCAGCAGG CGCCGCAGCC CTACGAGTTC TTCAGCGAAG AAAACAGCCC GAAATGGCGG 
GGACTATTGG TCCCGGCCCT GCGGAAGGTT CAGGAGCAAG TACATCCCAC CCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAA CTGATTTTTC AGCTGCTTAA TAAGCTATGC 
ATGGCTCAAC CAAGGACTGT TCAAGATGTT GAGGAACGAG TTCAAAAGAC CTTTCCTCAT 
CCTATTGATA AATGGGCAAT TGCTGATGCA CAATCTGCTA TAGAGAAACG AAAACGAAGA 
AATCCTCTCT TACTACCTGT GGACAAAATC CATCCTTCCT TGAAGGAAGT TTTGGGGTAT 
AAAGTGGACT ACCATGTGTC CCTCTACATT GTGGCTGTAT TGGAGTATAT CTCAGCAGAT 
ATTTTGAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAA 
GACATTAAAG TGTCCATGTG TGCAGATAAG GTTTTGATGG ACATGTTCGA TCAGGATGAT 
GATATAGGCT TGGTTTCTCT CTGTGAAGAT GAGCCTTGTT CTTCTGGTGA GCTAAACTAT 
TATGACCTCG TCAGGACTGA AATTGCAGAA GAAAGACAGT ATCTACGGGA GCTGAATATG 
ATCATTAAAG TGTTCCGGGA AGCCTTTCTC TTGGACAGAA AGTTGTTCAA GCCTTCTGAA 
ATTGAAAAGA TTTTCAGTAA CATTTCAGAT ATACATGAAT TGACTGTGAA ACTTTTAGGT 
TTAATTGAAG ACACAGTAGA AATGACAGAT GAAAGTAGTC CTCATCCATT AGCTGGTAGC 
TGTTTTGAAG ATTTAGCAGA GGAGCAAGCG TTTGATCCCT ATGAAACATT ATCACAGGAC 
ATTCTTGCAC CAGAGTTTAA TGACCACTTC AGCAAGTTGA TGGCCAGACC TGCAGTCGCT 
CTACATTTTC AGTCCATTGC TGACGGCTTT AAGGAGGCTG TTCGTTATGT CCTTCCACGC 
CTCATGCTGG TTCCCGTGTA TCACTGTTGG CATTACTTTG AATTATTAAA GTTGAAGGCA 
TGCAGTGAAG AGCAGGAGGA CAAAGAGTGC TTGAATCAGG CTATAACTGC CCTCATGAAC 
CTCCAAGGCA GCATGGACCG CATTTACAAG CAGCACTCCC CCAGACGCCG GCCTGGGGAT 
CCAGTTTGCC TTTTTTACAA TCGTCAATTA AGAAGCAAAC ACCTGGCTAT CAAAAAAATG 
AATGAAATTC AGAAAAACAT AGATGGGTGG GAAGGCAAAG ATATCGGACA GTGTTGTAAT 
GAGTTCATAA TGGAGGGGCC ACTGACCAGA ATTGGTGCTA AACACGAAAG GCATATCTTT 
CTCTTTGATG GCTTAATGAT CAGCTGTAAA CCCAATCATG GCCAGACCCG GCTTCCAGGA 
TATAGCAGTG CAGAATACAG ATTAAAGGAG AAGTTTGTCA TGAGGAAAAT TCAAATCTGT 
GATAAGGAAG ACGCCTGTGA GTACAGACAT GCTTTTGAAT TAGTGTCCAA AGATGAAAAC 
AGTGTAATAT TTGCTGCCAA ATCAGCTGAA GAGAAAAACA ACTGGATGGC AGCCCTCATT 
TCCCTGCACT ATCGCAGCAC TCTAGACAGA ATGCTGGACT CTGTGCTGCT GAAAGAAGAG 
AATGAGCAGC CCCTGAGGCT ACCCAGTCCA GATATGTATC GCTTTGTGGT AACAGACTCT 
GAGGAAAACA TTGTGTTTGA AGACAACTTG CAAAGCAGAA GTGGGATCCC CATAATTAAA 
GGAGGCACTG TGGTGAAGTT GATCGAAAGG CTAACATACC ACATGTATGC AGATCCCAAT 
TTTGTTCGTA CTTTTCTTAC TACATATCGT TCATTTTGTA AACCACAGGA ATTGCTAAAC 
TTGCTGATAG AACGGTTTGA AATTCCAGAA CCAGAACCTA CTGAGGCAGA CAAGCTGGCG 
TTAGAAAAAG GCGAGCAGCC AATCAGCGCA GATCTGAAAA GATTCCGCAA GGAATACGTC 
CAACCTGTGC AGCTTAGGGT CTTGAATGTC TTTCGCCACT GGGTTGAGCA TCATTATTAT 
GACTTTGAAA GAGACTTGGA ACTGCTTGAA AGACTAGAAT CCTTCATTTC AAGTGTAAGA 
GGGAAAGCCA TGAAGAAATG GGTAGAATCC ATTGCTAAAA TAATCAAGAG GAAGAAGCAA 
GCTCAGGCAA ATGGAATAAG CCATAATATC ACCTTTGAAA GTTCCCCCCC ACCAGTGGAA 
TGGCACATCA GTAGAACAGG ACAGTTCGAA ACATTTGACC TTATGACACT TCATCCAATA 
GAGATCGCAC GGCAGCTAAC ACTTTTGGAA TCTGACCTCT ACAGGAAAGT CCAGCCCTCT 
GAACTTGTAG GGAGTGTCTG GACCAAAGAA GATAAAGAAA TAAATTCTCC AAACTTATTA 
AAAATGATTC GCCATACAAC AAACCTCACC CTATGGTTTG AGAAATGCAT TGTGGAAGCA 
GAAAACTTTG AAGAACGGGT GGCAGTGCTC AGCAGAATAG TAGAAATTCT GCAAGTATTT 
CAAGACTTGA ATAATTTCAA TGGCGTGTTG GAGATAGTGA GTGCAGTCAA CTCCGTGTCA 
GTGTACAGGC TAGACCACAC GTTTGAGGCA CTGCAGGAAA GGAAGCGGAG AATTTTGGAT 
GACGCTGTGG AACTAAGTCA GGACCACTTT AAAAAGTACC TAGTAAAACT TAAGTCAATC 
AATCCGCCTT GTGTGCCTTT TTTTGGAATA TATTTAACAA ATATTCTGAA GACTGAAGAA 
GGGAACAGTG ACTTTCTAAA GAGGAAAGGG AAAGATTTGA TCAATTTCAG TAAGAGGAGG 
AAAGTGGCTG AAATAACTGG AGAGATCCAG CAGTATCAGA ACCAACCGTA CTGCTTACGG 
ACAGAACCAG AAATGAGGAG ATTCTTTGAA AACCTCAACC CCATGGGAAT TTTATCTGAA 
AAAGAGTTTA CAGATTATTT GTTCAACAAA TCATTAGAAA TCGAACCCCG AAACTGCAAA 
CAACCACCTC GATTTCCTAG GAAGTCAACC TTTTCCTTAA AATCTCCTGG AATAAGGCCC 
AATGCTGGCC GCCATGGCTC TACCTCAGGC ACGCTACGAG GTCACCCAAC GCCTCTGGAA 
AGAGAGCCTT ATAAGATAAG CTTTAGCCGG ATCGCTGAGA CAGAGCTAGA ATCAACAGTG 
TCTGCACCAA CCTCCCCCAA CACTCCATCC ACCCCACCAG TGTCTGCTTC TTCAGACCAC 
AGCGTGTTTC TAGATGTGGA CCTCAATAGC TCCTGTGGCA GCAACACCAT CTTTGCTCCA 
GTCCTCTTGC CACACTCAAA GACTTTCTTC AGCTCATGTG GAAGTTTACA CAAACTGAGT 
GAAGAGCCAC TAATTCCTCC TCCGCTTCCC CCTCGGAAAA AGTTTGATCA TGATGCTCTC 
AATTCCAAGG GAGCTGTGAA ATCTGATGAT GACCCTCCTG CTATTCCACC AAGACAGCCC 
CCTCCTCCGA AGGTAAAGCC AAGAGTTCCT GTCCTCATGG GTACATTTGA TGGGCCTGTG 
CCCAGTCCAC CTCCACCTCC TCCAAGAGAC CCTCTTCCTG ATACCCCTCC ACCAGTTCCT 
CTTCGGCCTC CGGAACACTT TATAAACTGT CCATTTAATC TTCAGCCGCC TCCACTGGGC 
CATCCTCACA GAGACCCAGA CTGGCTCAGA GACGTCAGCA CGTGTCCTAA CTCACCAAGC 
ACTCCTCCCA CTACGCCCTC TCCACGGATT CCACGCAGCT GTCACTTGCT CAGCTCCAGT 
CACAGCAGCC TTGCTCATCT TCCAGCTCCT CCTGTCCCAC CAAGGCAGAA TTCAAGCCCT 
CTCTTACCAA AGCTGCCACC AAAGACTTAC AAACGGGAGC TTTCCCACCC GCCACTGTAT 
AGACTGCCTC TGCTGGAAAA TGCAGAAACT CCTCAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sos2 ( XM_006515635.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006515698.1 Mus musculus SOS Ras/Rho guanine nucleotide exchange factor 2 (Sos2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu47691
Clone ID Related Accession (Same CDS sequence)	XM_006515635.1
Accession Version	XM_006515635.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4002bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	son of sevenless homolog 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGCAGG CGCCGCAGCC CTACGAGTTC TTCAGCGAAG AAAACAGCCC GAAATGGCGG 
GGACTATTGG TCCCGGCCCT GCGGAAGGTT CAGGAGCAAG TACATCCCAC CCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAA CTGATTTTTC AGCTGCTTAA TAAGCTATGC 
ATGGCTCAAC CAAGGACTGT TCAAGATGTT GAGGAACGAG TTCAAAAGAC CTTTCCTCAT 
CCTATTGATA AATGGGCAAT TGCTGATGCA CAATCTGCTA TAGAGAAACG AAAACGAAGA 
AATCCTCTCT TACTACCTGT GGACAAAATC CATCCTTCCT TGAAGGAAGT TTTGGGGTAT 
AAAGTGGACT ACCATGTGTC CCTCTACATT GTGGCTGTAT TGGAGTATAT CTCAGCAGAT 
ATTTTGAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAA 
GACATTAAAG TGTCCATGTG TGCAGATAAG GTTTTGATGG ACATGTTCGA TCAGGATGAT 
GATATAGGCT TGGTTTCTCT CTGTGAAGAT GAGCCTTGTT CTTCTGGTGA GCTAAACTAT 
TATGACCTCG TCAGGACTGA AATTGCAGAA GAAAGACAGT ATCTACGGGA GCTGAATATG 
ATCATTAAAG TGTTCCGGGA AGCCTTTCTC TTGGACAGAA AGTTGTTCAA GCCTTCTGAA 
ATTGAAAAGA TTTTCAGTAA CATTTCAGAT ATACATGAAT TGACTGTGAA ACTTTTAGGT 
TTAATTGAAG ACACAGTAGA AATGACAGAT GAAAGTAGTC CTCATCCATT AGCTGGTAGC 
TGTTTTGAAG ATTTAGCAGA GGAGCAAGCG TTTGATCCCT ATGAAACATT ATCACAGGAC 
ATTCTTGCAC CAGAGTTTAA TGACCACTTC AGCAAGTTGA TGGCCAGACC TGCAGTCGCT 
CTACATTTTC AGTCCATTGC TGACGGCTTT AAGGAGGCTG TTCGTTATGT CCTTCCACGC 
CTCATGCTGG TTCCCGTGTA TCACTGTTGG CATTACTTTG AATTATTAAA GCAGTTGAAG 
GCATGCAGTG AAGAGCAGGA GGACAAAGAG TGCTTGAATC AGGCTATAAC TGCCCTCATG 
AACCTCCAAG GCAGCATGGA CCGCATTTAC AAGCAGCACT CCCCCAGACG CCGGCCTGGG 
GATCCAGTTT GCCTTTTTTA CAATCGTCAA TTAAGAAGCA AACACCTGGC TATCAAAAAA 
ATGAATGAAA TTCAGAAAAA CATAGATGGG TGGGAAGGCA AAGATATCGG ACAGTGTTGT 
AATGAGTTCA TAATGGAGGG GCCACTGACC AGAATTGGTG CTAAACACGA AAGGCATATC 
TTTCTCTTTG ATGGCTTAAT GATCAGCTGT AAACCCAATC ATGGCCAGAC CCGGCTTCCA 
GGATATAGCA GTGCAGAATA CAGATTAAAG GAGAAGTTTG TCATGAGGAA AATTCAAATC 
TGTGATAAGG AAGACGCCTG TGAGTACAGA CATGCTTTTG AATTAGTGTC CAAAGATGAA 
AACAGTGTAA TATTTGCTGC CAAATCAGCT GAAGAGAAAA ACAACTGGAT GGCAGCCCTC 
ATTTCCCTGC ACTATCGCAG CACTCTAGAC AGAATGCTGG ACTCTGTGCT GCTGAAAGAA 
GAGAATGAGC AGCCCCTGAG GCTACCCAGT CCAGATATGT ATCGCTTTGT GGTAACAGAC 
TCTGAGGAAA ACATTGTGTT TGAAGACAAC TTGCAAAGCA GAAGTGGGAT CCCCATAATT 
AAAGGAGGCA CTGTGGTGAA GTTGATCGAA AGGCTAACAT ACCACATGTA TGCAGATCCC 
AATTTTGTTC GTACTTTTCT TACTACATAT CGTTCATTTT GTAAACCACA GGAATTGCTA 
AACTTGCTGA TAGAACGGTT TGAAATTCCA GAACCAGAAC CTACTGAGGC AGACAAGCTG 
GCGTTAGAAA AAGGCGAGCA GCCAATCAGC GCAGATCTGA AAAGATTCCG CAAGGAATAC 
GTCCAACCTG TGCAGCTTAG GGTCTTGAAT GTCTTTCGCC ACTGGGTTGA GCATCATTAT 
TATGACTTTG AAAGAGACTT GGAACTGCTT GAAAGACTAG AATCCTTCAT TTCAAGTGTA 
AGAGGGAAAG CCATGAAGAA ATGGGTAGAA TCCATTGCTA AAATAATCAA GAGGAAGAAG 
CAAGCTCAGG CAAATGGAAT AAGCCATAAT ATCACCTTTG AAAGTTCCCC CCCACCAGTG 
GAATGGCACA TCAGTAGAAC AGGACAGTTC GAAACATTTG ACCTTATGAC ACTTCATCCA 
ATAGAGATCG CACGGCAGCT AACACTTTTG GAATCTGACC TCTACAGGAA AGTCCAGCCC 
TCTGAACTTG TAGGGAGTGT CTGGACCAAA GAAGATAAAG AAATAAATTC TCCAAACTTA 
TTAAAAATGA TTCGCCATAC AACAAACCTC ACCCTATGGT TTGAGAAATG CATTGTGGAA 
GCAGAAAACT TTGAAGAACG GGTGGCAGTG CTCAGCAGAA TAGTAGAAAT TCTGCAAGTA 
TTTCAAGACT TGAATAATTT CAATGGCGTG TTGGAGATAG TGAGTGCAGT CAACTCCGTG 
TCAGTGTACA GGCTAGACCA CACGTTTGAG GCACTGCAGG AAAGGAAGCG GAGAATTTTG 
GATGACGCTG TGGAACTAAG TCAGGACCAC TTTAAAAAGT ACCTAGTAAA ACTTAAGTCA 
ATCAATCCGC CTTGTGTGCC TTTTTTTGGA ATATATTTAA CAAATATTCT GAAGACTGAA 
GAAGGGAACA GTGACTTTCT AAAGAGGAAA GGGAAAGATT TGATCAATTT CAGTAAGAGG 
AGGAAAGTGG CTGAAATAAC TGGAGAGATC CAGCAGTATC AGAACCAACC GTACTGCTTA 
CGGACAGAAC CAGAAATGAG GAGATTCTTT GAAAACCTCA ACCCCATGGG AATTTTATCT 
GAAAAAGAGT TTACAGATTA TTTGTTCAAC AAATCATTAG AAATCGAACC CCGAAACTGC 
AAACAACCAC CTCGATTTCC TAGGAAGTCA ACCTTTTCCT TAAAATCTCC TGGAATAAGG 
CCCAATGCTG GCCGCCATGG CTCTACCTCA GGCACGCTAC GAGGTCACCC AACGCCTCTG 
GAAAGAGAGC CTTATAAGAT AAGCTTTAGC CGGATCGCTG AGACAGAGCT AGAATCAACA 
GTGTCTGCAC CAACCTCCCC CAACACTCCA TCCACCCCAC CAGTGTCTGC TTCTTCAGAC 
CACAGCGTGT TTCTAGATGT GGACCTCAAT AGCTCCTGTG GCAGCAACAC CATCTTTGCT 
CCAGTCCTCT TGCCACACTC AAAGACTTTC TTCAGCTCAT GTGGAAGTTT ACACAAACTG 
AGTGAAGAGC CACTAATTCC TCCTCCGCTT CCCCCTCGGA AAAAGTTTGA TCATGATGCT 
CTCAATTCCA AGGGAGCTGT GAAATCTGAT GATGACCCTC CTGCTATTCC ACCAAGACAG 
CCCCCTCCTC CGAAGGTAAA GCCAAGAGTT CCTGTCCTCA TGGGTACATT TGATGGGCCT 
GTGCCCAGTC CACCTCCACC TCCTCCAAGA GACCCTCTTC CTGATACCCC TCCACCAGTT 
CCTCTTCGGC CTCCGGAACA CTTTATAAAC TGTCCATTTA ATCTTCAGCC GCCTCCACTG 
GGCCATCCTC ACAGAGACCC AGACTGGCTC AGAGACGTCA GCACGTGTCC TAACTCACCA 
AGCACTCCTC CCACTACGCC CTCTCCACGG ATTCCACGCA GCTGTCACTT GCTCAGCTCC 
AGTCACAGCA GCCTTGCTCA TCTTCCAGCT CCTCCTGTCC CACCAAGGCA GAATTCAAGC 
CCTCTCTTAC CAAAGCTGCC ACCAAAGACT TACAAACGGG AGCTTTCCCA CCCGCCACTG 
TATAGACTGC CTCTGCTGGA AAATGCAGAA ACTCCTCAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006515698.1
CDS	235..4236
Translation	MQQAPQPYEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGLVSLCEDEPCSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLLDRKLFKPSEIEKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDKECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEYRHAFELVSKDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERFEIPEPEPTEADKLALEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHYYDFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRFPRKSTFSLKSPGIRPNAGRHGSTSGTLRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNTPSTPPVSASSDHSVFLDVDLNSSCGSNTIFAPVLLPHSKTFFSSCGSLHKLSEEPLIPPPLPPRKKFDHDALNSKGAVKSDDDPPAIPPRQPPPPKVKPRVPVLMGTFDGPVPSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVSTCPNSPSTPPTTPSPRIPRSCHLLSSSHSSLAHLPAPPVPPRQNSSPLLPKLPPKTYKRELSHPPLYRLPLLENAETPQ

Target ORF information:

RefSeq Version	XM_006515635.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SOS Ras/Rho guanine nucleotide exchange factor 2 (Sos2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006515635.1

ORF Insert Sequence:

ATGCAGCAGG CGCCGCAGCC CTACGAGTTC TTCAGCGAAG AAAACAGCCC GAAATGGCGG 
GGACTATTGG TCCCGGCCCT GCGGAAGGTT CAGGAGCAAG TACATCCCAC CCTCTCAGCT 
AATGAAGAGT CTCTCTATTA TATTGAAGAA CTGATTTTTC AGCTGCTTAA TAAGCTATGC 
ATGGCTCAAC CAAGGACTGT TCAAGATGTT GAGGAACGAG TTCAAAAGAC CTTTCCTCAT 
CCTATTGATA AATGGGCAAT TGCTGATGCA CAATCTGCTA TAGAGAAACG AAAACGAAGA 
AATCCTCTCT TACTACCTGT GGACAAAATC CATCCTTCCT TGAAGGAAGT TTTGGGGTAT 
AAAGTGGACT ACCATGTGTC CCTCTACATT GTGGCTGTAT TGGAGTATAT CTCAGCAGAT 
ATTTTGAAAT TGGCTGGTAA TTATGTTTTT AATATCCGGC ATTATGAAAT ATCTCAGCAA 
GACATTAAAG TGTCCATGTG TGCAGATAAG GTTTTGATGG ACATGTTCGA TCAGGATGAT 
GATATAGGCT TGGTTTCTCT CTGTGAAGAT GAGCCTTGTT CTTCTGGTGA GCTAAACTAT 
TATGACCTCG TCAGGACTGA AATTGCAGAA GAAAGACAGT ATCTACGGGA GCTGAATATG 
ATCATTAAAG TGTTCCGGGA AGCCTTTCTC TTGGACAGAA AGTTGTTCAA GCCTTCTGAA 
ATTGAAAAGA TTTTCAGTAA CATTTCAGAT ATACATGAAT TGACTGTGAA ACTTTTAGGT 
TTAATTGAAG ACACAGTAGA AATGACAGAT GAAAGTAGTC CTCATCCATT AGCTGGTAGC 
TGTTTTGAAG ATTTAGCAGA GGAGCAAGCG TTTGATCCCT ATGAAACATT ATCACAGGAC 
ATTCTTGCAC CAGAGTTTAA TGACCACTTC AGCAAGTTGA TGGCCAGACC TGCAGTCGCT 
CTACATTTTC AGTCCATTGC TGACGGCTTT AAGGAGGCTG TTCGTTATGT CCTTCCACGC 
CTCATGCTGG TTCCCGTGTA TCACTGTTGG CATTACTTTG AATTATTAAA GCAGTTGAAG 
GCATGCAGTG AAGAGCAGGA GGACAAAGAG TGCTTGAATC AGGCTATAAC TGCCCTCATG 
AACCTCCAAG GCAGCATGGA CCGCATTTAC AAGCAGCACT CCCCCAGACG CCGGCCTGGG 
GATCCAGTTT GCCTTTTTTA CAATCGTCAA TTAAGAAGCA AACACCTGGC TATCAAAAAA 
ATGAATGAAA TTCAGAAAAA CATAGATGGG TGGGAAGGCA AAGATATCGG ACAGTGTTGT 
AATGAGTTCA TAATGGAGGG GCCACTGACC AGAATTGGTG CTAAACACGA AAGGCATATC 
TTTCTCTTTG ATGGCTTAAT GATCAGCTGT AAACCCAATC ATGGCCAGAC CCGGCTTCCA 
GGATATAGCA GTGCAGAATA CAGATTAAAG GAGAAGTTTG TCATGAGGAA AATTCAAATC 
TGTGATAAGG AAGACGCCTG TGAGTACAGA CATGCTTTTG AATTAGTGTC CAAAGATGAA 
AACAGTGTAA TATTTGCTGC CAAATCAGCT GAAGAGAAAA ACAACTGGAT GGCAGCCCTC 
ATTTCCCTGC ACTATCGCAG CACTCTAGAC AGAATGCTGG ACTCTGTGCT GCTGAAAGAA 
GAGAATGAGC AGCCCCTGAG GCTACCCAGT CCAGATATGT ATCGCTTTGT GGTAACAGAC 
TCTGAGGAAA ACATTGTGTT TGAAGACAAC TTGCAAAGCA GAAGTGGGAT CCCCATAATT 
AAAGGAGGCA CTGTGGTGAA GTTGATCGAA AGGCTAACAT ACCACATGTA TGCAGATCCC 
AATTTTGTTC GTACTTTTCT TACTACATAT CGTTCATTTT GTAAACCACA GGAATTGCTA 
AACTTGCTGA TAGAACGGTT TGAAATTCCA GAACCAGAAC CTACTGAGGC AGACAAGCTG 
GCGTTAGAAA AAGGCGAGCA GCCAATCAGC GCAGATCTGA AAAGATTCCG CAAGGAATAC 
GTCCAACCTG TGCAGCTTAG GGTCTTGAAT GTCTTTCGCC ACTGGGTTGA GCATCATTAT 
TATGACTTTG AAAGAGACTT GGAACTGCTT GAAAGACTAG AATCCTTCAT TTCAAGTGTA 
AGAGGGAAAG CCATGAAGAA ATGGGTAGAA TCCATTGCTA AAATAATCAA GAGGAAGAAG 
CAAGCTCAGG CAAATGGAAT AAGCCATAAT ATCACCTTTG AAAGTTCCCC CCCACCAGTG 
GAATGGCACA TCAGTAGAAC AGGACAGTTC GAAACATTTG ACCTTATGAC ACTTCATCCA 
ATAGAGATCG CACGGCAGCT AACACTTTTG GAATCTGACC TCTACAGGAA AGTCCAGCCC 
TCTGAACTTG TAGGGAGTGT CTGGACCAAA GAAGATAAAG AAATAAATTC TCCAAACTTA 
TTAAAAATGA TTCGCCATAC AACAAACCTC ACCCTATGGT TTGAGAAATG CATTGTGGAA 
GCAGAAAACT TTGAAGAACG GGTGGCAGTG CTCAGCAGAA TAGTAGAAAT TCTGCAAGTA 
TTTCAAGACT TGAATAATTT CAATGGCGTG TTGGAGATAG TGAGTGCAGT CAACTCCGTG 
TCAGTGTACA GGCTAGACCA CACGTTTGAG GCACTGCAGG AAAGGAAGCG GAGAATTTTG 
GATGACGCTG TGGAACTAAG TCAGGACCAC TTTAAAAAGT ACCTAGTAAA ACTTAAGTCA 
ATCAATCCGC CTTGTGTGCC TTTTTTTGGA ATATATTTAA CAAATATTCT GAAGACTGAA 
GAAGGGAACA GTGACTTTCT AAAGAGGAAA GGGAAAGATT TGATCAATTT CAGTAAGAGG 
AGGAAAGTGG CTGAAATAAC TGGAGAGATC CAGCAGTATC AGAACCAACC GTACTGCTTA 
CGGACAGAAC CAGAAATGAG GAGATTCTTT GAAAACCTCA ACCCCATGGG AATTTTATCT 
GAAAAAGAGT TTACAGATTA TTTGTTCAAC AAATCATTAG AAATCGAACC CCGAAACTGC 
AAACAACCAC CTCGATTTCC TAGGAAGTCA ACCTTTTCCT TAAAATCTCC TGGAATAAGG 
CCCAATGCTG GCCGCCATGG CTCTACCTCA GGCACGCTAC GAGGTCACCC AACGCCTCTG 
GAAAGAGAGC CTTATAAGAT AAGCTTTAGC CGGATCGCTG AGACAGAGCT AGAATCAACA 
GTGTCTGCAC CAACCTCCCC CAACACTCCA TCCACCCCAC CAGTGTCTGC TTCTTCAGAC 
CACAGCGTGT TTCTAGATGT GGACCTCAAT AGCTCCTGTG GCAGCAACAC CATCTTTGCT 
CCAGTCCTCT TGCCACACTC AAAGACTTTC TTCAGCTCAT GTGGAAGTTT ACACAAACTG 
AGTGAAGAGC CACTAATTCC TCCTCCGCTT CCCCCTCGGA AAAAGTTTGA TCATGATGCT 
CTCAATTCCA AGGGAGCTGT GAAATCTGAT GATGACCCTC CTGCTATTCC ACCAAGACAG 
CCCCCTCCTC CGAAGGTAAA GCCAAGAGTT CCTGTCCTCA TGGGTACATT TGATGGGCCT 
GTGCCCAGTC CACCTCCACC TCCTCCAAGA GACCCTCTTC CTGATACCCC TCCACCAGTT 
CCTCTTCGGC CTCCGGAACA CTTTATAAAC TGTCCATTTA ATCTTCAGCC GCCTCCACTG 
GGCCATCCTC ACAGAGACCC AGACTGGCTC AGAGACGTCA GCACGTGTCC TAACTCACCA 
AGCACTCCTC CCACTACGCC CTCTCCACGG ATTCCACGCA GCTGTCACTT GCTCAGCTCC 
AGTCACAGCA GCCTTGCTCA TCTTCCAGCT CCTCCTGTCC CACCAAGGCA GAATTCAAGC 
CCTCTCTTAC CAAAGCTGCC ACCAAAGACT TACAAACGGG AGCTTTCCCA CCCGCCACTG 
TATAGACTGC CTCTGCTGGA AAATGCAGAA ACTCCTCAAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.
Science signaling11(546)(2018 09)
Sheffels E,Sealover NE,Wang C,Kim DH,Vazirani IA,Lee E,M Terrell E,Morrison DK,Luo J,Kortum RL

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.
Molecular and cellular biology38(16)(2018 08)
Liceras-Boillos P,Jimeno D,García-Navas R,Lorenzo-Martín LF,Menacho-Marquez M,Segrelles C,Gómez C,Calzada N,Fuentes-Mateos R,Paramio JM,Bustelo XR,Baltanás FC,Santos E

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.
European journal of immunology45(8)2389-95(2015 Aug)
Guittard G,Kortum RL,Balagopalan L,Çuburu N,Nguyen P,Sommers CL,Samelson LE

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.
Molecular and cellular biology33(22)4562-78(2013 Nov)
Baltanás FC,Pérez-Andrés M,Ginel-Picardo A,Diaz D,Jimeno D,Liceras-Boillos P,Kortum RL,Samelson LE,Orfao A,Santos E

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Cell152(5)1008-20(2013 Feb)
Findlay GM,Smith MJ,Lanner F,Hsiung MS,Gish GD,Petsalaki E,Cockburn K,Kaneko T,Huang H,Bagshaw RD,Ketela T,Tucholska M,Taylor L,Bowtell DD,Moffat J,Ikura M,Li SS,Sidhu SS,Rossant J,Pawson T

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Sos2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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