Plaa cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Plaa
Entrez Gene ID	18786
Full Name	phospholipase A2, activating protein
Synonyms	2410007N06,AI536418,AU018445,AW208417,D4Ertd618e,PLA2P,PLAP,Ufd3
General protein information	Preferred Names phospholipase A2, activating protein Names phospholipase A-2-activating protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 C5\|4 43.34 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_172695.2	NP_766283.2	phospholipase A-2-activating protein

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	lub1	NP_596478.2
Gallus gallus (chicken)	PLAA	XP_424941.2
Danio rerio (zebrafish)	plaa	NP_997855.1
Arabidopsis thaliana (thale cress)	AT3G18860	NP_850612.1
Homo sapiens (human)	PLAA	NP_001026859.1
Drosophila melanogaster (fruit fly)	Plap	NP_001245829.1
Neurospora crassa	NCU00880	XP_964796.2
Canis lupus familiaris (dog)	PLAA	XP_531963.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008620	XP_314716.4
Eremothecium gossypii	AGOS_AER448W	NP_985303.2
Macaca mulatta (Rhesus monkey)	PLAA	XP_001105698.1
Bos taurus (cattle)	PLAA	NP_001098805.1
Saccharomyces cerevisiae (baker's yeast)	DOA1	NP_012709.1
Kluyveromyces lactis	KLLA0B14410g	XP_452172.1
Magnaporthe oryzae (rice blast fungus)	MGG_14014	XP_003721359.1
Pan troglodytes (chimpanzee)	PLAA	XP_520517.2
Mus musculus (house mouse)	Plaa	NP_766283.2
Rattus norvegicus (Norway rat)	Plaa	NP_446318.3
Xenopus tropicalis (tropical clawed frog)	plaa	NP_001116275.1

Gene Ontology
Bibliography

Related articles in PubMed

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P
American journal of human genetics100(5)706-724(2017 May)

Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy.
Falik Zaccai TC, Savitzki D, Zivony-Elboum Y, Vilboux T, Fitts EC, Shoval Y, Kalfon L, Samra N, Keren Z, Gross B, Chasnyk N, Straussberg R, Mullikin JC, Teer JK, Geiger D, Kornitzer D, Bitterman-Deutsch O, Samson AO, Wakamiya M, Peterson JW, Kirtley ML, Pinchuk IV, Baze WB, Gahl WA, Kleta R, Anikster Y, Chopra AK
Brain : a journal of neurology140(2)370-386(2017 02)

Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3.
Doroudi M, Schwartz Z, Boyan BD
The Journal of steroid biochemistry and molecular biology132(1-2)48-56(2012 Oct)

miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
Sun Y, Li XQ, Sahbaie P, Shi XY, Li WW, Liang DY, Clark JD
Anesthesiology117(3)626-38(2012 Sep)

An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation.
Zhao G, Li G, Schindelin H, Lennarz WJ
Proceedings of the National Academy of Sciences of the United States of America106(38)16197-202(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Plaa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plaa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15059	NM_172695.2 Latest version!	Mus musculus phospholipase A2, activating protein (Plaa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Plaa ( NM_172695.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_766283.2 Mus musculus phospholipase A2, activating protein (Plaa), mRNA.

Price & Availability↑

CloneID	OMu15059
Clone ID Related Accession (Same CDS sequence)	NM_172695.2
Accession Version	NM_172695.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2385bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571328000000
Organism	Mus musculus(house mouse)
Product	phospholipase A-2-activating protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA490654.1, AK075934.1, DV646766.1 and AL732597.10. On Sep 15, 2006 this sequence version replaced NM_172695.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.122489.1, BC139355.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGAGCG GCGCCTCCAG ATACCGGCTG AGCTGCTCGC TCCCGGGCCA CGAACTGGAC 
GTGAGGGGCC TGGTGTGCTG CCTCTACCCG CCGGGAGCCT TTGTGTCTGT GTCCCGGGAT 
CGGACCACCC GCCTCTGGGC TCCAGACAGT CCTAACAGGG GCTTTACAGA AATGCACTGT 
ATGAGCGGCC ACTCTAATTT TGTGTCTTGT GTGTGTATCA TACCCTCAAG TGACATATAT 
CCTCATGGAC TGATTGCCAC TGGAGGAAAT GACCACAATA TTTGCATTTT CTCGCTGGAC 
AGTCCAATGC CACTTTATAT TTTAAAGGGT CACAAAGATA CTGTTTGTAG TCTTTCTTCT 
GGAAAATTTG GGACATTACT TAGTGGCTCA TGGGACACCA CTGCTAAAGT CTGGCTGAAT 
GACAAATGCA TGATGACATT ACAGGGTCAT ACAGCCGCAG TATGGGCAGT AAAGATTTTA 
CCTGAACAGG GCTTAATGCT AACTGGATCA GCAGACAAGA CCATTAAACT ATGGAAGGCT 
GGAAGATGTG AGAGGACTTT TTTAGGGCAT GAAGACTGTG TAAGAGGCTT GGCAATCTTG 
AGTGAGACAG AATTTCTTTC CTGTGCAAAC GATGCTAGTA TTAGAAGGTG GCAGATCACT 
GGCGAGTGTC TGGAAGTATA CTTTGGACAT ACAAATTATA TTTATAGCAT ATCTGTCTTT 
CCAAACTCCA AAGATTTTGT GACCACTGCA GAAGACAGAT CTCTAAGAAT ATGGAAACAT 
GGTGAATGCG CCCAAACAAT CCGACTTCCA GCTCAGTCTA TATGGTGTTG CTGCGTACTG 
GAAAATGGTG ACATTGTGGT TGGTGCGAGT GATGGTATTA TTAGGGTGTT TACAGAGTCA 
GAGGAGCGGA CAGCAAGTGC TGAGGAAATC AAAGCTTTTG AGAGAGAGCT CTCTCAGGCA 
ACTATCGATT CCAAAACTGG TGACTTGGGG GATATTAATG CGGAGCAGCT TCCTGGGAGG 
GAACATCTCA GTGAGCCAGG TACTAGAGAA GGACAGACTC GTCTAATCAG AGATGGAGAG 
AGAGTTGAAG CCTATCAGTG GAGTGTTAGT GACGGGAGGT GGATAAAAAT TGGTGATGTT 
GTTGGCTCAT CTGGTGCTAA TCAGCAAACA TCTGGAAAAG TTTTATATGA AGGGAAAGAA 
TTTGATTATG TTTTCTCAAT CGATGTGAAT GAAGGTGGAC CATCGTATAA ATTACCATAT 
AATGTCAGTG ACGATCCCTG GCTAGTTGCA TACAACTTCT TGCAGAAAAA TGATTTGAAT 
CCCATGTTTC TGGATCAGGT GGCTAAATTT ATTATTGATA ACACAAAAGG TCAAACACTG 
GGACTTGGGA ATACCAGTTT TTCAGATCCG TTTACAGGTG GTGGTCGCTA TGTTCCAGGA 
ACTTCAGGAC CTTCCAACAC AGTGCAGACA GCAGATCCTT TCACAGGTGC TGGGCGTTAC 
ATGCCAGGTT CTGCAGGTAT GGACACCACC ATGACTGGAG TTGATCCATT TACAGGGAAC 
AGTGCCTACC GATCAGCTGC ATCTAAAACA GTGAACATTT ATTTCCCCAA AAAAGAAGCT 
CTTACCTTTG ACCAAGCAAA CCCTACACAA ATATTAGGAA AACTGAAGGA ACTTAATGGA 
ACTGCACCTG AAGAGAAGAA GCTAACTGAA GACGACTTAG TACTTCTTGA AAAGATACTG 
TCCCTGATTT GTAATAATTC CTCAGAAAAG CCAACGGCCC AGCAACTTCA GATTTTGTGG 
AAAGCTATCA ACTGGCCTGA AGACATTGTC TTTCCTGCAC TTGACATTCT TCGCCTATCG 
ATTAAGCATC CCAATGTGAA TGAGAATTTC TGCAATGAAA AAGGAGACCA GTTCAGCAGC 
CATCTTATCA ACCTTCTGAA CCCCAAAGGA AAGCCAGCAA ACCAGCTGCT TGCTCTTAGG 
ACTTTTTGCA ATTGCTTTGT TAGTCAGGCA GGACAAAAGC TCATGATGTC CCAGAGGGAG 
TCACTGATGT CACATGCAAT AGAACTGAAA TCCGGGAGTA ATAAGAACAT TCATATTGCT 
CTGGCTACAT TGACCTTGAA CTATTCTGTT TGTTTCCATA AAGACCATAA CATTGAAGGG 
AAAGCTCAAT GCCTCTCAGT AATTAGCACA ATCTTGGAAG TTGTGCAAGA CCTAGAAGCC 
ACGTTTAGAC TCCTTGTGGC TCTTGGGACA CTTATCAGTG ATGATTCAAA TGCTATACAA 
TTAGCCAAAT CTTTAGGTGT TGATTCTCAA ATAAAAAAGT ATGTCTCCGT ATCAGAGCCA 
GCTAAAGTGA GTGAATGCTG TAGACTTGTC TTACATTTGC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_766283.2
CDS	223..2607
Translation	MASGASRYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKAGRCERTFLGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYFGHTNYIYSISVFPNSKDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLENGDIVVGASDGIIRVFTESEERTASAEEIKAFERELSQATIDSKTGDLGDINAEQLPGREHLSEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMDTTMTGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGTAPEEKKLTEDDLVLLEKILSLICNNSSEKPTAQQLQILWKAINWPEDIVFPALDILRLSIKHPNVNENFCNEKGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLEATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYVSVSEPAKVSECCRLVLHLL

Target ORF information:

RefSeq Version	NM_172695.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus phospholipase A2, activating protein (Plaa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172695.2

ORF Insert Sequence:

ATGGCGAGCG GCGCCTCCAG ATACCGGCTG AGCTGCTCGC TCCCGGGCCA CGAACTGGAC 
GTGAGGGGCC TGGTGTGCTG CCTCTACCCG CCGGGAGCCT TTGTGTCTGT GTCCCGGGAT 
CGGACCACCC GCCTCTGGGC TCCAGACAGT CCTAACAGGG GCTTTACAGA AATGCACTGT 
ATGAGCGGCC ACTCTAATTT TGTGTCTTGT GTGTGTATCA TACCCTCAAG TGACATATAT 
CCTCATGGAC TGATTGCCAC TGGAGGAAAT GACCACAATA TTTGCATTTT CTCGCTGGAC 
AGTCCAATGC CACTTTATAT TTTAAAGGGT CACAAAGATA CTGTTTGTAG TCTTTCTTCT 
GGAAAATTTG GGACATTACT TAGTGGCTCA TGGGACACCA CTGCTAAAGT CTGGCTGAAT 
GACAAATGCA TGATGACATT ACAGGGTCAT ACAGCCGCAG TATGGGCAGT AAAGATTTTA 
CCTGAACAGG GCTTAATGCT AACTGGATCA GCAGACAAGA CCATTAAACT ATGGAAGGCT 
GGAAGATGTG AGAGGACTTT TTTAGGGCAT GAAGACTGTG TAAGAGGCTT GGCAATCTTG 
AGTGAGACAG AATTTCTTTC CTGTGCAAAC GATGCTAGTA TTAGAAGGTG GCAGATCACT 
GGCGAGTGTC TGGAAGTATA CTTTGGACAT ACAAATTATA TTTATAGCAT ATCTGTCTTT 
CCAAACTCCA AAGATTTTGT GACCACTGCA GAAGACAGAT CTCTAAGAAT ATGGAAACAT 
GGTGAATGCG CCCAAACAAT CCGACTTCCA GCTCAGTCTA TATGGTGTTG CTGCGTACTG 
GAAAATGGTG ACATTGTGGT TGGTGCGAGT GATGGTATTA TTAGGGTGTT TACAGAGTCA 
GAGGAGCGGA CAGCAAGTGC TGAGGAAATC AAAGCTTTTG AGAGAGAGCT CTCTCAGGCA 
ACTATCGATT CCAAAACTGG TGACTTGGGG GATATTAATG CGGAGCAGCT TCCTGGGAGG 
GAACATCTCA GTGAGCCAGG TACTAGAGAA GGACAGACTC GTCTAATCAG AGATGGAGAG 
AGAGTTGAAG CCTATCAGTG GAGTGTTAGT GACGGGAGGT GGATAAAAAT TGGTGATGTT 
GTTGGCTCAT CTGGTGCTAA TCAGCAAACA TCTGGAAAAG TTTTATATGA AGGGAAAGAA 
TTTGATTATG TTTTCTCAAT CGATGTGAAT GAAGGTGGAC CATCGTATAA ATTACCATAT 
AATGTCAGTG ACGATCCCTG GCTAGTTGCA TACAACTTCT TGCAGAAAAA TGATTTGAAT 
CCCATGTTTC TGGATCAGGT GGCTAAATTT ATTATTGATA ACACAAAAGG TCAAACACTG 
GGACTTGGGA ATACCAGTTT TTCAGATCCG TTTACAGGTG GTGGTCGCTA TGTTCCAGGA 
ACTTCAGGAC CTTCCAACAC AGTGCAGACA GCAGATCCTT TCACAGGTGC TGGGCGTTAC 
ATGCCAGGTT CTGCAGGTAT GGACACCACC ATGACTGGAG TTGATCCATT TACAGGGAAC 
AGTGCCTACC GATCAGCTGC ATCTAAAACA GTGAACATTT ATTTCCCCAA AAAAGAAGCT 
CTTACCTTTG ACCAAGCAAA CCCTACACAA ATATTAGGAA AACTGAAGGA ACTTAATGGA 
ACTGCACCTG AAGAGAAGAA GCTAACTGAA GACGACTTAG TACTTCTTGA AAAGATACTG 
TCCCTGATTT GTAATAATTC CTCAGAAAAG CCAACGGCCC AGCAACTTCA GATTTTGTGG 
AAAGCTATCA ACTGGCCTGA AGACATTGTC TTTCCTGCAC TTGACATTCT TCGCCTATCG 
ATTAAGCATC CCAATGTGAA TGAGAATTTC TGCAATGAAA AAGGAGACCA GTTCAGCAGC 
CATCTTATCA ACCTTCTGAA CCCCAAAGGA AAGCCAGCAA ACCAGCTGCT TGCTCTTAGG 
ACTTTTTGCA ATTGCTTTGT TAGTCAGGCA GGACAAAAGC TCATGATGTC CCAGAGGGAG 
TCACTGATGT CACATGCAAT AGAACTGAAA TCCGGGAGTA ATAAGAACAT TCATATTGCT 
CTGGCTACAT TGACCTTGAA CTATTCTGTT TGTTTCCATA AAGACCATAA CATTGAAGGG 
AAAGCTCAAT GCCTCTCAGT AATTAGCACA ATCTTGGAAG TTGTGCAAGA CCTAGAAGCC 
ACGTTTAGAC TCCTTGTGGC TCTTGGGACA CTTATCAGTG ATGATTCAAA TGCTATACAA 
TTAGCCAAAT CTTTAGGTGT TGATTCTCAA ATAAAAAAGT ATGTCTCCGT ATCAGAGCCA 
GCTAAAGTGA GTGAATGCTG TAGACTTGTC TTACATTTGC TGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
American journal of human genetics100(5)706-724(2017 May)
Hall EA,Nahorski MS,Murray LM,Shaheen R,Perkins E,Dissanayake KN,Kristaryanto Y,Jones RA,Vogt J,Rivagorda M,Handley MT,Mali GR,Quidwai T,Soares DC,Keighren MA,McKie L,Mort RL,Gammoh N,Garcia-Munoz A,Davey T,Vermeren M,Walsh D,Budd P,Aligianis IA,Faqeih E,Quigley AJ,Jackson IJ,Kulathu Y,Jackson M,Ribchester RR,von Kriegsheim A,Alkuraya FS,Woods CG,Maher ER,Mill P

Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy.
Brain : a journal of neurology140(2)370-386(2017 02)
Falik Zaccai TC,Savitzki D,Zivony-Elboum Y,Vilboux T,Fitts EC,Shoval Y,Kalfon L,Samra N,Keren Z,Gross B,Chasnyk N,Straussberg R,Mullikin JC,Teer JK,Geiger D,Kornitzer D,Bitterman-Deutsch O,Samson AO,Wakamiya M,Peterson JW,Kirtley ML,Pinchuk IV,Baze WB,Gahl WA,Kleta R,Anikster Y,Chopra AK

Phospholipase A2 activating protein is required for 1α,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3.
The Journal of steroid biochemistry and molecular biology132(1-2)48-56(2012 Oct)
Doroudi M,Schwartz Z,Boyan BD

miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
Anesthesiology117(3)626-38(2012 Sep)
Sun Y,Li XQ,Sahbaie P,Shi XY,Li WW,Liang DY,Clark JD

An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation.
Proceedings of the National Academy of Sciences of the United States of America106(38)16197-202(2009 Sep)
Zhao G,Li G,Schindelin H,Lennarz WJ

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Plaa cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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