Padi4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Padi4
Entrez Gene ID	18602
Full Name	peptidyl arginine deiminase, type IV
Synonyms	Pad4,Pdi4
General protein information	Preferred Names peptidyl arginine deiminase, type IV Names protein-arginine deiminase type-4 PAD type IV peptidylarginine deiminase IV protein-arginine deiminase type IV
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D3\|4 72.34 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006538633.2	XP_006538696.1	protein-arginine deiminase type-4 isoform X1
NM_011061.2	NP_035191.2	protein-arginine deiminase type-4

Pathways from BioSystems

Homologies

Bos taurus (cattle)	PADI4	NP_001179102.1
Homo sapiens (human)	PADI4	NP_036519.2
Pan troglodytes (chimpanzee)	PADI4	XP_513116.3
Mus musculus (house mouse)	Padi4	NP_035191.2
Macaca mulatta (Rhesus monkey)	PADI4	XP_002802253.1
Canis lupus familiaris (dog)	PADI4	XP_848494.1
Rattus norvegicus (Norway rat)	Padi4	NP_058923.1

Gene Ontology
Bibliography

Related articles in PubMed

Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth.
Yazdani HO, Roy E, Comerci AJ, van der Windt DJ, Zhang H, Huang H, Loughran P, Shiva S, Geller DA, Bartlett DL, Tsung A, Sheng T, Simmons RL, Tohme S
Cancer research79(21)5626-5639(2019 Nov)

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia.
Perdomo J, Leung HHL, Ahmadi Z, Yan F, Chong JJH, Passam FH, Chong BH
Nature communications10(1)1322(2019 03)

Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction.
Eghbalzadeh K, Georgi L, Louis T, Zhao H, Keser U, Weber C, Mollenhauer M, Conforti A, Wahlers T, Paunel-Görgülü A
Frontiers in immunology102313(2019)

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
Lee W, Ko SY, Mohamed MS, Kenny HA, Lengyel E, Naora H
The Journal of experimental medicine216(1)176-194(2019 01)

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Yuzhalin AE, Gordon-Weeks AN, Tognoli ML, Jones K, Markelc B, Konietzny R, Fischer R, Muth A, O'Neill E, Thompson PR, Venables PJ, Kessler BM, Lim SY, Muschel RJ
Nature communications9(1)4783(2018 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Padi4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Padi4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu34046	XM_006538633.2 Latest version!	Mus musculus peptidyl arginine deiminase, type IV (Padi4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OMu22043	NM_011061.2 Latest version!	Mus musculus peptidyl arginine deiminase, type IV (Padi4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Padi4 ( XM_006538633.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006538696.1 Mus musculus peptidyl arginine deiminase, type IV (Padi4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu34046
Clone ID Related Accession (Same CDS sequence)	XM_006538633.2
Accession Version	XM_006538633.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2004bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	protein-arginine deiminase type-4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006538633.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCCAAG GCGCGGTGAT CCACGTGGCC CCCGAGCAGC CCACTCACGC CGTGTGTGTG 
GTGGGCACAG CGACCCCGCT GGATGTCCGC GGTTCTGCTC CTAAGGGCTA CACAACCTTC 
GGCATCACAG CCTCTCCAGG AGTCATCGTA GATGTCATCC ATGGTCCTCC AGTCAAGAAG 
AGTACCATGG GGGCCTCCAA ATGGCCTCTG GACCCTGAGC TGGAGGTGAC CCTACAGGTG 
AAAGCAGCCA GCAGCAGAAC AGATGATGAA AAGGTTCGAG TTTCATACTA TGGACCCAAG 
ACCTCCCCAG TCCAAGCCCT GATCTACATC ACTGGGGTGG AACTGTCCCT GAGCGCAGAT 
GTCACCCGCA CAGGCAGAGT GAAGCCAGCC CAAGCCGGGA AGGATCAGAG CACCTGGACC 
TGGGGCCCGG GCGGCCGTGG CGCCATCCTG TTGGTGAACT GTGACAAAGA GGACCCTCAG 
GCCTCCGGAA TGGACTTTGA GGATGACAAG ATCTTGGACA ACAAAGACCT GCAGGACATG 
TCTCCAATGA CCCTAAGCAC GAAGACGCCC AAAGACTTCT TTGAAAAGTA TCAGCTGGTG 
TTGGAGGTGC CCAAGGCCAA GATGAACAGA GTGAGAGTCT TCCGGGCCAC ACGGGGCAAA 
CTGCCGTCCC GGTACAAGGT GGCCCTGGGA CCACAACAGT TCTCGTATTG CCTGGAGCTG 
CCCGGCGGCC AGCACAGCAC AGACTTCTAT GTGGAAGGCC TTGCTTTCCC AGACGCAGAC 
TTCAAAGGGC TCATTCCCCT CACCATCTCC CTGCTGGACA AGTCTAACCC GGAGCTCCCC 
GAGGCCCTGG TGTTCCAAGA CAGTGTGACG TTCCGTGTGG CCCCCTGGAT CATGACCCCC 
AACACTCAGC CCCCCCAGGA GGTGTACGTG TGCAGGGTTT CTGACAATGA AGACTTCCTA 
AAGTCACTAG CTACTCTGAC CAAGAAAGCC AAGTGCAAGC TGACTGTGTG CCCCGAGGAG 
GAGAATATAG ATGACCAATG GATGCAGGAC GAAATGGAGA TTGGCTACAT CCAGGCCCCA 
CACAAGACGC TGCCTGTGGT CTTTGACTCC CCGAGGGACA GAGGCCTGAA GGATTTCCCT 
GTCAAGCGAG TTATGGGTCC AAATTTTGGC TATGTGACCC GAAAGCTCTA TATGTCAGAG 
CTCACTGGGC TGGATGCCTT TGGGAACCTG GAGGTGAGTC CCCCAGTCAC TGTCAGAGGG 
AAGGAGTACC CACTGGGCAG AATTCTCATC GGGAATAGCG GTTACTCCAG CAGCGAGAGC 
CGGGACATGC ACCAGGCCCT GCAGGACTTC CTGAGCGCCC AGCAGGTGCA GGCCCCCGTG 
AGGCTCTTCT CCGATTGGCT CTTTGTGGGT CACGTGGATG AGTTCTTGAG CTTTGTCCCA 
GCGCGGGACA AGCAGCAGGG TTTTCGGCTG CTGCTGTCCA GCCCCAGAGC TTGCTATCAG 
CTGTTCCAGG AGCTACAGAG CCAGGGCCAC GGGGAGGCGA CACTGTTCGA AGGACTCAAG 
AGGAAAAGGC AGACAATCAA TGAAATTCTG TCCAACAAGA AATTAAGAGA CCAGAATGCC 
TATGTGGAGA GCTGTATCGA CTGGAACCGG GCGGTGCTGA AGCGGGAGCT GGGCCTGGCA 
GAGGGTGACA TCATCGACAT TCCGCAGCTC TTCAAGCTCG CGGGGAACTC CAGAGGGAAC 
TCTAAGGCCC AGGCCTTCTT CCCAAACATG GTGAACATGC TGGTCCTGGG CAAGTACCTG 
GGCATCCCCA AGCCCTTTGG GCCCATCATC GATGGCCACT GCTGCCTGGA GGAGGAGGTG 
CGTTCCCACC TGGAGCCGCT GGGTCTGCAC TGCACCTTCA TCAACGACTT CTACACCTAC 
CACGTGTACA ACGGGGAGGT TCACTGTGGC ACCAATGTGC GCAGGAAGCC CTTCACCTTC 
AAGTGGTGGC ACATGGTGCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006538696.1
CDS	60..2063
Translation	MAQGAVIHVAPEQPTHAVCVVGTATPLDVRGSAPKGYTTFGITASPGVIVDVIHGPPVKKSTMGASKWPLDPELEVTLQVKAASSRTDDEKVRVSYYGPKTSPVQALIYITGVELSLSADVTRTGRVKPAQAGKDQSTWTWGPGGRGAILLVNCDKEDPQASGMDFEDDKILDNKDLQDMSPMTLSTKTPKDFFEKYQLVLEVPKAKMNRVRVFRATRGKLPSRYKVALGPQQFSYCLELPGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDSVTFRVAPWIMTPNTQPPQEVYVCRVSDNEDFLKSLATLTKKAKCKLTVCPEEENIDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRKLYMSELTGLDAFGNLEVSPPVTVRGKEYPLGRILIGNSGYSSSESRDMHQALQDFLSAQQVQAPVRLFSDWLFVGHVDEFLSFVPARDKQQGFRLLLSSPRACYQLFQELQSQGHGEATLFEGLKRKRQTINEILSNKKLRDQNAYVESCIDWNRAVLKRELGLAEGDIIDIPQLFKLAGNSRGNSKAQAFFPNMVNMLVLGKYLGIPKPFGPIIDGHCCLEEEVRSHLEPLGLHCTFINDFYTYHVYNGEVHCGTNVRRKPFTFKWWHMVP

Target ORF information:

RefSeq Version	XM_006538633.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus peptidyl arginine deiminase, type IV (Padi4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006538633.2

ORF Insert Sequence:

ATGGCCCAAG GCGCGGTGAT CCACGTGGCC CCCGAGCAGC CCACTCACGC CGTGTGTGTG 
GTGGGCACAG CGACCCCGCT GGATGTCCGC GGTTCTGCTC CTAAGGGCTA CACAACCTTC 
GGCATCACAG CCTCTCCAGG AGTCATCGTA GATGTCATCC ATGGTCCTCC AGTCAAGAAG 
AGTACCATGG GGGCCTCCAA ATGGCCTCTG GACCCTGAGC TGGAGGTGAC CCTACAGGTG 
AAAGCAGCCA GCAGCAGAAC AGATGATGAA AAGGTTCGAG TTTCATACTA TGGACCCAAG 
ACCTCCCCAG TCCAAGCCCT GATCTACATC ACTGGGGTGG AACTGTCCCT GAGCGCAGAT 
GTCACCCGCA CAGGCAGAGT GAAGCCAGCC CAAGCCGGGA AGGATCAGAG CACCTGGACC 
TGGGGCCCGG GCGGCCGTGG CGCCATCCTG TTGGTGAACT GTGACAAAGA GGACCCTCAG 
GCCTCCGGAA TGGACTTTGA GGATGACAAG ATCTTGGACA ACAAAGACCT GCAGGACATG 
TCTCCAATGA CCCTAAGCAC GAAGACGCCC AAAGACTTCT TTGAAAAGTA TCAGCTGGTG 
TTGGAGGTGC CCAAGGCCAA GATGAACAGA GTGAGAGTCT TCCGGGCCAC ACGGGGCAAA 
CTGCCGTCCC GGTACAAGGT GGCCCTGGGA CCACAACAGT TCTCGTATTG CCTGGAGCTG 
CCCGGCGGCC AGCACAGCAC AGACTTCTAT GTGGAAGGCC TTGCTTTCCC AGACGCAGAC 
TTCAAAGGGC TCATTCCCCT CACCATCTCC CTGCTGGACA AGTCTAACCC GGAGCTCCCC 
GAGGCCCTGG TGTTCCAAGA CAGTGTGACG TTCCGTGTGG CCCCCTGGAT CATGACCCCC 
AACACTCAGC CCCCCCAGGA GGTGTACGTG TGCAGGGTTT CTGACAATGA AGACTTCCTA 
AAGTCACTAG CTACTCTGAC CAAGAAAGCC AAGTGCAAGC TGACTGTGTG CCCCGAGGAG 
GAGAATATAG ATGACCAATG GATGCAGGAC GAAATGGAGA TTGGCTACAT CCAGGCCCCA 
CACAAGACGC TGCCTGTGGT CTTTGACTCC CCGAGGGACA GAGGCCTGAA GGATTTCCCT 
GTCAAGCGAG TTATGGGTCC AAATTTTGGC TATGTGACCC GAAAGCTCTA TATGTCAGAG 
CTCACTGGGC TGGATGCCTT TGGGAACCTG GAGGTGAGTC CCCCAGTCAC TGTCAGAGGG 
AAGGAGTACC CACTGGGCAG AATTCTCATC GGGAATAGCG GTTACTCCAG CAGCGAGAGC 
CGGGACATGC ACCAGGCCCT GCAGGACTTC CTGAGCGCCC AGCAGGTGCA GGCCCCCGTG 
AGGCTCTTCT CCGATTGGCT CTTTGTGGGT CACGTGGATG AGTTCTTGAG CTTTGTCCCA 
GCGCGGGACA AGCAGCAGGG TTTTCGGCTG CTGCTGTCCA GCCCCAGAGC TTGCTATCAG 
CTGTTCCAGG AGCTACAGAG CCAGGGCCAC GGGGAGGCGA CACTGTTCGA AGGACTCAAG 
AGGAAAAGGC AGACAATCAA TGAAATTCTG TCCAACAAGA AATTAAGAGA CCAGAATGCC 
TATGTGGAGA GCTGTATCGA CTGGAACCGG GCGGTGCTGA AGCGGGAGCT GGGCCTGGCA 
GAGGGTGACA TCATCGACAT TCCGCAGCTC TTCAAGCTCG CGGGGAACTC CAGAGGGAAC 
TCTAAGGCCC AGGCCTTCTT CCCAAACATG GTGAACATGC TGGTCCTGGG CAAGTACCTG 
GGCATCCCCA AGCCCTTTGG GCCCATCATC GATGGCCACT GCTGCCTGGA GGAGGAGGTG 
CGTTCCCACC TGGAGCCGCT GGGTCTGCAC TGCACCTTCA TCAACGACTT CTACACCTAC 
CACGTGTACA ACGGGGAGGT TCACTGTGGC ACCAATGTGC GCAGGAAGCC CTTCACCTTC 
AAGTGGTGGC ACATGGTGCC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Padi4 ( NM_011061.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035191.2 Mus musculus peptidyl arginine deiminase, type IV (Padi4), mRNA.

Price & Availability↑

CloneID	OMu22043
Clone ID Related Accession (Same CDS sequence)	NM_011061.2
Accession Version	NM_011061.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2001bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577030400000
Organism	Mus musculus(house mouse)
Product	protein-arginine deiminase type-4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK137625.1, AB013850.1, AI645912.1 and BY544067.1. On Sep 6, 2007 this sequence version replaced NM_011061.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK137625.1, AB013850.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGCCCAAG GCGCGGTGAT CCACGTGGCC CCCGAGCAGC CCACTCACGC CGTGTGTGTG 
GTGGGCACAG CGACCCCGCT GGATGTCCGC GGTTCTGCTC CTAAGGGCTA CACAACCTTC 
GGCATCACAG CCTCTCCAGG AGTCATCGTA GATGTCATCC ATGGTCCTCC AGTCAAGAAG 
AGTACCATGG GGGCCTCCAA ATGGCCTCTG GACCCTGAGC TGGAGGTGAC CCTACAGGTG 
AAAGCAGCCA GCAGCAGAAC AGATGATGAA AAGGTTCGAG TTTCATACTA TGGACCCAAG 
ACCTCCCCAG TCCAAGCCCT GATCTACATC ACTGGGGTGG AACTGTCCCT GAGCGCAGAT 
GTCACCCGCA CAGGCAGAGT GAAGCCAGCC CAAGCCGGGA AGGATCAGAG CACCTGGACC 
TGGGGCCCGG GCGGCCGTGG CGCCATCCTG TTGGTGAACT GTGACAAAGA GGACCCTCAG 
GCCTCCGGAA TGGACTTTGA GGATGACAAG ATCTTGGACA ACAAAGACCT GCAGGACATG 
TCTCCAATGA CCCTAAGCAC GAAGACGCCC AAAGACTTCT TTGAAAAGTA TCAGCTGGTG 
TTGGAGGTGC CCAAGGCCAA GATGAACAGA GTGAGAGTCT TCCGGGCCAC ACGGGGCAAA 
CTGCCGTCCC GGTACAAGGT GGCCCTGGGA CCACAACAGT TCTCGTATTG CCTGGAGCTG 
CCCGGCGGCC AGCACAGCAC AGACTTCTAT GTGGAAGGCC TTGCTTTCCC AGACGCAGAC 
TTCAAAGGGC TCATTCCCCT CACCATCTCC CTGCTGGACA AGTCTAACCC GGAGCTCCCC 
GAGGCCCTGG TGTTCCAAGA CAGTGTGACG TTCCGTGTGG CCCCCTGGAT CATGACCCCC 
AACACTCAGC CCCCCCAGGA GGTGTACGTG TGCAGGGTTT CTGACAATGA AGACTTCCTA 
AAGTCACTAG CTACTCTGAC CAAGAAAGCC AAGTGCAAGC TGACTGTGTG CCCCGAGGAG 
GAGAATATAG ATGACCAATG GATGCAGGAC GAAATGGAGA TTGGCTACAT CCAGGCCCCA 
CACAAGACGC TGCCTGTGGT CTTTGACTCC CCGAGGGACA GAGGCCTGAA GGATTTCCCT 
GTCAAGCGAG TTATGGGTCC AAATTTTGGC TATGTGACCC GAAAGCTCTA TATGTCAGAG 
CTCACTGGGC TGGATGCCTT TGGGAACCTG GAGGTGAGTC CCCCAGTCAC TGTCAGAGGG 
AAGGAGTACC CACTGGGCAG AATTCTCATC GGGAATAGCG GTTACTCCAG CAGCGAGAGC 
CGGGACATGC ACCAGGCCCT GCAGGACTTC CTGAGCGCCC AGCAGGTGCA GGCCCCCGTG 
AGGCTCTTCT CCGATTGGCT CTTTGTGGGT CACGTGGATG AGTTCTTGAG CTTTGTCCCA 
GCGCGGGACA AGCAGGGTTT TCGGCTGCTG CTGTCCAGCC CCAGAGCTTG CTATCAGCTG 
TTCCAGGAGC TACAGAGCCA GGGCCACGGG GAGGCGACAC TGTTCGAAGG ACTCAAGAGG 
AAAAGGCAGA CAATCAATGA AATTCTGTCC AACAAGAAAT TAAGAGACCA GAATGCCTAT 
GTGGAGAGCT GTATCGACTG GAACCGGGCG GTGCTGAAGC GGGAGCTGGG CCTGGCAGAG 
GGTGACATCA TCGACATTCC GCAGCTCTTC AAGCTCGCGG GGAACTCCAG AGGGAACTCT 
AAGGCCCAGG CCTTCTTCCC AAACATGGTG AACATGCTGG TCCTGGGCAA GTACCTGGGC 
ATCCCCAAGC CCTTTGGGCC CATCATCGAT GGCCACTGCT GCCTGGAGGA GGAGGTGCGT 
TCCCACCTGG AGCCGCTGGG TCTGCACTGC ACCTTCATCA ACGACTTCTA CACCTACCAC 
GTGTACAACG GGGAGGTTCA CTGTGGCACC AATGTGCGCA GGAAGCCCTT CACCTTCAAG 
TGGTGGCACA TGGTGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035191.2
CDS	24..2024
Translation	MAQGAVIHVAPEQPTHAVCVVGTATPLDVRGSAPKGYTTFGITASPGVIVDVIHGPPVKKSTMGASKWPLDPELEVTLQVKAASSRTDDEKVRVSYYGPKTSPVQALIYITGVELSLSADVTRTGRVKPAQAGKDQSTWTWGPGGRGAILLVNCDKEDPQASGMDFEDDKILDNKDLQDMSPMTLSTKTPKDFFEKYQLVLEVPKAKMNRVRVFRATRGKLPSRYKVALGPQQFSYCLELPGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDSVTFRVAPWIMTPNTQPPQEVYVCRVSDNEDFLKSLATLTKKAKCKLTVCPEEENIDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRKLYMSELTGLDAFGNLEVSPPVTVRGKEYPLGRILIGNSGYSSSESRDMHQALQDFLSAQQVQAPVRLFSDWLFVGHVDEFLSFVPARDKQGFRLLLSSPRACYQLFQELQSQGHGEATLFEGLKRKRQTINEILSNKKLRDQNAYVESCIDWNRAVLKRELGLAEGDIIDIPQLFKLAGNSRGNSKAQAFFPNMVNMLVLGKYLGIPKPFGPIIDGHCCLEEEVRSHLEPLGLHCTFINDFYTYHVYNGEVHCGTNVRRKPFTFKWWHMVP

Target ORF information:

RefSeq Version	NM_011061.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus peptidyl arginine deiminase, type IV (Padi4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011061.2

ORF Insert Sequence:

ATGGCCCAAG GCGCGGTGAT CCACGTGGCC CCCGAGCAGC CCACTCACGC CGTGTGTGTG 
GTGGGCACAG CGACCCCGCT GGATGTCCGC GGTTCTGCTC CTAAGGGCTA CACAACCTTC 
GGCATCACAG CCTCTCCAGG AGTCATCGTA GATGTCATCC ATGGTCCTCC AGTCAAGAAG 
AGTACCATGG GGGCCTCCAA ATGGCCTCTG GACCCTGAGC TGGAGGTGAC CCTACAGGTG 
AAAGCAGCCA GCAGCAGAAC AGATGATGAA AAGGTTCGAG TTTCATACTA TGGACCCAAG 
ACCTCCCCAG TCCAAGCCCT GATCTACATC ACTGGGGTGG AACTGTCCCT GAGCGCAGAT 
GTCACCCGCA CAGGCAGAGT GAAGCCAGCC CAAGCCGGGA AGGATCAGAG CACCTGGACC 
TGGGGCCCGG GCGGCCGTGG CGCCATCCTG TTGGTGAACT GTGACAAAGA GGACCCTCAG 
GCCTCCGGAA TGGACTTTGA GGATGACAAG ATCTTGGACA ACAAAGACCT GCAGGACATG 
TCTCCAATGA CCCTAAGCAC GAAGACGCCC AAAGACTTCT TTGAAAAGTA TCAGCTGGTG 
TTGGAGGTGC CCAAGGCCAA GATGAACAGA GTGAGAGTCT TCCGGGCCAC ACGGGGCAAA 
CTGCCGTCCC GGTACAAGGT GGCCCTGGGA CCACAACAGT TCTCGTATTG CCTGGAGCTG 
CCCGGCGGCC AGCACAGCAC AGACTTCTAT GTGGAAGGCC TTGCTTTCCC AGACGCAGAC 
TTCAAAGGGC TCATTCCCCT CACCATCTCC CTGCTGGACA AGTCTAACCC GGAGCTCCCC 
GAGGCCCTGG TGTTCCAAGA CAGTGTGACG TTCCGTGTGG CCCCCTGGAT CATGACCCCC 
AACACTCAGC CCCCCCAGGA GGTGTACGTG TGCAGGGTTT CTGACAATGA AGACTTCCTA 
AAGTCACTAG CTACTCTGAC CAAGAAAGCC AAGTGCAAGC TGACTGTGTG CCCCGAGGAG 
GAGAATATAG ATGACCAATG GATGCAGGAC GAAATGGAGA TTGGCTACAT CCAGGCCCCA 
CACAAGACGC TGCCTGTGGT CTTTGACTCC CCGAGGGACA GAGGCCTGAA GGATTTCCCT 
GTCAAGCGAG TTATGGGTCC AAATTTTGGC TATGTGACCC GAAAGCTCTA TATGTCAGAG 
CTCACTGGGC TGGATGCCTT TGGGAACCTG GAGGTGAGTC CCCCAGTCAC TGTCAGAGGG 
AAGGAGTACC CACTGGGCAG AATTCTCATC GGGAATAGCG GTTACTCCAG CAGCGAGAGC 
CGGGACATGC ACCAGGCCCT GCAGGACTTC CTGAGCGCCC AGCAGGTGCA GGCCCCCGTG 
AGGCTCTTCT CCGATTGGCT CTTTGTGGGT CACGTGGATG AGTTCTTGAG CTTTGTCCCA 
GCGCGGGACA AGCAGGGTTT TCGGCTGCTG CTGTCCAGCC CCAGAGCTTG CTATCAGCTG 
TTCCAGGAGC TACAGAGCCA GGGCCACGGG GAGGCGACAC TGTTCGAAGG ACTCAAGAGG 
AAAAGGCAGA CAATCAATGA AATTCTGTCC AACAAGAAAT TAAGAGACCA GAATGCCTAT 
GTGGAGAGCT GTATCGACTG GAACCGGGCG GTGCTGAAGC GGGAGCTGGG CCTGGCAGAG 
GGTGACATCA TCGACATTCC GCAGCTCTTC AAGCTCGCGG GGAACTCCAG AGGGAACTCT 
AAGGCCCAGG CCTTCTTCCC AAACATGGTG AACATGCTGG TCCTGGGCAA GTACCTGGGC 
ATCCCCAAGC CCTTTGGGCC CATCATCGAT GGCCACTGCT GCCTGGAGGA GGAGGTGCGT 
TCCCACCTGG AGCCGCTGGG TCTGCACTGC ACCTTCATCA ACGACTTCTA CACCTACCAC 
GTGTACAACG GGGAGGTTCA CTGTGGCACC AATGTGCGCA GGAAGCCCTT CACCTTCAAG 
TGGTGGCACA TGGTGCCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth.
Cancer research79(21)5626-5639(2019 Nov)
Yazdani HO,Roy E,Comerci AJ,van der Windt DJ,Zhang H,Huang H,Loughran P,Shiva S,Geller DA,Bartlett DL,Tsung A,Sheng T,Simmons RL,Tohme S

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia.
Nature communications10(1)1322(2019 03)
Perdomo J,Leung HHL,Ahmadi Z,Yan F,Chong JJH,Passam FH,Chong BH

Compromised Anti-inflammatory Action of Neutrophil Extracellular Traps in PAD4-Deficient Mice Contributes to Aggravated Acute Inflammation After Myocardial Infarction.
Frontiers in immunology102313(2019)
Eghbalzadeh K,Georgi L,Louis T,Zhao H,Keser U,Weber C,Mollenhauer M,Conforti A,Wahlers T,Paunel-Görgülü A

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
The Journal of experimental medicine216(1)176-194(2019 01)
Lee W,Ko SY,Mohamed MS,Kenny HA,Lengyel E,Naora H

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Nature communications9(1)4783(2018 11)
Yuzhalin AE,Gordon-Weeks AN,Tognoli ML,Jones K,Markelc B,Konietzny R,Fischer R,Muth A,O'Neill E,Thompson PR,Venables PJ,Kessler BM,Lim SY,Muschel RJ

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Padi4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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