Nfkbib cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfkbib
Entrez Gene ID	18036
Full Name	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
Synonyms	I(Kappa)B(beta),I-kappa-B-beta,IKB-beta,IKappaBbeta,IkB,IkBb,NF-kappa-BIB,ikB-B
General protein information	Preferred Names nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Names NF-kappa-B inhibitor beta nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 B1
Summary	This gene encodes an inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB). The encoded protein prevents NF-kappaB-mediated transcription activation by sequestering it in the cytosol. In response to signals that induce NF-kappaB, such as cytokines and growth factors, the encoded protein undergoes phosphorylation, triggering its rapid ubiquitination and proteasomal degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001306222.1	NP_001293151.1	NF-kappa-B inhibitor beta
NM_010908.5	NP_035038.2	NF-kappa-B inhibitor beta

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Nfkbib	NP_110494.2
Pan troglodytes (chimpanzee)	NFKBIB	XP_001168499.1
Mus musculus (house mouse)	Nfkbib	NP_035038.2
Macaca mulatta (Rhesus monkey)	NFKBIB	XP_001085582.1
Bos taurus (cattle)	NFKBIB	NP_001069340.1
Danio rerio (zebrafish)	si:dkeyp-110c7.1	NP_001122267.1
Homo sapiens (human)	NFKBIB	NP_002494.2
Canis lupus familiaris (dog)	NFKBIB	XP_541633.1
Gallus gallus (chicken)	NFKBIB	XP_003643552.1

Gene Ontology
Bibliography

Related articles in PubMed

Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages.
McKenna S, Gossling M, Bugarini A, Hill E, Anderson AL, Rancourt RC, Balasubramaniyan N, El Kasmi KC, Wright CJ
Journal of immunology (Baltimore, Md. : 1950)195(8)3866-79(2015 Oct)

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer.
Tsui R, Kearns JD, Lynch C, Vu D, Ngo KA, Basak S, Ghosh G, Hoffmann A
Nature communications67068(2015 May)

Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation.
Ariestanti DM, Ando H, Hirose S, Nakamura N
The Journal of biological chemistry290(17)11032-40(2015 Apr)

Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development.
Lin JC, Lin SC, Chen WY, Yen YT, Lai CW, Tao MH, Lin YL, Miaw SC, Wu-Hsieh BA
Journal of immunology (Baltimore, Md. : 1950)193(3)1258-67(2014 Aug)

IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury.
Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ
American journal of respiratory cell and molecular biology50(2)429-38(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Nfkbib gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfkbib cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19334	NM_001306222.1 Latest version!	Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta (Nfkbib), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu19334	NM_010908.5 Latest version!	Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta (Nfkbib), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfkbib ( NM_001306222.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001293151.1 Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta (Nfkbib), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu19334
Clone ID Related Accession (Same CDS sequence)	NM_001306222.1 , NM_010908.5
Accession Version	NM_001306222.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1564848000000
Organism	Mus musculus(house mouse)
Product	NF-kappa-B inhibitor beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC171210.1, AK038631.1, AK010218.1 and BM899229.1. On Apr 28, 2015 this sequence version replaced XM_006539613.2. Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY176059.1, BC021938.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCGGGG TCGCGTGCTT GGGGAAAACT GCGGATGCCG ATGAATGGTG CGACAGCGGC 
CTGGGCTCTC TAGGTCCCGA CGCAGCGGCT CCCGGAGGAC CAGGTCTGGG CGCAGAGCTT 
GGCCCAGAGC TGTCGTGGGC GCCCTTAGTC TTTGGCTACG TCACTGAGGA TGGGGACACA 
GCCCTGCACT TGGCTGTGAT TCATCAGCAT GAGCCCTTCC TGGATTTCCT CCTGGGCTTC 
TCCGCCGGCA CCGAGTACCT TGACCTGCAG AATGACCTAG GCCAAACAGC CCTGCATCTA 
GCAGCCATCC TTGGGGAGGC ATCTACAGTA GAGAAGTTGT ATGCAGCCGG TGCAGGAGTG 
TTGGTGGCTG AGAGAGGGGG CCACACGGCA TTGCACTTGG CCTGCCGGGT CAGGGCACAC 
ACGTGCGCGT GCGTACTGCT CCAGCCCCGT CCCAGCCACC CAAGAGATGC CTCAGATACC 
TACCTCACTC AGAGCCAGGA CTGTACCCCA GACACCAGCC ATGCCCCTGC TGCCGTGGAT 
TCCCAACCCA ACCCAGAGAA CGAAGAGGAG CCGCGTGATG AAGACTGGAG GCTACAACTA 
GAAGCTGAAA ACTATGATGG CCATACCCCA CTCCATGTAG CTGTCATCCA CAAAGATGCA 
GAGATGGTCC GGCTGCTCAG GGATGCCGGA GCCGACCTCA ATAAACCGGA GCCTACGTGT 
GGCCGGACCC CTCTGCACCT GGCAGTAGAA GCCCAGGCAG CCAGCGTGCT GGAACTTCTC 
CTGAAAGCCG GTGCTGACCC CACCGCCCGC ATGTATGGGG GCCGCACCCC GCTTGGCAGT 
GCCCTGCTCC GGCCCAACCC CATCCTTGCC CGCCTCCTCC GTGCACATGG GGCCCCTGAA 
CCTGAGGACG AGGACGATAA GCTTAGCCCT TGCAGCAGCA GCGGCAGCGA CAGTGACAGT 
GACAACAGAG ATGAGGGCGA TGAATATGAT GACATCGTGG TTCACAGTGG CAGGAGCCAA 
AACCGACAAC CGCCTTCCCC GGCATCCAAA CCTCTTCCTG ATGACCCCAA CCCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001293151.1
CDS	223..1302
Translation	MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLGAELGPELSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVAERGGHTALHLACRVRAHTCACVLLQPRPSHPRDASDTYLTQSQDCTPDTSHAPAAVDSQPNPENEEEPRDEDWRLQLEAENYDGHTPLHVAVIHKDAEMVRLLRDAGADLNKPEPTCGRTPLHLAVEAQAASVLELLLKAGADPTARMYGGRTPLGSALLRPNPILARLLRAHGAPEPEDEDDKLSPCSSSGSDSDSDNRDEGDEYDDIVVHSGRSQNRQPPSPASKPLPDDPNPA

Target ORF information:

RefSeq Version	NM_001306222.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta (Nfkbib), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001306222.1

ORF Insert Sequence:

ATGGCCGGGG TCGCGTGCTT GGGGAAAACT GCGGATGCCG ATGAATGGTG CGACAGCGGC 
CTGGGCTCTC TAGGTCCCGA CGCAGCGGCT CCCGGAGGAC CAGGTCTGGG CGCAGAGCTT 
GGCCCAGAGC TGTCGTGGGC GCCCTTAGTC TTTGGCTACG TCACTGAGGA TGGGGACACA 
GCCCTGCACT TGGCTGTGAT TCATCAGCAT GAGCCCTTCC TGGATTTCCT CCTGGGCTTC 
TCCGCCGGCA CCGAGTACCT TGACCTGCAG AATGACCTAG GCCAAACAGC CCTGCATCTA 
GCAGCCATCC TTGGGGAGGC ATCTACAGTA GAGAAGTTGT ATGCAGCCGG TGCAGGAGTG 
TTGGTGGCTG AGAGAGGGGG CCACACGGCA TTGCACTTGG CCTGCCGGGT CAGGGCACAC 
ACGTGCGCGT GCGTACTGCT CCAGCCCCGT CCCAGCCACC CAAGAGATGC CTCAGATACC 
TACCTCACTC AGAGCCAGGA CTGTACCCCA GACACCAGCC ATGCCCCTGC TGCCGTGGAT 
TCCCAACCCA ACCCAGAGAA CGAAGAGGAG CCGCGTGATG AAGACTGGAG GCTACAACTA 
GAAGCTGAAA ACTATGATGG CCATACCCCA CTCCATGTAG CTGTCATCCA CAAAGATGCA 
GAGATGGTCC GGCTGCTCAG GGATGCCGGA GCCGACCTCA ATAAACCGGA GCCTACGTGT 
GGCCGGACCC CTCTGCACCT GGCAGTAGAA GCCCAGGCAG CCAGCGTGCT GGAACTTCTC 
CTGAAAGCCG GTGCTGACCC CACCGCCCGC ATGTATGGGG GCCGCACCCC GCTTGGCAGT 
GCCCTGCTCC GGCCCAACCC CATCCTTGCC CGCCTCCTCC GTGCACATGG GGCCCCTGAA 
CCTGAGGACG AGGACGATAA GCTTAGCCCT TGCAGCAGCA GCGGCAGCGA CAGTGACAGT 
GACAACAGAG ATGAGGGCGA TGAATATGAT GACATCGTGG TTCACAGTGG CAGGAGCCAA 
AACCGACAAC CGCCTTCCCC GGCATCCAAA CCTCTTCCTG ATGACCCCAA CCCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nfkbib ( NM_010908.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035038.2 Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta (Nfkbib), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu19334
Clone ID Related Accession (Same CDS sequence)	NM_001306222.1 , NM_010908.5
Accession Version	NM_010908.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577462400000
Organism	Mus musculus(house mouse)
Product	NF-kappa-B inhibitor beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC171210.1 and AK038631.1. On Apr 28, 2015 this sequence version replaced NM_010908.4. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK038631.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

ATGGCCGGGG TCGCGTGCTT GGGGAAAACT GCGGATGCCG ATGAATGGTG CGACAGCGGC 
CTGGGCTCTC TAGGTCCCGA CGCAGCGGCT CCCGGAGGAC CAGGTCTGGG CGCAGAGCTT 
GGCCCAGAGC TGTCGTGGGC GCCCTTAGTC TTTGGCTACG TCACTGAGGA TGGGGACACA 
GCCCTGCACT TGGCTGTGAT TCATCAGCAT GAGCCCTTCC TGGATTTCCT CCTGGGCTTC 
TCCGCCGGCA CCGAGTACCT TGACCTGCAG AATGACCTAG GCCAAACAGC CCTGCATCTA 
GCAGCCATCC TTGGGGAGGC ATCTACAGTA GAGAAGTTGT ATGCAGCCGG TGCAGGAGTG 
TTGGTGGCTG AGAGAGGGGG CCACACGGCA TTGCACTTGG CCTGCCGGGT CAGGGCACAC 
ACGTGCGCGT GCGTACTGCT CCAGCCCCGT CCCAGCCACC CAAGAGATGC CTCAGATACC 
TACCTCACTC AGAGCCAGGA CTGTACCCCA GACACCAGCC ATGCCCCTGC TGCCGTGGAT 
TCCCAACCCA ACCCAGAGAA CGAAGAGGAG CCGCGTGATG AAGACTGGAG GCTACAACTA 
GAAGCTGAAA ACTATGATGG CCATACCCCA CTCCATGTAG CTGTCATCCA CAAAGATGCA 
GAGATGGTCC GGCTGCTCAG GGATGCCGGA GCCGACCTCA ATAAACCGGA GCCTACGTGT 
GGCCGGACCC CTCTGCACCT GGCAGTAGAA GCCCAGGCAG CCAGCGTGCT GGAACTTCTC 
CTGAAAGCCG GTGCTGACCC CACCGCCCGC ATGTATGGGG GCCGCACCCC GCTTGGCAGT 
GCCCTGCTCC GGCCCAACCC CATCCTTGCC CGCCTCCTCC GTGCACATGG GGCCCCTGAA 
CCTGAGGACG AGGACGATAA GCTTAGCCCT TGCAGCAGCA GCGGCAGCGA CAGTGACAGT 
GACAACAGAG ATGAGGGCGA TGAATATGAT GACATCGTGG TTCACAGTGG CAGGAGCCAA 
AACCGACAAC CGCCTTCCCC GGCATCCAAA CCTCTTCCTG ATGACCCCAA CCCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035038.2
CDS	223..1302
Translation	MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLGAELGPELSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAAILGEASTVEKLYAAGAGVLVAERGGHTALHLACRVRAHTCACVLLQPRPSHPRDASDTYLTQSQDCTPDTSHAPAAVDSQPNPENEEEPRDEDWRLQLEAENYDGHTPLHVAVIHKDAEMVRLLRDAGADLNKPEPTCGRTPLHLAVEAQAASVLELLLKAGADPTARMYGGRTPLGSALLRPNPILARLLRAHGAPEPEDEDDKLSPCSSSGSDSDSDNRDEGDEYDDIVVHSGRSQNRQPPSPASKPLPDDPNPA

Target ORF information:

RefSeq Version	NM_010908.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta (Nfkbib), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010908.5

ORF Insert Sequence:

ATGGCCGGGG TCGCGTGCTT GGGGAAAACT GCGGATGCCG ATGAATGGTG CGACAGCGGC 
CTGGGCTCTC TAGGTCCCGA CGCAGCGGCT CCCGGAGGAC CAGGTCTGGG CGCAGAGCTT 
GGCCCAGAGC TGTCGTGGGC GCCCTTAGTC TTTGGCTACG TCACTGAGGA TGGGGACACA 
GCCCTGCACT TGGCTGTGAT TCATCAGCAT GAGCCCTTCC TGGATTTCCT CCTGGGCTTC 
TCCGCCGGCA CCGAGTACCT TGACCTGCAG AATGACCTAG GCCAAACAGC CCTGCATCTA 
GCAGCCATCC TTGGGGAGGC ATCTACAGTA GAGAAGTTGT ATGCAGCCGG TGCAGGAGTG 
TTGGTGGCTG AGAGAGGGGG CCACACGGCA TTGCACTTGG CCTGCCGGGT CAGGGCACAC 
ACGTGCGCGT GCGTACTGCT CCAGCCCCGT CCCAGCCACC CAAGAGATGC CTCAGATACC 
TACCTCACTC AGAGCCAGGA CTGTACCCCA GACACCAGCC ATGCCCCTGC TGCCGTGGAT 
TCCCAACCCA ACCCAGAGAA CGAAGAGGAG CCGCGTGATG AAGACTGGAG GCTACAACTA 
GAAGCTGAAA ACTATGATGG CCATACCCCA CTCCATGTAG CTGTCATCCA CAAAGATGCA 
GAGATGGTCC GGCTGCTCAG GGATGCCGGA GCCGACCTCA ATAAACCGGA GCCTACGTGT 
GGCCGGACCC CTCTGCACCT GGCAGTAGAA GCCCAGGCAG CCAGCGTGCT GGAACTTCTC 
CTGAAAGCCG GTGCTGACCC CACCGCCCGC ATGTATGGGG GCCGCACCCC GCTTGGCAGT 
GCCCTGCTCC GGCCCAACCC CATCCTTGCC CGCCTCCTCC GTGCACATGG GGCCCCTGAA 
CCTGAGGACG AGGACGATAA GCTTAGCCCT TGCAGCAGCA GCGGCAGCGA CAGTGACAGT 
GACAACAGAG ATGAGGGCGA TGAATATGAT GACATCGTGG TTCACAGTGG CAGGAGCCAA 
AACCGACAAC CGCCTTCCCC GGCATCCAAA CCTCTTCCTG ATGACCCCAA CCCTGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages.
Journal of immunology (Baltimore, Md. : 1950)195(8)3866-79(2015 Oct)
McKenna S,Gossling M,Bugarini A,Hill E,Anderson AL,Rancourt RC,Balasubramaniyan N,El Kasmi KC,Wright CJ

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer.
Nature communications67068(2015 May)
Tsui R,Kearns JD,Lynch C,Vu D,Ngo KA,Basak S,Ghosh G,Hoffmann A

Targeted Disruption of Ig-Hepta/Gpr116 Causes Emphysema-like Symptoms That Are Associated with Alveolar Macrophage Activation.
The Journal of biological chemistry290(17)11032-40(2015 Apr)
Ariestanti DM,Ando H,Hirose S,Nakamura N

Dengue viral protease interaction with NF-κB inhibitor α/β results in endothelial cell apoptosis and hemorrhage development.
Journal of immunology (Baltimore, Md. : 1950)193(3)1258-67(2014 Aug)
Lin JC,Lin SC,Chen WY,Yen YT,Lai CW,Tao MH,Lin YL,Miaw SC,Wu-Hsieh BA

IκBβ-mediated NF-κB activation confers protection against hyperoxic lung injury.
American journal of respiratory cell and molecular biology50(2)429-38(2014 Feb)
Michaelis KA,Agboke F,Liu T,Han K,Muthu M,Galambos C,Yang G,Dennery PA,Wright CJ

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Nfkbib cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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