Sik1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sik1
Entrez Gene ID	17691
Full Name	salt inducible kinase 1
Synonyms	Hrt-20,Msk,Sik,Sik-1,Snf1lk
General protein information	Preferred Names salt inducible kinase 1 Names serine/threonine-protein kinase SIK1 Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase) SNF1-like kinase myocardial SNF1-like kinase salt-inducible protein kinase 1 serine/threonine-protein kinase SNF1-like kinase 1 serine/threonine-protein kinase SNF1LK
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 17.25 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010831.2	NP_034961.2	serine/threonine-protein kinase SIK1
NM_010831.3	NP_034961.2	serine/threonine-protein kinase SIK1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SIK1	XP_544912.4
Rattus norvegicus (Norway rat)	Sik1	NP_067725.2
Bos taurus (cattle)	SIK1	XP_002685202.2
Mus musculus (house mouse)	Sik1	NP_034961.2
Gallus gallus (chicken)	SIK1	NP_990013.1
Pan troglodytes (chimpanzee)	SIK1	XP_531484.2
Macaca mulatta (Rhesus monkey)	SIK1	XP_002803160.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptional analysis of Foxp3+ Tregs and functions of two identified molecules during resolution of ALI.
Mock JR, Dial CF, Tune MK, Norton DL, Martin JR, Gomez JC, Hagan RS, Dang H, Doerschuk CM
JCI insight4(6)(2019 Mar)

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Paulo E, Wu D, Wang Y, Zhang Y, Wu Y, Swaney DL, Soucheray M, Jimenez-Morales D, Chawla A, Krogan NJ, Wang B
Scientific reports8(1)11001(2018 Jul)

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, Screaton RA, Sakamoto K, Ryan DP, Mino-Kenudson M, Castillo CF, Nomura DK, Haas W, Bardeesy N
Nature cell biology20(7)811-822(2018 07)

Salt-Inducible Kinase 1 (SIK1) is Induced by Alcohol and Suppresses Microglia Inflammation via NF-κB Signaling.
Zhang Y, Gao W, Yang K, Tao H, Yang H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology47(4)1411-1421(2018)

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.
Darling NJ, Toth R, Arthur JS, Clark K
The Biochemical journal474(4)521-537(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sik1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sik1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06981	NM_010831.3 Latest version!	Mus musculus salt inducible kinase 1 (Sik1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$391.30 $559.00
View Old Accession Versions >>
OMu06981	NM_010831.2	Mus musculus salt inducible kinase 1 (Sik1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sik1 ( NM_010831.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034961.2 Mus musculus salt inducible kinase 1 (Sik1), mRNA.

Price & Availability↑

CloneID	OMu06981
Clone ID Related Accession (Same CDS sequence)	NM_010831.2 , NM_010831.3
Accession Version	NM_010831.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2340bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1423843200000
Organism	Mus musculus(House mouse)
Product	serine/threonine-protein kinase SIK1
Comment

ATGGTGATCA TGTCGGAGTT CAGTGCGGTC CCCTCAGGCA CTGGCCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGCTTTTA CGACGTGGAA CGGACCCTGG GCAAAGGCAA TTTTGCAGTG 
GTTAAGCTGG CGCGGCACCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGACAAG 
ACACGGTTAG ATTCTAGCAA TCTGGAGAAG ATCTACCGGG AGGTCCAGCT CATGAAACTT 
TTGAACCACC CAAATATCAT CAAGCTTTAT CAGGTTATGG AGACAAAGGA TATGCTCTAC 
ATTGTCACAG AATTTGCAAA AAATGGAGAA ATGTTTGATT ATCTGACTTC CAACGGGCAC 
TTGAGTGAAA ACGAGGCTAG GCAGAAGTTC TGGCAGATTC TGTCAGCCGT GGAGTACTGC 
CACAACCACC ACATTGTCCA CCGGGACCTC AAGACGGAGA ACCTGCTCCT GGACAGCAAC 
ATGGATATCA AGCTAGCAGA TTTTGGATTT GGGAATTTCT ACAAGCCAGG CGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCA GCCCCTGAAG TCTTCGAGGG GAAGGAGTAC 
GAGGGTCCCC AGCTGGACGT CTGGAGCCTC GGTGTGGTGC TGTACGTCCT GGTCTGTGGC 
TCCCTCCCCT TCGACGGGCC CAACCTGCCT ACGCTGAGAC AGCGGGTACT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGACGC TGATCAGACG CATGCTGGTC 
GTGGACCCCG CTAAGCGCAT CACCATAGCC CAGATCCGCC AGCACCGGTG GATGCAGGCC 
GACCCCACTC TCCTGCAGCA GGATGACCCT GCCTTCGACA TGCAAGGCTA CACCTCCAAC 
CTGGGCGACT ACAACGAACA GGTGCTAGGG ATCATGCAGG CCCTCGGCAT CGACCGGCAG 
CGGACTATAG AGTCTCTGCA GAACAGCAGC TACAACCACT TTGCCGCCAT TTACTACCTC 
CTACTCGAGC GCCTCAAGGA GCATCGAAGC GCCCAGCCCT CATCCCGGCC CACCCCTGCA 
CCCACCAGAC AGCCCCAGCT CCGAAGCTCA GACCTCAGCA GTCTGGAGGT TCCTCAAGAA 
ATTCTCCCGT GTGACCCTTT CCGGCCCTCT CTGCTGTGCC CACAGCCCCA GGCCTTGGCT 
CAGTCTGTCC TGCAGGCTGA GATAGACTGT GATCTCCACA GCTCACTTCA GCCCTTATTA 
TTCCCCCTGG ATACCAACTG CAGTGGAGTG TTCCGGCACC GATCCATCTC CCCCAGCAGT 
CTGCTGGACA CAGCTATCAG CGAGGAGGCC AGGCAGGGTC CCAGCCTAGA GGAGGAACAG 
GAGGTCCAGG AACCCCTGCC CGGAAGCACA GGCCGGAGGC ACACATTGGC TGAAGTCTCC 
ACCCATTTCT CCCCGCTCAA CCCTCCTTGC ATAATTGTCT CCTCCTCTGC CACGGCGAGT 
CCCTCGGAAG GGACCAGCTC CGACAGCTGC CTCCCCTTCT CTGCAAGTGA AGGTCCTGCA 
GGGCTTGGCA GTGGCCTGGC CACCCCAGGG CTGCTGGGCA CCAGCTCTCC AGTCAGATTG 
GCCTCGCCCT TCCTGGGATC ACAGTCAGCC ACCCCTGTGC TCCAGACTCA GGCAGGTCTG 
GGCACAGCCG TCTTACCTCC CGTCAGCTTC CAGGAGGGAC GGAGAGCGTC TGATACCTCT 
CTCACTCAGG GGCTGAAGGC CTTCCGGCAG CAGCTGAGGA AAAATGCGAG GACCAAGGGG 
TTCCTGGGAC TGAACAAGAT CAAAGGGTTG GCTCGCCAGG TGTGCCAGTC CTCCGTCCGA 
ACTCCCCGGG GAGGGATGAG TACCTTCCAC ACCCCAGCCC CAAGCTCCGG CCTGCAAGGC 
TGCACGACCA GCAATCGGGA GGGCAGGAGC CTACTTGAAG AGGTCCTGCA CCAGCAGAGG 
CTGCTCCAGT TACAGCACCA CTCTTCTACC GCCGCCGCCT CATCTGGCTG CCAGCAGGGC 
CCCCAGCTGT CCCCGGTCCC CTATGTGCTT GCTCCCTGTG ACAGCCTCCT CGTGTCTGGA 
ATTCCACTGC TGCCAACACC CCTTCTCCAG GCTGGCATGT CCCCTGTGGC GTCTGCTGCG 
CATCTCCTGG ATACCCACTT GCACATCAGT GCTGGCCCAG TGGCCCTCCC CACTGGGCCC 
CTGCCACAGT GCCTCACCAG GCTGTCCCCA GGCTGTGATC CAGCTGGGCT GCCACAGGGG 
GACTGTGAGA TGGAGGACCT GACCTCTGGC CAGCGGGGGA CATTCGTCCT GGTACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_034961.2

Translation

MVIMSEFSAVPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADPTLLQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGIDRQRTIESLQNSSYNHFAAIYYLLLERLKEHRSAQPSSRPTPAPTRQPQLRSSDLSSLEVPQEILPCDPFRPSLLCPQPQALAQSVLQAEIDCDLHSSLQPLLFPLDTNCSGVFRHRSISPSSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPPCIIVSSSATASPSEGTSSDSCLPFSASEGPAGLGSGLATPGLLGTSSPVRLASPFLGSQSATPVLQTQAGLGTAVLPPVSFQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVCQSSVRTPRGGMSTFHTPAPSSGLQGCTTSNREGRSLLEEVLHQQRLLQLQHHSSTAAASSGCQQGPQLSPVPYVLAPCDSLLVSGIPLLPTPLLQAGMSPVASAAHLLDTHLHISAGPVALPTGPLPQCLTRLSPGCDPAGLPQGDCEMEDLTSGQRGTFVLVQ

Target ORF information:

RefSeq Version	NM_010831.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus salt inducible kinase 1 (Sik1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010831.2

ORF Insert Sequence:

ATGGTGATCA TGTCGGAGTT CAGTGCGGTC CCCTCAGGCA CTGGCCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGCTTTTA CGACGTGGAA CGGACCCTGG GCAAAGGCAA TTTTGCAGTG 
GTTAAGCTGG CGCGGCACCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGACAAG 
ACACGGTTAG ATTCTAGCAA TCTGGAGAAG ATCTACCGGG AGGTCCAGCT CATGAAACTT 
TTGAACCACC CAAATATCAT CAAGCTTTAT CAGGTTATGG AGACAAAGGA TATGCTCTAC 
ATTGTCACAG AATTTGCAAA AAATGGAGAA ATGTTTGATT ATCTGACTTC CAACGGGCAC 
TTGAGTGAAA ACGAGGCTAG GCAGAAGTTC TGGCAGATTC TGTCAGCCGT GGAGTACTGC 
CACAACCACC ACATTGTCCA CCGGGACCTC AAGACGGAGA ACCTGCTCCT GGACAGCAAC 
ATGGATATCA AGCTAGCAGA TTTTGGATTT GGGAATTTCT ACAAGCCAGG CGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCA GCCCCTGAAG TCTTCGAGGG GAAGGAGTAC 
GAGGGTCCCC AGCTGGACGT CTGGAGCCTC GGTGTGGTGC TGTACGTCCT GGTCTGTGGC 
TCCCTCCCCT TCGACGGGCC CAACCTGCCT ACGCTGAGAC AGCGGGTACT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGACGC TGATCAGACG CATGCTGGTC 
GTGGACCCCG CTAAGCGCAT CACCATAGCC CAGATCCGCC AGCACCGGTG GATGCAGGCC 
GACCCCACTC TCCTGCAGCA GGATGACCCT GCCTTCGACA TGCAAGGCTA CACCTCCAAC 
CTGGGCGACT ACAACGAACA GGTGCTAGGG ATCATGCAGG CCCTCGGCAT CGACCGGCAG 
CGGACTATAG AGTCTCTGCA GAACAGCAGC TACAACCACT TTGCCGCCAT TTACTACCTC 
CTACTCGAGC GCCTCAAGGA GCATCGAAGC GCCCAGCCCT CATCCCGGCC CACCCCTGCA 
CCCACCAGAC AGCCCCAGCT CCGAAGCTCA GACCTCAGCA GTCTGGAGGT TCCTCAAGAA 
ATTCTCCCGT GTGACCCTTT CCGGCCCTCT CTGCTGTGCC CACAGCCCCA GGCCTTGGCT 
CAGTCTGTCC TGCAGGCTGA GATAGACTGT GATCTCCACA GCTCACTTCA GCCCTTATTA 
TTCCCCCTGG ATACCAACTG CAGTGGAGTG TTCCGGCACC GATCCATCTC CCCCAGCAGT 
CTGCTGGACA CAGCTATCAG CGAGGAGGCC AGGCAGGGTC CCAGCCTAGA GGAGGAACAG 
GAGGTCCAGG AACCCCTGCC CGGAAGCACA GGCCGGAGGC ACACATTGGC TGAAGTCTCC 
ACCCATTTCT CCCCGCTCAA CCCTCCTTGC ATAATTGTCT CCTCCTCTGC CACGGCGAGT 
CCCTCGGAAG GGACCAGCTC CGACAGCTGC CTCCCCTTCT CTGCAAGTGA AGGTCCTGCA 
GGGCTTGGCA GTGGCCTGGC CACCCCAGGG CTGCTGGGCA CCAGCTCTCC AGTCAGATTG 
GCCTCGCCCT TCCTGGGATC ACAGTCAGCC ACCCCTGTGC TCCAGACTCA GGCAGGTCTG 
GGCACAGCCG TCTTACCTCC CGTCAGCTTC CAGGAGGGAC GGAGAGCGTC TGATACCTCT 
CTCACTCAGG GGCTGAAGGC CTTCCGGCAG CAGCTGAGGA AAAATGCGAG GACCAAGGGG 
TTCCTGGGAC TGAACAAGAT CAAAGGGTTG GCTCGCCAGG TGTGCCAGTC CTCCGTCCGA 
ACTCCCCGGG GAGGGATGAG TACCTTCCAC ACCCCAGCCC CAAGCTCCGG CCTGCAAGGC 
TGCACGACCA GCAATCGGGA GGGCAGGAGC CTACTTGAAG AGGTCCTGCA CCAGCAGAGG 
CTGCTCCAGT TACAGCACCA CTCTTCTACC GCCGCCGCCT CATCTGGCTG CCAGCAGGGC 
CCCCAGCTGT CCCCGGTCCC CTATGTGCTT GCTCCCTGTG ACAGCCTCCT CGTGTCTGGA 
ATTCCACTGC TGCCAACACC CCTTCTCCAG GCTGGCATGT CCCCTGTGGC GTCTGCTGCG 
CATCTCCTGG ATACCCACTT GCACATCAGT GCTGGCCCAG TGGCCCTCCC CACTGGGCCC 
CTGCCACAGT GCCTCACCAG GCTGTCCCCA GGCTGTGATC CAGCTGGGCT GCCACAGGGG 
GACTGTGAGA TGGAGGACCT GACCTCTGGC CAGCGGGGGA CATTCGTCCT GGTACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sik1 ( NM_010831.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034961.2 Mus musculus salt inducible kinase 1 (Sik1), mRNA.

Price & Availability↑

CloneID	OMu06981
Clone ID Related Accession (Same CDS sequence)	NM_010831.2 , NM_010831.3
Accession Version	NM_010831.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2340bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568044800000
Organism	Mus musculus(house mouse)
Product	serine/threonine-protein kinase SIK1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC166654.1 and AK141817.1. On Jan 24, 2017 this sequence version replaced NM_010831.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK141817.1, U11494.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGATCA TGTCGGAGTT CAGTGCGGTC CCCTCAGGCA CTGGCCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGCTTTTA CGACGTGGAA CGGACCCTGG GCAAAGGCAA TTTTGCAGTG 
GTTAAGCTGG CGCGGCACCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGACAAG 
ACACGGTTAG ATTCTAGCAA TCTGGAGAAG ATCTACCGGG AGGTCCAGCT CATGAAACTT 
TTGAACCACC CAAATATCAT CAAGCTTTAT CAGGTTATGG AGACAAAGGA TATGCTCTAC 
ATTGTCACAG AATTTGCAAA AAATGGAGAA ATGTTTGATT ATCTGACTTC CAACGGGCAC 
TTGAGTGAAA ACGAGGCTAG GCAGAAGTTC TGGCAGATTC TGTCAGCCGT GGAGTACTGC 
CACAACCACC ACATTGTCCA CCGGGACCTC AAGACGGAGA ACCTGCTCCT GGACAGCAAC 
ATGGATATCA AGCTAGCAGA TTTTGGATTT GGGAATTTCT ACAAGCCAGG CGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCA GCCCCTGAAG TCTTCGAGGG GAAGGAGTAC 
GAGGGTCCCC AGCTGGACGT CTGGAGCCTC GGTGTGGTGC TGTACGTCCT GGTCTGTGGC 
TCCCTCCCCT TCGACGGGCC CAACCTGCCT ACGCTGAGAC AGCGGGTACT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGACGC TGATCAGACG CATGCTGGTC 
GTGGACCCCG CTAAGCGCAT CACCATAGCC CAGATCCGCC AGCACCGGTG GATGCAGGCC 
GACCCCACTC TCCTGCAGCA GGATGACCCT GCCTTCGACA TGCAAGGCTA CACCTCCAAC 
CTGGGCGACT ACAACGAACA GGTGCTAGGG ATCATGCAGG CCCTCGGCAT CGACCGGCAG 
CGGACTATAG AGTCTCTGCA GAACAGCAGC TACAACCACT TTGCCGCCAT TTACTACCTC 
CTACTCGAGC GCCTCAAGGA GCATCGAAGC GCCCAGCCCT CATCCCGGCC CACCCCTGCA 
CCCACCAGAC AGCCCCAGCT CCGAAGCTCA GACCTCAGCA GTCTGGAGGT TCCTCAAGAA 
ATTCTCCCGT GTGACCCTTT CCGGCCCTCT CTGCTGTGCC CACAGCCCCA GGCCTTGGCT 
CAGTCTGTCC TGCAGGCTGA GATAGACTGT GATCTCCACA GCTCACTTCA GCCCTTATTA 
TTCCCCCTGG ATACCAACTG CAGTGGAGTG TTCCGGCACC GATCCATCTC CCCCAGCAGT 
CTGCTGGACA CAGCTATCAG CGAGGAGGCC AGGCAGGGTC CCAGCCTAGA GGAGGAACAG 
GAGGTCCAGG AACCCCTGCC CGGAAGCACA GGCCGGAGGC ACACATTGGC TGAAGTCTCC 
ACCCATTTCT CCCCGCTCAA CCCTCCTTGC ATAATTGTCT CCTCCTCTGC CACGGCGAGT 
CCCTCGGAAG GGACCAGCTC CGACAGCTGC CTCCCCTTCT CTGCAAGTGA AGGTCCTGCA 
GGGCTTGGCA GTGGCCTGGC CACCCCAGGG CTGCTGGGCA CCAGCTCTCC AGTCAGATTG 
GCCTCGCCCT TCCTGGGATC ACAGTCAGCC ACCCCTGTGC TCCAGACTCA GGCAGGTCTG 
GGCACAGCCG TCTTACCTCC CGTCAGCTTC CAGGAGGGAC GGAGAGCGTC TGATACCTCT 
CTCACTCAGG GGCTGAAGGC CTTCCGGCAG CAGCTGAGGA AAAATGCGAG GACCAAGGGG 
TTCCTGGGAC TGAACAAGAT CAAAGGGTTG GCTCGCCAGG TGTGCCAGTC CTCCGTCCGA 
ACTCCCCGGG GAGGGATGAG TACCTTCCAC ACCCCAGCCC CAAGCTCCGG CCTGCAAGGC 
TGCACGACCA GCAATCGGGA GGGCAGGAGC CTACTTGAAG AGGTCCTGCA CCAGCAGAGG 
CTGCTCCAGT TACAGCACCA CTCTTCTACC GCCGCCGCCT CATCTGGCTG CCAGCAGGGC 
CCCCAGCTGT CCCCGGTCCC CTATGTGCTT GCTCCCTGTG ACAGCCTCCT CGTGTCTGGA 
ATTCCACTGC TGCCAACACC CCTTCTCCAG GCTGGCATGT CCCCTGTGGC GTCTGCTGCG 
CATCTCCTGG ATACCCACTT GCACATCAGT GCTGGCCCAG TGGCCCTCCC CACTGGGCCC 
CTGCCACAGT GCCTCACCAG GCTGTCCCCA GGCTGTGATC CAGCTGGGCT GCCACAGGGG 
GACTGTGAGA TGGAGGACCT GACCTCTGGC CAGCGGGGGA CATTCGTCCT GGTACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034961.2
CDS	149..2488
Translation	MVIMSEFSAVPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADPTLLQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGIDRQRTIESLQNSSYNHFAAIYYLLLERLKEHRSAQPSSRPTPAPTRQPQLRSSDLSSLEVPQEILPCDPFRPSLLCPQPQALAQSVLQAEIDCDLHSSLQPLLFPLDTNCSGVFRHRSISPSSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLAEVSTHFSPLNPPCIIVSSSATASPSEGTSSDSCLPFSASEGPAGLGSGLATPGLLGTSSPVRLASPFLGSQSATPVLQTQAGLGTAVLPPVSFQEGRRASDTSLTQGLKAFRQQLRKNARTKGFLGLNKIKGLARQVCQSSVRTPRGGMSTFHTPAPSSGLQGCTTSNREGRSLLEEVLHQQRLLQLQHHSSTAAASSGCQQGPQLSPVPYVLAPCDSLLVSGIPLLPTPLLQAGMSPVASAAHLLDTHLHISAGPVALPTGPLPQCLTRLSPGCDPAGLPQGDCEMEDLTSGQRGTFVLVQ

Target ORF information:

RefSeq Version	NM_010831.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus salt inducible kinase 1 (Sik1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010831.3

ORF Insert Sequence:

ATGGTGATCA TGTCGGAGTT CAGTGCGGTC CCCTCAGGCA CTGGCCAGGG CCAGCAGAAG 
CCCCTCCGGG TGGGCTTTTA CGACGTGGAA CGGACCCTGG GCAAAGGCAA TTTTGCAGTG 
GTTAAGCTGG CGCGGCACCG AGTCACCAAA ACGCAGGTTG CAATAAAAAT AATTGACAAG 
ACACGGTTAG ATTCTAGCAA TCTGGAGAAG ATCTACCGGG AGGTCCAGCT CATGAAACTT 
TTGAACCACC CAAATATCAT CAAGCTTTAT CAGGTTATGG AGACAAAGGA TATGCTCTAC 
ATTGTCACAG AATTTGCAAA AAATGGAGAA ATGTTTGATT ATCTGACTTC CAACGGGCAC 
TTGAGTGAAA ACGAGGCTAG GCAGAAGTTC TGGCAGATTC TGTCAGCCGT GGAGTACTGC 
CACAACCACC ACATTGTCCA CCGGGACCTC AAGACGGAGA ACCTGCTCCT GGACAGCAAC 
ATGGATATCA AGCTAGCAGA TTTTGGATTT GGGAATTTCT ACAAGCCAGG CGAGCCTCTG 
TCCACGTGGT GTGGGAGCCC CCCGTATGCA GCCCCTGAAG TCTTCGAGGG GAAGGAGTAC 
GAGGGTCCCC AGCTGGACGT CTGGAGCCTC GGTGTGGTGC TGTACGTCCT GGTCTGTGGC 
TCCCTCCCCT TCGACGGGCC CAACCTGCCT ACGCTGAGAC AGCGGGTACT GGAGGGCCGC 
TTCCGCATCC CCTTCTTCAT GTCTCAAGAC TGTGAGACGC TGATCAGACG CATGCTGGTC 
GTGGACCCCG CTAAGCGCAT CACCATAGCC CAGATCCGCC AGCACCGGTG GATGCAGGCC 
GACCCCACTC TCCTGCAGCA GGATGACCCT GCCTTCGACA TGCAAGGCTA CACCTCCAAC 
CTGGGCGACT ACAACGAACA GGTGCTAGGG ATCATGCAGG CCCTCGGCAT CGACCGGCAG 
CGGACTATAG AGTCTCTGCA GAACAGCAGC TACAACCACT TTGCCGCCAT TTACTACCTC 
CTACTCGAGC GCCTCAAGGA GCATCGAAGC GCCCAGCCCT CATCCCGGCC CACCCCTGCA 
CCCACCAGAC AGCCCCAGCT CCGAAGCTCA GACCTCAGCA GTCTGGAGGT TCCTCAAGAA 
ATTCTCCCGT GTGACCCTTT CCGGCCCTCT CTGCTGTGCC CACAGCCCCA GGCCTTGGCT 
CAGTCTGTCC TGCAGGCTGA GATAGACTGT GATCTCCACA GCTCACTTCA GCCCTTATTA 
TTCCCCCTGG ATACCAACTG CAGTGGAGTG TTCCGGCACC GATCCATCTC CCCCAGCAGT 
CTGCTGGACA CAGCTATCAG CGAGGAGGCC AGGCAGGGTC CCAGCCTAGA GGAGGAACAG 
GAGGTCCAGG AACCCCTGCC CGGAAGCACA GGCCGGAGGC ACACATTGGC TGAAGTCTCC 
ACCCATTTCT CCCCGCTCAA CCCTCCTTGC ATAATTGTCT CCTCCTCTGC CACGGCGAGT 
CCCTCGGAAG GGACCAGCTC CGACAGCTGC CTCCCCTTCT CTGCAAGTGA AGGTCCTGCA 
GGGCTTGGCA GTGGCCTGGC CACCCCAGGG CTGCTGGGCA CCAGCTCTCC AGTCAGATTG 
GCCTCGCCCT TCCTGGGATC ACAGTCAGCC ACCCCTGTGC TCCAGACTCA GGCAGGTCTG 
GGCACAGCCG TCTTACCTCC CGTCAGCTTC CAGGAGGGAC GGAGAGCGTC TGATACCTCT 
CTCACTCAGG GGCTGAAGGC CTTCCGGCAG CAGCTGAGGA AAAATGCGAG GACCAAGGGG 
TTCCTGGGAC TGAACAAGAT CAAAGGGTTG GCTCGCCAGG TGTGCCAGTC CTCCGTCCGA 
ACTCCCCGGG GAGGGATGAG TACCTTCCAC ACCCCAGCCC CAAGCTCCGG CCTGCAAGGC 
TGCACGACCA GCAATCGGGA GGGCAGGAGC CTACTTGAAG AGGTCCTGCA CCAGCAGAGG 
CTGCTCCAGT TACAGCACCA CTCTTCTACC GCCGCCGCCT CATCTGGCTG CCAGCAGGGC 
CCCCAGCTGT CCCCGGTCCC CTATGTGCTT GCTCCCTGTG ACAGCCTCCT CGTGTCTGGA 
ATTCCACTGC TGCCAACACC CCTTCTCCAG GCTGGCATGT CCCCTGTGGC GTCTGCTGCG 
CATCTCCTGG ATACCCACTT GCACATCAGT GCTGGCCCAG TGGCCCTCCC CACTGGGCCC 
CTGCCACAGT GCCTCACCAG GCTGTCCCCA GGCTGTGATC CAGCTGGGCT GCCACAGGGG 
GACTGTGAGA TGGAGGACCT GACCTCTGGC CAGCGGGGGA CATTCGTCCT GGTACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptional analysis of Foxp3+ Tregs and functions of two identified molecules during resolution of ALI.
JCI insight4(6)(2019 Mar)
Mock JR,Dial CF,Tune MK,Norton DL,Martin JR,Gomez JC,Hagan RS,Dang H,Doerschuk CM

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Scientific reports8(1)11001(2018 Jul)
Paulo E,Wu D,Wang Y,Zhang Y,Wu Y,Swaney DL,Soucheray M,Jimenez-Morales D,Chawla A,Krogan NJ,Wang B

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Nature cell biology20(7)811-822(2018 07)
Patra KC,Kato Y,Mizukami Y,Widholz S,Boukhali M,Revenco I,Grossman EA,Ji F,Sadreyev RI,Liss AS,Screaton RA,Sakamoto K,Ryan DP,Mino-Kenudson M,Castillo CF,Nomura DK,Haas W,Bardeesy N

Salt-Inducible Kinase 1 (SIK1) is Induced by Alcohol and Suppresses Microglia Inflammation via NF-κB Signaling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology47(4)1411-1421(2018)
Zhang Y,Gao W,Yang K,Tao H,Yang H

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages.
The Biochemical journal474(4)521-537(2017 02)
Darling NJ,Toth R,Arthur JS,Clark K

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Sik1 cDNA ORF clone, Mus musculus(house mouse)

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