Mpl cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mpl
Entrez Gene ID	17480
Full Name	myeloproliferative leukemia virus oncogene
Synonyms	CD110,TPO-R,c-mpl,hlb219
General protein information	Preferred Names myeloproliferative leukemia virus oncogene Names thrombopoietin receptor myeloproliferative leukemia protein proto-oncogene c-Mpl
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 D2.1\|4 54.61 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010823.3	NP_034953.2	thrombopoietin receptor isoform 2 precursor
XM_030253295.1	XP_030109155.1	thrombopoietin receptor isoform X2
NM_001285497.1	NP_001272426.1	thrombopoietin receptor isoform 4 precursor
NM_001122949.2	NP_001116421.1	thrombopoietin receptor isoform 1 precursor
XM_011240468.2	XP_011238770.1	thrombopoietin receptor isoform X1
NM_001285496.1	NP_001272425.1	thrombopoietin receptor isoform 3 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	MPL	XP_002801551.1
Mus musculus (house mouse)	Mpl	NP_001116421.1
Gallus gallus (chicken)	MPL	NP_001001782.1
Bos taurus (cattle)	MPL	NP_001179592.1
Rattus norvegicus (Norway rat)	Mpl	XP_345573.5
Danio rerio (zebrafish)	mpl	NP_001003858.1
Homo sapiens (human)	MPL	NP_005364.1

Gene Ontology
Bibliography

Related articles in PubMed

Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice.
Kohlscheen S, Schenk F, Rommel MGE, Cullmann K, Modlich U
Blood133(13)1465-1478(2019 03)

c-MPL Is a Candidate Surface Marker and Confers Self-Renewal, Quiescence, Chemotherapy Resistance, and Leukemia Initiation Potential in Leukemia Stem Cells.
Li H, Zhao N, Li Y, Xing H, Chen S, Xu Y, Tang K, Tian Z, Wang M, Rao Q, Wang J
Stem cells (Dayton, Ohio)36(11)1685-1696(2018 11)

Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag.
Kao YR, Chen J, Narayanagari SR, Todorova TI, Aivalioti MM, Ferreira M, Ramos PM, Pallaud C, Mantzaris I, Shastri A, Bussel JB, Verma A, Steidl U, Will B
Science translational medicine10(458)(2018 09)

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia.
Kanaji T, Vo MN, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, Yuzuriha A, Eto K, Belani R, Do MH, Yang XL, Ruggeri ZM, Schimmel P
Proceedings of the National Academy of Sciences of the United States of America115(35)E8228-E8235(2018 08)

Identification and characterization of an isoform of murine Mpl.
Sabath DF, Lofton-Day C, Lin N, Lok S, Kaushansky K, Broudy VC
Biochimica et biophysica acta1574(3)383-6(2002 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mpl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mpl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20138	NM_001285497.1 Latest version!	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu68213	XM_011240468.2 Latest version!	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu88458	XM_030253295.1 Latest version!	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu20037	NM_010823.3 Latest version!	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu20123	NM_001285496.1 Latest version!	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu20279	NM_001122949.2 Latest version!	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mpl ( NM_001285497.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001272426.1 Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OMu20138
Clone ID Related Accession (Same CDS sequence)	NM_001285497.1
Accession Version	NM_001285497.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1398bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Mus musculus(house mouse)
Product	thrombopoietin receptor isoform 4 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL627212.21 and AK041166.1. Transcript Variant: This variant (4) lacks two alternate exons, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101943.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849378 [ECO:0000350] ##Evidence-Data-END##

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GGCCTGCCAG CTCCCCCCAG GGTCATCAAG 
GCCAGGGGTG GGAGCCAACC AGGGGAACTT CAGATCCACT GGGAGGCCCC TGCTCCTGAA 
ATCAGTGACT TCCTGAGGCA TGAACTCCGC TATGGCCCCA CGGACTCCAG CAACGCCACT 
GCCCCCTCCG TCATTCAGCT GCTCTCCACA GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGTGA GGACCTCCCC AGCTGGAGAA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGAGAC TGAGGCATGC 
TTTGTGGCCC TCGCTTCCAG ACCTACACCG GGTCCTAGGC CAGTACCTCA GAGACACTGC 
AGCCCTAAGT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272426.1
CDS	43..1440
Translation	MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPVRTSPAGEAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKETEACFVALASRPTPGPRPVPQRHCSPKSF

Target ORF information:

RefSeq Version	NM_001285497.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001285497.1

ORF Insert Sequence:

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GGCCTGCCAG CTCCCCCCAG GGTCATCAAG 
GCCAGGGGTG GGAGCCAACC AGGGGAACTT CAGATCCACT GGGAGGCCCC TGCTCCTGAA 
ATCAGTGACT TCCTGAGGCA TGAACTCCGC TATGGCCCCA CGGACTCCAG CAACGCCACT 
GCCCCCTCCG TCATTCAGCT GCTCTCCACA GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGTGA GGACCTCCCC AGCTGGAGAA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGAGAC TGAGGCATGC 
TTTGTGGCCC TCGCTTCCAG ACCTACACCG GGTCCTAGGC CAGTACCTCA GAGACACTGC 
AGCCCTAAGT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpl ( XM_011240468.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011238770.1 Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu68213
Clone ID Related Accession (Same CDS sequence)	XM_011240468.2
Accession Version	XM_011240468.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1059bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	thrombopoietin receptor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011240468.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGGTAG TGACAATTGG ACTTCAGTGC TTTACCTTGG ATCTGAAGAT GGTCACCTGC 
CAGTGGCAGC AACAAGACCG CACTAGCTCC CAAGGCTTCT TCCGCCACAG CAGGACGAGG 
TGCTGCCCCA CAGACAGGGA CCCCACCTGG GAGAAATGTG AAGAGGAGGA ACCGCGTCCA 
GGATCACAGC CCGCTCTCGT CTCCCGCTGC CACTTCAAGT CACGAAATGA CAGTGTTATT 
CACATCCTTG TAGAGGTGAC CACAGCGCAA GGTGCCGTTC ACAGCTACCT GGGCTCCCCT 
TTTTGGATCC ACCAGGCTGT GCTCCTTCCC ACCCCGAGCC TGCACTGGAG GGAGGTCTCA 
AGTGGAAGGC TGGAGTTGGA GTGGCAGCAC CAGTCATCTT GGGCAGCTCA AGAGACCTGC 
TACCAGCTCC GGTACACGGG AGAAGGCCGT GAGGACTGGA AGGTGCTGGA GCCATCTCTC 
GGTGCCCGGG GAGGGACCCT AGAGCTGCGC CCCCGAGCTC GCTACAGCTT GCAGCTGCGT 
GCCAGGCTCA ACGGCCCCAC CTACCAAGGT CCCTGGAGCG CCTGGTCTCC CCCAGCTAGG 
GTGTCCACGG GCTCCGAGAC TGCTTGGATC ACCTTGGTGA CTGCTCTGCT CCTGGTGCTG 
AGCCTCAGTG CCCTTCTGGG CCTACTGCTG CTAAAGTGGC AATTTCCTGC GCACTACAGG 
AGACTGAGGC ATGCTTTGTG GCCCTCGCTT CCAGACCTAC ACCGGGTCCT AGGCCAGTAC 
CTCAGAGACA CTGCAGCCCT AAGTCCTTCT AAGGCCACGG TTACCGATAG CTGTGAAGAA 
GTGGAACCCA GCCTCCTGGA AATCCTCCCT AAGTCCTCAG AGAGCACTCC TTTACCTCTG 
TGTCCCTCCC AACCTCAGAT GGACTACAGA GGACTGCAAC CTTGCCTGCG GACCATGCCC 
CTGTCTGTGT GTCCACCCAT GGCTGAGACG GGGTCCTGCT GCACCACACA CATTGCCAAC 
CACTCCTACC TACCACTAAG CTATTGGCAG CAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011238770.1
CDS	71..1129
Translation	MQVVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP

Target ORF information:

RefSeq Version	XM_011240468.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011240468.2

ORF Insert Sequence:

ATGCAGGTAG TGACAATTGG ACTTCAGTGC TTTACCTTGG ATCTGAAGAT GGTCACCTGC 
CAGTGGCAGC AACAAGACCG CACTAGCTCC CAAGGCTTCT TCCGCCACAG CAGGACGAGG 
TGCTGCCCCA CAGACAGGGA CCCCACCTGG GAGAAATGTG AAGAGGAGGA ACCGCGTCCA 
GGATCACAGC CCGCTCTCGT CTCCCGCTGC CACTTCAAGT CACGAAATGA CAGTGTTATT 
CACATCCTTG TAGAGGTGAC CACAGCGCAA GGTGCCGTTC ACAGCTACCT GGGCTCCCCT 
TTTTGGATCC ACCAGGCTGT GCTCCTTCCC ACCCCGAGCC TGCACTGGAG GGAGGTCTCA 
AGTGGAAGGC TGGAGTTGGA GTGGCAGCAC CAGTCATCTT GGGCAGCTCA AGAGACCTGC 
TACCAGCTCC GGTACACGGG AGAAGGCCGT GAGGACTGGA AGGTGCTGGA GCCATCTCTC 
GGTGCCCGGG GAGGGACCCT AGAGCTGCGC CCCCGAGCTC GCTACAGCTT GCAGCTGCGT 
GCCAGGCTCA ACGGCCCCAC CTACCAAGGT CCCTGGAGCG CCTGGTCTCC CCCAGCTAGG 
GTGTCCACGG GCTCCGAGAC TGCTTGGATC ACCTTGGTGA CTGCTCTGCT CCTGGTGCTG 
AGCCTCAGTG CCCTTCTGGG CCTACTGCTG CTAAAGTGGC AATTTCCTGC GCACTACAGG 
AGACTGAGGC ATGCTTTGTG GCCCTCGCTT CCAGACCTAC ACCGGGTCCT AGGCCAGTAC 
CTCAGAGACA CTGCAGCCCT AAGTCCTTCT AAGGCCACGG TTACCGATAG CTGTGAAGAA 
GTGGAACCCA GCCTCCTGGA AATCCTCCCT AAGTCCTCAG AGAGCACTCC TTTACCTCTG 
TGTCCCTCCC AACCTCAGAT GGACTACAGA GGACTGCAAC CTTGCCTGCG GACCATGCCC 
CTGTCTGTGT GTCCACCCAT GGCTGAGACG GGGTCCTGCT GCACCACACA CATTGCCAAC 
CACTCCTACC TACCACTAAG CTATTGGCAG CAGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpl ( XM_030253295.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030109155.1 Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu88458
Clone ID Related Accession (Same CDS sequence)	XM_030253295.1
Accession Version	XM_030253295.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1038bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	thrombopoietin receptor isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGAAGA GGCAGCACCC AGTGGGACAT ACCAGCTGCT GTATGCCTAC CGAGGGCCTG 
CCAGCTCCCC CCAGGGTCAT CAAGGCCAGG GGTGGGAGCC AACCAGGGGA ACTTCAGATC 
CACTGGGAGG CCCCTGCTCC TGAAATCAGT GACTTCCTGA GGCATGAACT CCGCTATGGC 
CCCACGGACT CCAGCAACGC CACTGCCCCC TCCGTCATTC AGCTGCTCTC CACAGAAACC 
TGCTGCCCCA CTTTGTGGAT GCCGAACCCA GTCCCTGTTC TTGACCAGCC TCCGTGTGTT 
CATCCGACAG CATCCCAACC GCATGGACCA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGAGAC TGAGGCATGC 
TTTGTGGCCC TCGCTTCCAG ACCTACACCG GGTCCTAGGC CAGTACCTCA GAGACACTGC 
AGCCCTAAGT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030109155.1
CDS	375..1412
Translation	MRKRQHPVGHTSCCMPTEGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKETEACFVALASRPTPGPRPVPQRHCSPKSF

Target ORF information:

RefSeq Version	XM_030253295.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030253295.1

ORF Insert Sequence:

ATGAGGAAGA GGCAGCACCC AGTGGGACAT ACCAGCTGCT GTATGCCTAC CGAGGGCCTG 
CCAGCTCCCC CCAGGGTCAT CAAGGCCAGG GGTGGGAGCC AACCAGGGGA ACTTCAGATC 
CACTGGGAGG CCCCTGCTCC TGAAATCAGT GACTTCCTGA GGCATGAACT CCGCTATGGC 
CCCACGGACT CCAGCAACGC CACTGCCCCC TCCGTCATTC AGCTGCTCTC CACAGAAACC 
TGCTGCCCCA CTTTGTGGAT GCCGAACCCA GTCCCTGTTC TTGACCAGCC TCCGTGTGTT 
CATCCGACAG CATCCCAACC GCATGGACCA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGAGAC TGAGGCATGC 
TTTGTGGCCC TCGCTTCCAG ACCTACACCG GGTCCTAGGC CAGTACCTCA GAGACACTGC 
AGCCCTAAGT CCTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpl ( NM_010823.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034953.2 Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu20037
Clone ID Related Accession (Same CDS sequence)	NM_010823.3
Accession Version	NM_010823.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Mus musculus(house mouse)
Product	thrombopoietin receptor isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL627212.21 and AK041166.1. On Oct 22, 2013 this sequence version replaced NM_010823.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z22649.1, AK041166.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849376, SAMN00849381 [ECO:0000350] ##Evidence-Data-END##

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GGCCTGCCAG CTCCCCCCAG GGTCATCAAG 
GCCAGGGGTG GGAGCCAACC AGGGGAACTT CAGATCCACT GGGAGGCCCC TGCTCCTGAA 
ATCAGTGACT TCCTGAGGCA TGAACTCCGC TATGGCCCCA CGGACTCCAG CAACGCCACT 
GCCCCCTCCG TCATTCAGCT GCTCTCCACA GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGCTC CATTTCTGAC AGTGAAGGGT GGAAGCTGTC TCGTCTCAGG CCTCCAGGCT 
GGCAAATCCT ACTGGCTCCA GCTACGCAGC CAACCCGACG GGGTCTCCCT TCGTGGCTCC 
TGGGGACCCT GGTCCTTCCC TGTGACTGTG GATCTTCCAG GAGATGCAGT GACAATTGGA 
CTTCAGTGCT TTACCTTGGA TCTGAAGATG GTCACCTGCC AGTGGCAGCA ACAAGACCGC 
ACTAGCTCCC AAGGCTTCTT CCGCCACAGC AGGACGAGGT GCTGCCCCAC AGACAGGGAC 
CCCACCTGGG AGAAATGTGA AGAGGAGGAA CCGCGTCCAG GATCACAGCC CGCTCTCGTC 
TCCCGCTGCC ACTTCAAGTC ACGAAATGAC AGTGTTATTC ACATCCTTGT AGAGGTGACC 
ACAGCGCAAG GTGCCGTTCA CAGCTACCTG GGCTCCCCTT TTTGGATCCA CCAGGCTGTG 
CTCCTTCCCA CCCCGAGCCT GCACTGGAGG GAGGTCTCAA GTGGAAGGCT GGAGTTGGAG 
TGGCAGCACC AGTCATCTTG GGCAGCTCAA GAGACCTGCT ACCAGCTCCG GTACACGGGA 
GAAGGCCGTG AGGACTGGAA GGTGCTGGAG CCATCTCTCG GTGCCCGGGG AGGGACCCTA 
GAGCTGCGCC CCCGAGCTCG CTACAGCTTG CAGCTGCGTG CCAGGCTCAA CGGCCCCACC 
TACCAAGGTC CCTGGAGCGC CTGGTCTCCC CCAGCTAGGG TGTCCACGGG CTCCGAGACT 
GCTTGGATCA CCTTGGTGAC TGCTCTGCTC CTGGTGCTGA GCCTCAGTGC CCTTCTGGGC 
CTACTGCTGC TAAAGTGGCA ATTTCCTGCG CACTACAGGA GACTGAGGCA TGCTTTGTGG 
CCCTCGCTTC CAGACCTACA CCGGGTCCTA GGCCAGTACC TCAGAGACAC TGCAGCCCTA 
AGTCCTTCTA AGGCCACGGT TACCGATAGC TGTGAAGAAG TGGAACCCAG CCTCCTGGAA 
ATCCTCCCTA AGTCCTCAGA GAGCACTCCT TTACCTCTGT GTCCCTCCCA ACCTCAGATG 
GACTACAGAG GACTGCAACC TTGCCTGCGG ACCATGCCCC TGTCTGTGTG TCCACCCATG 
GCTGAGACGG GGTCCTGCTG CACCACACAC ATTGCCAACC ACTCCTACCT ACCACTAAGC 
TATTGGCAGC AGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034953.2
CDS	43..1920
Translation	MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP

Target ORF information:

RefSeq Version	NM_010823.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010823.3

ORF Insert Sequence:

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GGCCTGCCAG CTCCCCCCAG GGTCATCAAG 
GCCAGGGGTG GGAGCCAACC AGGGGAACTT CAGATCCACT GGGAGGCCCC TGCTCCTGAA 
ATCAGTGACT TCCTGAGGCA TGAACTCCGC TATGGCCCCA CGGACTCCAG CAACGCCACT 
GCCCCCTCCG TCATTCAGCT GCTCTCCACA GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGCTC CATTTCTGAC AGTGAAGGGT GGAAGCTGTC TCGTCTCAGG CCTCCAGGCT 
GGCAAATCCT ACTGGCTCCA GCTACGCAGC CAACCCGACG GGGTCTCCCT TCGTGGCTCC 
TGGGGACCCT GGTCCTTCCC TGTGACTGTG GATCTTCCAG GAGATGCAGT GACAATTGGA 
CTTCAGTGCT TTACCTTGGA TCTGAAGATG GTCACCTGCC AGTGGCAGCA ACAAGACCGC 
ACTAGCTCCC AAGGCTTCTT CCGCCACAGC AGGACGAGGT GCTGCCCCAC AGACAGGGAC 
CCCACCTGGG AGAAATGTGA AGAGGAGGAA CCGCGTCCAG GATCACAGCC CGCTCTCGTC 
TCCCGCTGCC ACTTCAAGTC ACGAAATGAC AGTGTTATTC ACATCCTTGT AGAGGTGACC 
ACAGCGCAAG GTGCCGTTCA CAGCTACCTG GGCTCCCCTT TTTGGATCCA CCAGGCTGTG 
CTCCTTCCCA CCCCGAGCCT GCACTGGAGG GAGGTCTCAA GTGGAAGGCT GGAGTTGGAG 
TGGCAGCACC AGTCATCTTG GGCAGCTCAA GAGACCTGCT ACCAGCTCCG GTACACGGGA 
GAAGGCCGTG AGGACTGGAA GGTGCTGGAG CCATCTCTCG GTGCCCGGGG AGGGACCCTA 
GAGCTGCGCC CCCGAGCTCG CTACAGCTTG CAGCTGCGTG CCAGGCTCAA CGGCCCCACC 
TACCAAGGTC CCTGGAGCGC CTGGTCTCCC CCAGCTAGGG TGTCCACGGG CTCCGAGACT 
GCTTGGATCA CCTTGGTGAC TGCTCTGCTC CTGGTGCTGA GCCTCAGTGC CCTTCTGGGC 
CTACTGCTGC TAAAGTGGCA ATTTCCTGCG CACTACAGGA GACTGAGGCA TGCTTTGTGG 
CCCTCGCTTC CAGACCTACA CCGGGTCCTA GGCCAGTACC TCAGAGACAC TGCAGCCCTA 
AGTCCTTCTA AGGCCACGGT TACCGATAGC TGTGAAGAAG TGGAACCCAG CCTCCTGGAA 
ATCCTCCCTA AGTCCTCAGA GAGCACTCCT TTACCTCTGT GTCCCTCCCA ACCTCAGATG 
GACTACAGAG GACTGCAACC TTGCCTGCGG ACCATGCCCC TGTCTGTGTG TCCACCCATG 
GCTGAGACGG GGTCCTGCTG CACCACACAC ATTGCCAACC ACTCCTACCT ACCACTAAGC 
TATTGGCAGC AGCCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpl ( NM_001285496.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001272425.1 Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 3, mRNA.

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CloneID	OMu20123
Clone ID Related Accession (Same CDS sequence)	NM_001285496.1
Accession Version	NM_001285496.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1722bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Mus musculus(house mouse)
Product	thrombopoietin receptor isoform 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL627212.21 and AK041166.1. Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (3, also known as c-mpl-II) that is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF360122.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849378 [ECO:0000350] ##Evidence-Data-END##

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGTGA GGACCTCCCC AGCTGGAGAA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGTGCT GGAGCCATCT 
CTCGGTGCCC GGGGAGGGAC CCTAGAGCTG CGCCCCCGAG CTCGCTACAG CTTGCAGCTG 
CGTGCCAGGC TCAACGGCCC CACCTACCAA GGTCCCTGGA GCGCCTGGTC TCCCCCAGCT 
AGGGTGTCCA CGGGCTCCGA GACTGCTTGG ATCACCTTGG TGACTGCTCT GCTCCTGGTG 
CTGAGCCTCA GTGCCCTTCT GGGCCTACTG CTGCTAAAGT GGCAATTTCC TGCGCACTAC 
AGGAGACTGA GGCATGCTTT GTGGCCCTCG CTTCCAGACC TACACCGGGT CCTAGGCCAG 
TACCTCAGAG ACACTGCAGC CCTAAGTCCT TCTAAGGCCA CGGTTACCGA TAGCTGTGAA 
GAAGTGGAAC CCAGCCTCCT GGAAATCCTC CCTAAGTCCT CAGAGAGCAC TCCTTTACCT 
CTGTGTCCCT CCCAACCTCA GATGGACTAC AGAGGACTGC AACCTTGCCT GCGGACCATG 
CCCCTGTCTG TGTGTCCACC CATGGCTGAG ACGGGGTCCT GCTGCACCAC ACACATTGCC 
AACCACTCCT ACCTACCACT AAGCTATTGG CAGCAGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001272425.1
CDS	43..1764
Translation	MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPVRTSPAGEAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP

Target ORF information:

RefSeq Version	NM_001285496.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001285496.1

ORF Insert Sequence:

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGTGA GGACCTCCCC AGCTGGAGAA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGTGCT GGAGCCATCT 
CTCGGTGCCC GGGGAGGGAC CCTAGAGCTG CGCCCCCGAG CTCGCTACAG CTTGCAGCTG 
CGTGCCAGGC TCAACGGCCC CACCTACCAA GGTCCCTGGA GCGCCTGGTC TCCCCCAGCT 
AGGGTGTCCA CGGGCTCCGA GACTGCTTGG ATCACCTTGG TGACTGCTCT GCTCCTGGTG 
CTGAGCCTCA GTGCCCTTCT GGGCCTACTG CTGCTAAAGT GGCAATTTCC TGCGCACTAC 
AGGAGACTGA GGCATGCTTT GTGGCCCTCG CTTCCAGACC TACACCGGGT CCTAGGCCAG 
TACCTCAGAG ACACTGCAGC CCTAAGTCCT TCTAAGGCCA CGGTTACCGA TAGCTGTGAA 
GAAGTGGAAC CCAGCCTCCT GGAAATCCTC CCTAAGTCCT CAGAGAGCAC TCCTTTACCT 
CTGTGTCCCT CCCAACCTCA GATGGACTAC AGAGGACTGC AACCTTGCCT GCGGACCATG 
CCCCTGTCTG TGTGTCCACC CATGGCTGAG ACGGGGTCCT GCTGCACCAC ACACATTGCC 
AACCACTCCT ACCTACCACT AAGCTATTGG CAGCAGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mpl ( NM_001122949.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001116421.1 Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 1, mRNA.

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CloneID	OMu20279
Clone ID Related Accession (Same CDS sequence)	NM_001122949.2
Accession Version	NM_001122949.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1902bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575820800000
Organism	Mus musculus(house mouse)
Product	thrombopoietin receptor isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL627212.21 and AK041166.1. On Oct 22, 2013 this sequence version replaced NM_001122949.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as c-mpl-I). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X73677.1, BC103515.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849378 [ECO:0000350] ##Evidence-Data-END##

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GGCCTGCCAG CTCCCCCCAG GGTCATCAAG 
GCCAGGGGTG GGAGCCAACC AGGGGAACTT CAGATCCACT GGGAGGCCCC TGCTCCTGAA 
ATCAGTGACT TCCTGAGGCA TGAACTCCGC TATGGCCCCA CGGACTCCAG CAACGCCACT 
GCCCCCTCCG TCATTCAGCT GCTCTCCACA GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGTGA GGACCTCCCC AGCTGGAGAA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGTGCT GGAGCCATCT 
CTCGGTGCCC GGGGAGGGAC CCTAGAGCTG CGCCCCCGAG CTCGCTACAG CTTGCAGCTG 
CGTGCCAGGC TCAACGGCCC CACCTACCAA GGTCCCTGGA GCGCCTGGTC TCCCCCAGCT 
AGGGTGTCCA CGGGCTCCGA GACTGCTTGG ATCACCTTGG TGACTGCTCT GCTCCTGGTG 
CTGAGCCTCA GTGCCCTTCT GGGCCTACTG CTGCTAAAGT GGCAATTTCC TGCGCACTAC 
AGGAGACTGA GGCATGCTTT GTGGCCCTCG CTTCCAGACC TACACCGGGT CCTAGGCCAG 
TACCTCAGAG ACACTGCAGC CCTAAGTCCT TCTAAGGCCA CGGTTACCGA TAGCTGTGAA 
GAAGTGGAAC CCAGCCTCCT GGAAATCCTC CCTAAGTCCT CAGAGAGCAC TCCTTTACCT 
CTGTGTCCCT CCCAACCTCA GATGGACTAC AGAGGACTGC AACCTTGCCT GCGGACCATG 
CCCCTGTCTG TGTGTCCACC CATGGCTGAG ACGGGGTCCT GCTGCACCAC ACACATTGCC 
AACCACTCCT ACCTACCACT AAGCTATTGG CAGCAGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116421.1
CDS	43..1944
Translation	MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPVRTSPAGEAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP

Target ORF information:

RefSeq Version	NM_001122949.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus myeloproliferative leukemia virus oncogene (Mpl), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122949.2

ORF Insert Sequence:

ATGCCCTCTT GGGCCCTCTT CATGGTCACC TCCTGCCTCC TCTTGGCCCT TCCAAACCAG 
GCACAAGTCA CCAGCCAAGA TGTCTTCTTG CTGGCCTTGG GCACAGAGCC CCTGAACTGC 
TTCTCCCAAA CATTTGAGGA CCTCACCTGC TTCTGGGATG AGGAAGAGGC AGCACCCAGT 
GGGACATACC AGCTGCTGTA TGCCTACCGA GGAGAGAAGC CCCGTGCATG CCCCCTGTAT 
TCCCAGAGTG TGCCCACCTT TGGAACCCGG TATGTGTGCC AGTTTCCAGC CCAGGATGAA 
GTGCGCCTCT TCTTTCCGCT GCACCTCTGG GTGAAGAATG TGTCCCTCAA CCAGACTTTG 
ATCCAGCGGG TGCTGTTTGT GGATAGTGTG GGCCTGCCAG CTCCCCCCAG GGTCATCAAG 
GCCAGGGGTG GGAGCCAACC AGGGGAACTT CAGATCCACT GGGAGGCCCC TGCTCCTGAA 
ATCAGTGACT TCCTGAGGCA TGAACTCCGC TATGGCCCCA CGGACTCCAG CAACGCCACT 
GCCCCCTCCG TCATTCAGCT GCTCTCCACA GAAACCTGCT GCCCCACTTT GTGGATGCCG 
AACCCAGTCC CTGTTCTTGA CCAGCCTCCG TGTGTTCATC CGACAGCATC CCAACCGCAT 
GGACCAGTGA GGACCTCCCC AGCTGGAGAA GCTCCATTTC TGACAGTGAA GGGTGGAAGC 
TGTCTCGTCT CAGGCCTCCA GGCTGGCAAA TCCTACTGGC TCCAGCTACG CAGCCAACCC 
GACGGGGTCT CCCTTCGTGG CTCCTGGGGA CCCTGGTCCT TCCCTGTGAC TGTGGATCTT 
CCAGGAGATG CAGTGACAAT TGGACTTCAG TGCTTTACCT TGGATCTGAA GATGGTCACC 
TGCCAGTGGC AGCAACAAGA CCGCACTAGC TCCCAAGGCT TCTTCCGCCA CAGCAGGACG 
AGGTGCTGCC CCACAGACAG GGACCCCACC TGGGAGAAAT GTGAAGAGGA GGAACCGCGT 
CCAGGATCAC AGCCCGCTCT CGTCTCCCGC TGCCACTTCA AGTCACGAAA TGACAGTGTT 
ATTCACATCC TTGTAGAGGT GACCACAGCG CAAGGTGCCG TTCACAGCTA CCTGGGCTCC 
CCTTTTTGGA TCCACCAGGC TGTGCTCCTT CCCACCCCGA GCCTGCACTG GAGGGAGGTC 
TCAAGTGGAA GGCTGGAGTT GGAGTGGCAG CACCAGTCAT CTTGGGCAGC TCAAGAGACC 
TGCTACCAGC TCCGGTACAC GGGAGAAGGC CGTGAGGACT GGAAGGTGCT GGAGCCATCT 
CTCGGTGCCC GGGGAGGGAC CCTAGAGCTG CGCCCCCGAG CTCGCTACAG CTTGCAGCTG 
CGTGCCAGGC TCAACGGCCC CACCTACCAA GGTCCCTGGA GCGCCTGGTC TCCCCCAGCT 
AGGGTGTCCA CGGGCTCCGA GACTGCTTGG ATCACCTTGG TGACTGCTCT GCTCCTGGTG 
CTGAGCCTCA GTGCCCTTCT GGGCCTACTG CTGCTAAAGT GGCAATTTCC TGCGCACTAC 
AGGAGACTGA GGCATGCTTT GTGGCCCTCG CTTCCAGACC TACACCGGGT CCTAGGCCAG 
TACCTCAGAG ACACTGCAGC CCTAAGTCCT TCTAAGGCCA CGGTTACCGA TAGCTGTGAA 
GAAGTGGAAC CCAGCCTCCT GGAAATCCTC CCTAAGTCCT CAGAGAGCAC TCCTTTACCT 
CTGTGTCCCT CCCAACCTCA GATGGACTAC AGAGGACTGC AACCTTGCCT GCGGACCATG 
CCCCTGTCTG TGTGTCCACC CATGGCTGAG ACGGGGTCCT GCTGCACCAC ACACATTGCC 
AACCACTCCT ACCTACCACT AAGCTATTGG CAGCAGCCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Endothelial protein C receptor supports hematopoietic stem cell engraftment and expansion in Mpl-deficient mice.
Blood133(13)1465-1478(2019 03)
Kohlscheen S,Schenk F,Rommel MGE,Cullmann K,Modlich U

c-MPL Is a Candidate Surface Marker and Confers Self-Renewal, Quiescence, Chemotherapy Resistance, and Leukemia Initiation Potential in Leukemia Stem Cells.
Stem cells (Dayton, Ohio)36(11)1685-1696(2018 11)
Li H,Zhao N,Li Y,Xing H,Chen S,Xu Y,Tang K,Tian Z,Wang M,Rao Q,Wang J

Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag.
Science translational medicine10(458)(2018 09)
Kao YR,Chen J,Narayanagari SR,Todorova TI,Aivalioti MM,Ferreira M,Ramos PM,Pallaud C,Mantzaris I,Shastri A,Bussel JB,Verma A,Steidl U,Will B

Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia.
Proceedings of the National Academy of Sciences of the United States of America115(35)E8228-E8235(2018 08)
Kanaji T,Vo MN,Kanaji S,Zarpellon A,Shapiro R,Morodomi Y,Yuzuriha A,Eto K,Belani R,Do MH,Yang XL,Ruggeri ZM,Schimmel P

Identification and characterization of an isoform of murine Mpl.
Biochimica et biophysica acta1574(3)383-6(2002 Apr)
Sabath DF,Lofton-Day C,Lin N,Lok S,Kaushansky K,Broudy VC

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Mpl cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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