Itpa cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itpa
Entrez Gene ID	16434
Full Name	inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Synonyms	2010016I08Rik,AU020102,Itp
General protein information	Preferred Names inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Names inosine triphosphate pyrophosphatase ITPase NTPase non-canonical purine NTP pyrophosphatase non-standard purine NTP pyrophosphatase nucleoside triphosphate pyrophosphatase nucleoside-triphosphate diphosphatase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2 F1\|2 63.24 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_025922.3	NP_080198.2	inosine triphosphate pyrophosphatase isoform 1
NM_001362648.1	NP_001349577.1	inosine triphosphate pyrophosphatase isoform 2
NM_025922.2	NP_080198.2	inosine triphosphate pyrophosphatase
XM_017315731.2	XP_017171220.1	inosine triphosphate pyrophosphatase isoform X1
XM_017315731.1	XP_017171220.1	inosine triphosphate pyrophosphatase isoform X1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008374	XP_317079.2
Canis lupus familiaris (dog)	ITPA	XP_851574.3
Mus musculus (house mouse)	Itpa	NP_080198.2
Drosophila melanogaster (fruit fly)	CG8891	NP_608890.1
Xenopus tropicalis (tropical clawed frog)	itpa	XP_002934214.1
Rattus norvegicus (Norway rat)	Itpa	NP_001101244.1
Caenorhabditis elegans (roundworm)	hap-1	NP_498121.1
Neurospora crassa	NCU01441	XP_955963.1
Pan troglodytes (chimpanzee)	ITPA	XP_003953718.1
Bos taurus (cattle)	ITPA	NP_001069750.1
Gallus gallus (chicken)	ITPA	NP_001258859.1
Danio rerio (zebrafish)	LOC101882233	XP_005160507.1
Magnaporthe oryzae (rice blast fungus)	MGG_06911	XP_003709645.1
Macaca mulatta (Rhesus monkey)	ITPA	XP_001115179.1
Danio rerio (zebrafish)	itpa	XP_005160503.1
Arabidopsis thaliana (thale cress)	AT4G13720	NP_567410.1
Oryza sativa (rice)	Os10g0457500	NP_001064763.1
Homo sapiens (human)	ITPA	NP_258412.1
Schizosaccharomyces pombe (fission yeast)	SPCC830.10	NP_588480.1

Gene Ontology
Bibliography

Related articles in PubMed

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy.
Handley MT, Reddy K, Wills J, Rosser E, Kamath A, Halachev M, Falkous G, Williams D, Cox P, Meynert A, Raymond ES, Morrison H, Brown S, Allan E, Aligianis I, Jackson AP, Ramsahoye BH, von Kriegsheim A, Taylor RW, Finch AJ, FitzPatrick DR
PLoS genetics15(3)e1007605(2019 03)

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells.
Yoneshima Y, Abolhassani N, Iyama T, Sakumi K, Shiomi N, Mori M, Shiomi T, Noda T, Tsuchimoto D, Nakabeppu Y
Scientific reports632849(2016 09)

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.
Sakumi K, Abolhassani N, Behmanesh M, Iyama T, Tsuchimoto D, Nakabeppu Y
Mutation research703(1)43-50(2010 Nov)

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.
Iyama T, Abolhassani N, Tsuchimoto D, Nonaka M, Nakabeppu Y
Nucleic acids research38(14)4834-43(2010 Aug)

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.
Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y
Nucleic acids research38(9)2891-903(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Itpa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itpa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu84058	NM_001362648.1 Latest version!	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OMu01274	NM_025922.3 Latest version!	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OMu01274	XM_017315731.2 Latest version!	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OMu01274	NM_025922.2	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OMu01274	XM_017315731.1	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itpa ( NM_025922.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080198.2 Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), mRNA.

Price & Availability↑

CloneID	OMu01274
Clone ID Related Accession (Same CDS sequence)	NM_025922.3 , NM_025922.2 , XM_017315731.2 , XM_017315731.1
Accession Version	NM_025922.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1494518400000
Organism	Mus musculus(house mouse)
Product	inosine triphosphate pyrophosphatase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC026508.1. On Jun 19, 2003 this sequence version replaced NM_025922.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026508.1, AB100501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080198.2
CDS	30..626
Translation	MAASLVGKKIVFVTGNAKKLEEVIQILGDNFPCTLEAQKIDLPEYQGEPDEISIQKCREAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKSEKNTISHRFRALHKLQEYFSVAAGAGDH

Target ORF information:

RefSeq Version	NM_025922.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025922.2

ORF Insert Sequence:

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itpa ( NM_001362648.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001349577.1 Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu84058
Clone ID Related Accession (Same CDS sequence)	NM_001362648.1
Accession Version	NM_001362648.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569340800000
Organism	Mus musculus(house mouse)
Product	inosine triphosphate pyrophosphatase isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK153806.1, BY255189.1 and BC026508.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY255189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGATTTC CATACAGAAG TGTCGGGAGG CAGCTCGACA GAAAATGGTT CCTACAGAAG 
CTGAAGCCTG AAGGTCTCCA CCAGCTCCTG GCCGGCTTTG AAGACAAATC GGCCTATGCA 
CTCTGCACAT TCGCTCTCAG CACTGGGGAC CCAAGCCAGC CAGTGCTTCT CTTCAGAGGC 
CAGACCTCGG GACAGATTGT GATGCCACGA GGCAGCCGGG ACTTTGGCTG GGATCCCTGC 
TTTCAGCCTG ATGGATATGA GCAAACGTAT GCAGAGATGC CAAAGTCTGA GAAGAACACC 
ATTTCTCATC GGTTCCGGGC CCTGCACAAG CTACAGGAGT ACTTTAGTGT GGCTGCTGGG 
GCTGGTGACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001349577.1
CDS	217..591
Translation	MRFPYRSVGRQLDRKWFLQKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKSEKNTISHRFRALHKLQEYFSVAAGAGDH

Target ORF information:

RefSeq Version	NM_001362648.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001362648.1

ORF Insert Sequence:

ATGAGATTTC CATACAGAAG TGTCGGGAGG CAGCTCGACA GAAAATGGTT CCTACAGAAG 
CTGAAGCCTG AAGGTCTCCA CCAGCTCCTG GCCGGCTTTG AAGACAAATC GGCCTATGCA 
CTCTGCACAT TCGCTCTCAG CACTGGGGAC CCAAGCCAGC CAGTGCTTCT CTTCAGAGGC 
CAGACCTCGG GACAGATTGT GATGCCACGA GGCAGCCGGG ACTTTGGCTG GGATCCCTGC 
TTTCAGCCTG ATGGATATGA GCAAACGTAT GCAGAGATGC CAAAGTCTGA GAAGAACACC 
ATTTCTCATC GGTTCCGGGC CCTGCACAAG CTACAGGAGT ACTTTAGTGT GGCTGCTGGG 
GCTGGTGACC ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itpa ( NM_025922.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080198.2 Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu01274
Clone ID Related Accession (Same CDS sequence)	NM_025922.3 , NM_025922.2 , XM_017315731.2 , XM_017315731.1
Accession Version	NM_025922.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569340800000
Organism	Mus musculus(house mouse)
Product	inosine triphosphate pyrophosphatase isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK153806.1 and BC026508.1. On Apr 24, 2018 this sequence version replaced NM_025922.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026508.1, AK008279.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080198.2
CDS	69..665
Translation	MAASLVGKKIVFVTGNAKKLEEVIQILGDNFPCTLEAQKIDLPEYQGEPDEISIQKCREAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKSEKNTISHRFRALHKLQEYFSVAAGAGDH

Target ORF information:

RefSeq Version	NM_025922.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025922.3

ORF Insert Sequence:

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itpa ( XM_017315731.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017171220.1 Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01274
Clone ID Related Accession (Same CDS sequence)	NM_025922.3 , NM_025922.2 , XM_017315731.2 , XM_017315731.1
Accession Version	XM_017315731.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	inosine triphosphate pyrophosphatase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017315731.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017171220.1
CDS	678..1274
Translation	MAASLVGKKIVFVTGNAKKLEEVIQILGDNFPCTLEAQKIDLPEYQGEPDEISIQKCREAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKSEKNTISHRFRALHKLQEYFSVAAGAGDH

Target ORF information:

RefSeq Version	XM_017315731.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017315731.2

ORF Insert Sequence:

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itpa ( XM_017315731.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017171220.1 Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu01274
Clone ID Related Accession (Same CDS sequence)	NM_025922.3 , NM_025922.2 , XM_017315731.2 , XM_017315731.1
Accession Version	XM_017315731.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1466438400000
Organism	Mus musculus(house mouse)
Product	inosine triphosphate pyrophosphatase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000068.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017171220.1
CDS	639..1235
Translation	MAASLVGKKIVFVTGNAKKLEEVIQILGDNFPCTLEAQKIDLPEYQGEPDEISIQKCREAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKSEKNTISHRFRALHKLQEYFSVAAGAGDH

Target ORF information:

RefSeq Version	XM_017315731.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017315731.1

ORF Insert Sequence:

ATGGCTGCGT CTTTGGTCGG GAAGAAGATC GTGTTTGTGA CGGGAAACGC CAAGAAGCTG 
GAGGAGGTCA TTCAGATTCT CGGAGATAAT TTTCCATGCA CTTTGGAGGC TCAGAAAATT 
GACCTGCCTG AGTACCAGGG AGAACCGGAT GAGATTTCCA TACAGAAGTG TCGGGAGGCA 
GCTCGACAGG TGCAGGGCCC TGTCCTGGTG GAAGATACCT GTCTGTGCTT TAACGCACTT 
GGGGGACTGC CTGGCCCCTA CATAAAATGG TTCCTACAGA AGCTGAAGCC TGAAGGTCTC 
CACCAGCTCC TGGCCGGCTT TGAAGACAAA TCGGCCTATG CACTCTGCAC ATTCGCTCTC 
AGCACTGGGG ACCCAAGCCA GCCAGTGCTT CTCTTCAGAG GCCAGACCTC GGGACAGATT 
GTGATGCCAC GAGGCAGCCG GGACTTTGGC TGGGATCCCT GCTTTCAGCC TGATGGATAT 
GAGCAAACGT ATGCAGAGAT GCCAAAGTCT GAGAAGAACA CCATTTCTCA TCGGTTCCGG 
GCCCTGCACA AGCTACAGGA GTACTTTAGT GTGGCTGCTG GGGCTGGTGA CCACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ITPase deficiency causes a Martsolf-like syndrome with a lethal infantile dilated cardiomyopathy.
PLoS genetics15(3)e1007605(2019 03)
Handley MT,Reddy K,Wills J,Rosser E,Kamath A,Halachev M,Falkous G,Williams D,Cox P,Meynert A,Raymond ES,Morrison H,Brown S,Allan E,Aligianis I,Jackson AP,Ramsahoye BH,von Kriegsheim A,Taylor RW,Finch AJ,FitzPatrick DR

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells.
Scientific reports632849(2016 09)
Yoneshima Y,Abolhassani N,Iyama T,Sakumi K,Shiomi N,Mori M,Shiomi T,Noda T,Tsuchimoto D,Nakabeppu Y

ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.
Mutation research703(1)43-50(2010 Nov)
Sakumi K,Abolhassani N,Behmanesh M,Iyama T,Tsuchimoto D,Nakabeppu Y

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.
Nucleic acids research38(14)4834-43(2010 Aug)
Iyama T,Abolhassani N,Tsuchimoto D,Nonaka M,Nakabeppu Y

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.
Nucleic acids research38(9)2891-903(2010 May)
Abolhassani N,Iyama T,Tsuchimoto D,Sakumi K,Ohno M,Behmanesh M,Nakabeppu Y

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Itpa cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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