Itgb5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Itgb5
Entrez Gene ID	16419
Full Name	integrin beta 5
Synonyms	AA475909,AI874634,ESTM23,[b]-5,[b]5,[b]5A,[b]5B,beta-5,beta5
General protein information	Preferred Names integrin beta 5 Names integrin beta-5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_010580.2	NP_034710.2	integrin beta-5 isoform 2 precursor
XM_030248983.1	XP_030104843.1	integrin beta-5 isoform X1
NM_001145884.1	NP_001139356.1	integrin beta-5 isoform 1 precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Itgb5	NP_001139356.1
Canis lupus familiaris (dog)	ITGB5	XP_851245.2
Homo sapiens (human)	ITGB5	NP_002204.2
Bos taurus (cattle)	ITGB5	NP_777104.1
Rattus norvegicus (Norway rat)	Itgb5	NP_671480.2
Danio rerio (zebrafish)	itgb5	NP_001076305.1
Xenopus tropicalis (tropical clawed frog)	LOC100216279	NP_001135704.1
Pan troglodytes (chimpanzee)	ITGB5	XP_516706.4
Macaca mulatta (Rhesus monkey)	ITGB5	XP_001113909.1
Gallus gallus (chicken)	ITGB5	NP_989814.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression and characterization of αvβ5 integrin on intestinal macrophages.
Kumawat AK, Yu C, Mann EA, Schridde A, Finnemann SC, Mowat AM
European journal of immunology48(7)1181-1187(2018 07)

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.
Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW
Cell reports19(2)351-363(2017 04)

Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Jia D, Zhu Q, Liu H, Zuo C, He Y, Chen G, Lu A
Circulation. Cardiovascular genetics10(1)(2017 Feb)

Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro.
Tanaka S, Maekawa A, Matsubara L, Imanishi A, Yano M, Roeder RG, Hasegawa N, Asano S, Ito M
Biochemical and biophysical research communications478(4)1706-12(2016 09)

Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice.
Beier JI, Guo L, Ritzenthaler JD, Joshi-Barve S, Roman J, Arteel GE
Annals of hepatology15(5)762-72(2016 Sep-Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Itgb5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgb5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu17544	NM_010580.2 Latest version!	Mus musculus integrin beta 5 (Itgb5), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OMu86886	XM_030248983.1 Latest version!	Mus musculus integrin beta 5 (Itgb5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OMu17586	NM_001145884.1 Latest version!	Mus musculus integrin beta 5 (Itgb5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$468.30 $669.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Itgb5 ( NM_010580.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034710.2 Mus musculus integrin beta 5 (Itgb5), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17544
Clone ID Related Accession (Same CDS sequence)	NM_010580.2
Accession Version	NM_010580.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2451bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	integrin beta-5 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF022110.1, BC058246.1 and CJ316400.1. On Mar 17, 2009 this sequence version replaced NM_010580.1. Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate coding exon compared to transcript variant 1. This results in a frame-shift, translation termination at a downstream stop codon, and a longer isoform (2) with a distinct C-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF043257.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGGG TGCCCGCGAC CCTCTACGCC TGTCTGCTCG GGCTCTGCGC GCTCGTTCCG 
CGCCTCGCAG GGCTCAACAT ATGCACTAGT GGAAGTGCCA CCTCGTGTGA AGAATGCCTG 
TTGATCCACC CAAAATGTGC CTGGTGCTCC AAAGAGTACT TTGGCAATCC ACGGTCCATC 
ACCTCTCGGT GTGACCTGAA GGCAAACCTC ATCCGGAATG GCTGTGAAGG TGAGATTGAG 
AGTCCAGCCA GCAGCACCCA CGTCCTCCGG AACCTACCTC TCAGCAGCAA GGGTTCCAGT 
GCCACGGGCT CTGACGTCAT CCAGATGACG CCGCAGGAGA TTGCAGTGAG CCTCCGGCCA 
GGCGAGCAGA CTACGTTCCA GCTGCAGGTG CGCCAGGTGG AGGACTACCC TGTAGACCTG 
TACTACCTGA TGGACCTCTC CCTCTCCATG AAGGATGACT TGGAGAACAT CCGGAGCCTG 
GGCACCAAGC TTGCGGAGGA AATGAGGAAG CTCACTAGTA ACTTCCGCTT AGGTTTCGGG 
TCTTTTGTTG ACAAGGACAT CTCTCCTTTC TCCTACACGG CACCGAGATA CCAGACCAAT 
CCGTGTATTG GTTACAAGTT ATTCCCCAAC TGCGTCCCCT CCTTCGGGTT CCGGCATCTG 
CTGCCTCTCA CAGACAGAGT CGACAGCTTC AACGAGGAAG TGAGGAAGCA GAGGGTGTCC 
CGGAACCGAG ATGCCCCCGA GGGGGGGTTT GATGCGGTCC TCCAGGCTGC TGTCTGCAAG 
GAGAAGATCG GATGGCGAAA AGATGCTCTG CACTTGCTGG TGTTCACAAC AGACGATGTG 
CCCCACATCG CACTGGATGG AAAACTGGGT GGCCTGGTCC AGCCCCACGA TGGCCAGTGT 
CACCTGAATG AAGCCAATGA GTACACAGCC TCTAACCAGA TGGACTATCC ATCGCTTGCC 
TTGCTTGGGG AGAAGCTGGC AGAGAACAAT ATCAACCTCA TTTTTGCTGT GACGAAGAAC 
CACTATATGC TCTACAAGAA TTTTACAGCC CTGATACCTG GAACCACTGT GGAGATTTTG 
CATGGAGATT CCAAAAATAT TATTCAACTG ATTATCAATG CGTACAGTAG CATCCGGGCT 
AAAGTGGAGC TGTCAGTGTG GGATCAGCCA GAAGACCTTA ATCTCTTCTT CACTGCCACC 
TGCCAAGATG GCATATCTTA CCCTGGTCAG AGGAAGTGTG AGGGTCTGAA GATTGGGGAC 
ACGGCATCCT TTGAAGTGTC CGTGGAGGCT CGGAGCTGCC CCGGCAGACA AGCAGCACAG 
TCTTTCACCT TGAGGCCCGT GGGCTTCCGG GACAGTCTGC AGGTGGAAGT CGCCTACAAT 
TGCACATGCG GCTGTAGCAC GGGGCTGGAG CCCAACAGTG CCAGATGCAG TGGGAATGGA 
ACATACACCT GTGGGCTGTG CGAGTGTGAC CCCGGCTACC TGGGCACTAG GTGCGAGTGC 
CAGGAGGGGG AGAACCAGAG CGGGTACCAG AACCTGTGCC GGGAGGCAGA GGGCAAGCCT 
CTGTGCAGCG GGCGTGGAGA GTGTAGCTGC AACCAGTGCT CCTGCTTCGA GAGTGAGTTC 
GGGAGGATCT ACGGACCTTT CTGCGAGTGT GACAGCTTTT CCTGTGCCAG AAACAAGGGC 
GTCCTATGCT CAGGCCATGG AGAGTGTCAC TGTGGAGAAT GCAAATGCCA CGCAGGTTAC 
ATTGGGGACA ATTGTAACTG CTCAACAGAC GTCAGCACAT GCAGGGCCAA GGATGGGCAG 
ATCTGCAGTG ACCGAGGCCG TTGTGTCTGT GGGCAGTGCC AGTGCACAGA GCCTGGAGCC 
TTTGGGGAGA CGTGTGAGAA GTGCCCAACC TGCCCGGATG CTTGCAGCTC TAAGAGAGAC 
TGTGTCGAAT GCTTGCTACT TCACCAGGGG AAACCTGACA ACCAGACCTG CCACCACCAG 
TGCAAAGATG AGGTGATCAC GTGGGTAGAC ACCATCGTCA AAGATGACCA GGAGGCTGTG 
CTTTGCTTCT ACAAAACTGC TAAGGACTGC GTTATGATGT TCAGCTACAC AGAACTGCCC 
AATGGGAGGT CCAACTTGAC GGTCCTCCGG GAGCCAGAAT GTGGAAGTGC CCCCAATGCC 
ATGACCATCC TGCTGGCTGT GGTTGGCAGC ATCCTCCTGA TTGGGATGGC ACTCCTGGCC 
ATCTGGAAGC TGCTCGTCAC CATCCACGAC CGCCGAGAGT TTGCCAAGTT CCAAAGCCTC 
AAACCCCCTG TACAGAAAGC CCATCTCCAC ACACACTGTC GATTTCGCCT TCAACAAGTT 
CAACAAATCC TACAATGGCT CAGTGGACTG AGGCTCCTGG ATGGCTGGAG GGGGACTAAG 
GATGAAGACT CTGGCGTGCC TTGGACTTCC TGGACCATTT GCTCACGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034710.2
CDS	297..2747
Translation	MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSATGSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCRAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSLKPPVQKAHLHTHCRFRLQQVQQILQWLSGLRLLDGWRGTKDEDSGVPWTSWTICSR

Target ORF information:

RefSeq Version	NM_010580.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus integrin beta 5 (Itgb5), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010580.2

ORF Insert Sequence:

ATGCCGCGGG TGCCCGCGAC CCTCTACGCC TGTCTGCTCG GGCTCTGCGC GCTCGTTCCG 
CGCCTCGCAG GGCTCAACAT ATGCACTAGT GGAAGTGCCA CCTCGTGTGA AGAATGCCTG 
TTGATCCACC CAAAATGTGC CTGGTGCTCC AAAGAGTACT TTGGCAATCC ACGGTCCATC 
ACCTCTCGGT GTGACCTGAA GGCAAACCTC ATCCGGAATG GCTGTGAAGG TGAGATTGAG 
AGTCCAGCCA GCAGCACCCA CGTCCTCCGG AACCTACCTC TCAGCAGCAA GGGTTCCAGT 
GCCACGGGCT CTGACGTCAT CCAGATGACG CCGCAGGAGA TTGCAGTGAG CCTCCGGCCA 
GGCGAGCAGA CTACGTTCCA GCTGCAGGTG CGCCAGGTGG AGGACTACCC TGTAGACCTG 
TACTACCTGA TGGACCTCTC CCTCTCCATG AAGGATGACT TGGAGAACAT CCGGAGCCTG 
GGCACCAAGC TTGCGGAGGA AATGAGGAAG CTCACTAGTA ACTTCCGCTT AGGTTTCGGG 
TCTTTTGTTG ACAAGGACAT CTCTCCTTTC TCCTACACGG CACCGAGATA CCAGACCAAT 
CCGTGTATTG GTTACAAGTT ATTCCCCAAC TGCGTCCCCT CCTTCGGGTT CCGGCATCTG 
CTGCCTCTCA CAGACAGAGT CGACAGCTTC AACGAGGAAG TGAGGAAGCA GAGGGTGTCC 
CGGAACCGAG ATGCCCCCGA GGGGGGGTTT GATGCGGTCC TCCAGGCTGC TGTCTGCAAG 
GAGAAGATCG GATGGCGAAA AGATGCTCTG CACTTGCTGG TGTTCACAAC AGACGATGTG 
CCCCACATCG CACTGGATGG AAAACTGGGT GGCCTGGTCC AGCCCCACGA TGGCCAGTGT 
CACCTGAATG AAGCCAATGA GTACACAGCC TCTAACCAGA TGGACTATCC ATCGCTTGCC 
TTGCTTGGGG AGAAGCTGGC AGAGAACAAT ATCAACCTCA TTTTTGCTGT GACGAAGAAC 
CACTATATGC TCTACAAGAA TTTTACAGCC CTGATACCTG GAACCACTGT GGAGATTTTG 
CATGGAGATT CCAAAAATAT TATTCAACTG ATTATCAATG CGTACAGTAG CATCCGGGCT 
AAAGTGGAGC TGTCAGTGTG GGATCAGCCA GAAGACCTTA ATCTCTTCTT CACTGCCACC 
TGCCAAGATG GCATATCTTA CCCTGGTCAG AGGAAGTGTG AGGGTCTGAA GATTGGGGAC 
ACGGCATCCT TTGAAGTGTC CGTGGAGGCT CGGAGCTGCC CCGGCAGACA AGCAGCACAG 
TCTTTCACCT TGAGGCCCGT GGGCTTCCGG GACAGTCTGC AGGTGGAAGT CGCCTACAAT 
TGCACATGCG GCTGTAGCAC GGGGCTGGAG CCCAACAGTG CCAGATGCAG TGGGAATGGA 
ACATACACCT GTGGGCTGTG CGAGTGTGAC CCCGGCTACC TGGGCACTAG GTGCGAGTGC 
CAGGAGGGGG AGAACCAGAG CGGGTACCAG AACCTGTGCC GGGAGGCAGA GGGCAAGCCT 
CTGTGCAGCG GGCGTGGAGA GTGTAGCTGC AACCAGTGCT CCTGCTTCGA GAGTGAGTTC 
GGGAGGATCT ACGGACCTTT CTGCGAGTGT GACAGCTTTT CCTGTGCCAG AAACAAGGGC 
GTCCTATGCT CAGGCCATGG AGAGTGTCAC TGTGGAGAAT GCAAATGCCA CGCAGGTTAC 
ATTGGGGACA ATTGTAACTG CTCAACAGAC GTCAGCACAT GCAGGGCCAA GGATGGGCAG 
ATCTGCAGTG ACCGAGGCCG TTGTGTCTGT GGGCAGTGCC AGTGCACAGA GCCTGGAGCC 
TTTGGGGAGA CGTGTGAGAA GTGCCCAACC TGCCCGGATG CTTGCAGCTC TAAGAGAGAC 
TGTGTCGAAT GCTTGCTACT TCACCAGGGG AAACCTGACA ACCAGACCTG CCACCACCAG 
TGCAAAGATG AGGTGATCAC GTGGGTAGAC ACCATCGTCA AAGATGACCA GGAGGCTGTG 
CTTTGCTTCT ACAAAACTGC TAAGGACTGC GTTATGATGT TCAGCTACAC AGAACTGCCC 
AATGGGAGGT CCAACTTGAC GGTCCTCCGG GAGCCAGAAT GTGGAAGTGC CCCCAATGCC 
ATGACCATCC TGCTGGCTGT GGTTGGCAGC ATCCTCCTGA TTGGGATGGC ACTCCTGGCC 
ATCTGGAAGC TGCTCGTCAC CATCCACGAC CGCCGAGAGT TTGCCAAGTT CCAAAGCCTC 
AAACCCCCTG TACAGAAAGC CCATCTCCAC ACACACTGTC GATTTCGCCT TCAACAAGTT 
CAACAAATCC TACAATGGCT CAGTGGACTG AGGCTCCTGG ATGGCTGGAG GGGGACTAAG 
GATGAAGACT CTGGCGTGCC TTGGACTTCC TGGACCATTT GCTCACGCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itgb5 ( XM_030248983.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030104843.1 Mus musculus integrin beta 5 (Itgb5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu86886
Clone ID Related Accession (Same CDS sequence)	XM_030248983.1
Accession Version	XM_030248983.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1815bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	integrin beta-5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGGAAG GAATGACTGA TGGGACATTT CCCAGAGAGG GTGGGATTTA CGGGGCTGTG 
TTTTCTCAAG GAGGGAGGAG CCCACCCTCC TTGGGGACAG TGACATCAGA GGCTGGAGGC 
TTGAGGTTTA GGAGAGAGAA GAGAGCACTG GCTAACGGAC ATTCTTCTGG AGCTGTGGTT 
CATCTTAGGA ACCAGGAGAA GATCGGATGG CGAAAAGATG CTCTGCACTT GCTGGTGTTC 
ACAACAGACG ATGTGCCCCA CATCGCACTG GATGGAAAAC TGGGTGGCCT GGTCCAGCCC 
CACGATGGCC AGTGTCACCT GAATGAAGCC AATGAGTACA CAGCCTCTAA CCAGATGGAC 
TATCCATCGC TTGCCTTGCT TGGGGAGAAG CTGGCAGAGA ACAATATCAA CCTCATTTTT 
GCTGTGACGA AGAACCACTA TATGCTCTAC AAGAATTTTA CAGCCCTGAT ACCTGGAACC 
ACTGTGGAGA TTTTGCATGG AGATTCCAAA AATATTATTC AACTGATTAT CAATGCGTAC 
AGTAGCATCC GGGCTAAAGT GGAGCTGTCA GTGTGGGATC AGCCAGAAGA CCTTAATCTC 
TTCTTCACTG CCACCTGCCA AGATGGCATA TCTTACCCTG GTCAGAGGAA GTGTGAGGGT 
CTGAAGATTG GGGACACGGC ATCCTTTGAA GTGTCCGTGG AGGCTCGGAG CTGCCCCGGC 
AGACAAGCAG CACAGTCTTT CACCTTGAGG CCCGTGGGCT TCCGGGACAG TCTGCAGGTG 
GAAGTCGCCT ACAATTGCAC ATGCGGCTGT AGCACGGGGC TGGAGCCCAA CAGTGCCAGA 
TGCAGTGGGA ATGGAACATA CACCTGTGGG CTGTGCGAGT GTGACCCCGG CTACCTGGGC 
ACTAGGTGCG AGTGCCAGGA GGGGGAGAAC CAGAGCGGGT ACCAGAACCT GTGCCGGGAG 
GCAGAGGGCA AGCCTCTGTG CAGCGGGCGT GGAGAGTGTA GCTGCAACCA GTGCTCCTGC 
TTCGAGAGTG AGTTCGGGAG GATCTACGGA CCTTTCTGCG AGTGTGACAG CTTTTCCTGT 
GCCAGAAACA AGGGCGTCCT ATGCTCAGGC CATGGAGAGT GTCACTGTGG AGAATGCAAA 
TGCCACGCAG GTTACATTGG GGACAATTGT AACTGCTCAA CAGACGTCAG CACATGCAGG 
GCCAAGGATG GGCAGATCTG CAGTGACCGA GGCCGTTGTG TCTGTGGGCA GTGCCAGTGC 
ACAGAGCCTG GAGCCTTTGG GGAGACGTGT GAGAAGTGCC CAACCTGCCC GGATGCTTGC 
AGCTCTAAGA GAGACTGTGT CGAATGCTTG CTACTTCACC AGGGGAAACC TGACAACCAG 
ACCTGCCACC ACCAGTGCAA AGATGAGGTG ATCACGTGGG TAGACACCAT CGTCAAAGAT 
GACCAGGAGG CTGTGCTTTG CTTCTACAAA ACTGCTAAGG ACTGCGTTAT GATGTTCAGC 
TACACAGAAC TGCCCAATGG GAGGTCCAAC TTGACGGTCC TCCGGGAGCC AGAATGTGGA 
AGTGCCCCCA ATGCCATGAC CATCCTGCTG GCTGTGGTTG GCAGCATCCT CCTGATTGGG 
ATGGCACTCC TGGCCATCTG GAAGCTGCTC GTCACCATCC ACGACCGCCG AGAGTTTGCC 
AAGTTCCAAA GTGAGCGCTC CAGGGCCCGT TATGAAATGG CCTCAAACCC CCTGTACAGA 
AAGCCCATCT CCACACACAC TGTCGATTTC GCCTTCAACA AGTTCAACAA ATCCTACAAT 
GGCTCAGTGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030104843.1
CDS	4..1818
Translation	MWEGMTDGTFPREGGIYGAVFSQGGRSPPSLGTVTSEAGGLRFRREKRALANGHSSGAVVHLRNQEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCRAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSVD

Target ORF information:

RefSeq Version	XM_030248983.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus integrin beta 5 (Itgb5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030248983.1

ORF Insert Sequence:

ATGTGGGAAG GAATGACTGA TGGGACATTT CCCAGAGAGG GTGGGATTTA CGGGGCTGTG 
TTTTCTCAAG GAGGGAGGAG CCCACCCTCC TTGGGGACAG TGACATCAGA GGCTGGAGGC 
TTGAGGTTTA GGAGAGAGAA GAGAGCACTG GCTAACGGAC ATTCTTCTGG AGCTGTGGTT 
CATCTTAGGA ACCAGGAGAA GATCGGATGG CGAAAAGATG CTCTGCACTT GCTGGTGTTC 
ACAACAGACG ATGTGCCCCA CATCGCACTG GATGGAAAAC TGGGTGGCCT GGTCCAGCCC 
CACGATGGCC AGTGTCACCT GAATGAAGCC AATGAGTACA CAGCCTCTAA CCAGATGGAC 
TATCCATCGC TTGCCTTGCT TGGGGAGAAG CTGGCAGAGA ACAATATCAA CCTCATTTTT 
GCTGTGACGA AGAACCACTA TATGCTCTAC AAGAATTTTA CAGCCCTGAT ACCTGGAACC 
ACTGTGGAGA TTTTGCATGG AGATTCCAAA AATATTATTC AACTGATTAT CAATGCGTAC 
AGTAGCATCC GGGCTAAAGT GGAGCTGTCA GTGTGGGATC AGCCAGAAGA CCTTAATCTC 
TTCTTCACTG CCACCTGCCA AGATGGCATA TCTTACCCTG GTCAGAGGAA GTGTGAGGGT 
CTGAAGATTG GGGACACGGC ATCCTTTGAA GTGTCCGTGG AGGCTCGGAG CTGCCCCGGC 
AGACAAGCAG CACAGTCTTT CACCTTGAGG CCCGTGGGCT TCCGGGACAG TCTGCAGGTG 
GAAGTCGCCT ACAATTGCAC ATGCGGCTGT AGCACGGGGC TGGAGCCCAA CAGTGCCAGA 
TGCAGTGGGA ATGGAACATA CACCTGTGGG CTGTGCGAGT GTGACCCCGG CTACCTGGGC 
ACTAGGTGCG AGTGCCAGGA GGGGGAGAAC CAGAGCGGGT ACCAGAACCT GTGCCGGGAG 
GCAGAGGGCA AGCCTCTGTG CAGCGGGCGT GGAGAGTGTA GCTGCAACCA GTGCTCCTGC 
TTCGAGAGTG AGTTCGGGAG GATCTACGGA CCTTTCTGCG AGTGTGACAG CTTTTCCTGT 
GCCAGAAACA AGGGCGTCCT ATGCTCAGGC CATGGAGAGT GTCACTGTGG AGAATGCAAA 
TGCCACGCAG GTTACATTGG GGACAATTGT AACTGCTCAA CAGACGTCAG CACATGCAGG 
GCCAAGGATG GGCAGATCTG CAGTGACCGA GGCCGTTGTG TCTGTGGGCA GTGCCAGTGC 
ACAGAGCCTG GAGCCTTTGG GGAGACGTGT GAGAAGTGCC CAACCTGCCC GGATGCTTGC 
AGCTCTAAGA GAGACTGTGT CGAATGCTTG CTACTTCACC AGGGGAAACC TGACAACCAG 
ACCTGCCACC ACCAGTGCAA AGATGAGGTG ATCACGTGGG TAGACACCAT CGTCAAAGAT 
GACCAGGAGG CTGTGCTTTG CTTCTACAAA ACTGCTAAGG ACTGCGTTAT GATGTTCAGC 
TACACAGAAC TGCCCAATGG GAGGTCCAAC TTGACGGTCC TCCGGGAGCC AGAATGTGGA 
AGTGCCCCCA ATGCCATGAC CATCCTGCTG GCTGTGGTTG GCAGCATCCT CCTGATTGGG 
ATGGCACTCC TGGCCATCTG GAAGCTGCTC GTCACCATCC ACGACCGCCG AGAGTTTGCC 
AAGTTCCAAA GTGAGCGCTC CAGGGCCCGT TATGAAATGG CCTCAAACCC CCTGTACAGA 
AAGCCCATCT CCACACACAC TGTCGATTTC GCCTTCAACA AGTTCAACAA ATCCTACAAT 
GGCTCAGTGG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Itgb5 ( NM_001145884.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001139356.1 Mus musculus integrin beta 5 (Itgb5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17586
Clone ID Related Accession (Same CDS sequence)	NM_001145884.1
Accession Version	NM_001145884.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2400bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Mus musculus(house mouse)
Product	integrin beta-5 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF022110.1, BC058246.1 and CJ316400.1. Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF022110.1, BC058246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCGGG TGCCCGCGAC CCTCTACGCC TGTCTGCTCG GGCTCTGCGC GCTCGTTCCG 
CGCCTCGCAG GGCTCAACAT ATGCACTAGT GGAAGTGCCA CCTCGTGTGA AGAATGCCTG 
TTGATCCACC CAAAATGTGC CTGGTGCTCC AAAGAGTACT TTGGCAATCC ACGGTCCATC 
ACCTCTCGGT GTGACCTGAA GGCAAACCTC ATCCGGAATG GCTGTGAAGG TGAGATTGAG 
AGTCCAGCCA GCAGCACCCA CGTCCTCCGG AACCTACCTC TCAGCAGCAA GGGTTCCAGT 
GCCACGGGCT CTGACGTCAT CCAGATGACG CCGCAGGAGA TTGCAGTGAG CCTCCGGCCA 
GGCGAGCAGA CTACGTTCCA GCTGCAGGTG CGCCAGGTGG AGGACTACCC TGTAGACCTG 
TACTACCTGA TGGACCTCTC CCTCTCCATG AAGGATGACT TGGAGAACAT CCGGAGCCTG 
GGCACCAAGC TTGCGGAGGA AATGAGGAAG CTCACTAGTA ACTTCCGCTT AGGTTTCGGG 
TCTTTTGTTG ACAAGGACAT CTCTCCTTTC TCCTACACGG CACCGAGATA CCAGACCAAT 
CCGTGTATTG GTTACAAGTT ATTCCCCAAC TGCGTCCCCT CCTTCGGGTT CCGGCATCTG 
CTGCCTCTCA CAGACAGAGT CGACAGCTTC AACGAGGAAG TGAGGAAGCA GAGGGTGTCC 
CGGAACCGAG ATGCCCCCGA GGGGGGGTTT GATGCGGTCC TCCAGGCTGC TGTCTGCAAG 
GAGAAGATCG GATGGCGAAA AGATGCTCTG CACTTGCTGG TGTTCACAAC AGACGATGTG 
CCCCACATCG CACTGGATGG AAAACTGGGT GGCCTGGTCC AGCCCCACGA TGGCCAGTGT 
CACCTGAATG AAGCCAATGA GTACACAGCC TCTAACCAGA TGGACTATCC ATCGCTTGCC 
TTGCTTGGGG AGAAGCTGGC AGAGAACAAT ATCAACCTCA TTTTTGCTGT GACGAAGAAC 
CACTATATGC TCTACAAGAA TTTTACAGCC CTGATACCTG GAACCACTGT GGAGATTTTG 
CATGGAGATT CCAAAAATAT TATTCAACTG ATTATCAATG CGTACAGTAG CATCCGGGCT 
AAAGTGGAGC TGTCAGTGTG GGATCAGCCA GAAGACCTTA ATCTCTTCTT CACTGCCACC 
TGCCAAGATG GCATATCTTA CCCTGGTCAG AGGAAGTGTG AGGGTCTGAA GATTGGGGAC 
ACGGCATCCT TTGAAGTGTC CGTGGAGGCT CGGAGCTGCC CCGGCAGACA AGCAGCACAG 
TCTTTCACCT TGAGGCCCGT GGGCTTCCGG GACAGTCTGC AGGTGGAAGT CGCCTACAAT 
TGCACATGCG GCTGTAGCAC GGGGCTGGAG CCCAACAGTG CCAGATGCAG TGGGAATGGA 
ACATACACCT GTGGGCTGTG CGAGTGTGAC CCCGGCTACC TGGGCACTAG GTGCGAGTGC 
CAGGAGGGGG AGAACCAGAG CGGGTACCAG AACCTGTGCC GGGAGGCAGA GGGCAAGCCT 
CTGTGCAGCG GGCGTGGAGA GTGTAGCTGC AACCAGTGCT CCTGCTTCGA GAGTGAGTTC 
GGGAGGATCT ACGGACCTTT CTGCGAGTGT GACAGCTTTT CCTGTGCCAG AAACAAGGGC 
GTCCTATGCT CAGGCCATGG AGAGTGTCAC TGTGGAGAAT GCAAATGCCA CGCAGGTTAC 
ATTGGGGACA ATTGTAACTG CTCAACAGAC GTCAGCACAT GCAGGGCCAA GGATGGGCAG 
ATCTGCAGTG ACCGAGGCCG TTGTGTCTGT GGGCAGTGCC AGTGCACAGA GCCTGGAGCC 
TTTGGGGAGA CGTGTGAGAA GTGCCCAACC TGCCCGGATG CTTGCAGCTC TAAGAGAGAC 
TGTGTCGAAT GCTTGCTACT TCACCAGGGG AAACCTGACA ACCAGACCTG CCACCACCAG 
TGCAAAGATG AGGTGATCAC GTGGGTAGAC ACCATCGTCA AAGATGACCA GGAGGCTGTG 
CTTTGCTTCT ACAAAACTGC TAAGGACTGC GTTATGATGT TCAGCTACAC AGAACTGCCC 
AATGGGAGGT CCAACTTGAC GGTCCTCCGG GAGCCAGAAT GTGGAAGTGC CCCCAATGCC 
ATGACCATCC TGCTGGCTGT GGTTGGCAGC ATCCTCCTGA TTGGGATGGC ACTCCTGGCC 
ATCTGGAAGC TGCTCGTCAC CATCCACGAC CGCCGAGAGT TTGCCAAGTT CCAAAGTGAG 
CGCTCCAGGG CCCGTTATGA AATGGCCTCA AACCCCCTGT ACAGAAAGCC CATCTCCACA 
CACACTGTCG ATTTCGCCTT CAACAAGTTC AACAAATCCT ACAATGGCTC AGTGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139356.1
CDS	297..2696
Translation	MPRVPATLYACLLGLCALVPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSATGSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCRAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSVD

Target ORF information:

RefSeq Version	NM_001145884.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus integrin beta 5 (Itgb5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145884.1

ORF Insert Sequence:

ATGCCGCGGG TGCCCGCGAC CCTCTACGCC TGTCTGCTCG GGCTCTGCGC GCTCGTTCCG 
CGCCTCGCAG GGCTCAACAT ATGCACTAGT GGAAGTGCCA CCTCGTGTGA AGAATGCCTG 
TTGATCCACC CAAAATGTGC CTGGTGCTCC AAAGAGTACT TTGGCAATCC ACGGTCCATC 
ACCTCTCGGT GTGACCTGAA GGCAAACCTC ATCCGGAATG GCTGTGAAGG TGAGATTGAG 
AGTCCAGCCA GCAGCACCCA CGTCCTCCGG AACCTACCTC TCAGCAGCAA GGGTTCCAGT 
GCCACGGGCT CTGACGTCAT CCAGATGACG CCGCAGGAGA TTGCAGTGAG CCTCCGGCCA 
GGCGAGCAGA CTACGTTCCA GCTGCAGGTG CGCCAGGTGG AGGACTACCC TGTAGACCTG 
TACTACCTGA TGGACCTCTC CCTCTCCATG AAGGATGACT TGGAGAACAT CCGGAGCCTG 
GGCACCAAGC TTGCGGAGGA AATGAGGAAG CTCACTAGTA ACTTCCGCTT AGGTTTCGGG 
TCTTTTGTTG ACAAGGACAT CTCTCCTTTC TCCTACACGG CACCGAGATA CCAGACCAAT 
CCGTGTATTG GTTACAAGTT ATTCCCCAAC TGCGTCCCCT CCTTCGGGTT CCGGCATCTG 
CTGCCTCTCA CAGACAGAGT CGACAGCTTC AACGAGGAAG TGAGGAAGCA GAGGGTGTCC 
CGGAACCGAG ATGCCCCCGA GGGGGGGTTT GATGCGGTCC TCCAGGCTGC TGTCTGCAAG 
GAGAAGATCG GATGGCGAAA AGATGCTCTG CACTTGCTGG TGTTCACAAC AGACGATGTG 
CCCCACATCG CACTGGATGG AAAACTGGGT GGCCTGGTCC AGCCCCACGA TGGCCAGTGT 
CACCTGAATG AAGCCAATGA GTACACAGCC TCTAACCAGA TGGACTATCC ATCGCTTGCC 
TTGCTTGGGG AGAAGCTGGC AGAGAACAAT ATCAACCTCA TTTTTGCTGT GACGAAGAAC 
CACTATATGC TCTACAAGAA TTTTACAGCC CTGATACCTG GAACCACTGT GGAGATTTTG 
CATGGAGATT CCAAAAATAT TATTCAACTG ATTATCAATG CGTACAGTAG CATCCGGGCT 
AAAGTGGAGC TGTCAGTGTG GGATCAGCCA GAAGACCTTA ATCTCTTCTT CACTGCCACC 
TGCCAAGATG GCATATCTTA CCCTGGTCAG AGGAAGTGTG AGGGTCTGAA GATTGGGGAC 
ACGGCATCCT TTGAAGTGTC CGTGGAGGCT CGGAGCTGCC CCGGCAGACA AGCAGCACAG 
TCTTTCACCT TGAGGCCCGT GGGCTTCCGG GACAGTCTGC AGGTGGAAGT CGCCTACAAT 
TGCACATGCG GCTGTAGCAC GGGGCTGGAG CCCAACAGTG CCAGATGCAG TGGGAATGGA 
ACATACACCT GTGGGCTGTG CGAGTGTGAC CCCGGCTACC TGGGCACTAG GTGCGAGTGC 
CAGGAGGGGG AGAACCAGAG CGGGTACCAG AACCTGTGCC GGGAGGCAGA GGGCAAGCCT 
CTGTGCAGCG GGCGTGGAGA GTGTAGCTGC AACCAGTGCT CCTGCTTCGA GAGTGAGTTC 
GGGAGGATCT ACGGACCTTT CTGCGAGTGT GACAGCTTTT CCTGTGCCAG AAACAAGGGC 
GTCCTATGCT CAGGCCATGG AGAGTGTCAC TGTGGAGAAT GCAAATGCCA CGCAGGTTAC 
ATTGGGGACA ATTGTAACTG CTCAACAGAC GTCAGCACAT GCAGGGCCAA GGATGGGCAG 
ATCTGCAGTG ACCGAGGCCG TTGTGTCTGT GGGCAGTGCC AGTGCACAGA GCCTGGAGCC 
TTTGGGGAGA CGTGTGAGAA GTGCCCAACC TGCCCGGATG CTTGCAGCTC TAAGAGAGAC 
TGTGTCGAAT GCTTGCTACT TCACCAGGGG AAACCTGACA ACCAGACCTG CCACCACCAG 
TGCAAAGATG AGGTGATCAC GTGGGTAGAC ACCATCGTCA AAGATGACCA GGAGGCTGTG 
CTTTGCTTCT ACAAAACTGC TAAGGACTGC GTTATGATGT TCAGCTACAC AGAACTGCCC 
AATGGGAGGT CCAACTTGAC GGTCCTCCGG GAGCCAGAAT GTGGAAGTGC CCCCAATGCC 
ATGACCATCC TGCTGGCTGT GGTTGGCAGC ATCCTCCTGA TTGGGATGGC ACTCCTGGCC 
ATCTGGAAGC TGCTCGTCAC CATCCACGAC CGCCGAGAGT TTGCCAAGTT CCAAAGTGAG 
CGCTCCAGGG CCCGTTATGA AATGGCCTCA AACCCCCTGT ACAGAAAGCC CATCTCCACA 
CACACTGTCG ATTTCGCCTT CAACAAGTTC AACAAATCCT ACAATGGCTC AGTGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression and characterization of αvβ5 integrin on intestinal macrophages.
European journal of immunology48(7)1181-1187(2018 07)
Kumawat AK,Yu C,Mann EA,Schridde A,Finnemann SC,Mowat AM

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.
Cell reports19(2)351-363(2017 04)
Ha T,Moon KH,Dai L,Hatakeyama J,Yoon K,Park HS,Kong YY,Shimamura K,Kim JW

Osteoprotegerin Disruption Attenuates HySu-Induced Pulmonary Hypertension Through Integrin αvβ3/FAK/AKT Pathway Suppression.
Circulation. Cardiovascular genetics10(1)(2017 Feb)
Jia D,Zhu Q,Liu H,Zuo C,He Y,Chen G,Lu A

Periostin supports hematopoietic progenitor cells and niche-dependent myeloblastoma cells in vitro.
Biochemical and biophysical research communications478(4)1706-12(2016 09)
Tanaka S,Maekawa A,Matsubara L,Imanishi A,Yano M,Roeder RG,Hasegawa N,Asano S,Ito M

Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice.
Annals of hepatology15(5)762-72(2016 Sep-Oct)
Beier JI,Guo L,Ritzenthaler JD,Joshi-Barve S,Roman J,Arteel GE

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Itgb5 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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