Il5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Il5
Entrez Gene ID	16191
Full Name	interleukin 5
Synonyms	Il-5
General protein information	Preferred Names interleukin 5 Names interleukin-5 B-cell growth factor II BCGF-II T-cell replacing factor TRF cytotoxic T-lymphocyte inducer eosinophil differentiation factor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B1.3\|11 31.99 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010558.1	NP_034688.1	interleukin-5 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	IL5	NP_000870.1
Mus musculus (house mouse)	Il5	NP_034688.1
Rattus norvegicus (Norway rat)	Il5	NP_068606.1
Canis lupus familiaris (dog)	IL5	NP_001006951.1
Pan troglodytes (chimpanzee)	IL5	XP_001163452.1
Macaca mulatta (Rhesus monkey)	IL5	NP_001040598.1
Bos taurus (cattle)	IL5	NP_776347.1

Gene Ontology
Bibliography

Related articles in PubMed

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.
Frohberger SJ, Ajendra J, Surendar J, Stamminger W, Ehrens A, Buerfent BC, Gentil K, Hoerauf A, Hübner MP
Parasites & vectors12(1)248(2019 May)

Attenuated Airway Eosinophilic Inflammations in IL-38 Knockout Mouse Model.
Matsuoka M, Kawayama T, Tominaga M, Kaieda S, Tokunaga Y, Kaku Y, Imaoka H, Kinoshita T, Okamoto M, Akiba J, Hoshino T
The Kurume medical journal65(2)37-46(2019 May)

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.
Galle-Treger L, Sankaranarayanan I, Hurrell BP, Howard E, Lo R, Maazi H, Lewis G, Banie H, Epstein AL, Hu P, Rehan VK, Gilliland FD, Allayee H, Soroosh P, Sharpe AH, Akbari O
Nature communications10(1)713(2019 02)

IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation.
Hiraishi Y, Yamaguchi S, Yoshizaki T, Nambu A, Shimura E, Takamori A, Narushima S, Nakanishi W, Asada Y, Numata T, Suzukawa M, Yamauchi Y, Matsuda A, Arae K, Morita H, Hoshino T, Suto H, Okumura K, Matsumoto K, Saito H, Sudo K, Iikura M, Nagase T, Nakae S
Scientific reports8(1)18052(2018 12)

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.
Schneider C, O'Leary CE, von Moltke J, Liang HE, Ang QY, Turnbaugh PJ, Radhakrishnan S, Pellizzon M, Ma A, Locksley RM
Cell174(2)271-284.e14(2018 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Il5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22066	NM_010558.1 Latest version!	Mus musculus interleukin 5 (Il5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00

ORF Online Only Promotion

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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Il5 ( NM_010558.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034688.1 Mus musculus interleukin 5 (Il5), mRNA.

Price & Availability↑

CloneID	OMu22066
Clone ID Related Accession (Same CDS sequence)	NM_010558.1
Accession Version	NM_010558.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Mus musculus(house mouse)
Product	interleukin-5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X06270.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X06270.1, BC125366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164133 [ECO:0000348] ##Evidence-Data-END##

ATGAGAAGGA TGCTTCTGCA CTTGAGTGTT CTGACTCTCA GCTGTGTCTG GGCCACTGCC 
ATGGAGATTC CCATGAGCAC AGTGGTGAAA GAGACCTTGA CACAGCTGTC CGCTCACCGA 
GCTCTGTTGA CAAGCAATGA GACGATGAGG CTTCCTGTCC CTACTCATAA AAATCACCAG 
CTATGCATTG GAGAAATCTT TCAGGGGCTA GACATACTGA AGAATCAAAC TGTCCGTGGG 
GGTACTGTGG AAATGCTATT CCAAAACCTG TCATTAATAA AGAAATACAT TGACCGCCAA 
AAAGAGAAGT GTGGCGAGGA GAGACGGAGG ACGAGGCAGT TCCTGGATTA CCTGCAAGAG 
TTCCTTGGTG TGATGAGTAC AGAGTGGGCA ATGGAAGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034688.1
CDS	44..445
Translation	MRRMLLHLSVLTLSCVWATAMEIPMSTVVKETLTQLSAHRALLTSNETMRLPVPTHKNHQLCIGEIFQGLDILKNQTVRGGTVEMLFQNLSLIKKYIDRQKEKCGEERRRTRQFLDYLQEFLGVMSTEWAMEG

Target ORF information:

RefSeq Version	NM_010558.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus interleukin 5 (Il5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010558.1

ORF Insert Sequence:

ATGAGAAGGA TGCTTCTGCA CTTGAGTGTT CTGACTCTCA GCTGTGTCTG GGCCACTGCC 
ATGGAGATTC CCATGAGCAC AGTGGTGAAA GAGACCTTGA CACAGCTGTC CGCTCACCGA 
GCTCTGTTGA CAAGCAATGA GACGATGAGG CTTCCTGTCC CTACTCATAA AAATCACCAG 
CTATGCATTG GAGAAATCTT TCAGGGGCTA GACATACTGA AGAATCAAAC TGTCCGTGGG 
GGTACTGTGG AAATGCTATT CCAAAACCTG TCATTAATAA AGAAATACAT TGACCGCCAA 
AAAGAGAAGT GTGGCGAGGA GAGACGGAGG ACGAGGCAGT TCCTGGATTA CCTGCAAGAG 
TTCCTTGGTG TGATGAGTAC AGAGTGGGCA ATGGAAGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils.
Parasites & vectors12(1)248(2019 May)
Frohberger SJ,Ajendra J,Surendar J,Stamminger W,Ehrens A,Buerfent BC,Gentil K,Hoerauf A,Hübner MP

Attenuated Airway Eosinophilic Inflammations in IL-38 Knockout Mouse Model.
The Kurume medical journal65(2)37-46(2019 May)
Matsuoka M,Kawayama T,Tominaga M,Kaieda S,Tokunaga Y,Kaku Y,Imaoka H,Kinoshita T,Okamoto M,Akiba J,Hoshino T

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.
Nature communications10(1)713(2019 02)
Galle-Treger L,Sankaranarayanan I,Hurrell BP,Howard E,Lo R,Maazi H,Lewis G,Banie H,Epstein AL,Hu P,Rehan VK,Gilliland FD,Allayee H,Soroosh P,Sharpe AH,Akbari O

IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation.
Scientific reports8(1)18052(2018 12)
Hiraishi Y,Yamaguchi S,Yoshizaki T,Nambu A,Shimura E,Takamori A,Narushima S,Nakanishi W,Asada Y,Numata T,Suzukawa M,Yamauchi Y,Matsuda A,Arae K,Morita H,Hoshino T,Suto H,Okumura K,Matsumoto K,Saito H,Sudo K,Iikura M,Nagase T,Nakae S

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.
Cell174(2)271-284.e14(2018 07)
Schneider C,O'Leary CE,von Moltke J,Liang HE,Ang QY,Turnbaugh PJ,Radhakrishnan S,Pellizzon M,Ma A,Locksley RM

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Il5 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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