| Gene Symbol | Irf8 |
| Entrez Gene ID | 15900 |
| Full Name | interferon regulatory factor 8 |
| Synonyms | AI893568,ICSBP,IRF-8,Icsbp1,Myls |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]. |
- REAGENT SERVICES Hot!
-
PRODUCTS
-
Most Popular Reagents
-
Instruments
-
Antibodies
-
ELISA Kits
-
Protein Electrophoresis and Blotting
-
Protein and Antibody Purification
-
Recombinant Proteins
-
Molecular Biology
-
Stable Cell Lines
-
Cell Isolation and Activation
-
IVD Raw Materials
-
Therapy Applications
-
Resources
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Anti-Camelid VHH]()
MonoRab™ Anti-VHH Antibodies
-
![ELISA Kits]()
ELISA Kits
-
![Precast Gels]()
SurePAGE™ Precast Gels
-
![Quatro ProAb Automated Protein and Antibody Purification System]()
AmMag™ Quatro ProAb Automated Protein and Antibody Purification System
-
![Target Proteins]()
Target Proteins
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Stable Cell Lines]()
Stable Cell Lines
-
![Cell Isolation and Activation]()
Cell Isolation and Activation
-
![Quick
Order]()
Quick Order
-
![Quick
Order]()
Quick Order
- APPLICATIONS
- RESOURCES
- ABOUT US
Irf8 cDNA ORF clone, Mus musculus(house mouse)
-
Gene
-
Clones
gRNAs
The following Irf8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Irf8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
-
Reference Sequences (Refseq)
CloneID OMu19549 Clone ID Related Accession (Same CDS sequence) NM_008320.4 , NM_001301811.1 Accession Version NM_008320.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1275bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575648000000 Organism Mus musculus(house mouse) Product interferon regulatory factor 8 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK150370.1, AK151324.1, AK018533.1 and BF662476.1. On Sep 17, 2014 this sequence version replaced NM_008320.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005450.1, AK036488.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGTGACC GGAACGGCGG GCGGCGGCTG CGGCAGTGGC TGATCGAACA GATCGACAGC
AGCATGTACC CGGGGCTGAT CTGGGAAAAT GATGAGAAGA CCATGTTCCG TATCCCCTGG
AAGCATGCCG GCAAGCAGGA TTACAATCAG GAGGTGGATG CTTCCATCTT CAAGGCCTGG
GCAGTTTTTA AAGGGAAGTT TAAAGAGGGA GACAAAGCTG AACCAGCCAC GTGGAAGACG
AGGTTACGCT GTGCTCTGAA CAAGAGCCCA GATTTTGAAG AAGTGACTGA CCGGTCCCAG
CTGGACATTT CTGAGCCATA TAAAGTTTAC CGAATTGTCC CCGAGGAAGA ACAAAAATGC
AAGCTGGGCG TGGCACCTGC AGGCTGCATG AGCGAAGTTC CTGAGATGGA GTGTGGCCGC
TCAGAGATTG AGGAGCTGAT CAAGGAACCT TCTGTGGATG AGTACATGGG TATGACCAAG
AGGAGCCCAT CCCCACCAGA GGCCTGCAGG AGCCAGATCC TCCCTGACTG GTGGGTCCAG
CAGCCCAGTG CAGGCCTGCC ACTGGTGACC GGATATGCCG CCTATGACAC ACACCATTCA
GCTTTCTCCC AGATGGTCAT CAGCTTCTAC TACGGGGGCA AGCTGGTGGG CCAGGCCACC
ACCACCTGCC TTGAAGGCTG CCGTCTCTCC CTGAGCCAGC CGGGGCTGCC TAAGTTGTAT
GGGCCGGATG GCCTGGAACC CGTGTGCTTT CCGACGGCCG ACACCATCCC CAGTGAGCGG
CAGAGGCAGG TGACCCGGAA GCTGTTTGGG CACCTGGAAC GTGGCGTGCT ACTGCACAGC
AACCGCAAGG GCGTGTTCGT GAAGCGGCTG TGCCAGGGCC GCGTGTTCTG CAGCGGCAAC
GCGGTGGTGT GCAAGGGCAG GCCCAACAAG CTGGAGCGGG ACGAGGTGGT GCAGGTCTTT
GACACCAACC AGTTCATCCG AGAGCTGCAG CAATTCTACG CCACCCAGAG CCGCCTACCT
GACAGCAGGG TGGTCCTGTG CTTCGGGGAG GAGTTTCCGG ACACTGTGCC CTTGCGCTCC
AAACTCATTC TGGTGCAGGT AGAGCAGCTG TATGCCAGGC AGCTGGTGGA GGAAGCGGGC
AAGAGCTGCG GTGCTGGCTC CCTGATGCCA GCCCTGGAGG AGCCCCAGCC GGACCAGGCT
TTCCGCATGT TTCCGGATAT CTGTACCTCA CACCAGAGAC CCTTTTTTAG AGAAAATCAA
CAGATCACCG TCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_032346.1 CDS 54..1328 Translation 
Target ORF information:
RefSeq Version NM_008320.4 Organism Mus musculus(house mouse) Definition Mus musculus interferon regulatory factor 8 (Irf8), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_008320.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGTGACC GGAACGGCGG GCGGCGGCTG CGGCAGTGGC TGATCGAACA GATCGACAGC
AGCATGTACC CGGGGCTGAT CTGGGAAAAT GATGAGAAGA CCATGTTCCG TATCCCCTGG
AAGCATGCCG GCAAGCAGGA TTACAATCAG GAGGTGGATG CTTCCATCTT CAAGGCCTGG
GCAGTTTTTA AAGGGAAGTT TAAAGAGGGA GACAAAGCTG AACCAGCCAC GTGGAAGACG
AGGTTACGCT GTGCTCTGAA CAAGAGCCCA GATTTTGAAG AAGTGACTGA CCGGTCCCAG
CTGGACATTT CTGAGCCATA TAAAGTTTAC CGAATTGTCC CCGAGGAAGA ACAAAAATGC
AAGCTGGGCG TGGCACCTGC AGGCTGCATG AGCGAAGTTC CTGAGATGGA GTGTGGCCGC
TCAGAGATTG AGGAGCTGAT CAAGGAACCT TCTGTGGATG AGTACATGGG TATGACCAAG
AGGAGCCCAT CCCCACCAGA GGCCTGCAGG AGCCAGATCC TCCCTGACTG GTGGGTCCAG
CAGCCCAGTG CAGGCCTGCC ACTGGTGACC GGATATGCCG CCTATGACAC ACACCATTCA
GCTTTCTCCC AGATGGTCAT CAGCTTCTAC TACGGGGGCA AGCTGGTGGG CCAGGCCACC
ACCACCTGCC TTGAAGGCTG CCGTCTCTCC CTGAGCCAGC CGGGGCTGCC TAAGTTGTAT
GGGCCGGATG GCCTGGAACC CGTGTGCTTT CCGACGGCCG ACACCATCCC CAGTGAGCGG
CAGAGGCAGG TGACCCGGAA GCTGTTTGGG CACCTGGAAC GTGGCGTGCT ACTGCACAGC
AACCGCAAGG GCGTGTTCGT GAAGCGGCTG TGCCAGGGCC GCGTGTTCTG CAGCGGCAAC
GCGGTGGTGT GCAAGGGCAG GCCCAACAAG CTGGAGCGGG ACGAGGTGGT GCAGGTCTTT
GACACCAACC AGTTCATCCG AGAGCTGCAG CAATTCTACG CCACCCAGAG CCGCCTACCT
GACAGCAGGG TGGTCCTGTG CTTCGGGGAG GAGTTTCCGG ACACTGTGCC CTTGCGCTCC
AAACTCATTC TGGTGCAGGT AGAGCAGCTG TATGCCAGGC AGCTGGTGGA GGAAGCGGGC
AAGAGCTGCG GTGCTGGCTC CCTGATGCCA GCCCTGGAGG AGCCCCAGCC GGACCAGGCT
TTCCGCATGT TTCCGGATAT CTGTACCTCA CACCAGAGAC CCTTTTTTAG AGAAAATCAA
CAGATCACCG TCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu19549 Clone ID Related Accession (Same CDS sequence) NM_008320.4 , NM_001301811.1 Accession Version NM_001301811.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1275bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575648000000 Organism Mus musculus(house mouse) Product interferon regulatory factor 8 Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK137450.1, AK018533.1 and BF662476.1. On Sep 17, 2014 this sequence version replaced XM_006530704.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK137450.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGTGACC GGAACGGCGG GCGGCGGCTG CGGCAGTGGC TGATCGAACA GATCGACAGC
AGCATGTACC CGGGGCTGAT CTGGGAAAAT GATGAGAAGA CCATGTTCCG TATCCCCTGG
AAGCATGCCG GCAAGCAGGA TTACAATCAG GAGGTGGATG CTTCCATCTT CAAGGCCTGG
GCAGTTTTTA AAGGGAAGTT TAAAGAGGGA GACAAAGCTG AACCAGCCAC GTGGAAGACG
AGGTTACGCT GTGCTCTGAA CAAGAGCCCA GATTTTGAAG AAGTGACTGA CCGGTCCCAG
CTGGACATTT CTGAGCCATA TAAAGTTTAC CGAATTGTCC CCGAGGAAGA ACAAAAATGC
AAGCTGGGCG TGGCACCTGC AGGCTGCATG AGCGAAGTTC CTGAGATGGA GTGTGGCCGC
TCAGAGATTG AGGAGCTGAT CAAGGAACCT TCTGTGGATG AGTACATGGG TATGACCAAG
AGGAGCCCAT CCCCACCAGA GGCCTGCAGG AGCCAGATCC TCCCTGACTG GTGGGTCCAG
CAGCCCAGTG CAGGCCTGCC ACTGGTGACC GGATATGCCG CCTATGACAC ACACCATTCA
GCTTTCTCCC AGATGGTCAT CAGCTTCTAC TACGGGGGCA AGCTGGTGGG CCAGGCCACC
ACCACCTGCC TTGAAGGCTG CCGTCTCTCC CTGAGCCAGC CGGGGCTGCC TAAGTTGTAT
GGGCCGGATG GCCTGGAACC CGTGTGCTTT CCGACGGCCG ACACCATCCC CAGTGAGCGG
CAGAGGCAGG TGACCCGGAA GCTGTTTGGG CACCTGGAAC GTGGCGTGCT ACTGCACAGC
AACCGCAAGG GCGTGTTCGT GAAGCGGCTG TGCCAGGGCC GCGTGTTCTG CAGCGGCAAC
GCGGTGGTGT GCAAGGGCAG GCCCAACAAG CTGGAGCGGG ACGAGGTGGT GCAGGTCTTT
GACACCAACC AGTTCATCCG AGAGCTGCAG CAATTCTACG CCACCCAGAG CCGCCTACCT
GACAGCAGGG TGGTCCTGTG CTTCGGGGAG GAGTTTCCGG ACACTGTGCC CTTGCGCTCC
AAACTCATTC TGGTGCAGGT AGAGCAGCTG TATGCCAGGC AGCTGGTGGA GGAAGCGGGC
AAGAGCTGCG GTGCTGGCTC CCTGATGCCA GCCCTGGAGG AGCCCCAGCC GGACCAGGCT
TTCCGCATGT TTCCGGATAT CTGTACCTCA CACCAGAGAC CCTTTTTTAG AGAAAATCAA
CAGATCACCG TCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001288740.1 CDS 590..1864 Translation
Target ORF information:
RefSeq Version NM_001301811.1 Organism Mus musculus(house mouse) Definition Mus musculus interferon regulatory factor 8 (Irf8), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001301811.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261ATGTGTGACC GGAACGGCGG GCGGCGGCTG CGGCAGTGGC TGATCGAACA GATCGACAGC
AGCATGTACC CGGGGCTGAT CTGGGAAAAT GATGAGAAGA CCATGTTCCG TATCCCCTGG
AAGCATGCCG GCAAGCAGGA TTACAATCAG GAGGTGGATG CTTCCATCTT CAAGGCCTGG
GCAGTTTTTA AAGGGAAGTT TAAAGAGGGA GACAAAGCTG AACCAGCCAC GTGGAAGACG
AGGTTACGCT GTGCTCTGAA CAAGAGCCCA GATTTTGAAG AAGTGACTGA CCGGTCCCAG
CTGGACATTT CTGAGCCATA TAAAGTTTAC CGAATTGTCC CCGAGGAAGA ACAAAAATGC
AAGCTGGGCG TGGCACCTGC AGGCTGCATG AGCGAAGTTC CTGAGATGGA GTGTGGCCGC
TCAGAGATTG AGGAGCTGAT CAAGGAACCT TCTGTGGATG AGTACATGGG TATGACCAAG
AGGAGCCCAT CCCCACCAGA GGCCTGCAGG AGCCAGATCC TCCCTGACTG GTGGGTCCAG
CAGCCCAGTG CAGGCCTGCC ACTGGTGACC GGATATGCCG CCTATGACAC ACACCATTCA
GCTTTCTCCC AGATGGTCAT CAGCTTCTAC TACGGGGGCA AGCTGGTGGG CCAGGCCACC
ACCACCTGCC TTGAAGGCTG CCGTCTCTCC CTGAGCCAGC CGGGGCTGCC TAAGTTGTAT
GGGCCGGATG GCCTGGAACC CGTGTGCTTT CCGACGGCCG ACACCATCCC CAGTGAGCGG
CAGAGGCAGG TGACCCGGAA GCTGTTTGGG CACCTGGAAC GTGGCGTGCT ACTGCACAGC
AACCGCAAGG GCGTGTTCGT GAAGCGGCTG TGCCAGGGCC GCGTGTTCTG CAGCGGCAAC
GCGGTGGTGT GCAAGGGCAG GCCCAACAAG CTGGAGCGGG ACGAGGTGGT GCAGGTCTTT
GACACCAACC AGTTCATCCG AGAGCTGCAG CAATTCTACG CCACCCAGAG CCGCCTACCT
GACAGCAGGG TGGTCCTGTG CTTCGGGGAG GAGTTTCCGG ACACTGTGCC CTTGCGCTCC
AAACTCATTC TGGTGCAGGT AGAGCAGCTG TATGCCAGGC AGCTGGTGGA GGAAGCGGGC
AAGAGCTGCG GTGCTGGCTC CCTGATGCCA GCCCTGGAGG AGCCCCAGCC GGACCAGGCT
TTCCGCATGT TTCCGGATAT CTGTACCTCA CACCAGAGAC CCTTTTTTAG AGAAAATCAA
CAGATCACCG TCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.
Nature immunology20(9)1174-1185(2019 09)
Bagadia P,Huang X,Liu TT,Durai V,Grajales-Reyes GE,Nitschké M,Modrusan Z,Granja JM,Satpathy AT,Briseño CG,Gargaro M,Iwata A,Kim S,Chang HY,Shaw AS,Murphy TL,Murphy KM
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.
Nature immunology20(9)1161-1173(2019 09)
Durai V,Bagadia P,Granja JM,Satpathy AT,Kulkarni DH,Davidson JT 4th,Wu R,Patel SJ,Iwata A,Liu TT,Huang X,Briseño CG,Grajales-Reyes GE,Wöhner M,Tagoh H,Kee BL,Newberry RD,Busslinger M,Chang HY,Murphy TL,Murphy KM
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Nature neuroscience22(6)1021-1035(2019 06)
Van Hove H,Martens L,Scheyltjens I,De Vlaminck K,Pombo Antunes AR,De Prijck S,Vandamme N,De Schepper S,Van Isterdael G,Scott CL,Aerts J,Berx G,Boeckxstaens GE,Vandenbroucke RE,Vereecke L,Moechars D,Guilliams M,Van Ginderachter JA,Saeys Y,Movahedi K
Transcription factors IRF8 and PU.1 are required for follicular B cell development and BCL6-driven germinal center responses.
Proceedings of the National Academy of Sciences of the United States of America116(19)9511-9520(2019 May)
Wang H,Jain S,Li P,Lin JX,Oh J,Qi C,Gao Y,Sun J,Sakai T,Naghashfar Z,Abbasi S,Kovalchuk AL,Bolland S,Nutt SL,Leonard WJ,Morse HC 3rd
Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury.
Journal of neurochemistry129(6)988-1001(2014 Jun)
Xiang M,Wang L,Guo S,Lu YY,Lei H,Jiang DS,Zhang Y,Liu Y,Zhou Y,Zhang XD,Li H
-
-
Most Popular Services
-
Services & Products
-
News & Blogs
- The enemy of my enemy is my friend: Plasmodium falciparum, the malaria parasite, abolishes cancer immune evasion and inhibits blood vessel formation in tumor
- Walruses, Bats, and Humans Cuddle Their Young to Help The Brain Develop
- New Study Identifies Four Viruses that Can Produce Insulin-like hormones that Stimulate Human Cells
- The cause of heart disease is linked to a specific type of foreign lipid
- New Study Shows How Chimpanzees Can Spontaneously Learn
- Severe Respiratory Infections: New Mechanism for Pathology
- CRISPR/Cas9 Editing: T Cell Engineering for Immunotherapies
- Chinese scientists use CRISPR technology to repair pathogenic mutations in viable human embryos
-
-
-
PubMed
-
