| Gene Symbol | Gch1 |
| Entrez Gene ID | 14528 |
| Full Name | GTP cyclohydrolase 1 |
| Synonyms | GTP-CH,GTPCH,Gch |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
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Gch1 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Gch1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gch1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu01360 Clone ID Related Accession (Same CDS sequence) NM_008102.3 , NM_008102.4 Accession Version NM_008102.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 726bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1495814400000 Organism Mus musculus(house mouse) Product GTP cyclohydrolase 1 precursor Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC154589.3 and AC159006.2. On Nov 17, 2006 this sequence version replaced NM_008102.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005643.1, AK150657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG
CCCGGGGCCA GCCCGCCTGC CGAGAAGTCC CGGCCGCCCG AGGCCAAGGG CGCACAGCCG
GCCGACGCCT GGAAGGCAGG GCGGCACCGC AGCGAGGAGG AAAACCAGGT GAACCTCCCC
AAACTGGCGG CCGCTTACTC GTCCATTCTG CTCTCGCTGG GCGAGGACCC CCAGCGGCAG
GGGCTGCTCA AGACGCCCTG GAGGGCGGCC ACCGCCATGC AGTACTTCAC CAAGGGATAC
CAGGAGACCA TCTCAGATGT CCTGAATGAT GCTATATTTG ATGAAGATCA TGACGAGATG
GTGATTGTGA AGGACATAGA TATGTTCTCC ATGTGTGAGC ATCACCTTGT TCCATTTGTA
GGAAGGGTCC ATATTGGCTA TCTTCCTAAC AAGCAAGTCC TTGGTCTCAG TAAACTTGCC
AGGATTGTAG AAATCTACAG TAGACGACTA CAAGTTCAAG AGCGCCTCAC CAAACAGATT
GCGGTGGCCA TCACAGAAGC CTTGCAGCCT GCTGGCGTTG GAGTAGTGAT TGAAGCGACA
CACATGTGCA TGGTAATGCG AGGCGTGCAG AAAATGAACA GCAAGACTGT CACTAGCACC
ATGCTGGGCG TGTTCCGGGA AGACCCCAAG ACTCGGGAGG AGTTCCTCAC ACTAATCAGG
AGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_032128.1 CDS 136..861 Translation 
Target ORF information:
RefSeq Version NM_008102.3 Organism Mus musculus(house mouse) Definition Mus musculus GTP cyclohydrolase 1 (Gch1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_008102.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG
CCCGGGGCCA GCCCGCCTGC CGAGAAGTCC CGGCCGCCCG AGGCCAAGGG CGCACAGCCG
GCCGACGCCT GGAAGGCAGG GCGGCACCGC AGCGAGGAGG AAAACCAGGT GAACCTCCCC
AAACTGGCGG CCGCTTACTC GTCCATTCTG CTCTCGCTGG GCGAGGACCC CCAGCGGCAG
GGGCTGCTCA AGACGCCCTG GAGGGCGGCC ACCGCCATGC AGTACTTCAC CAAGGGATAC
CAGGAGACCA TCTCAGATGT CCTGAATGAT GCTATATTTG ATGAAGATCA TGACGAGATG
GTGATTGTGA AGGACATAGA TATGTTCTCC ATGTGTGAGC ATCACCTTGT TCCATTTGTA
GGAAGGGTCC ATATTGGCTA TCTTCCTAAC AAGCAAGTCC TTGGTCTCAG TAAACTTGCC
AGGATTGTAG AAATCTACAG TAGACGACTA CAAGTTCAAG AGCGCCTCAC CAAACAGATT
GCGGTGGCCA TCACAGAAGC CTTGCAGCCT GCTGGCGTTG GAGTAGTGAT TGAAGCGACA
CACATGTGCA TGGTAATGCG AGGCGTGCAG AAAATGAACA GCAAGACTGT CACTAGCACC
ATGCTGGGCG TGTTCCGGGA AGACCCCAAG ACTCGGGAGG AGTTCCTCAC ACTAATCAGG
AGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu01360 Clone ID Related Accession (Same CDS sequence) NM_008102.3 , NM_008102.4 Accession Version NM_008102.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 726bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577548800000 Organism Mus musculus(house mouse) Product GTP cyclohydrolase 1 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154589.3 and AC159006.2. On Apr 14, 2018 this sequence version replaced NM_008102.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150657.1, AK152571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG
CCCGGGGCCA GCCCGCCTGC CGAGAAGTCC CGGCCGCCCG AGGCCAAGGG CGCACAGCCG
GCCGACGCCT GGAAGGCAGG GCGGCACCGC AGCGAGGAGG AAAACCAGGT GAACCTCCCC
AAACTGGCGG CCGCTTACTC GTCCATTCTG CTCTCGCTGG GCGAGGACCC CCAGCGGCAG
GGGCTGCTCA AGACGCCCTG GAGGGCGGCC ACCGCCATGC AGTACTTCAC CAAGGGATAC
CAGGAGACCA TCTCAGATGT CCTGAATGAT GCTATATTTG ATGAAGATCA TGACGAGATG
GTGATTGTGA AGGACATAGA TATGTTCTCC ATGTGTGAGC ATCACCTTGT TCCATTTGTA
GGAAGGGTCC ATATTGGCTA TCTTCCTAAC AAGCAAGTCC TTGGTCTCAG TAAACTTGCC
AGGATTGTAG AAATCTACAG TAGACGACTA CAAGTTCAAG AGCGCCTCAC CAAACAGATT
GCGGTGGCCA TCACAGAAGC CTTGCAGCCT GCTGGCGTTG GAGTAGTGAT TGAAGCGACA
CACATGTGCA TGGTAATGCG AGGCGTGCAG AAAATGAACA GCAAGACTGT CACTAGCACC
ATGCTGGGCG TGTTCCGGGA AGACCCCAAG ACTCGGGAGG AGTTCCTCAC ACTAATCAGG
AGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_032128.1 CDS 147..872 Translation
Target ORF information:
RefSeq Version NM_008102.4 Organism Mus musculus(house mouse) Definition Mus musculus GTP cyclohydrolase 1 (Gch1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_008102.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721ATGGAGAAGC CGCGGGGAGT CAGGTGCACC AATGGGTTCT CCGAGCGGGA GCTGCCGCGG
CCCGGGGCCA GCCCGCCTGC CGAGAAGTCC CGGCCGCCCG AGGCCAAGGG CGCACAGCCG
GCCGACGCCT GGAAGGCAGG GCGGCACCGC AGCGAGGAGG AAAACCAGGT GAACCTCCCC
AAACTGGCGG CCGCTTACTC GTCCATTCTG CTCTCGCTGG GCGAGGACCC CCAGCGGCAG
GGGCTGCTCA AGACGCCCTG GAGGGCGGCC ACCGCCATGC AGTACTTCAC CAAGGGATAC
CAGGAGACCA TCTCAGATGT CCTGAATGAT GCTATATTTG ATGAAGATCA TGACGAGATG
GTGATTGTGA AGGACATAGA TATGTTCTCC ATGTGTGAGC ATCACCTTGT TCCATTTGTA
GGAAGGGTCC ATATTGGCTA TCTTCCTAAC AAGCAAGTCC TTGGTCTCAG TAAACTTGCC
AGGATTGTAG AAATCTACAG TAGACGACTA CAAGTTCAAG AGCGCCTCAC CAAACAGATT
GCGGTGGCCA TCACAGAAGC CTTGCAGCCT GCTGGCGTTG GAGTAGTGAT TGAAGCGACA
CACATGTGCA TGGTAATGCG AGGCGTGCAG AAAATGAACA GCAAGACTGT CACTAGCACC
ATGCTGGGCG TGTTCCGGGA AGACCCCAAG ACTCGGGAGG AGTTCCTCAC ACTAATCAGG
AGCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
A novel GTPCH deficiency mouse model exhibiting tetrahydrobiopterin-related metabolic disturbance and infancy-onset motor impairments.
Metabolism: clinical and experimental9496-104(2019 05)
Jiang X,Liu H,Shao Y,Peng M,Zhang W,Li D,Li X,Cai Y,Tan T,Lu X,Xu J,Su X,Lin Y,Liu Z,Huang Y,Zeng C,Tang YP,Liu L
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.
Nature563(7732)564-568(2018 11)
Cronin SJF,Seehus C,Weidinger A,Talbot S,Reissig S,Seifert M,Pierson Y,McNeill E,Longhi MS,Turnes BL,Kreslavsky T,Kogler M,Hoffmann D,Ticevic M,da Luz Scheffer D,Tortola L,Cikes D,Jais A,Rangachari M,Rao S,Paolino M,Novatchkova M,Aichinger M,Barrett L,Latremoliere A,Wirnsberger G,Lametschwandtner G,Busslinger M,Zicha S,Latini A,Robson SC,Waisman A,Andrews N,Costigan M,Channon KM,Weiss G,Kozlov AV,Tebbe M,Johnsson K,Woolf CJ,Penninger JM
Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis.
Nature communications9(1)3356(2018 08)
Scavuzzo MA,Hill MC,Chmielowiec J,Yang D,Teaw J,Sheng K,Kong Y,Bettini M,Zong C,Martin JF,Borowiak M
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Cardiovascular research114(10)1385-1399(2018 08)
Douglas G,Hale AB,Patel J,Chuaiphichai S,Al Haj Zen A,Rashbrook VS,Trelfa L,Crabtree MJ,McNeill E,Channon KM
Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy.
Scientific reports627925(2016 06)
Wu HE,Baumgardt SL,Fang J,Paterson M,Liu Y,Du J,Shi Y,Qiao S,Bosnjak ZJ,Warltier DC,Kersten JR,Ge ZD
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