F2rl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	F2rl1
Entrez Gene ID	14063
Full Name	coagulation factor II (thrombin) receptor-like 1
Synonyms	Gpcr11,PAR-2,Par2
General protein information	Preferred Names coagulation factor II (thrombin) receptor-like 1 Names proteinase-activated receptor 2 G-protein coupled receptor 11 Protease-activated receptor-2 coagulation factor II receptor-like 1 thrombin receptor-like 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 D1\|13 49.53 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007974.4	NP_032000.3	proteinase-activated receptor 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	F2RL1	NP_005233.3
Macaca mulatta (Rhesus monkey)	F2RL1	XP_001106263.1
Mus musculus (house mouse)	F2rl1	NP_032000.3
Gallus gallus (chicken)	F2RL1	NP_001012626.1
Danio rerio (zebrafish)	f2rl1.2	NP_001092248.1
Canis lupus familiaris (dog)	F2RL1	NP_001139463.1
Rattus norvegicus (Norway rat)	F2rl1	NP_446349.1
Pan troglodytes (chimpanzee)	F2RL1	XP_001145175.1
Xenopus tropicalis (tropical clawed frog)	f2rl1	XP_004910449.1
Bos taurus (cattle)	F2RL1	NP_001039748.1

Gene Ontology
Bibliography

Related articles in PubMed

Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity.
Watanabe M, Oe Y, Sato E, Sekimoto A, Sato H, Ito S, Takahashi N
American journal of physiology. Renal physiology316(4)F654-F659(2019 04)

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.
Caminero A, McCarville JL, Galipeau HJ, Deraison C, Bernier SP, Constante M, Rolland C, Meisel M, Murray JA, Yu XB, Alaedini A, Coombes BK, Bercik P, Southward CM, Ruf W, Jabri B, Chirdo FG, Casqueiro J, Surette MG, Vergnolle N, Verdu EF
Nature communications10(1)1198(2019 03)

IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation.
Hiraishi Y, Yamaguchi S, Yoshizaki T, Nambu A, Shimura E, Takamori A, Narushima S, Nakanishi W, Asada Y, Numata T, Suzukawa M, Yamauchi Y, Matsuda A, Arae K, Morita H, Hoshino T, Suto H, Okumura K, Matsumoto K, Saito H, Sudo K, Iikura M, Nagase T, Nakae S
Scientific reports8(1)18052(2018 12)

Protease-activated receptor 2 (PAR2) upregulates granulocyte colony stimulating factor (G-CSF) expression in breast cancer cells.
Carvalho É, Hugo de Almeida V, Rondon AMR, Possik PA, Viola JPB, Monteiro RQ
Biochemical and biophysical research communications504(1)270-276(2018 09)

Activated protein C reverses epigenetically sustained p66
Shahzad K, Gadi I, Nazir S, Al-Dabet MM, Kohli S, Bock F, Breitenstein L, Ranjan S, Fuchs T, Halloul Z, Nawroth PP, Pelicci PG, Braun-Dullaeus RC, Camerer E, Esmon CT, Isermann B
Communications biology1104(2018)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following F2rl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F2rl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13444	NM_007974.4 Latest version!	Mus musculus coagulation factor II (thrombin) receptor-like 1 (F2rl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F2rl1 ( NM_007974.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032000.3 Mus musculus coagulation factor II (thrombin) receptor-like 1 (F2rl1), mRNA.

Price & Availability↑

CloneID	OMu13444
Clone ID Related Accession (Same CDS sequence)	NM_007974.4
Accession Version	NM_007974.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1578067200000
Organism	Mus musculus(house mouse)
Product	proteinase-activated receptor 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY029876.1, AK160916.1 and DV551864.1. On Apr 1, 2008 this sequence version replaced NM_007974.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY029876.1, AK160916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCGAAGTC TCAGCCTGGC GTGGCTGCTG GGAGGTATCA CCCTTCTGGC GGCCTCGGTC 
TCCTGCAGCC GGACCGAGAA CCTTGCACCG GGACGCAACA ACAGTAAAGG AAGAAGTCTT 
ATTGGCAGAT TAGAAACCCA GCCTCCAATC ACTGGGAAAG GGGTTCCGGT AGAACCAGGC 
TTTTCCATCG ATGAGTTCTC TGCGTCCATC CTCACCGGGA AGCTGACCAC GGTCTTTCTT 
CCGGTCGTCT ACATTATTGT GTTTGTGATT GGTTTGCCCA GTAATGGCAT GGCCCTCTGG 
ATCTTCCTTT TCCGAACGAA GAAGAAACAC CCCGCCGTGA TTTACATGGC CAACCTGGCC 
TTGGCCGACC TCCTCTCTGT CATCTGGTTC CCCCTGAAGA TCTCCTACCA CCTACATGGC 
AACAACTGGG TCTACGGGGA GGCCCTGTGC AAGGTGCTCA TTGGCTTTTT CTATGGTAAC 
ATGTATTGCT CCATCCTCTT CATGACCTGC CTCAGCGTGC AGAGGTACTG GGTGATCGTG 
AACCCCATGG GACACCCCAG GAAGAAGGCA AACATCGCCG TTGGCGTCTC CTTGGCAATC 
TGGCTCCTGA TTTTTCTGGT CACCATCCCT TTGTATGTCA TGAAGCAGAC CATCTACATT 
CCAGCATTGA ACATCACCAC CTGTCACGAT GTGCTGCCTG AGGAGGTATT GGTGGGGGAC 
ATGTTCAATT ACTTCCTCTC ACTGGCCATT GGAGTCTTCC TGTTCCCGGC CCTCCTTACT 
GCATCTGCCT ACGTGCTCAT GATCAAGACG CTCCGCTCTT CTGCTATGGA TGAACACTCA 
GAGAAGAAAA GGCAGAGGGC TATCCGACTC ATCATCACCG TGCTGGCCAT GTACTTCATC 
TGCTTTGCTC CTAGCAACCT TCTGCTCGTA GTGCATTATT TCCTAATCAA AACCCAGAGG 
CAGAGCCACG TCTACGCCCT CTACCTTGTC GCCCTCTGCC TGTCGACCCT CAACAGCTGC 
ATAGACCCCT TTGTCTATTA CTTTGTCTCA AAAGATTTCA GGGATCACGC CAGAAACGCG 
CTCCTCTGCC GAAGTGTCCG CACTGTGAAT CGCATGCAAA TCTCGCTCAG CTCCAACAAG 
TTCTCCAGGA AGTCCGGCTC CTACTCTTCA AGCTCAACCA GTGTTAAAAC CTCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032000.3
CDS	114..1313
Translation	MRSLSLAWLLGGITLLAASVSCSRTENLAPGRNNSKGRSLIGRLETQPPITGKGVPVEPGFSIDEFSASILTGKLTTVFLPVVYIIVFVIGLPSNGMALWIFLFRTKKKHPAVIYMANLALADLLSVIWFPLKISYHLHGNNWVYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHPRKKANIAVGVSLAIWLLIFLVTIPLYVMKQTIYIPALNITTCHDVLPEEVLVGDMFNYFLSLAIGVFLFPALLTASAYVLMIKTLRSSAMDEHSEKKRQRAIRLIITVLAMYFICFAPSNLLLVVHYFLIKTQRQSHVYALYLVALCLSTLNSCIDPFVYYFVSKDFRDHARNALLCRSVRTVNRMQISLSSNKFSRKSGSYSSSSTSVKTSY

Target ORF information:

RefSeq Version	NM_007974.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus coagulation factor II (thrombin) receptor-like 1 (F2rl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007974.4

ORF Insert Sequence:

ATGCGAAGTC TCAGCCTGGC GTGGCTGCTG GGAGGTATCA CCCTTCTGGC GGCCTCGGTC 
TCCTGCAGCC GGACCGAGAA CCTTGCACCG GGACGCAACA ACAGTAAAGG AAGAAGTCTT 
ATTGGCAGAT TAGAAACCCA GCCTCCAATC ACTGGGAAAG GGGTTCCGGT AGAACCAGGC 
TTTTCCATCG ATGAGTTCTC TGCGTCCATC CTCACCGGGA AGCTGACCAC GGTCTTTCTT 
CCGGTCGTCT ACATTATTGT GTTTGTGATT GGTTTGCCCA GTAATGGCAT GGCCCTCTGG 
ATCTTCCTTT TCCGAACGAA GAAGAAACAC CCCGCCGTGA TTTACATGGC CAACCTGGCC 
TTGGCCGACC TCCTCTCTGT CATCTGGTTC CCCCTGAAGA TCTCCTACCA CCTACATGGC 
AACAACTGGG TCTACGGGGA GGCCCTGTGC AAGGTGCTCA TTGGCTTTTT CTATGGTAAC 
ATGTATTGCT CCATCCTCTT CATGACCTGC CTCAGCGTGC AGAGGTACTG GGTGATCGTG 
AACCCCATGG GACACCCCAG GAAGAAGGCA AACATCGCCG TTGGCGTCTC CTTGGCAATC 
TGGCTCCTGA TTTTTCTGGT CACCATCCCT TTGTATGTCA TGAAGCAGAC CATCTACATT 
CCAGCATTGA ACATCACCAC CTGTCACGAT GTGCTGCCTG AGGAGGTATT GGTGGGGGAC 
ATGTTCAATT ACTTCCTCTC ACTGGCCATT GGAGTCTTCC TGTTCCCGGC CCTCCTTACT 
GCATCTGCCT ACGTGCTCAT GATCAAGACG CTCCGCTCTT CTGCTATGGA TGAACACTCA 
GAGAAGAAAA GGCAGAGGGC TATCCGACTC ATCATCACCG TGCTGGCCAT GTACTTCATC 
TGCTTTGCTC CTAGCAACCT TCTGCTCGTA GTGCATTATT TCCTAATCAA AACCCAGAGG 
CAGAGCCACG TCTACGCCCT CTACCTTGTC GCCCTCTGCC TGTCGACCCT CAACAGCTGC 
ATAGACCCCT TTGTCTATTA CTTTGTCTCA AAAGATTTCA GGGATCACGC CAGAAACGCG 
CTCCTCTGCC GAAGTGTCCG CACTGTGAAT CGCATGCAAA TCTCGCTCAG CTCCAACAAG 
TTCTCCAGGA AGTCCGGCTC CTACTCTTCA AGCTCAACCA GTGTTAAAAC CTCCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity.
American journal of physiology. Renal physiology316(4)F654-F659(2019 04)
Watanabe M,Oe Y,Sato E,Sekimoto A,Sato H,Ito S,Takahashi N

Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.
Nature communications10(1)1198(2019 03)
Caminero A,McCarville JL,Galipeau HJ,Deraison C,Bernier SP,Constante M,Rolland C,Meisel M,Murray JA,Yu XB,Alaedini A,Coombes BK,Bercik P,Southward CM,Ruf W,Jabri B,Chirdo FG,Casqueiro J,Surette MG,Vergnolle N,Verdu EF

IL-33, IL-25 and TSLP contribute to development of fungal-associated protease-induced innate-type airway inflammation.
Scientific reports8(1)18052(2018 12)
Hiraishi Y,Yamaguchi S,Yoshizaki T,Nambu A,Shimura E,Takamori A,Narushima S,Nakanishi W,Asada Y,Numata T,Suzukawa M,Yamauchi Y,Matsuda A,Arae K,Morita H,Hoshino T,Suto H,Okumura K,Matsumoto K,Saito H,Sudo K,Iikura M,Nagase T,Nakae S

Protease-activated receptor 2 (PAR2) upregulates granulocyte colony stimulating factor (G-CSF) expression in breast cancer cells.
Biochemical and biophysical research communications504(1)270-276(2018 09)
Carvalho É,Hugo de Almeida V,Rondon AMR,Possik PA,Viola JPB,Monteiro RQ

Activated protein C reverses epigenetically sustained p66
Communications biology1104(2018)
Shahzad K,Gadi I,Nazir S,Al-Dabet MM,Kohli S,Bock F,Breitenstein L,Ranjan S,Fuchs T,Halloul Z,Nawroth PP,Pelicci PG,Braun-Dullaeus RC,Camerer E,Esmon CT,Isermann B

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F2rl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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