Dsc2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dsc2
Entrez Gene ID	13506
Full Name	desmocollin 2
Synonyms	AW228162
General protein information	Preferred Names desmocollin 2 Names desmocollin-2 epithelial type 2 desmocollin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 A2\|18 11.14 cM
Summary	This gene encodes a member of the desmocollin protein subfamily. Desmocollins are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001317363.1	NP_001304292.1	desmocollin-2 isoform 3
NM_001317365.1	NP_001304294.1	desmocollin-2 isoform Dsc2a preproprotein
NM_013505.4	NP_038533.1	desmocollin-2 isoform Dsc2b preproprotein

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	LOC712942	XP_001102096.2
Homo sapiens (human)	DSC2	NP_077740.1
Mus musculus (house mouse)	Dsc2	NP_038533.1
Gallus gallus (chicken)	DSC2	XP_004939874.1
Canis lupus familiaris (dog)	DSC2	XP_866930.1
Rattus norvegicus (Norway rat)	Dsc2	NP_001028860.1
Xenopus tropicalis (tropical clawed frog)	dsc3	NP_001122136.1
Pan troglodytes (chimpanzee)	DSC2	XP_512077.3
Bos taurus (cattle)	DSC2	NP_001159998.1

Gene Ontology
Bibliography

Related articles in PubMed

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.
Choi YJ, Laclef C, Yang N, Andreu-Cervera A, Lewis J, Mao X, Li L, Snedecor ER, Takemaru KI, Qin C, Schneider-Maunoury S, Shroyer KR, Hannun YA, Koch PJ, Clark RA, Payne AS, Kowalczyk AP, Chen J
PLoS genetics15(1)e1007914(2019 01)

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Gross A, Pack LAP, Schacht GM, Kant S, Ungewiss H, Meir M, Schlegel N, Preisinger C, Boor P, Guldiken N, Krusche CA, Sellge G, Trautwein C, Waschke J, Heuser A, Leube RE, Strnad P
Mucosal immunology11(6)1630-1639(2018 11)

MicroRNA-130a Regulation of Desmocollin 2 in a Novel Model of Arrhythmogenic Cardiomyopathy.
Mazurek SR, Calway T, Harmon C, Farrell P, Kim GH
MicroRNA (Shariqah, United Arab Emirates)6(2)143-150(2017)

Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling.
Brodehl A, Belke DD, Garnett L, Martens K, Abdelfatah N, Rodriguez M, Diao C, Chen YX, Gordon PM, Nygren A, Gerull B
PloS one12(3)e0174019(2017)

Structure and function of desmosomal proteins and their role in development and disease.
Huber O
Cellular and molecular life sciences : CMLS60(9)1872-90(2003 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dsc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dsc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu14841	NM_013505.4 Latest version!	Mus musculus desmocollin 2 (Dsc2), transcript variant Dsc2b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OMu54355	NM_001317365.1 Latest version!	Mus musculus desmocollin 2 (Dsc2), transcript variant Dsc2a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OMu83517	NM_001317363.1 Latest version!	Mus musculus desmocollin 2 (Dsc2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dsc2 ( NM_013505.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038533.1 Mus musculus desmocollin 2 (Dsc2), transcript variant Dsc2b, mRNA.

Price & Availability↑

CloneID	OMu14841
Clone ID Related Accession (Same CDS sequence)	NM_013505.4
Accession Version	NM_013505.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2547bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570377600000
Organism	Mus musculus(house mouse)
Product	desmocollin-2 isoform Dsc2b preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY093917.1, AK048547.1, BY422831.1 and BY425109.1. On Dec 2, 2015 this sequence version replaced NM_013505.3. Transcript Variant: This variant (Dsc2b) contains an additional exon at the 3' end, which results in a frameshift, compared to variant Dsc2a. The encoded isoform (Dsc2b) has a shorter and distinct C-terminus compared to isoform Dsc2a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK172168.1, AK048547.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTG TGGGATCTAT GCGCTCCGGG AGCCCTGCCT TCGGCCTGGG ACACCTGTTG 
ACCCTTGCGA TCCTTGCACT TGCCTCTGAT GCCTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCCGAGAA ATTTGTTGGC AGAGTGAACC TGATGGACTG CCTTAAATCA 
GCAGACATAG TTCATCTGAG TGATCCTGAC TTCCAAGTCT TAGAAGATGG TTCTGTGTAC 
ACAACCAGTT CTGTTGTTTT GTCCTCGGGG CAAAGAAGCT TTACTATATG GCTTTTTAGC 
ACAGACAGCC AAGAAGAAAG GGAGATATCT GTCCATTTAG AGGGCCCAGT AGAGGTACTA 
AATAAAAGAC CGCATACAGA GAAGGTTCTC AGCCGTGCCA AGAGAAGATG GGCTCCTATC 
CCTTGTTCCA TGCTAGAGAA TTCATTGGGT CCCTTCCCAC TTTTCCTTCA ACAGATCCAG 
TCTGACACAG CTCAAAACTA TACCATATAC TATTCCATCA GAGGTCCAGG AGTTGATAAA 
GAACCTCTAA ACTTATTTTA TGTGGAAAGA GATACTGGAA ACCTGTATTG CACTGGTCGT 
GTAGATCGTG AGCAGTATGA GTCCTTTGAG CTGACTGCAT TTGCAACAAC TCCAGATGGG 
TATACGCCAG AGTACCCACT GCCGCTCCTC ATTAAAATAG AGGACGAGAA CGATAATTAC 
CCGATCTTTA CACAGAAACT GTACAGCTTC ACAGTTCAGG AAAATAGTCG CATTGGTTCT 
ATTGTGGGGG AGGTCTGTGC AACCGACCTG GATGAGCCAG ACACAATGCA CACTCGCCTG 
AGGTACTCCA TCCTGGAGCA GTCGCCTTCT CCACCCATGC TATTTACTAT GCATCCCAGC 
ACTGGTGTGA TCACTACCAC GTCGGCTCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGCTAATAA AAGTCCAGGA TATGGATGGC CAGTATTTTG GTTTGCACAC AACAGCAAAG 
TGCATCATTA CTATTGAAGA TGTGAATGAC AACCTGCCCA CGTTCACTCG CACTACGTAT 
GTGACATCAG TGGAAGAAAA TACAGTTAAT GTGGAAATCT TGCGACTTAC TGTTCAGGAT 
AAAGATTTAG TTAACTCACC TAATTGGAGA GCTAATTACA CCATTTTGAA GGGCAATGAA 
AATGGAAATT TTAAAATCGT AACAGATCCT AAAACCAATG AAGGCATTCT GTGTGTGATT 
AAGCCTCTGG ACTATGAAGA ACGGCAACAG GTGACCCTGC AAATTGGAGT AGTTAATGAA 
GCTCCATACA CTAGAGAGGC TAGCTCAAAG TCACCCATGA GCACAGCCAC AGTGACTGTC 
ACCGTGACAA ATCAGGATGA GGGCCCCGAG TGTATCCCTC CAATGCAAAC TGTGAGGATT 
CAAGAAAATG TACCAGTTGG GACTAGAAAT GATGGATATA AGGCATATGA CCCAGAGACC 
AGAAGCAGCA GTGGCATAAG GTACAGAAAG TTAAGTGACC CAAGAGGGTG GGTCACTGTT 
AATGAAGATT CAGGATCGAT CACTATTTTC CGAGCGTTGG ATCGAGAGGC TGAGACTGTC 
AGAAATGGCA TTTACAATAT TACAGTCCTT GCGTTAGATG CAGATGGGAG AAGCTGTACT 
GGAACTCTGG GAATCATACT TGAAGATGTG AATGATAATG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAAGGC TACCATGTCC TCTGCTGAAA TTGTTGCAGT TGATCTCGAT 
GATCCAGTGA ATGGCCCACC ATTTGATTTC AGTTTGGAGA GCTCTGATTC GGAAGTTCAG 
AGGATGTGGA GGCTAACAAG AATCAATGAT ACAGCAGCTC GTCTTTCCTA TCAGAACGAC 
CCTTCATTTG GATCCTATGC AGTTCCCATT CGAGTTACAG ACAGACTTGG TCTGTCCTCA 
GTAACCACAT TGAATGTCCT TGTATGTGAC TGCATTACTG AAAGTGACTG CACACTCCGC 
TCTGGAGAAA GGACTGGCTA TGCTGATGTG AGACTTGGAC CATGGGCCAT CCTTGCTATA 
CTGTTGGGCA TAGCCTTGCT ATTTTGTATC CTGTTTACAT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCTGAT GACTTAGCTC AACAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTT TATTCCACAA ACGGCTTGAC AACTCAAACT 
ATGGGAGCTT CTGGGCAGAC AGCTTTCACC ACCATGGGAA CTGGAGTCAA AAGTGGAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGG CAGCAGACTT TGGACTCACG CAGAGGGGCT 
GGCTATCATC ACCATACCCT GGATCCTTGC AGGGGAGGAC ATGTGGAGGT GGACAACTAC 
AGACACACTT ACTCAGAGTG GTACAATTTC ATTCAGCCCC GACTTGGTGA TGAAACCATT 
AGAGGACACA CTCTGATTAA AAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038533.1
CDS	303..2849
Translation	MAAVGSMRSGSPAFGLGHLLTLAILALASDACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIVHLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREISVHLEGPVEVLNKRPHTEKVLSRAKRRWAPIPCSMLENSLGPFPLFLQQIQSDTAQNYTIYYSIRGPGVDKEPLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDNYPIFTQKLYSFTVQENSRIGSIVGEVCATDLDEPDTMHTRLRYSILEQSPSPPMLFTMHPSTGVITTTSAQLDRELIDKYQLLIKVQDMDGQYFGLHTTAKCIITIEDVNDNLPTFTRTTYVTSVEENTVNVEILRLTVQDKDLVNSPNWRANYTILKGNENGNFKIVTDPKTNEGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASSKSPMSTATVTVTVTNQDEGPECIPPMQTVRIQENVPVGTRNDGYKAYDPETRSSSGIRYRKLSDPRGWVTVNEDSGSITIFRALDREAETVRNGIYNITVLALDADGRSCTGTLGIILEDVNDNGPFIPKQTVVICKATMSSAEIVAVDLDDPVNGPPFDFSLESSDSEVQRMWRLTRINDTAARLSYQNDPSFGSYAVPIRVTDRLGLSSVTTLNVLVCDCITESDCTLRSGERTGYADVRLGPWAILAILLGIALLFCILFTLVCSVSRASKQQKILPDDLAQQNLIVSNTEAPGDDKVYSTNGLTTQTMGASGQTAFTTMGTGVKSGGQETIEMVKGGQQTLDSRRGAGYHHHTLDPCRGGHVEVDNYRHTYSEWYNFIQPRLGDETIRGHTLIKN

Target ORF information:

RefSeq Version	NM_013505.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmocollin 2 (Dsc2), transcript variant Dsc2b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013505.4

ORF Insert Sequence:

ATGGCGGCTG TGGGATCTAT GCGCTCCGGG AGCCCTGCCT TCGGCCTGGG ACACCTGTTG 
ACCCTTGCGA TCCTTGCACT TGCCTCTGAT GCCTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCCGAGAA ATTTGTTGGC AGAGTGAACC TGATGGACTG CCTTAAATCA 
GCAGACATAG TTCATCTGAG TGATCCTGAC TTCCAAGTCT TAGAAGATGG TTCTGTGTAC 
ACAACCAGTT CTGTTGTTTT GTCCTCGGGG CAAAGAAGCT TTACTATATG GCTTTTTAGC 
ACAGACAGCC AAGAAGAAAG GGAGATATCT GTCCATTTAG AGGGCCCAGT AGAGGTACTA 
AATAAAAGAC CGCATACAGA GAAGGTTCTC AGCCGTGCCA AGAGAAGATG GGCTCCTATC 
CCTTGTTCCA TGCTAGAGAA TTCATTGGGT CCCTTCCCAC TTTTCCTTCA ACAGATCCAG 
TCTGACACAG CTCAAAACTA TACCATATAC TATTCCATCA GAGGTCCAGG AGTTGATAAA 
GAACCTCTAA ACTTATTTTA TGTGGAAAGA GATACTGGAA ACCTGTATTG CACTGGTCGT 
GTAGATCGTG AGCAGTATGA GTCCTTTGAG CTGACTGCAT TTGCAACAAC TCCAGATGGG 
TATACGCCAG AGTACCCACT GCCGCTCCTC ATTAAAATAG AGGACGAGAA CGATAATTAC 
CCGATCTTTA CACAGAAACT GTACAGCTTC ACAGTTCAGG AAAATAGTCG CATTGGTTCT 
ATTGTGGGGG AGGTCTGTGC AACCGACCTG GATGAGCCAG ACACAATGCA CACTCGCCTG 
AGGTACTCCA TCCTGGAGCA GTCGCCTTCT CCACCCATGC TATTTACTAT GCATCCCAGC 
ACTGGTGTGA TCACTACCAC GTCGGCTCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGCTAATAA AAGTCCAGGA TATGGATGGC CAGTATTTTG GTTTGCACAC AACAGCAAAG 
TGCATCATTA CTATTGAAGA TGTGAATGAC AACCTGCCCA CGTTCACTCG CACTACGTAT 
GTGACATCAG TGGAAGAAAA TACAGTTAAT GTGGAAATCT TGCGACTTAC TGTTCAGGAT 
AAAGATTTAG TTAACTCACC TAATTGGAGA GCTAATTACA CCATTTTGAA GGGCAATGAA 
AATGGAAATT TTAAAATCGT AACAGATCCT AAAACCAATG AAGGCATTCT GTGTGTGATT 
AAGCCTCTGG ACTATGAAGA ACGGCAACAG GTGACCCTGC AAATTGGAGT AGTTAATGAA 
GCTCCATACA CTAGAGAGGC TAGCTCAAAG TCACCCATGA GCACAGCCAC AGTGACTGTC 
ACCGTGACAA ATCAGGATGA GGGCCCCGAG TGTATCCCTC CAATGCAAAC TGTGAGGATT 
CAAGAAAATG TACCAGTTGG GACTAGAAAT GATGGATATA AGGCATATGA CCCAGAGACC 
AGAAGCAGCA GTGGCATAAG GTACAGAAAG TTAAGTGACC CAAGAGGGTG GGTCACTGTT 
AATGAAGATT CAGGATCGAT CACTATTTTC CGAGCGTTGG ATCGAGAGGC TGAGACTGTC 
AGAAATGGCA TTTACAATAT TACAGTCCTT GCGTTAGATG CAGATGGGAG AAGCTGTACT 
GGAACTCTGG GAATCATACT TGAAGATGTG AATGATAATG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAAGGC TACCATGTCC TCTGCTGAAA TTGTTGCAGT TGATCTCGAT 
GATCCAGTGA ATGGCCCACC ATTTGATTTC AGTTTGGAGA GCTCTGATTC GGAAGTTCAG 
AGGATGTGGA GGCTAACAAG AATCAATGAT ACAGCAGCTC GTCTTTCCTA TCAGAACGAC 
CCTTCATTTG GATCCTATGC AGTTCCCATT CGAGTTACAG ACAGACTTGG TCTGTCCTCA 
GTAACCACAT TGAATGTCCT TGTATGTGAC TGCATTACTG AAAGTGACTG CACACTCCGC 
TCTGGAGAAA GGACTGGCTA TGCTGATGTG AGACTTGGAC CATGGGCCAT CCTTGCTATA 
CTGTTGGGCA TAGCCTTGCT ATTTTGTATC CTGTTTACAT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCTGAT GACTTAGCTC AACAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTT TATTCCACAA ACGGCTTGAC AACTCAAACT 
ATGGGAGCTT CTGGGCAGAC AGCTTTCACC ACCATGGGAA CTGGAGTCAA AAGTGGAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGG CAGCAGACTT TGGACTCACG CAGAGGGGCT 
GGCTATCATC ACCATACCCT GGATCCTTGC AGGGGAGGAC ATGTGGAGGT GGACAACTAC 
AGACACACTT ACTCAGAGTG GTACAATTTC ATTCAGCCCC GACTTGGTGA TGAAACCATT 
AGAGGACACA CTCTGATTAA AAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dsc2 ( NM_001317365.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001304294.1 Mus musculus desmocollin 2 (Dsc2), transcript variant Dsc2a, mRNA.

Price & Availability↑

CloneID	OMu54355
Clone ID Related Accession (Same CDS sequence)	NM_001317365.1
Accession Version	NM_001317365.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2709bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570377600000
Organism	Mus musculus(house mouse)
Product	desmocollin-2 isoform Dsc2a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY093917.1, AK048547.1, BY422831.1 and BY425109.1. On Dec 2, 2015 this sequence version replaced XM_006525592.1. Transcript Variant: This variant (Dsc2a) encodes the longest isoform (Dsc2a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCTG TGGGATCTAT GCGCTCCGGG AGCCCTGCCT TCGGCCTGGG ACACCTGTTG 
ACCCTTGCGA TCCTTGCACT TGCCTCTGAT GCCTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCCGAGAA ATTTGTTGGC AGAGTGAACC TGATGGACTG CCTTAAATCA 
GCAGACATAG TTCATCTGAG TGATCCTGAC TTCCAAGTCT TAGAAGATGG TTCTGTGTAC 
ACAACCAGTT CTGTTGTTTT GTCCTCGGGG CAAAGAAGCT TTACTATATG GCTTTTTAGC 
ACAGACAGCC AAGAAGAAAG GGAGATATCT GTCCATTTAG AGGGCCCAGT AGAGGTACTA 
AATAAAAGAC CGCATACAGA GAAGGTTCTC AGCCGTGCCA AGAGAAGATG GGCTCCTATC 
CCTTGTTCCA TGCTAGAGAA TTCATTGGGT CCCTTCCCAC TTTTCCTTCA ACAGATCCAG 
TCTGACACAG CTCAAAACTA TACCATATAC TATTCCATCA GAGGTCCAGG AGTTGATAAA 
GAACCTCTAA ACTTATTTTA TGTGGAAAGA GATACTGGAA ACCTGTATTG CACTGGTCGT 
GTAGATCGTG AGCAGTATGA GTCCTTTGAG CTGACTGCAT TTGCAACAAC TCCAGATGGG 
TATACGCCAG AGTACCCACT GCCGCTCCTC ATTAAAATAG AGGACGAGAA CGATAATTAC 
CCGATCTTTA CACAGAAACT GTACAGCTTC ACAGTTCAGG AAAATAGTCG CATTGGTTCT 
ATTGTGGGGG AGGTCTGTGC AACCGACCTG GATGAGCCAG ACACAATGCA CACTCGCCTG 
AGGTACTCCA TCCTGGAGCA GTCGCCTTCT CCACCCATGC TATTTACTAT GCATCCCAGC 
ACTGGTGTGA TCACTACCAC GTCGGCTCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGCTAATAA AAGTCCAGGA TATGGATGGC CAGTATTTTG GTTTGCACAC AACAGCAAAG 
TGCATCATTA CTATTGAAGA TGTGAATGAC AACCTGCCCA CGTTCACTCG CACTACGTAT 
GTGACATCAG TGGAAGAAAA TACAGTTAAT GTGGAAATCT TGCGACTTAC TGTTCAGGAT 
AAAGATTTAG TTAACTCACC TAATTGGAGA GCTAATTACA CCATTTTGAA GGGCAATGAA 
AATGGAAATT TTAAAATCGT AACAGATCCT AAAACCAATG AAGGCATTCT GTGTGTGATT 
AAGCCTCTGG ACTATGAAGA ACGGCAACAG GTGACCCTGC AAATTGGAGT AGTTAATGAA 
GCTCCATACA CTAGAGAGGC TAGCTCAAAG TCACCCATGA GCACAGCCAC AGTGACTGTC 
ACCGTGACAA ATCAGGATGA GGGCCCCGAG TGTATCCCTC CAATGCAAAC TGTGAGGATT 
CAAGAAAATG TACCAGTTGG GACTAGAAAT GATGGATATA AGGCATATGA CCCAGAGACC 
AGAAGCAGCA GTGGCATAAG GTACAGAAAG TTAAGTGACC CAAGAGGGTG GGTCACTGTT 
AATGAAGATT CAGGATCGAT CACTATTTTC CGAGCGTTGG ATCGAGAGGC TGAGACTGTC 
AGAAATGGCA TTTACAATAT TACAGTCCTT GCGTTAGATG CAGATGGGAG AAGCTGTACT 
GGAACTCTGG GAATCATACT TGAAGATGTG AATGATAATG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAAGGC TACCATGTCC TCTGCTGAAA TTGTTGCAGT TGATCTCGAT 
GATCCAGTGA ATGGCCCACC ATTTGATTTC AGTTTGGAGA GCTCTGATTC GGAAGTTCAG 
AGGATGTGGA GGCTAACAAG AATCAATGAT ACAGCAGCTC GTCTTTCCTA TCAGAACGAC 
CCTTCATTTG GATCCTATGC AGTTCCCATT CGAGTTACAG ACAGACTTGG TCTGTCCTCA 
GTAACCACAT TGAATGTCCT TGTATGTGAC TGCATTACTG AAAGTGACTG CACACTCCGC 
TCTGGAGAAA GGACTGGCTA TGCTGATGTG AGACTTGGAC CATGGGCCAT CCTTGCTATA 
CTGTTGGGCA TAGCCTTGCT ATTTTGTATC CTGTTTACAT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCTGAT GACTTAGCTC AACAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTT TATTCCACAA ACGGCTTGAC AACTCAAACT 
ATGGGAGCTT CTGGGCAGAC AGCTTTCACC ACCATGGGAA CTGGAGTCAA AAGTGGAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGG CAGCAGACTT TGGACTCACG CAGAGGGGCT 
GGCTATCATC ACCATACCCT GGATCCTTGC AGGGGAGGAC ATGTGGAGGT GGACAACTAC 
AGACACACTT ACTCAGAGTG GTACAATTTC ATTCAGCCCC GACTTGGTGA TAAGGTACAG 
TTTTGCCATA CGGATGACAA CCAGAAGCTT GCTCAAGACT ACGTCCTCAC ATACAACTAT 
GAGGGAAAAG GCTCGGCTGC TGGCTCTGTG GGTTGCTGTA GTGACCTACA GGAAGAAGAC 
GGGCTTGAGT TTTTGGACCA TCTGGAGCCC AAATTTAGGA CATTGGCAGA AGTATGTGCA 
AAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304294.1
CDS	303..3011
Translation	MAAVGSMRSGSPAFGLGHLLTLAILALASDACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIVHLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREISVHLEGPVEVLNKRPHTEKVLSRAKRRWAPIPCSMLENSLGPFPLFLQQIQSDTAQNYTIYYSIRGPGVDKEPLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDNYPIFTQKLYSFTVQENSRIGSIVGEVCATDLDEPDTMHTRLRYSILEQSPSPPMLFTMHPSTGVITTTSAQLDRELIDKYQLLIKVQDMDGQYFGLHTTAKCIITIEDVNDNLPTFTRTTYVTSVEENTVNVEILRLTVQDKDLVNSPNWRANYTILKGNENGNFKIVTDPKTNEGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASSKSPMSTATVTVTVTNQDEGPECIPPMQTVRIQENVPVGTRNDGYKAYDPETRSSSGIRYRKLSDPRGWVTVNEDSGSITIFRALDREAETVRNGIYNITVLALDADGRSCTGTLGIILEDVNDNGPFIPKQTVVICKATMSSAEIVAVDLDDPVNGPPFDFSLESSDSEVQRMWRLTRINDTAARLSYQNDPSFGSYAVPIRVTDRLGLSSVTTLNVLVCDCITESDCTLRSGERTGYADVRLGPWAILAILLGIALLFCILFTLVCSVSRASKQQKILPDDLAQQNLIVSNTEAPGDDKVYSTNGLTTQTMGASGQTAFTTMGTGVKSGGQETIEMVKGGQQTLDSRRGAGYHHHTLDPCRGGHVEVDNYRHTYSEWYNFIQPRLGDKVQFCHTDDNQKLAQDYVLTYNYEGKGSAAGSVGCCSDLQEEDGLEFLDHLEPKFRTLAEVCAKR

Target ORF information:

RefSeq Version	NM_001317365.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmocollin 2 (Dsc2), transcript variant Dsc2a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317365.1

ORF Insert Sequence:

ATGGCGGCTG TGGGATCTAT GCGCTCCGGG AGCCCTGCCT TCGGCCTGGG ACACCTGTTG 
ACCCTTGCGA TCCTTGCACT TGCCTCTGAT GCCTGTAAAG AAGTCGTCCT CCAGGTCCCC 
TCTGAACTAC CTGCCGAGAA ATTTGTTGGC AGAGTGAACC TGATGGACTG CCTTAAATCA 
GCAGACATAG TTCATCTGAG TGATCCTGAC TTCCAAGTCT TAGAAGATGG TTCTGTGTAC 
ACAACCAGTT CTGTTGTTTT GTCCTCGGGG CAAAGAAGCT TTACTATATG GCTTTTTAGC 
ACAGACAGCC AAGAAGAAAG GGAGATATCT GTCCATTTAG AGGGCCCAGT AGAGGTACTA 
AATAAAAGAC CGCATACAGA GAAGGTTCTC AGCCGTGCCA AGAGAAGATG GGCTCCTATC 
CCTTGTTCCA TGCTAGAGAA TTCATTGGGT CCCTTCCCAC TTTTCCTTCA ACAGATCCAG 
TCTGACACAG CTCAAAACTA TACCATATAC TATTCCATCA GAGGTCCAGG AGTTGATAAA 
GAACCTCTAA ACTTATTTTA TGTGGAAAGA GATACTGGAA ACCTGTATTG CACTGGTCGT 
GTAGATCGTG AGCAGTATGA GTCCTTTGAG CTGACTGCAT TTGCAACAAC TCCAGATGGG 
TATACGCCAG AGTACCCACT GCCGCTCCTC ATTAAAATAG AGGACGAGAA CGATAATTAC 
CCGATCTTTA CACAGAAACT GTACAGCTTC ACAGTTCAGG AAAATAGTCG CATTGGTTCT 
ATTGTGGGGG AGGTCTGTGC AACCGACCTG GATGAGCCAG ACACAATGCA CACTCGCCTG 
AGGTACTCCA TCCTGGAGCA GTCGCCTTCT CCACCCATGC TATTTACTAT GCATCCCAGC 
ACTGGTGTGA TCACTACCAC GTCGGCTCAG CTGGACAGAG AGTTAATTGA CAAGTACCAG 
TTGCTAATAA AAGTCCAGGA TATGGATGGC CAGTATTTTG GTTTGCACAC AACAGCAAAG 
TGCATCATTA CTATTGAAGA TGTGAATGAC AACCTGCCCA CGTTCACTCG CACTACGTAT 
GTGACATCAG TGGAAGAAAA TACAGTTAAT GTGGAAATCT TGCGACTTAC TGTTCAGGAT 
AAAGATTTAG TTAACTCACC TAATTGGAGA GCTAATTACA CCATTTTGAA GGGCAATGAA 
AATGGAAATT TTAAAATCGT AACAGATCCT AAAACCAATG AAGGCATTCT GTGTGTGATT 
AAGCCTCTGG ACTATGAAGA ACGGCAACAG GTGACCCTGC AAATTGGAGT AGTTAATGAA 
GCTCCATACA CTAGAGAGGC TAGCTCAAAG TCACCCATGA GCACAGCCAC AGTGACTGTC 
ACCGTGACAA ATCAGGATGA GGGCCCCGAG TGTATCCCTC CAATGCAAAC TGTGAGGATT 
CAAGAAAATG TACCAGTTGG GACTAGAAAT GATGGATATA AGGCATATGA CCCAGAGACC 
AGAAGCAGCA GTGGCATAAG GTACAGAAAG TTAAGTGACC CAAGAGGGTG GGTCACTGTT 
AATGAAGATT CAGGATCGAT CACTATTTTC CGAGCGTTGG ATCGAGAGGC TGAGACTGTC 
AGAAATGGCA TTTACAATAT TACAGTCCTT GCGTTAGATG CAGATGGGAG AAGCTGTACT 
GGAACTCTGG GAATCATACT TGAAGATGTG AATGATAATG GCCCATTCAT ACCCAAGCAG 
ACAGTGGTGA TATGCAAGGC TACCATGTCC TCTGCTGAAA TTGTTGCAGT TGATCTCGAT 
GATCCAGTGA ATGGCCCACC ATTTGATTTC AGTTTGGAGA GCTCTGATTC GGAAGTTCAG 
AGGATGTGGA GGCTAACAAG AATCAATGAT ACAGCAGCTC GTCTTTCCTA TCAGAACGAC 
CCTTCATTTG GATCCTATGC AGTTCCCATT CGAGTTACAG ACAGACTTGG TCTGTCCTCA 
GTAACCACAT TGAATGTCCT TGTATGTGAC TGCATTACTG AAAGTGACTG CACACTCCGC 
TCTGGAGAAA GGACTGGCTA TGCTGATGTG AGACTTGGAC CATGGGCCAT CCTTGCTATA 
CTGTTGGGCA TAGCCTTGCT ATTTTGTATC CTGTTTACAT TAGTCTGTAG TGTTTCCCGG 
GCATCAAAAC AACAGAAAAT TCTTCCTGAT GACTTAGCTC AACAGAACCT AATTGTATCA 
AACACCGAGG CTCCTGGAGA TGACAAAGTT TATTCCACAA ACGGCTTGAC AACTCAAACT 
ATGGGAGCTT CTGGGCAGAC AGCTTTCACC ACCATGGGAA CTGGAGTCAA AAGTGGAGGG 
CAAGAGACCA TTGAGATGGT AAAAGGAGGG CAGCAGACTT TGGACTCACG CAGAGGGGCT 
GGCTATCATC ACCATACCCT GGATCCTTGC AGGGGAGGAC ATGTGGAGGT GGACAACTAC 
AGACACACTT ACTCAGAGTG GTACAATTTC ATTCAGCCCC GACTTGGTGA TAAGGTACAG 
TTTTGCCATA CGGATGACAA CCAGAAGCTT GCTCAAGACT ACGTCCTCAC ATACAACTAT 
GAGGGAAAAG GCTCGGCTGC TGGCTCTGTG GGTTGCTGTA GTGACCTACA GGAAGAAGAC 
GGGCTTGAGT TTTTGGACCA TCTGGAGCCC AAATTTAGGA CATTGGCAGA AGTATGTGCA 
AAGAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dsc2 ( NM_001317363.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001304292.1 Mus musculus desmocollin 2 (Dsc2), transcript variant 3, mRNA.

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CloneID	OMu83517
Clone ID Related Accession (Same CDS sequence)	NM_001317363.1
Accession Version	NM_001317363.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2118bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577462400000
Organism	Mus musculus(house mouse)
Product	desmocollin-2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY093917.1, AK028604.1, AK048547.1, BY422831.1 and BY425109.1. Transcript Variant: This variant (3) includes an alternate exon in its 5' UTR, uses a downstream in-frame start codon, and contains an additional exon at the 3' end, compared to variant Dsc2a. The encoded isoform (3) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform Dsc2a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028604.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTAGAGA ATTCATTGGG TCCCTTCCCA CTTTTCCTTC AACAGATCCA GTCTGACACA 
GCTCAAAACT ATACCATATA CTATTCCATC AGAGGTCCAG GAGTTGATAA AGAACCTCTA 
AACTTATTTT ATGTGGAAAG AGATACTGGA AACCTGTATT GCACTGGTCG TGTAGATCGT 
GAGCAGTATG AGTCCTTTGA GCTGACTGCA TTTGCAACAA CTCCAGATGG GTATACGCCA 
GAGTACCCAC TGCCGCTCCT CATTAAAATA GAGGACGAGA ACGATAATTA CCCGATCTTT 
ACACAGAAAC TGTACAGCTT CACAGTTCAG GAAAATAGTC GCATTGGTTC TATTGTGGGG 
GAGGTCTGTG CAACCGACCT GGATGAGCCA GACACAATGC ACACTCGCCT GAGGTACTCC 
ATCCTGGAGC AGTCGCCTTC TCCACCCATG CTATTTACTA TGCATCCCAG CACTGGTGTG 
ATCACTACCA CGTCGGCTCA GCTGGACAGA GAGTTAATTG ACAAGTACCA GTTGCTAATA 
AAAGTCCAGG ATATGGATGG CCAGTATTTT GGTTTGCACA CAACAGCAAA GTGCATCATT 
ACTATTGAAG ATGTGAATGA CAACCTGCCC ACGTTCACTC GCACTACGTA TGTGACATCA 
GTGGAAGAAA ATACAGTTAA TGTGGAAATC TTGCGACTTA CTGTTCAGGA TAAAGATTTA 
GTTAACTCAC CTAATTGGAG AGCTAATTAC ACCATTTTGA AGGGCAATGA AAATGGAAAT 
TTTAAAATCG TAACAGATCC TAAAACCAAT GAAGGCATTC TGTGTGTGAT TAAGCCTCTG 
GACTATGAAG AACGGCAACA GGTGACCCTG CAAATTGGAG TAGTTAATGA AGCTCCATAC 
ACTAGAGAGG CTAGCTCAAA GTCACCCATG AGCACAGCCA CAGTGACTGT CACCGTGACA 
AATCAGGATG AGGGCCCCGA GTGTATCCCT CCAATGCAAA CTGTGAGGAT TCAAGAAAAT 
GTACCAGTTG GGACTAGAAA TGATGGATAT AAGGCATATG ACCCAGAGAC CAGAAGCAGC 
AGTGGCATAA GGTACAGAAA GTTAAGTGAC CCAAGAGGGT GGGTCACTGT TAATGAAGAT 
TCAGGATCGA TCACTATTTT CCGAGCGTTG GATCGAGAGG CTGAGACTGT CAGAAATGGC 
ATTTACAATA TTACAGTCCT TGCGTTAGAT GCAGATGGGA GAAGCTGTAC TGGAACTCTG 
GGAATCATAC TTGAAGATGT GAATGATAAT GGCCCATTCA TACCCAAGCA GACAGTGGTG 
ATATGCAAGG CTACCATGTC CTCTGCTGAA ATTGTTGCAG TTGATCTCGA TGATCCAGTG 
AATGGCCCAC CATTTGATTT CAGTTTGGAG AGCTCTGATT CGGAAGTTCA GAGGATGTGG 
AGGCTAACAA GAATCAATGA TACAGCAGCT CGTCTTTCCT ATCAGAACGA CCCTTCATTT 
GGATCCTATG CAGTTCCCAT TCGAGTTACA GACAGACTTG GTCTGTCCTC AGTAACCACA 
TTGAATGTCC TTGTATGTGA CTGCATTACT GAAAGTGACT GCACACTCCG CTCTGGAGAA 
AGGACTGGCT ATGCTGATGT GAGACTTGGA CCATGGGCCA TCCTTGCTAT ACTGTTGGGC 
ATAGCCTTGC TATTTTGTAT CCTGTTTACA TTAGTCTGTA GTGTTTCCCG GGCATCAAAA 
CAACAGAAAA TTCTTCCTGA TGACTTAGCT CAACAGAACC TAATTGTATC AAACACCGAG 
GCTCCTGGAG ATGACAAAGT TTATTCCACA AACGGCTTGA CAACTCAAAC TATGGGAGCT 
TCTGGGCAGA CAGCTTTCAC CACCATGGGA ACTGGAGTCA AAAGTGGAGG GCAAGAGACC 
ATTGAGATGG TAAAAGGAGG GCAGCAGACT TTGGACTCAC GCAGAGGGGC TGGCTATCAT 
CACCATACCC TGGATCCTTG CAGGGGAGGA CATGTGGAGG TGGACAACTA CAGACACACT 
TACTCAGAGT GGTACAATTT CATTCAGCCC CGACTTGGTG ATGAAACCAT TAGAGGACAC 
ACTCTGATTA AAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304292.1
CDS	767..2884
Translation	MLENSLGPFPLFLQQIQSDTAQNYTIYYSIRGPGVDKEPLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDNYPIFTQKLYSFTVQENSRIGSIVGEVCATDLDEPDTMHTRLRYSILEQSPSPPMLFTMHPSTGVITTTSAQLDRELIDKYQLLIKVQDMDGQYFGLHTTAKCIITIEDVNDNLPTFTRTTYVTSVEENTVNVEILRLTVQDKDLVNSPNWRANYTILKGNENGNFKIVTDPKTNEGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASSKSPMSTATVTVTVTNQDEGPECIPPMQTVRIQENVPVGTRNDGYKAYDPETRSSSGIRYRKLSDPRGWVTVNEDSGSITIFRALDREAETVRNGIYNITVLALDADGRSCTGTLGIILEDVNDNGPFIPKQTVVICKATMSSAEIVAVDLDDPVNGPPFDFSLESSDSEVQRMWRLTRINDTAARLSYQNDPSFGSYAVPIRVTDRLGLSSVTTLNVLVCDCITESDCTLRSGERTGYADVRLGPWAILAILLGIALLFCILFTLVCSVSRASKQQKILPDDLAQQNLIVSNTEAPGDDKVYSTNGLTTQTMGASGQTAFTTMGTGVKSGGQETIEMVKGGQQTLDSRRGAGYHHHTLDPCRGGHVEVDNYRHTYSEWYNFIQPRLGDETIRGHTLIKN

Target ORF information:

RefSeq Version	NM_001317363.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus desmocollin 2 (Dsc2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317363.1

ORF Insert Sequence:

ATGCTAGAGA ATTCATTGGG TCCCTTCCCA CTTTTCCTTC AACAGATCCA GTCTGACACA 
GCTCAAAACT ATACCATATA CTATTCCATC AGAGGTCCAG GAGTTGATAA AGAACCTCTA 
AACTTATTTT ATGTGGAAAG AGATACTGGA AACCTGTATT GCACTGGTCG TGTAGATCGT 
GAGCAGTATG AGTCCTTTGA GCTGACTGCA TTTGCAACAA CTCCAGATGG GTATACGCCA 
GAGTACCCAC TGCCGCTCCT CATTAAAATA GAGGACGAGA ACGATAATTA CCCGATCTTT 
ACACAGAAAC TGTACAGCTT CACAGTTCAG GAAAATAGTC GCATTGGTTC TATTGTGGGG 
GAGGTCTGTG CAACCGACCT GGATGAGCCA GACACAATGC ACACTCGCCT GAGGTACTCC 
ATCCTGGAGC AGTCGCCTTC TCCACCCATG CTATTTACTA TGCATCCCAG CACTGGTGTG 
ATCACTACCA CGTCGGCTCA GCTGGACAGA GAGTTAATTG ACAAGTACCA GTTGCTAATA 
AAAGTCCAGG ATATGGATGG CCAGTATTTT GGTTTGCACA CAACAGCAAA GTGCATCATT 
ACTATTGAAG ATGTGAATGA CAACCTGCCC ACGTTCACTC GCACTACGTA TGTGACATCA 
GTGGAAGAAA ATACAGTTAA TGTGGAAATC TTGCGACTTA CTGTTCAGGA TAAAGATTTA 
GTTAACTCAC CTAATTGGAG AGCTAATTAC ACCATTTTGA AGGGCAATGA AAATGGAAAT 
TTTAAAATCG TAACAGATCC TAAAACCAAT GAAGGCATTC TGTGTGTGAT TAAGCCTCTG 
GACTATGAAG AACGGCAACA GGTGACCCTG CAAATTGGAG TAGTTAATGA AGCTCCATAC 
ACTAGAGAGG CTAGCTCAAA GTCACCCATG AGCACAGCCA CAGTGACTGT CACCGTGACA 
AATCAGGATG AGGGCCCCGA GTGTATCCCT CCAATGCAAA CTGTGAGGAT TCAAGAAAAT 
GTACCAGTTG GGACTAGAAA TGATGGATAT AAGGCATATG ACCCAGAGAC CAGAAGCAGC 
AGTGGCATAA GGTACAGAAA GTTAAGTGAC CCAAGAGGGT GGGTCACTGT TAATGAAGAT 
TCAGGATCGA TCACTATTTT CCGAGCGTTG GATCGAGAGG CTGAGACTGT CAGAAATGGC 
ATTTACAATA TTACAGTCCT TGCGTTAGAT GCAGATGGGA GAAGCTGTAC TGGAACTCTG 
GGAATCATAC TTGAAGATGT GAATGATAAT GGCCCATTCA TACCCAAGCA GACAGTGGTG 
ATATGCAAGG CTACCATGTC CTCTGCTGAA ATTGTTGCAG TTGATCTCGA TGATCCAGTG 
AATGGCCCAC CATTTGATTT CAGTTTGGAG AGCTCTGATT CGGAAGTTCA GAGGATGTGG 
AGGCTAACAA GAATCAATGA TACAGCAGCT CGTCTTTCCT ATCAGAACGA CCCTTCATTT 
GGATCCTATG CAGTTCCCAT TCGAGTTACA GACAGACTTG GTCTGTCCTC AGTAACCACA 
TTGAATGTCC TTGTATGTGA CTGCATTACT GAAAGTGACT GCACACTCCG CTCTGGAGAA 
AGGACTGGCT ATGCTGATGT GAGACTTGGA CCATGGGCCA TCCTTGCTAT ACTGTTGGGC 
ATAGCCTTGC TATTTTGTAT CCTGTTTACA TTAGTCTGTA GTGTTTCCCG GGCATCAAAA 
CAACAGAAAA TTCTTCCTGA TGACTTAGCT CAACAGAACC TAATTGTATC AAACACCGAG 
GCTCCTGGAG ATGACAAAGT TTATTCCACA AACGGCTTGA CAACTCAAAC TATGGGAGCT 
TCTGGGCAGA CAGCTTTCAC CACCATGGGA ACTGGAGTCA AAAGTGGAGG GCAAGAGACC 
ATTGAGATGG TAAAAGGAGG GCAGCAGACT TTGGACTCAC GCAGAGGGGC TGGCTATCAT 
CACCATACCC TGGATCCTTG CAGGGGAGGA CATGTGGAGG TGGACAACTA CAGACACACT 
TACTCAGAGT GGTACAATTT CATTCAGCCC CGACTTGGTG ATGAAACCAT TAGAGGACAC 
ACTCTGATTA AAAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.
PLoS genetics15(1)e1007914(2019 01)
Choi YJ,Laclef C,Yang N,Andreu-Cervera A,Lewis J,Mao X,Li L,Snedecor ER,Takemaru KI,Qin C,Schneider-Maunoury S,Shroyer KR,Hannun YA,Koch PJ,Clark RA,Payne AS,Kowalczyk AP,Chen J

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Mucosal immunology11(6)1630-1639(2018 11)
Gross A,Pack LAP,Schacht GM,Kant S,Ungewiss H,Meir M,Schlegel N,Preisinger C,Boor P,Guldiken N,Krusche CA,Sellge G,Trautwein C,Waschke J,Heuser A,Leube RE,Strnad P

MicroRNA-130a Regulation of Desmocollin 2 in a Novel Model of Arrhythmogenic Cardiomyopathy.
MicroRNA (Shariqah, United Arab Emirates)6(2)143-150(2017)
Mazurek SR,Calway T,Harmon C,Farrell P,Kim GH

Transgenic mice overexpressing desmocollin-2 (DSC2) develop cardiomyopathy associated with myocardial inflammation and fibrotic remodeling.
PloS one12(3)e0174019(2017)
Brodehl A,Belke DD,Garnett L,Martens K,Abdelfatah N,Rodriguez M,Diao C,Chen YX,Gordon PM,Nygren A,Gerull B

Structure and function of desmosomal proteins and their role in development and disease.
Cellular and molecular life sciences : CMLS60(9)1872-90(2003 Sep)
Huber O

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Dsc2 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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