Cga cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cga
Entrez Gene ID	12640
Full Name	glycoprotein hormones, alpha subunit
Synonyms	CG-alpha,FSHA,GPHA1,GPHalpha,HCG,LHA,Tsha,aGSU,alpha-GSU,alphaGSU,alphaSU
General protein information	Preferred Names glycoprotein hormones, alpha subunit Names glycoprotein hormones alpha chain FSH-alpha LSH-alpha TSH-alpha anterior pituitary glycoprotein hormones common subunit alpha follicle-stimulating hormone alpha chain follitropin alpha chain luteinizing hormone alpha chain lutropin alpha chain thyroid-stimulating hormone alpha chain thyrotropin alpha chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 A5\|4 16.86 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006537586.2	XP_006537649.1	glycoprotein hormones alpha chain isoform X1
NM_009889.2	NP_034019.1	glycoprotein hormones alpha chain precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CGA	XP_003950934.1
Canis lupus familiaris (dog)	CGA	NP_001002988.1
Rattus norvegicus (Norway rat)	Cga	NP_446370.2
Xenopus tropicalis (tropical clawed frog)	cga	XP_002933966.1
Homo sapiens (human)	CGA	NP_001239312.1
Macaca mulatta (Rhesus monkey)	CGA	XP_001090917.1
Mus musculus (house mouse)	Cga	NP_034019.1
Bos taurus (cattle)	CGA	NP_776326.1
Gallus gallus (chicken)	CGA	NP_001264950.1
Danio rerio (zebrafish)	cga	NP_991250.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression.
Haj M, Wijeweera A, Rudnizky S, Taunton J, Pnueli L, Melamed P
The Journal of biological chemistry292(50)20720-20731(2017 12)

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP
Development (Cambridge, England)144(18)3289-3302(2017 09)

Androgens Mediate Sex-Dependent Gonadotropin Expression During Late Prenatal Development in the Mouse.
Kreisman MJ, Song CI, Yip K, Natale BV, Natale DR, Breen KM
Endocrinology158(9)2884-2894(2017 09)

Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression.
Moon MK, Kang GH, Kim HH, Han SK, Koo YD, Cho SW, Kim YA, Oh BC, Park do J, Chung SS, Park KS, Park YJ
Molecular and cellular endocrinology43650-8(2016 11)

Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation.
Gergics P, Christian HC, Choo MS, Ajmal A, Camper SA
Endocrinology157(9)3631-46(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cga gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cga cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15958	NM_009889.2 Latest version!	Mus musculus glycoprotein hormones, alpha subunit (Cga), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OMu15958	XM_006537586.2 Latest version!	Mus musculus glycoprotein hormones, alpha subunit (Cga), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cga ( NM_009889.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034019.1 Mus musculus glycoprotein hormones, alpha subunit (Cga), mRNA.

Price & Availability↑

CloneID	OMu15958
Clone ID Related Accession (Same CDS sequence)	XM_006537586.2 , NM_009889.2
Accession Version	NM_009889.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571587200000
Organism	Mus musculus(house mouse)
Product	glycoprotein hormones alpha chain precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL929565.16. On Nov 17, 2006 this sequence version replaced NM_009889.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CJ048537.1, CB232038.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN01164138 [ECO:0000348] ##Evidence-Data-END##

ATGGATTACT ACAGAAAATA TGCAGCTGTC ATTCTGGTCA TGCTGTCCAT GTTCCTGCAT 
ATTCTTCATT CTCTTCCTGA TGGAGACTTT ATTATTCAGG GTTGCCCAGA ATGTAAACTA 
AAGGAAAATA AATACTTCTC CAAGCTAGGA GCCCCCATCT ACCAGTGTAT GGGCTGTTGC 
TTCTCCAGGG CATATCCCAC TCCCGCCAGG TCCAAGAAGA CAATGCTGGT TCCAAAGAAT 
ATTACCTCGG AGGCCACATG CTGTGTGGCC AAAGCATTTA CTAAGGCCAC AGTAATGGGA 
AATGCCAGAG TGGAGAATCA TACGGAGTGC CACTGTAGCA CTTGCTACTA CCACAAGTCG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034019.1
CDS	98..460
Translation	MDYYRKYAAVILVMLSMFLHILHSLPDGDFIIQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNARVENHTECHCSTCYYHKS

Target ORF information:

RefSeq Version	NM_009889.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycoprotein hormones, alpha subunit (Cga), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009889.2

ORF Insert Sequence:

ATGGATTACT ACAGAAAATA TGCAGCTGTC ATTCTGGTCA TGCTGTCCAT GTTCCTGCAT 
ATTCTTCATT CTCTTCCTGA TGGAGACTTT ATTATTCAGG GTTGCCCAGA ATGTAAACTA 
AAGGAAAATA AATACTTCTC CAAGCTAGGA GCCCCCATCT ACCAGTGTAT GGGCTGTTGC 
TTCTCCAGGG CATATCCCAC TCCCGCCAGG TCCAAGAAGA CAATGCTGGT TCCAAAGAAT 
ATTACCTCGG AGGCCACATG CTGTGTGGCC AAAGCATTTA CTAAGGCCAC AGTAATGGGA 
AATGCCAGAG TGGAGAATCA TACGGAGTGC CACTGTAGCA CTTGCTACTA CCACAAGTCG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cga ( XM_006537586.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006537649.1 Mus musculus glycoprotein hormones, alpha subunit (Cga), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu15958
Clone ID Related Accession (Same CDS sequence)	XM_006537586.2 , NM_009889.2
Accession Version	XM_006537586.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 363bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1565107200000
Organism	Mus musculus(house mouse)
Product	glycoprotein hormones alpha chain isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006537586.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTACT ACAGAAAATA TGCAGCTGTC ATTCTGGTCA TGCTGTCCAT GTTCCTGCAT 
ATTCTTCATT CTCTTCCTGA TGGAGACTTT ATTATTCAGG GTTGCCCAGA ATGTAAACTA 
AAGGAAAATA AATACTTCTC CAAGCTAGGA GCCCCCATCT ACCAGTGTAT GGGCTGTTGC 
TTCTCCAGGG CATATCCCAC TCCCGCCAGG TCCAAGAAGA CAATGCTGGT TCCAAAGAAT 
ATTACCTCGG AGGCCACATG CTGTGTGGCC AAAGCATTTA CTAAGGCCAC AGTAATGGGA 
AATGCCAGAG TGGAGAATCA TACGGAGTGC CACTGTAGCA CTTGCTACTA CCACAAGTCG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006537649.1
CDS	98..460
Translation	MDYYRKYAAVILVMLSMFLHILHSLPDGDFIIQGCPECKLKENKYFSKLGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKAFTKATVMGNARVENHTECHCSTCYYHKS

Target ORF information:

RefSeq Version	XM_006537586.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus glycoprotein hormones, alpha subunit (Cga), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006537586.2

ORF Insert Sequence:

ATGGATTACT ACAGAAAATA TGCAGCTGTC ATTCTGGTCA TGCTGTCCAT GTTCCTGCAT 
ATTCTTCATT CTCTTCCTGA TGGAGACTTT ATTATTCAGG GTTGCCCAGA ATGTAAACTA 
AAGGAAAATA AATACTTCTC CAAGCTAGGA GCCCCCATCT ACCAGTGTAT GGGCTGTTGC 
TTCTCCAGGG CATATCCCAC TCCCGCCAGG TCCAAGAAGA CAATGCTGGT TCCAAAGAAT 
ATTACCTCGG AGGCCACATG CTGTGTGGCC AAAGCATTTA CTAAGGCCAC AGTAATGGGA 
AATGCCAGAG TGGAGAATCA TACGGAGTGC CACTGTAGCA CTTGCTACTA CCACAAGTCG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression.
The Journal of biological chemistry292(50)20720-20731(2017 12)
Haj M,Wijeweera A,Rudnizky S,Taunton J,Pnueli L,Melamed P

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Development (Cambridge, England)144(18)3289-3302(2017 09)
Carreno G,Apps JR,Lodge EJ,Panousopoulos L,Haston S,Gonzalez-Meljem JM,Hahn H,Andoniadou CL,Martinez-Barbera JP

Androgens Mediate Sex-Dependent Gonadotropin Expression During Late Prenatal Development in the Mouse.
Endocrinology158(9)2884-2894(2017 09)
Kreisman MJ,Song CI,Yip K,Natale BV,Natale DR,Breen KM

Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression.
Molecular and cellular endocrinology43650-8(2016 11)
Moon MK,Kang GH,Kim HH,Han SK,Koo YD,Cho SW,Kim YA,Oh BC,Park do J,Chung SS,Park KS,Park YJ

Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation.
Endocrinology157(9)3631-46(2016 09)
Gergics P,Christian HC,Choo MS,Ajmal A,Camper SA