Casq1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Casq1
Entrez Gene ID	12372
Full Name	calsequestrin 1
Synonyms	CSQ,CSQ-1,CSQ1,sCSQ
General protein information	Preferred Names calsequestrin 1 Names calsequestrin-1 calmitine calsequestrin, skeletal muscle isoform
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 H3\|1 79.54 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009813.2	NP_033943.2	calsequestrin-1 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	CASQ1	NP_001222.3
Danio rerio (zebrafish)	casq1b	NP_001070192.1
Canis lupus familiaris (dog)	CASQ1	XP_850097.1
Bos taurus (cattle)	CASQ1	NP_001071345.1
Caenorhabditis elegans (roundworm)	csq-1	NP_510438.1
Xenopus tropicalis (tropical clawed frog)	casq1	NP_988894.1
Mus musculus (house mouse)	Casq1	NP_033943.2
Rattus norvegicus (Norway rat)	Casq1	NP_001153066.1
Pan troglodytes (chimpanzee)	CASQ1	XP_001171165.2
Danio rerio (zebrafish)	casq1a	NP_001003620.2

Gene Ontology
Bibliography

Related articles in PubMed

Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative Stress.
Guarnier FA, Michelucci A, Serano M, Pietrangelo L, Pecorai C, Boncompagni S, Protasi F
Oxidative medicine and cellular longevity20184652480(2018)

Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.
Michelucci A, Paolini C, Boncompagni S, Canato M, Reggiani C, Protasi F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(8)3649-3662(2017 08)

MED12 regulates a transcriptional network of calcium-handling genes in the heart.
Baskin KK, Makarewich CA, DeLeon SM, Ye W, Chen B, Beetz N, Schrewe H, Bassel-Duby R, Olson EN
JCI insight2(14)(2017 Jul)

Calsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle.
Manno C, Figueroa LC, Gillespie D, Fitts R, Kang C, Franzini-Armstrong C, Rios E
Proceedings of the National Academy of Sciences of the United States of America114(4)E638-E647(2017 01)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Casq1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Casq1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13282	NM_009813.2 Latest version!	Mus musculus calsequestrin 1 (Casq1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Casq1 ( NM_009813.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033943.2 Mus musculus calsequestrin 1 (Casq1), mRNA.

Price & Availability↑

CloneID	OMu13282
Clone ID Related Accession (Same CDS sequence)	NM_009813.2
Accession Version	NM_009813.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1218bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568995200000
Organism	Mus musculus(house mouse)
Product	calsequestrin-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY772893.1, BC064057.1, CR756967.1, AK049865.1 and AW108209.1. On Apr 23, 2009 this sequence version replaced NM_009813.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064057.1, U93291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGAGCTA CCGACAGGAT GGGGGCCAGA GCAGTGTCCG AGCTGCGGCT GGCACTGCTG 
TTTGTACTGG TGCTAGGGAC GCCCAGGTTA GGGGTCCAGG GGGAAGATGG GTTGGACTTC 
CCTGAGTACG ACGGTGTGGA CCGTGTGATC AATGTGAACG CCAAGAACTA CAAGAACGTG 
TTTAAGAAGT ATGAGGTGCT GGCCCTCCTC TACCATGAGC CCCCCGAGGA CGACAAGGCC 
TCGCAGAGAC AATTTGAGAT GGAGGAGCTA ATCCTGGAGT TAGCAGCCCA AGTCTTAGAA 
GACAAGGGTG TTGGCTTTGG CCTGGTGGAC TCAGAGAAGG ATGCAGCTGT GGCCAAGAAA 
CTAGGACTAA CTGAAGAAGA CAGCGTTTAT GTGTTCAAAG GAGATGAAGT CATTGAATAT 
GACGGCGAGT TTTCTGCAGA CACTCTGGTG GAGTTTCTGC TTGATGTCCT AGAAGACCCT 
GTAGAGTTGA TTGAAGGTGA ACGAGAGCTG CAGGCATTTG AGAATATTGA AGATGAAATC 
AAACTCATTG GCTACTTCAA GAGCAAAGAC TCAGAGCATT ACAAAGCCTA CGAGGACGCA 
GCTGAAGAGT TCCATCCCTA CATCCCTTTC TTCGCTACCT TCGACAGCAA GGTGGCAAAG 
AAGCTGACTC TGAAGTTGAA TGAGATTGAT TTCTACGAGG CCTTCATGGA AGAGCCTATG 
ACCATCCCAG ACAAGCCCAA CAGTGAAGAG GAGATTGTCA GCTTCGTGGA GGAGCACAGG 
AGATCAACCC TGAGGAAACT GAAGCCTGAG AGTATGTACG AGACTTGGGA GGATGACCTG 
GATGGAATCC ACATTGTCGC CTTTGCAGAG GAAGCAGATC CCGATGGCTA TGAGTTCTTA 
GAGACTCTCA AGGCTGTGGC CCAAGACAAC ACTGAGAACC CCGACCTCAG TATCATCTGG 
ATTGATCCTG ATGACTTCCC GCTGCTGGTC CCGTACTGGG AGAAGACCTT TGACATTGAC 
CTGTCAGCTC CACAAATAGG AGTTGTCAAT GTTACAGACG CCGACAGCAT ATGGATGGAG 
ATGGATAACG AGGAGGACCT GCCTTCTGCT GATGAGCTGG AGGACTGGCT GGAGGACGTG 
CTGGAGGGCG AGATCAACAC AGAGGATGAC GACGACGATG ACGACGATGA CGATGACGAT 
GATGATGACG ACGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033943.2
CDS	206..1423
Translation	MRATDRMGARAVSELRLALLFVLVLGTPRLGVQGEDGLDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEEDSVYVFKGDEVIEYDGEFSADTLVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAYEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPMTIPDKPNSEEEIVSFVEEHRRSTLRKLKPESMYETWEDDLDGIHIVAFAEEADPDGYEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSIWMEMDNEEDLPSADELEDWLEDVLEGEINTEDDDDDDDDDDDDDDDDD

Target ORF information:

RefSeq Version	NM_009813.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus calsequestrin 1 (Casq1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009813.2

ORF Insert Sequence:

ATGAGAGCTA CCGACAGGAT GGGGGCCAGA GCAGTGTCCG AGCTGCGGCT GGCACTGCTG 
TTTGTACTGG TGCTAGGGAC GCCCAGGTTA GGGGTCCAGG GGGAAGATGG GTTGGACTTC 
CCTGAGTACG ACGGTGTGGA CCGTGTGATC AATGTGAACG CCAAGAACTA CAAGAACGTG 
TTTAAGAAGT ATGAGGTGCT GGCCCTCCTC TACCATGAGC CCCCCGAGGA CGACAAGGCC 
TCGCAGAGAC AATTTGAGAT GGAGGAGCTA ATCCTGGAGT TAGCAGCCCA AGTCTTAGAA 
GACAAGGGTG TTGGCTTTGG CCTGGTGGAC TCAGAGAAGG ATGCAGCTGT GGCCAAGAAA 
CTAGGACTAA CTGAAGAAGA CAGCGTTTAT GTGTTCAAAG GAGATGAAGT CATTGAATAT 
GACGGCGAGT TTTCTGCAGA CACTCTGGTG GAGTTTCTGC TTGATGTCCT AGAAGACCCT 
GTAGAGTTGA TTGAAGGTGA ACGAGAGCTG CAGGCATTTG AGAATATTGA AGATGAAATC 
AAACTCATTG GCTACTTCAA GAGCAAAGAC TCAGAGCATT ACAAAGCCTA CGAGGACGCA 
GCTGAAGAGT TCCATCCCTA CATCCCTTTC TTCGCTACCT TCGACAGCAA GGTGGCAAAG 
AAGCTGACTC TGAAGTTGAA TGAGATTGAT TTCTACGAGG CCTTCATGGA AGAGCCTATG 
ACCATCCCAG ACAAGCCCAA CAGTGAAGAG GAGATTGTCA GCTTCGTGGA GGAGCACAGG 
AGATCAACCC TGAGGAAACT GAAGCCTGAG AGTATGTACG AGACTTGGGA GGATGACCTG 
GATGGAATCC ACATTGTCGC CTTTGCAGAG GAAGCAGATC CCGATGGCTA TGAGTTCTTA 
GAGACTCTCA AGGCTGTGGC CCAAGACAAC ACTGAGAACC CCGACCTCAG TATCATCTGG 
ATTGATCCTG ATGACTTCCC GCTGCTGGTC CCGTACTGGG AGAAGACCTT TGACATTGAC 
CTGTCAGCTC CACAAATAGG AGTTGTCAAT GTTACAGACG CCGACAGCAT ATGGATGGAG 
ATGGATAACG AGGAGGACCT GCCTTCTGCT GATGAGCTGG AGGACTGGCT GGAGGACGTG 
CTGGAGGGCG AGATCAACAC AGAGGATGAC GACGACGATG ACGACGATGA CGATGACGAT 
GATGATGACG ACGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aerobic Training Prevents Heatstrokes in Calsequestrin-1 Knockout Mice by Reducing Oxidative Stress.
Oxidative medicine and cellular longevity20184652480(2018)
Guarnier FA,Michelucci A,Serano M,Pietrangelo L,Pecorai C,Boncompagni S,Protasi F

Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(8)3649-3662(2017 08)
Michelucci A,Paolini C,Boncompagni S,Canato M,Reggiani C,Protasi F

MED12 regulates a transcriptional network of calcium-handling genes in the heart.
JCI insight2(14)(2017 Jul)
Baskin KK,Makarewich CA,DeLeon SM,Ye W,Chen B,Beetz N,Schrewe H,Bassel-Duby R,Olson EN

Calsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle.
Proceedings of the National Academy of Sciences of the United States of America114(4)E638-E647(2017 01)
Manno C,Figueroa LC,Gillespie D,Fitts R,Kang C,Franzini-Armstrong C,Rios E

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bućan M,Murray SA

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Casq1 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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