Capza2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Capza2
Entrez Gene ID	12343
Full Name	capping protein (actin filament) muscle Z-line, alpha 2
Synonyms	1110053K06Rik,AW208808,Cappa2
General protein information	Preferred Names capping protein (actin filament) muscle Z-line, alpha 2 Names F-actin-capping protein subunit alpha-2 capZ alpha-2 capping protein alpha 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 A2\|6 7.96 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_007604.2	NP_031630.1	F-actin-capping protein subunit alpha-2
NM_007604.3	NP_031630.1	F-actin-capping protein subunit alpha-2

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0B13453g	XP_452130.1
Homo sapiens (human)	CAPZA2	NP_006127.1
Canis lupus familiaris (dog)	CAPZA2	NP_001013013.1
Bos taurus (cattle)	CAPZA2	NP_001013016.1
Saccharomyces cerevisiae (baker's yeast)	CAP1	NP_012918.1
Neurospora crassa	NCU03911	XP_957550.1
Mus musculus (house mouse)	Capza2	NP_031630.1
Gallus gallus (chicken)	CAPZA2	NP_001004380.1
Magnaporthe oryzae (rice blast fungus)	MGG_12818	XP_003717048.1
Macaca mulatta (Rhesus monkey)	CAPZA2	NP_001162080.1
Xenopus tropicalis (tropical clawed frog)	capza2	NP_001017254.1
Eremothecium gossypii	AGOS_ABR007C	NP_982953.1
Pan troglodytes (chimpanzee)	CAPZA2	NP_001129289.1
Rattus norvegicus (Norway rat)	Capza2	NP_001009180.1

Gene Ontology
Bibliography

Related articles in PubMed

Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Perez-Garcia V, Fineberg E, Wilson R, Murray A, Mazzeo CI, Tudor C, Sienerth A, White JK, Tuck E, Ryder EJ, Gleeson D, Siragher E, Wardle-Jones H, Staudt N, Wali N, Collins J, Geyer S, Busch-Nentwich EM, Galli A, Smith JC, Robertson E, Adams DJ, Weninger WJ, Mohun T, Hemberger M
Nature555(7697)463-468(2018 03)

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.
Revenu C, Ubelmann F, Hurbain I, El-Marjou F, Dingli F, Loew D, Delacour D, Gilet J, Brot-Laroche E, Rivero F, Louvard D, Robine S
Molecular biology of the cell23(2)324-36(2012 Jan)

Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth.
Davis DA, Wilson MH, Giraud J, Xie Z, Tseng HC, England C, Herscovitz H, Tsai LH, Delalle I
PLoS biology7(10)e1000208(2009 Oct)

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.
Robledo RF, Ciciotte SL, Gwynn B, Sahr KE, Gilligan DM, Mohandas N, Peters LL
Blood112(10)4298-307(2008 Nov)

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
Eyers CE, McNeill H, Knebel A, Morrice N, Arthur SJ, Cuenda A, Cohen P
The Biochemical journal389(Pt 1)127-35(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Capza2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Capza2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu00463	NM_007604.3 Latest version!	Mus musculus capping protein (actin filament) muscle Z-line, alpha 2 (Capza2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$188.30 $269.00
View Old Accession Versions >>
OMu00463	NM_007604.2	Mus musculus capping protein (actin filament) muscle Z-line, alpha 2 (Capza2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Capza2 ( NM_007604.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031630.1 Mus musculus capping protein (actin filament) muscle Z-line, alpha 2 (Capza2), mRNA.

Price & Availability↑

CloneID	OMu00463
Clone ID Related Accession (Same CDS sequence)	NM_007604.2 , NM_007604.3
Accession Version	NM_007604.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514217600000
Organism	Mus musculus(house mouse)
Product	F-actin-capping protein subunit alpha-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC082589.1. On Sep 19, 2004 this sequence version replaced NM_007604.1. ##Evidence-Data-START## Transcript exon combination :: BC082589.1, AK150751.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGATC TGGAGGAGCA GTTGTCCGAT GAGGAGAAGG TTCGTATAGC AGCAAAATTC 
ATCATTCACG CCCCTCCTGG AGAATTTAAT GAGGTTTTTA ATGATGTTCG ATTATTGCTT 
AATAATGATA ATCTTCTCAG GGAAGGAGCC GCACATGCAT TTGCACAGTA TAACCTGGAC 
CAGTTTACAC CAGTAAAAAT TGAAGGCTAT GAAGATCAGG TTTTGATAAC AGAACATGGA 
GACTTGGGAA ATGGAAAATT TTTGGATCCA AAAAACAGAA TCTGTTTCAA ATTTGATCAT 
TTAAGAAAGG AAGCAACTGA TCCAAGGCCC TACGAAGCAG AAAATGCCAT TGAATCCTGG 
AGAACTTCAG TAGAAACTGC ACTGCGAGCT TATGTAAAAG AGCATTATCC GAATGGGGTC 
TGCACTGTGT ATGGCAAAAA AGTAGATGGG CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTTC AAGCAAAAAA CTTTTGGAAT GGTCGTTGGA GGTCAGAGTG GAAGTTTACA 
GTCACTCCTT CCACCACACA GGTGGTTGGC ATTTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTCAC AGTATCTAAT 
GAGGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACGATG TCGGACACTA CCTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TGACACGTAC TAAGATCGAC TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031630.1
CDS	25..885
Translation	MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Target ORF information:

RefSeq Version	NM_007604.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus capping protein (actin filament) muscle Z-line, alpha 2 (Capza2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007604.2

ORF Insert Sequence:

ATGGCGGATC TGGAGGAGCA GTTGTCCGAT GAGGAGAAGG TTCGTATAGC AGCAAAATTC 
ATCATTCACG CCCCTCCTGG AGAATTTAAT GAGGTTTTTA ATGATGTTCG ATTATTGCTT 
AATAATGATA ATCTTCTCAG GGAAGGAGCC GCACATGCAT TTGCACAGTA TAACCTGGAC 
CAGTTTACAC CAGTAAAAAT TGAAGGCTAT GAAGATCAGG TTTTGATAAC AGAACATGGA 
GACTTGGGAA ATGGAAAATT TTTGGATCCA AAAAACAGAA TCTGTTTCAA ATTTGATCAT 
TTAAGAAAGG AAGCAACTGA TCCAAGGCCC TACGAAGCAG AAAATGCCAT TGAATCCTGG 
AGAACTTCAG TAGAAACTGC ACTGCGAGCT TATGTAAAAG AGCATTATCC GAATGGGGTC 
TGCACTGTGT ATGGCAAAAA AGTAGATGGG CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTTC AAGCAAAAAA CTTTTGGAAT GGTCGTTGGA GGTCAGAGTG GAAGTTTACA 
GTCACTCCTT CCACCACACA GGTGGTTGGC ATTTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTCAC AGTATCTAAT 
GAGGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACGATG TCGGACACTA CCTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TGACACGTAC TAAGATCGAC TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Capza2 ( NM_007604.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_031630.1 Mus musculus capping protein (actin filament) muscle Z-line, alpha 2 (Capza2), mRNA.

Price & Availability↑

CloneID	OMu00463
Clone ID Related Accession (Same CDS sequence)	NM_007604.2 , NM_007604.3
Accession Version	NM_007604.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1571760000000
Organism	Mus musculus(house mouse)
Product	F-actin-capping protein subunit alpha-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY232398.1, BC082589.1, BM204346.2 and CX734558.1. On Feb 14, 2018 this sequence version replaced NM_007604.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK150751.1, BC082589.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGATC TGGAGGAGCA GTTGTCCGAT GAGGAGAAGG TTCGTATAGC AGCAAAATTC 
ATCATTCACG CCCCTCCTGG AGAATTTAAT GAGGTTTTTA ATGATGTTCG ATTATTGCTT 
AATAATGATA ATCTTCTCAG GGAAGGAGCC GCACATGCAT TTGCACAGTA TAACCTGGAC 
CAGTTTACAC CAGTAAAAAT TGAAGGCTAT GAAGATCAGG TTTTGATAAC AGAACATGGA 
GACTTGGGAA ATGGAAAATT TTTGGATCCA AAAAACAGAA TCTGTTTCAA ATTTGATCAT 
TTAAGAAAGG AAGCAACTGA TCCAAGGCCC TACGAAGCAG AAAATGCCAT TGAATCCTGG 
AGAACTTCAG TAGAAACTGC ACTGCGAGCT TATGTAAAAG AGCATTATCC GAATGGGGTC 
TGCACTGTGT ATGGCAAAAA AGTAGATGGG CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTTC AAGCAAAAAA CTTTTGGAAT GGTCGTTGGA GGTCAGAGTG GAAGTTTACA 
GTCACTCCTT CCACCACACA GGTGGTTGGC ATTTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTCAC AGTATCTAAT 
GAGGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACGATG TCGGACACTA CCTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TGACACGTAC TAAGATCGAC TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_031630.1
CDS	113..973
Translation	MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPYEAENAIESWRTSVETALRAYVKEHYPNGVCTVYGKKVDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTVTPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA

Target ORF information:

RefSeq Version	NM_007604.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus capping protein (actin filament) muscle Z-line, alpha 2 (Capza2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007604.3

ORF Insert Sequence:

ATGGCGGATC TGGAGGAGCA GTTGTCCGAT GAGGAGAAGG TTCGTATAGC AGCAAAATTC 
ATCATTCACG CCCCTCCTGG AGAATTTAAT GAGGTTTTTA ATGATGTTCG ATTATTGCTT 
AATAATGATA ATCTTCTCAG GGAAGGAGCC GCACATGCAT TTGCACAGTA TAACCTGGAC 
CAGTTTACAC CAGTAAAAAT TGAAGGCTAT GAAGATCAGG TTTTGATAAC AGAACATGGA 
GACTTGGGAA ATGGAAAATT TTTGGATCCA AAAAACAGAA TCTGTTTCAA ATTTGATCAT 
TTAAGAAAGG AAGCAACTGA TCCAAGGCCC TACGAAGCAG AAAATGCCAT TGAATCCTGG 
AGAACTTCAG TAGAAACTGC ACTGCGAGCT TATGTAAAAG AGCATTATCC GAATGGGGTC 
TGCACTGTGT ATGGCAAAAA AGTAGATGGG CAGCAAACCA TTATTGCATG CATAGAAAGC 
CATCAGTTTC AAGCAAAAAA CTTTTGGAAT GGTCGTTGGA GGTCAGAGTG GAAGTTTACA 
GTCACTCCTT CCACCACACA GGTGGTTGGC ATTTTGAAAA TTCAGGTTCA TTATTATGAA 
GATGGTAATG TTCAGCTAGT GAGTCATAAA GATATACAAG ATTCCCTCAC AGTATCTAAT 
GAGGTGCAAA CAGCAAAAGA ATTTATAAAG ATTGTAGAAG CTGCAGAAAA TGAATACCAG 
ACTGCCATCA GTGAGAATTA TCAGACGATG TCGGACACTA CCTTCAAAGC CTTACGTCGA 
CAGTTGCCAG TGACACGTAC TAAGATCGAC TGGAACAAGA TCCTTAGCTA CAAGATTGGC 
AAAGAGATGC AGAATGCATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Placentation defects are highly prevalent in embryonic lethal mouse mutants.
Nature555(7697)463-468(2018 03)
Perez-Garcia V,Fineberg E,Wilson R,Murray A,Mazzeo CI,Tudor C,Sienerth A,White JK,Tuck E,Ryder EJ,Gleeson D,Siragher E,Wardle-Jones H,Staudt N,Wali N,Collins J,Geyer S,Busch-Nentwich EM,Galli A,Smith JC,Robertson E,Adams DJ,Weninger WJ,Mohun T,Hemberger M

A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.
Molecular biology of the cell23(2)324-36(2012 Jan)
Revenu C,Ubelmann F,Hurbain I,El-Marjou F,Dingli F,Loew D,Delacour D,Gilet J,Brot-Laroche E,Rivero F,Louvard D,Robine S

Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth.
PLoS biology7(10)e1000208(2009 Oct)
Davis DA,Wilson MH,Giraud J,Xie Z,Tseng HC,England C,Herscovitz H,Tsai LH,Delalle I

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.
Blood112(10)4298-307(2008 Nov)
Robledo RF,Ciciotte SL,Gwynn B,Sahr KE,Gilligan DM,Mohandas N,Peters LL

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
The Biochemical journal389(Pt 1)127-35(2005 Jul)
Eyers CE,McNeill H,Knebel A,Morrice N,Arthur SJ,Cuenda A,Cohen P

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Capza2 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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