| Gene Symbol | Apoc3 |
| Entrez Gene ID | 11814 |
| Full Name | apolipoprotein C-III |
| Synonyms | apo-CIII,apoC-III |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. |
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Apoc3 cDNA ORF clone, Mus musculus(house mouse)
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Gene
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Clones
gRNAs
The following Apoc3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Apoc3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OMu00021 Clone ID Related Accession (Same CDS sequence) NM_001289833.1 Accession Version NM_001289833.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 195bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1567785600000 Organism Mus musculus(house mouse) Product apolipoprotein C-III isoform c Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC116503.17. Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus compared to isoform a. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI553221.1, AA623288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181ATGGAACAAG CCTCCAAGAC GGTCCAGGAT GCGCTAAGTA GCGTGCAGGA GTCCGATATA
GCTGTGGTGG CCAGGGGCTG GATGGACAAT CACTTCAGAT CCCTGAAAGG CTACTGGAGC
AAGTTTACTG ACAAGTTCAC CGGCTTCTGG GATTCTAACC CTGAGGACCA ACCAACTCCA
GCTATTGAGT CGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001276762.1 CDS 92..286 Translation 
Target ORF information:
RefSeq Version NM_001289833.1 Organism Mus musculus(house mouse) Definition Mus musculus apolipoprotein C-III (Apoc3), transcript variant 4, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001289833.1
ORF Insert Sequence:
1
61
121
181ATGGAACAAG CCTCCAAGAC GGTCCAGGAT GCGCTAAGTA GCGTGCAGGA GTCCGATATA
GCTGTGGTGG CCAGGGGCTG GATGGACAAT CACTTCAGAT CCCTGAAAGG CTACTGGAGC
AAGTTTACTG ACAAGTTCAC CGGCTTCTGG GATTCTAACC CTGAGGACCA ACCAACTCCA
GCTATTGAGT CGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu13770 Clone ID Related Accession (Same CDS sequence) NM_001289755.1 Accession Version NM_001289755.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 414bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1567785600000 Organism Mus musculus(house mouse) Product apolipoprotein C-III isoform a Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC116503.17. On Jan 31, 2014 this sequence version replaced XM_006509955.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB949719.1, CA456578.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361ATGCCCCTGG GGAGGAGAGG AAGGAAGGGA AGAAACAAAG AGCTGGAGGG AGAAGCTCTC
ACCACCCAGC CATCTAGCCC ACAGAAGGCT TGGGACTCAT GGTACGTAGG TGCCATGCAG
CCCCGGACGC TCCTCACTGT GGCCCTCTTG GCTCTCCTGG CATCTGCCCG AGCTGAAGAG
GTAGAGGGAT CCTTGCTGCT GGGCTCTGTA CAGGGCTACA TGGAACAAGC CTCCAAGACG
GTCCAGGATG CGCTAAGTAG CGTGCAGGAG TCCGATATAG CTGTGGTGGC CAGGGGCTGG
ATGGACAATC ACTTCAGATC CCTGAAAGGC TACTGGAGCA AGTTTACTGA CAAGTTCACC
GGCTTCTGGG ATTCTAACCC TGAGGACCAA CCAACTCCAG CTATTGAGTC GTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001276684.1 CDS 45..458 Translation
Target ORF information:
RefSeq Version NM_001289755.1 Organism Mus musculus(house mouse) Definition Mus musculus apolipoprotein C-III (Apoc3), transcript variant 1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001289755.1
ORF Insert Sequence:
1
61
121
181
241
301
361ATGCCCCTGG GGAGGAGAGG AAGGAAGGGA AGAAACAAAG AGCTGGAGGG AGAAGCTCTC
ACCACCCAGC CATCTAGCCC ACAGAAGGCT TGGGACTCAT GGTACGTAGG TGCCATGCAG
CCCCGGACGC TCCTCACTGT GGCCCTCTTG GCTCTCCTGG CATCTGCCCG AGCTGAAGAG
GTAGAGGGAT CCTTGCTGCT GGGCTCTGTA CAGGGCTACA TGGAACAAGC CTCCAAGACG
GTCCAGGATG CGCTAAGTAG CGTGCAGGAG TCCGATATAG CTGTGGTGGC CAGGGGCTGG
ATGGACAATC ACTTCAGATC CCTGAAAGGC TACTGGAGCA AGTTTACTGA CAAGTTCACC
GGCTTCTGGG ATTCTAACCC TGAGGACCAA CCAACTCCAG CTATTGAGTC GTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu13748 Clone ID Related Accession (Same CDS sequence) NM_001289756.1 , NM_023114.4 Accession Version NM_001289756.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577376000000 Organism Mus musculus(house mouse) Product apolipoprotein C-III isoform b precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from W61891.1, AC116503.17 and AK008260.1. On Jan 31, 2014 this sequence version replaced XM_006509954.1. Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: W61891.1, W50727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241ATGCAGCCCC GGACGCTCCT CACTGTGGCC CTCTTGGCTC TCCTGGCATC TGCCCGAGCT
GAAGAGGTAG AGGGATCCTT GCTGCTGGGC TCTGTACAGG GCTACATGGA ACAAGCCTCC
AAGACGGTCC AGGATGCGCT AAGTAGCGTG CAGGAGTCCG ATATAGCTGT GGTGGCCAGG
GGCTGGATGG ACAATCACTT CAGATCCCTG AAAGGCTACT GGAGCAAGTT TACTGACAAG
TTCACCGGCT TCTGGGATTC TAACCCTGAG GACCAACCAA CTCCAGCTAT TGAGTCGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001276685.1 CDS 129..428 Translation
Target ORF information:
RefSeq Version NM_001289756.1 Organism Mus musculus(house mouse) Definition Mus musculus apolipoprotein C-III (Apoc3), transcript variant 2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_001289756.1
ORF Insert Sequence:
1
61
121
181
241ATGCAGCCCC GGACGCTCCT CACTGTGGCC CTCTTGGCTC TCCTGGCATC TGCCCGAGCT
GAAGAGGTAG AGGGATCCTT GCTGCTGGGC TCTGTACAGG GCTACATGGA ACAAGCCTCC
AAGACGGTCC AGGATGCGCT AAGTAGCGTG CAGGAGTCCG ATATAGCTGT GGTGGCCAGG
GGCTGGATGG ACAATCACTT CAGATCCCTG AAAGGCTACT GGAGCAAGTT TACTGACAAG
TTCACCGGCT TCTGGGATTC TAACCCTGAG GACCAACCAA CTCCAGCTAT TGAGTCGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OMu13748 Clone ID Related Accession (Same CDS sequence) NM_001289756.1 , NM_023114.4 Accession Version NM_023114.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577376000000 Organism Mus musculus(house mouse) Product apolipoprotein C-III isoform b precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK008260.1 and AC116503.17. On Jan 31, 2014 this sequence version replaced NM_023114.3. Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB949799.1, AK002908.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241ATGCAGCCCC GGACGCTCCT CACTGTGGCC CTCTTGGCTC TCCTGGCATC TGCCCGAGCT
GAAGAGGTAG AGGGATCCTT GCTGCTGGGC TCTGTACAGG GCTACATGGA ACAAGCCTCC
AAGACGGTCC AGGATGCGCT AAGTAGCGTG CAGGAGTCCG ATATAGCTGT GGTGGCCAGG
GGCTGGATGG ACAATCACTT CAGATCCCTG AAAGGCTACT GGAGCAAGTT TACTGACAAG
TTCACCGGCT TCTGGGATTC TAACCCTGAG GACCAACCAA CTCCAGCTAT TGAGTCGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_075603.1 CDS 55..354 Translation
Target ORF information:
RefSeq Version NM_023114.4 Organism Mus musculus(house mouse) Definition Mus musculus apolipoprotein C-III (Apoc3), transcript variant 3, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_023114.4
ORF Insert Sequence:
1
61
121
181
241ATGCAGCCCC GGACGCTCCT CACTGTGGCC CTCTTGGCTC TCCTGGCATC TGCCCGAGCT
GAAGAGGTAG AGGGATCCTT GCTGCTGGGC TCTGTACAGG GCTACATGGA ACAAGCCTCC
AAGACGGTCC AGGATGCGCT AAGTAGCGTG CAGGAGTCCG ATATAGCTGT GGTGGCCAGG
GGCTGGATGG ACAATCACTT CAGATCCCTG AAAGGCTACT GGAGCAAGTT TACTGACAAG
TTCACCGGCT TCTGGGATTC TAACCCTGAG GACCAACCAA CTCCAGCTAT TGAGTCGTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice.
Lipids in health and disease17(1)220(2018 Sep)
Yingchun H,Yahong M,Jiangping W,Xiaokui H,Xiaohong Z
Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure.
Journal of lipid research59(4)706-713(2018 04)
Larsson M,Allan CM,Heizer PJ,Tu Y,Sandoval NP,Jung RS,Walzem RL,Beigneux AP,Young SG,Fong LG
The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation.
Journal of lipid research58(11)2188-2196(2017 11)
Sundaram M,Curtis KR,Amir Alipour M,LeBlond ND,Margison KD,Yaworski RA,Parks RJ,McIntyre AD,Hegele RA,Fullerton MD,Yao Z
Key differences between apoC-III regulation and expression in intestine and liver.
Biochemical and biophysical research communications491(3)747-753(2017 09)
West G,Rodia C,Li D,Johnson Z,Dong H,Kohan AB
A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels.
Nature medicine23(9)1086-1094(2017 Sep)
Khetarpal SA,Zeng X,Millar JS,Vitali C,Somasundara AVH,Zanoni P,Landro JA,Barucci N,Zavadoski WJ,Sun Z,de Haard H,Toth IV,Peloso GM,Natarajan P,Cuchel M,Lund-Katz S,Phillips MC,Tall AR,Kathiresan S,DaSilva-Jardine P,Yates NA,Rader DJ
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