PCLAF cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PCLAF
Entrez Gene ID	9768
Full Name	PCNA clamp associated factor
Synonyms	KIAA0101,L5,NS5ATP9,OEATC,OEATC-1,OEATC1,PAF,PAF15,p15(PAF),p15/PAF,p15PAF
General protein information	Preferred Names PCNA clamp associated factor Names PCNA-associated factor HCV NS5A-transactivated protein 9 PCNA-associated factor of 15 kDa hepatitis C virus NS5A-transactivated protein 9 overexpressed in anaplastic thyroid carcinoma 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q22.31
Disorder MIM:	610696

mRNA and Protein(s)

mRNA	Protein	Name
NM_014736.5	NP_055551.1	PCNA-associated factor isoform 1
NM_001029989.2	NP_001025160.1	PCNA-associated factor isoform 2
NM_014736.6	NP_055551.1	PCNA-associated factor isoform 1
NM_001029989.3	NP_001025160.1	PCNA-associated factor isoform 2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	kiaa0101	NP_001005130.1
Homo sapiens (human)	KIAA0101	NP_055551.1
Bos taurus (cattle)	KIAA0101	NP_001015678.1
Mus musculus (house mouse)	2810417H13Rik	NP_080791.2
Macaca mulatta (Rhesus monkey)	KIAA0101	XP_002804860.1
Pan troglodytes (chimpanzee)	KIAA0101	XP_003952718.1
Rattus norvegicus (Norway rat)	Ns5atp9	NP_958821.1
Danio rerio (zebrafish)	LOC100333229	XP_002666801.2

Gene Ontology
Bibliography

Related articles in PubMed

MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF.
Zhao H, Lai X, Zhang W, Zhu H, Zhang S, Wu W, Wang S, Tang M, Deng Z, Tan J
Artificial cells, nanomedicine, and biotechnology47(1)278-289(2019 Dec)

NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.
Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM, Lan K
PLoS pathogens15(2)e1007628(2019 02)

PCNA-associated factor P15
Jin C, Liu Z, Li Y, Bu H, Wang Y, Xu Y, Qiu C, Yan S, Yuan C, Li R, Diao N, Zhang Z, Wang X, Liu L, Kong B
International journal of cancer143(11)2973-2984(2018 12)

p15PAF binding to PCNA modulates the DNA sliding surface.
De March M, Barrera-Vilarmau S, Crespan E, Mentegari E, Merino N, Gonzalez-Magaña A, Romano-Moreno M, Maga G, Crehuet R, Onesti S, Blanco FJ, De Biasio A
Nucleic acids research46(18)9816-9828(2018 10)

KIAA0101 inhibition suppresses cell proliferation and cell cycle progression by promoting the interaction between p53 and Sp1 in breast cancer.
Lv W, Su B, Li Y, Geng C, Chen N
Biochemical and biophysical research communications503(2)600-606(2018 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PCLAF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCLAF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14187	NM_001029989.3 Latest version!	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu14601	NM_014736.6 Latest version!	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu14601	NM_014736.5	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu14187	NM_001029989.2	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PCLAF ( NM_001029989.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025160.1 Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14187
Clone ID Related Accession (Same CDS sequence)	NM_001029989.2 , NM_001029989.3
Accession Version	NM_001029989.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	PCNA-associated factor isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF691807.1, AV757440.1, BC005832.2 and AC087632.10. On Dec 24, 2013 this sequence version replaced NM_001029989.1. Transcript Variant: This variant (2) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.371086.1, ERR279864.4230.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGAGC ATGTCCTTTG CAACCTGATC ACACAAATGA TGAAAAAGAA TAGAACTTTC 
TCATTCATCT TTGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025160.1
CDS	140..337
Translation	MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKEHVLCNLITQMMKKNRTFSFIFE

Target ORF information:

RefSeq Version	NM_001029989.2
Organism	Homo sapiens(human)
Definition	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029989.2

ORF Insert Sequence:

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGAGC ATGTCCTTTG CAACCTGATC ACACAAATGA TGAAAAAGAA TAGAACTTTC 
TCATTCATCT TTGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCLAF ( NM_001029989.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001025160.1 Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu14187
Clone ID Related Accession (Same CDS sequence)	NM_001029989.2 , NM_001029989.3
Accession Version	NM_001029989.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 198bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	PCNA-associated factor isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AV757440.1, BC005832.2 and AC087632.10. On May 31, 2019 this sequence version replaced NM_001029989.2. Transcript Variant: This variant (2) lacks an exon in the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA479443.1, DA606433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267769 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGAGC ATGTCCTTTG CAACCTGATC ACACAAATGA TGAAAAAGAA TAGAACTTTC 
TCATTCATCT TTGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001025160.1
CDS	71..268
Translation	MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKEHVLCNLITQMMKKNRTFSFIFE

Target ORF information:

RefSeq Version	NM_001029989.3
Organism	Homo sapiens(human)
Definition	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001029989.3

ORF Insert Sequence:

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGAGC ATGTCCTTTG CAACCTGATC ACACAAATGA TGAAAAAGAA TAGAACTTTC 
TCATTCATCT TTGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCLAF ( NM_014736.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055551.1 Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14601
Clone ID Related Accession (Same CDS sequence)	NM_014736.5 , NM_014736.6
Accession Version	NM_014736.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1513440000000
Organism	Homo sapiens(human)
Product	PCNA-associated factor isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF691807.1, BC005832.2 and AC087632.10. On Dec 24, 2013 this sequence version replaced NM_014736.4. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005832.2, SRR1163657.390869.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142680, SAMEA2149398 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGCTG AAAATAAATA TGCAGGAGGG AACCCCGTTT GCGTGCGCCC AACTCCCAAG 
TGGCAAAAAG GAATTGGAGA ATTCTTTAGG TTGTCCCCTA AAGATTCTGA AAAAGAGAAT 
CAGATTCCTG AAGAGGCAGG AAGCAGTGGC TTAGGAAAAG CAAAGAGAAA AGCATGTCCT 
TTGCAACCTG ATCACACAAA TGATGAAAAA GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055551.1
CDS	140..475
Translation	MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSEKENQIPEEAGSSGLGKAKRKACPLQPDHTNDEKE

Target ORF information:

RefSeq Version	NM_014736.5
Organism	Homo sapiens(human)
Definition	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014736.5

ORF Insert Sequence:

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGCTG AAAATAAATA TGCAGGAGGG AACCCCGTTT GCGTGCGCCC AACTCCCAAG 
TGGCAAAAAG GAATTGGAGA ATTCTTTAGG TTGTCCCCTA AAGATTCTGA AAAAGAGAAT 
CAGATTCCTG AAGAGGCAGG AAGCAGTGGC TTAGGAAAAG CAAAGAGAAA AGCATGTCCT 
TTGCAACCTG ATCACACAAA TGATGAAAAA GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PCLAF ( NM_014736.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_055551.1 Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu14601
Clone ID Related Accession (Same CDS sequence)	NM_014736.5 , NM_014736.6
Accession Version	NM_014736.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	PCNA-associated factor isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BF691807.1, BC005832.2 and AC087632.10. On Nov 24, 2018 this sequence version replaced NM_014736.5. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290748.1, SRR1163655.601241.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142680, SAMEA2149398 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000300035.9/ ENSP00000300035.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGCTG AAAATAAATA TGCAGGAGGG AACCCCGTTT GCGTGCGCCC AACTCCCAAG 
TGGCAAAAAG GAATTGGAGA ATTCTTTAGG TTGTCCCCTA AAGATTCTGA AAAAGAGAAT 
CAGATTCCTG AAGAGGCAGG AAGCAGTGGC TTAGGAAAAG CAAAGAGAAA AGCATGTCCT 
TTGCAACCTG ATCACACAAA TGATGAAAAA GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055551.1
CDS	71..406
Translation	MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSEKENQIPEEAGSSGLGKAKRKACPLQPDHTNDEKE

Target ORF information:

RefSeq Version	NM_014736.6
Organism	Homo sapiens(human)
Definition	Homo sapiens PCNA clamp associated factor (PCLAF), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014736.6

ORF Insert Sequence:

ATGGTGCGGA CTAAAGCAGA CAGTGTTCCA GGCACTTACA GAAAAGTGGT GGCTGCTCGA 
GCCCCCAGAA AGGTGCTTGG TTCTTCCACC TCTGCCACTA ATTCGACATC AGTTTCATCG 
AGGAAAGCTG AAAATAAATA TGCAGGAGGG AACCCCGTTT GCGTGCGCCC AACTCCCAAG 
TGGCAAAAAG GAATTGGAGA ATTCTTTAGG TTGTCCCCTA AAGATTCTGA AAAAGAGAAT 
CAGATTCCTG AAGAGGCAGG AAGCAGTGGC TTAGGAAAAG CAAAGAGAAA AGCATGTCCT 
TTGCAACCTG ATCACACAAA TGATGAAAAA GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF.
Artificial cells, nanomedicine, and biotechnology47(1)278-289(2019 Dec)
Zhao H,Lai X,Zhang W,Zhu H,Zhang S,Wu W,Wang S,Tang M,Deng Z,Tan J

NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.
PLoS pathogens15(2)e1007628(2019 02)
Zhang F,Liang D,Lin X,Zou Z,Sun R,Wang X,Liang X,Kaye KM,Lan K

PCNA-associated factor P15
International journal of cancer143(11)2973-2984(2018 12)
Jin C,Liu Z,Li Y,Bu H,Wang Y,Xu Y,Qiu C,Yan S,Yuan C,Li R,Diao N,Zhang Z,Wang X,Liu L,Kong B

p15PAF binding to PCNA modulates the DNA sliding surface.
Nucleic acids research46(18)9816-9828(2018 10)
De March M,Barrera-Vilarmau S,Crespan E,Mentegari E,Merino N,Gonzalez-Magaña A,Romano-Moreno M,Maga G,Crehuet R,Onesti S,Blanco FJ,De Biasio A

KIAA0101 inhibition suppresses cell proliferation and cell cycle progression by promoting the interaction between p53 and Sp1 in breast cancer.
Biochemical and biophysical research communications503(2)600-606(2018 09)
Lv W,Su B,Li Y,Geng C,Chen N

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PCLAF cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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