TOX cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TOX
Entrez Gene ID	9760
Full Name	thymocyte selection associated high mobility group box
Synonyms	TOX1
General protein information	Preferred Names thymocyte selection associated high mobility group box Names thymocyte selection-associated high mobility group box protein TOX thymus high mobility group box protein TOX
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q12.1
Summary	The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009].
Disorder MIM:	606863

mRNA and Protein(s)

mRNA	Protein	Name
XM_017014085.1	XP_016869574.1	thymocyte selection-associated high mobility group box protein TOX isoform X1
NM_014729.2	NP_055544.1	thymocyte selection-associated high mobility group box protein TOX
NM_014729.3	NP_055544.1	thymocyte selection-associated high mobility group box protein TOX

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Tox	NP_001102124.1
Danio rerio (zebrafish)	tox	NP_001243623.1
Mus musculus (house mouse)	Tox	NP_663757.3
Homo sapiens (human)	TOX	NP_055544.1
Canis lupus familiaris (dog)	TOX	XP_544093.3
Pan troglodytes (chimpanzee)	TOX	XP_519777.2
Macaca mulatta (Rhesus monkey)	TOX	XP_001088869.1
Bos taurus (cattle)	TOX	NP_001095566.1
Gallus gallus (chicken)	TOX	NP_001026196.1
Xenopus tropicalis (tropical clawed frog)	tox	XP_002936155.2

Gene Ontology
Bibliography

Related articles in PubMed

TOX is a critical regulator of tumour-specific T cell differentiation.
Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara S, Zamarin D, Walther T, Snyder A, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman MS, Kaye J, Betel D, Philip M, Schietinger A
Nature571(7764)270-274(2019 07)

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.
Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D
Nature571(7764)265-269(2019 07)

TOX expression decreases with progression of colorectal cancers and is associated with CD4 T-cell density and Fusobacterium nucleatum infection.
Chen T, Li Q, Zhang X, Long R, Wu Y, Wu J, Fu X
Human pathology7993-101(2018 09)

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.
Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn JS, Abraham BJ, Namiki Y, Mansour M, Abdelfattah NS, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Boukhali M, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman LB, Sadreyev RI, Asara JM, Oettinger MA, Haas W, Look AT, Young RA, Mostoslavsky R, Dellaire G, Langenau DM
Cancer discovery7(11)1336-1353(2017 11)

TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese.
Li S, Xu C, Tian Y, Wang X, Jiang R, Zhang M, Wang L, Yang G, Gao Y, Song C, He Y, Zhang Y, Li J, Li WD
Scientific reports745203(2017 03)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TOX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TOX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu98335	XM_017014085.1 Latest version!	Homo sapiens thymocyte selection associated high mobility group box (TOX), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu18565	NM_014729.3 Latest version!	Homo sapiens thymocyte selection associated high mobility group box (TOX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu18565	NM_014729.2	Homo sapiens thymocyte selection associated high mobility group box (TOX), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TOX ( NM_014729.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055544.1 Homo sapiens thymocyte selection associated high mobility group box (TOX), mRNA.

Price & Availability↑

CloneID	OHu18565
Clone ID Related Accession (Same CDS sequence)	NM_014729.2 , NM_014729.3
Accession Version	NM_014729.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1507392000000
Organism	Homo sapiens(human)
Product	thymocyte selection-associated high mobility group box protein TOX
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB018351.1 and CA439630.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 30, 2004 this sequence version replaced XM_376776.1, NM_014729.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB018351.1, SRR1660809.135967.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGACGTAA GATTTTATCC ACCTCCAGCC CAGCCCGCCG CTGCGCCCGA CGCTCCCTGT 
CTGGGACCTT CTCCCTGCCT GGACCCCTAC TATTGCAACA AGTTTGACGG TGAGAACATG 
TATATGAGCA TGACAGAGCC GAGCCAGGAC TATGTGCCAG CCAGCCAGTC CTACCCTGGT 
CCAAGCCTGG AAAGTGAAGA CTTCAACATT CCACCAATTA CTCCTCCTTC CCTCCCAGAC 
CACTCGCTGG TGCACCTGAA TGAAGTTGAG TCTGGTTACC ATTCTCTGTG TCACCCCATG 
AACCATAATG GCCTGCTACC ATTTCATCCA CAAAACATGG ACCTCCCTGA AATCACAGTC 
TCCAATATGC TGGGCCAGGA TGGAACACTG CTTTCTAATT CCATTTCTGT GATGCCAGAT 
ATACGAAACC CAGAAGGAAC TCAGTACAGT TCCCATCCTC AGATGGCAGC CATGAGACCA 
AGGGGCCAGC CTGCAGACAT CAGGCAGCAG CCAGGAATGA TGCCACATGG CCAGCTGACT 
ACCATTAACC AGTCACAGCT AAGTGCTCAA CTTGGTTTGA ATATGGGAGG AAGCAATGTT 
CCCCACAACT CACCATCTCC ACCTGGAAGC AAGTCTGCAA CTCCTTCACC ATCCAGTTCA 
GTGCATGAAG ATGAAGGCGA TGATACCTCT AAGATCAATG GTGGAGAGAA GCGGCCTGCC 
TCTGATATGG GGAAAAAACC AAAAACTCCC AAAAAGAAGA AGAAGAAGGA TCCCAATGAG 
CCCCAGAAGC CTGTGTCTGC CTATGCGTTA TTCTTTCGTG ATACTCAGGC CGCCATCAAG 
GGCCAAAATC CAAACGCTAC CTTTGGCGAA GTCTCTAAAA TTGTGGCTTC AATGTGGGAC 
GGTTTAGGAG AAGAGCAAAA ACAGGTCTAT AAAAAGAAAA CCGAGGCTGC GAAGAAGGAG 
TACCTGAAGC AACTCGCAGC ATACAGAGCC AGCCTTGTAT CCAAGAGCTA CAGTGAACCT 
GTTGACGTGA AGACATCTCA ACCTCCTCAG CTGATCAATT CGAAGCCGTC GGTGTTCCAT 
GGGCCCAGCC AGGCCCACTC GGCCCTGTAC CTAAGTTCCC ACTATCACCA ACAACCGGGA 
ATGAATCCTC ACCTAACTGC CATGCATCCT AGTCTCCCCA GGAACATAGC CCCCAAGCCG 
AATAACCAAA TGCCAGTGAC TGTCTCTATA GCAAACATGG CTGTGTCCCC TCCTCCTCCC 
CTCCAGATCA GCCCGCCTCT TCACCAGCAT CTCAACATGC AGCAGCACCA GCCGCTCACC 
ATGCAGCAGC CCCTTGGGAA CCAGCTCCCC ATGCAGGTCC AGTCTGCCTT ACACTCACCC 
ACCATGCAGC AAGGATTTAC TCTTCAACCC GACTATCAGA CTATTATCAA TCCTACATCT 
ACAGCTGCAC AAGTTGTCAC CCAGGCAATG GAGTATGTGC GTTCGGGGTG CAGAAATCCT 
CCCCCACAAC CGGTGGACTG GAATAACGAC TACTGCAGTA GTGGGGGCAT GCAGAGGGAC 
AAAGCACTGT ACCTTACTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055544.1
CDS	222..1802
Translation	MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWNNDYCSSGGMQRDKALYLT

Target ORF information:

RefSeq Version	NM_014729.2
Organism	Homo sapiens(human)
Definition	Homo sapiens thymocyte selection associated high mobility group box (TOX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014729.2

ORF Insert Sequence:

ATGGACGTAA GATTTTATCC ACCTCCAGCC CAGCCCGCCG CTGCGCCCGA CGCTCCCTGT 
CTGGGACCTT CTCCCTGCCT GGACCCCTAC TATTGCAACA AGTTTGACGG TGAGAACATG 
TATATGAGCA TGACAGAGCC GAGCCAGGAC TATGTGCCAG CCAGCCAGTC CTACCCTGGT 
CCAAGCCTGG AAAGTGAAGA CTTCAACATT CCACCAATTA CTCCTCCTTC CCTCCCAGAC 
CACTCGCTGG TGCACCTGAA TGAAGTTGAG TCTGGTTACC ATTCTCTGTG TCACCCCATG 
AACCATAATG GCCTGCTACC ATTTCATCCA CAAAACATGG ACCTCCCTGA AATCACAGTC 
TCCAATATGC TGGGCCAGGA TGGAACACTG CTTTCTAATT CCATTTCTGT GATGCCAGAT 
ATACGAAACC CAGAAGGAAC TCAGTACAGT TCCCATCCTC AGATGGCAGC CATGAGACCA 
AGGGGCCAGC CTGCAGACAT CAGGCAGCAG CCAGGAATGA TGCCACATGG CCAGCTGACT 
ACCATTAACC AGTCACAGCT AAGTGCTCAA CTTGGTTTGA ATATGGGAGG AAGCAATGTT 
CCCCACAACT CACCATCTCC ACCTGGAAGC AAGTCTGCAA CTCCTTCACC ATCCAGTTCA 
GTGCATGAAG ATGAAGGCGA TGATACCTCT AAGATCAATG GTGGAGAGAA GCGGCCTGCC 
TCTGATATGG GGAAAAAACC AAAAACTCCC AAAAAGAAGA AGAAGAAGGA TCCCAATGAG 
CCCCAGAAGC CTGTGTCTGC CTATGCGTTA TTCTTTCGTG ATACTCAGGC CGCCATCAAG 
GGCCAAAATC CAAACGCTAC CTTTGGCGAA GTCTCTAAAA TTGTGGCTTC AATGTGGGAC 
GGTTTAGGAG AAGAGCAAAA ACAGGTCTAT AAAAAGAAAA CCGAGGCTGC GAAGAAGGAG 
TACCTGAAGC AACTCGCAGC ATACAGAGCC AGCCTTGTAT CCAAGAGCTA CAGTGAACCT 
GTTGACGTGA AGACATCTCA ACCTCCTCAG CTGATCAATT CGAAGCCGTC GGTGTTCCAT 
GGGCCCAGCC AGGCCCACTC GGCCCTGTAC CTAAGTTCCC ACTATCACCA ACAACCGGGA 
ATGAATCCTC ACCTAACTGC CATGCATCCT AGTCTCCCCA GGAACATAGC CCCCAAGCCG 
AATAACCAAA TGCCAGTGAC TGTCTCTATA GCAAACATGG CTGTGTCCCC TCCTCCTCCC 
CTCCAGATCA GCCCGCCTCT TCACCAGCAT CTCAACATGC AGCAGCACCA GCCGCTCACC 
ATGCAGCAGC CCCTTGGGAA CCAGCTCCCC ATGCAGGTCC AGTCTGCCTT ACACTCACCC 
ACCATGCAGC AAGGATTTAC TCTTCAACCC GACTATCAGA CTATTATCAA TCCTACATCT 
ACAGCTGCAC AAGTTGTCAC CCAGGCAATG GAGTATGTGC GTTCGGGGTG CAGAAATCCT 
CCCCCACAAC CGGTGGACTG GAATAACGAC TACTGCAGTA GTGGGGGCAT GCAGAGGGAC 
AAAGCACTGT ACCTTACTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOX ( XM_017014085.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016869574.1 Homo sapiens thymocyte selection associated high mobility group box (TOX), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu98335
Clone ID Related Accession (Same CDS sequence)	XM_017014085.1
Accession Version	XM_017014085.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	thymocyte selection-associated high mobility group box protein TOX isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000008.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACGTAA GATTTTATCC ACCTCCAGCC CAGCCCGCCG CTGCGCCCGA CGCTCCCTGT 
CTGGGACCTT CTCCCTGCCT GGACCCCTAC TATTGCAACA AGTCCTACCC TGGTCCAAGC 
CTGGAAAGTG AAGACTTCAA CATTCCACCA ATTACTCCTC CTTCCCTCCC AGACCACTCG 
CTGGTGCACC TGAATGAAGT TGAGTCTGGT TACCATTCTC TGTGTCACCC CATGAACCAT 
AATGGCCTGC TACCATTTCA TCCACAAAAC ATGGACCTCC CTGAAATCAC AGTCTCCAAT 
ATGCTGGGCC AGGATGGAAC ACTGCTTTCT AATTCCATTT CTGTGATGCC AGATATACGA 
AACCCAGAAG GAACTCAGTA CAGTTCCCAT CCTCAGATGG CAGCCATGAG ACCAAGGGGC 
CAGCCTGCAG ACATCAGGCA GCAGCCAGGA ATGATGCCAC ATGGCCAGCT GACTACCATT 
AACCAGTCAC AGCTAAGTGC TCAACTTGGT TTGAATATGG GAGGAAGCAA TGTTCCCCAC 
AACTCACCAT CTCCACCTGG AAGCAAGTCT GCAACTCCTT CACCATCCAG TTCAGTGCAT 
GAAGATGAAG GCGATGATAC CTCTAAGATC AATGGTGGAG AGAAGCGGCC TGCCTCTGAT 
ATGGGGAAAA AACCAAAAAC TCCCAAAAAG AAGAAGAAGA AGGATCCCAA TGAGCCCCAG 
AAGCCTGTGT CTGCCTATGC GTTATTCTTT CGTGATACTC AGGCCGCCAT CAAGGGCCAA 
AATCCAAACG CTACCTTTGG CGAAGTCTCT AAAATTGTGG CTTCAATGTG GGACGGTTTA 
GGAGAAGAGC AAAAACAGGT CTATAAAAAG AAAACCGAGG CTGCGAAGAA GGAGTACCTG 
AAGCAACTCG CAGCATACAG AGCCAGCCTT GTATCCAAGA GCTACAGTGA ACCTGTTGAC 
GTGAAGACAT CTCAACCTCC TCAGCTGATC AATTCGAAGC CGTCGGTGTT CCATGGGCCC 
AGCCAGGCCC ACTCGGCCCT GTACCTAAGT TCCCACTATC ACCAACAACC GGGAATGAAT 
CCTCACCTAA CTGCCATGCA TCCTAGTCTC CCCAGGAACA TAGCCCCCAA GCCGAATAAC 
CAAATGCCAG TGACTGTCTC TATAGCAAAC ATGGCTGTGT CCCCTCCTCC TCCCCTCCAG 
ATCAGCCCGC CTCTTCACCA GCATCTCAAC ATGCAGCAGC ACCAGCCGCT CACCATGCAG 
CAGCCCCTTG GGAACCAGCT CCCCATGCAG GTCCAGTCTG CCTTACACTC ACCCACCATG 
CAGCAAGGAT TTACTCTTCA ACCCGACTAT CAGACTATTA TCAATCCTAC ATCTACAGCT 
GCACAAGTTG TCACCCAGGC AATGGAGTAT GTGCGTTCGG GGTGCAGAAA TCCTCCCCCA 
CAACCGGTGG ACTGGAATAA CGACTACTGC AGTAGTGGGG GCATGCAGAG GGACAAAGCA 
CTGTACCTTA CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016869574.1
CDS	307..1821
Translation	MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWNNDYCSSGGMQRDKALYLT

Target ORF information:

RefSeq Version	XM_017014085.1
Organism	Homo sapiens(human)
Definition	Homo sapiens thymocyte selection associated high mobility group box (TOX), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017014085.1

ORF Insert Sequence:

ATGGACGTAA GATTTTATCC ACCTCCAGCC CAGCCCGCCG CTGCGCCCGA CGCTCCCTGT 
CTGGGACCTT CTCCCTGCCT GGACCCCTAC TATTGCAACA AGTCCTACCC TGGTCCAAGC 
CTGGAAAGTG AAGACTTCAA CATTCCACCA ATTACTCCTC CTTCCCTCCC AGACCACTCG 
CTGGTGCACC TGAATGAAGT TGAGTCTGGT TACCATTCTC TGTGTCACCC CATGAACCAT 
AATGGCCTGC TACCATTTCA TCCACAAAAC ATGGACCTCC CTGAAATCAC AGTCTCCAAT 
ATGCTGGGCC AGGATGGAAC ACTGCTTTCT AATTCCATTT CTGTGATGCC AGATATACGA 
AACCCAGAAG GAACTCAGTA CAGTTCCCAT CCTCAGATGG CAGCCATGAG ACCAAGGGGC 
CAGCCTGCAG ACATCAGGCA GCAGCCAGGA ATGATGCCAC ATGGCCAGCT GACTACCATT 
AACCAGTCAC AGCTAAGTGC TCAACTTGGT TTGAATATGG GAGGAAGCAA TGTTCCCCAC 
AACTCACCAT CTCCACCTGG AAGCAAGTCT GCAACTCCTT CACCATCCAG TTCAGTGCAT 
GAAGATGAAG GCGATGATAC CTCTAAGATC AATGGTGGAG AGAAGCGGCC TGCCTCTGAT 
ATGGGGAAAA AACCAAAAAC TCCCAAAAAG AAGAAGAAGA AGGATCCCAA TGAGCCCCAG 
AAGCCTGTGT CTGCCTATGC GTTATTCTTT CGTGATACTC AGGCCGCCAT CAAGGGCCAA 
AATCCAAACG CTACCTTTGG CGAAGTCTCT AAAATTGTGG CTTCAATGTG GGACGGTTTA 
GGAGAAGAGC AAAAACAGGT CTATAAAAAG AAAACCGAGG CTGCGAAGAA GGAGTACCTG 
AAGCAACTCG CAGCATACAG AGCCAGCCTT GTATCCAAGA GCTACAGTGA ACCTGTTGAC 
GTGAAGACAT CTCAACCTCC TCAGCTGATC AATTCGAAGC CGTCGGTGTT CCATGGGCCC 
AGCCAGGCCC ACTCGGCCCT GTACCTAAGT TCCCACTATC ACCAACAACC GGGAATGAAT 
CCTCACCTAA CTGCCATGCA TCCTAGTCTC CCCAGGAACA TAGCCCCCAA GCCGAATAAC 
CAAATGCCAG TGACTGTCTC TATAGCAAAC ATGGCTGTGT CCCCTCCTCC TCCCCTCCAG 
ATCAGCCCGC CTCTTCACCA GCATCTCAAC ATGCAGCAGC ACCAGCCGCT CACCATGCAG 
CAGCCCCTTG GGAACCAGCT CCCCATGCAG GTCCAGTCTG CCTTACACTC ACCCACCATG 
CAGCAAGGAT TTACTCTTCA ACCCGACTAT CAGACTATTA TCAATCCTAC ATCTACAGCT 
GCACAAGTTG TCACCCAGGC AATGGAGTAT GTGCGTTCGG GGTGCAGAAA TCCTCCCCCA 
CAACCGGTGG ACTGGAATAA CGACTACTGC AGTAGTGGGG GCATGCAGAG GGACAAAGCA 
CTGTACCTTA CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TOX ( NM_014729.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055544.1 Homo sapiens thymocyte selection associated high mobility group box (TOX), mRNA.

Price & Availability↑

CloneID	OHu18565
Clone ID Related Accession (Same CDS sequence)	NM_014729.2 , NM_014729.3
Accession Version	NM_014729.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1573833600000
Organism	Homo sapiens(human)
Product	thymocyte selection-associated high mobility group box protein TOX
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB018351.1, CA439630.1 and AC091195.6. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_014729.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB018351.1, SRR1660809.135967.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361421.2/ ENSP00000354842.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACGTAA GATTTTATCC ACCTCCAGCC CAGCCCGCCG CTGCGCCCGA CGCTCCCTGT 
CTGGGACCTT CTCCCTGCCT GGACCCCTAC TATTGCAACA AGTTTGACGG TGAGAACATG 
TATATGAGCA TGACAGAGCC GAGCCAGGAC TATGTGCCAG CCAGCCAGTC CTACCCTGGT 
CCAAGCCTGG AAAGTGAAGA CTTCAACATT CCACCAATTA CTCCTCCTTC CCTCCCAGAC 
CACTCGCTGG TGCACCTGAA TGAAGTTGAG TCTGGTTACC ATTCTCTGTG TCACCCCATG 
AACCATAATG GCCTGCTACC ATTTCATCCA CAAAACATGG ACCTCCCTGA AATCACAGTC 
TCCAATATGC TGGGCCAGGA TGGAACACTG CTTTCTAATT CCATTTCTGT GATGCCAGAT 
ATACGAAACC CAGAAGGAAC TCAGTACAGT TCCCATCCTC AGATGGCAGC CATGAGACCA 
AGGGGCCAGC CTGCAGACAT CAGGCAGCAG CCAGGAATGA TGCCACATGG CCAGCTGACT 
ACCATTAACC AGTCACAGCT AAGTGCTCAA CTTGGTTTGA ATATGGGAGG AAGCAATGTT 
CCCCACAACT CACCATCTCC ACCTGGAAGC AAGTCTGCAA CTCCTTCACC ATCCAGTTCA 
GTGCATGAAG ATGAAGGCGA TGATACCTCT AAGATCAATG GTGGAGAGAA GCGGCCTGCC 
TCTGATATGG GGAAAAAACC AAAAACTCCC AAAAAGAAGA AGAAGAAGGA TCCCAATGAG 
CCCCAGAAGC CTGTGTCTGC CTATGCGTTA TTCTTTCGTG ATACTCAGGC CGCCATCAAG 
GGCCAAAATC CAAACGCTAC CTTTGGCGAA GTCTCTAAAA TTGTGGCTTC AATGTGGGAC 
GGTTTAGGAG AAGAGCAAAA ACAGGTCTAT AAAAAGAAAA CCGAGGCTGC GAAGAAGGAG 
TACCTGAAGC AACTCGCAGC ATACAGAGCC AGCCTTGTAT CCAAGAGCTA CAGTGAACCT 
GTTGACGTGA AGACATCTCA ACCTCCTCAG CTGATCAATT CGAAGCCGTC GGTGTTCCAT 
GGGCCCAGCC AGGCCCACTC GGCCCTGTAC CTAAGTTCCC ACTATCACCA ACAACCGGGA 
ATGAATCCTC ACCTAACTGC CATGCATCCT AGTCTCCCCA GGAACATAGC CCCCAAGCCG 
AATAACCAAA TGCCAGTGAC TGTCTCTATA GCAAACATGG CTGTGTCCCC TCCTCCTCCC 
CTCCAGATCA GCCCGCCTCT TCACCAGCAT CTCAACATGC AGCAGCACCA GCCGCTCACC 
ATGCAGCAGC CCCTTGGGAA CCAGCTCCCC ATGCAGGTCC AGTCTGCCTT ACACTCACCC 
ACCATGCAGC AAGGATTTAC TCTTCAACCC GACTATCAGA CTATTATCAA TCCTACATCT 
ACAGCTGCAC AAGTTGTCAC CCAGGCAATG GAGTATGTGC GTTCGGGGTG CAGAAATCCT 
CCCCCACAAC CGGTGGACTG GAATAACGAC TACTGCAGTA GTGGGGGCAT GCAGAGGGAC 
AAAGCACTGT ACCTTACTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055544.1
CDS	161..1741
Translation	MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALHSPTMQQGFTLQPDYQTIINPTSTAAQVVTQAMEYVRSGCRNPPPQPVDWNNDYCSSGGMQRDKALYLT

Target ORF information:

RefSeq Version	NM_014729.3
Organism	Homo sapiens(human)
Definition	Homo sapiens thymocyte selection associated high mobility group box (TOX), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014729.3

ORF Insert Sequence:

ATGGACGTAA GATTTTATCC ACCTCCAGCC CAGCCCGCCG CTGCGCCCGA CGCTCCCTGT 
CTGGGACCTT CTCCCTGCCT GGACCCCTAC TATTGCAACA AGTTTGACGG TGAGAACATG 
TATATGAGCA TGACAGAGCC GAGCCAGGAC TATGTGCCAG CCAGCCAGTC CTACCCTGGT 
CCAAGCCTGG AAAGTGAAGA CTTCAACATT CCACCAATTA CTCCTCCTTC CCTCCCAGAC 
CACTCGCTGG TGCACCTGAA TGAAGTTGAG TCTGGTTACC ATTCTCTGTG TCACCCCATG 
AACCATAATG GCCTGCTACC ATTTCATCCA CAAAACATGG ACCTCCCTGA AATCACAGTC 
TCCAATATGC TGGGCCAGGA TGGAACACTG CTTTCTAATT CCATTTCTGT GATGCCAGAT 
ATACGAAACC CAGAAGGAAC TCAGTACAGT TCCCATCCTC AGATGGCAGC CATGAGACCA 
AGGGGCCAGC CTGCAGACAT CAGGCAGCAG CCAGGAATGA TGCCACATGG CCAGCTGACT 
ACCATTAACC AGTCACAGCT AAGTGCTCAA CTTGGTTTGA ATATGGGAGG AAGCAATGTT 
CCCCACAACT CACCATCTCC ACCTGGAAGC AAGTCTGCAA CTCCTTCACC ATCCAGTTCA 
GTGCATGAAG ATGAAGGCGA TGATACCTCT AAGATCAATG GTGGAGAGAA GCGGCCTGCC 
TCTGATATGG GGAAAAAACC AAAAACTCCC AAAAAGAAGA AGAAGAAGGA TCCCAATGAG 
CCCCAGAAGC CTGTGTCTGC CTATGCGTTA TTCTTTCGTG ATACTCAGGC CGCCATCAAG 
GGCCAAAATC CAAACGCTAC CTTTGGCGAA GTCTCTAAAA TTGTGGCTTC AATGTGGGAC 
GGTTTAGGAG AAGAGCAAAA ACAGGTCTAT AAAAAGAAAA CCGAGGCTGC GAAGAAGGAG 
TACCTGAAGC AACTCGCAGC ATACAGAGCC AGCCTTGTAT CCAAGAGCTA CAGTGAACCT 
GTTGACGTGA AGACATCTCA ACCTCCTCAG CTGATCAATT CGAAGCCGTC GGTGTTCCAT 
GGGCCCAGCC AGGCCCACTC GGCCCTGTAC CTAAGTTCCC ACTATCACCA ACAACCGGGA 
ATGAATCCTC ACCTAACTGC CATGCATCCT AGTCTCCCCA GGAACATAGC CCCCAAGCCG 
AATAACCAAA TGCCAGTGAC TGTCTCTATA GCAAACATGG CTGTGTCCCC TCCTCCTCCC 
CTCCAGATCA GCCCGCCTCT TCACCAGCAT CTCAACATGC AGCAGCACCA GCCGCTCACC 
ATGCAGCAGC CCCTTGGGAA CCAGCTCCCC ATGCAGGTCC AGTCTGCCTT ACACTCACCC 
ACCATGCAGC AAGGATTTAC TCTTCAACCC GACTATCAGA CTATTATCAA TCCTACATCT 
ACAGCTGCAC AAGTTGTCAC CCAGGCAATG GAGTATGTGC GTTCGGGGTG CAGAAATCCT 
CCCCCACAAC CGGTGGACTG GAATAACGAC TACTGCAGTA GTGGGGGCAT GCAGAGGGAC 
AAAGCACTGT ACCTTACTTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TOX is a critical regulator of tumour-specific T cell differentiation.
Nature571(7764)270-274(2019 07)
Scott AC,Dündar F,Zumbo P,Chandran SS,Klebanoff CA,Shakiba M,Trivedi P,Menocal L,Appleby H,Camara S,Zamarin D,Walther T,Snyder A,Femia MR,Comen EA,Wen HY,Hellmann MD,Anandasabapathy N,Liu Y,Altorki NK,Lauer P,Levy O,Glickman MS,Kaye J,Betel D,Philip M,Schietinger A

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.
Nature571(7764)265-269(2019 07)
Alfei F,Kanev K,Hofmann M,Wu M,Ghoneim HE,Roelli P,Utzschneider DT,von Hoesslin M,Cullen JG,Fan Y,Eisenberg V,Wohlleber D,Steiger K,Merkler D,Delorenzi M,Knolle PA,Cohen CJ,Thimme R,Youngblood B,Zehn D

TOX expression decreases with progression of colorectal cancers and is associated with CD4 T-cell density and Fusobacterium nucleatum infection.
Human pathology7993-101(2018 09)
Chen T,Li Q,Zhang X,Long R,Wu Y,Wu J,Fu X

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.
Cancer discovery7(11)1336-1353(2017 11)
Lobbardi R,Pinder J,Martinez-Pastor B,Theodorou M,Blackburn JS,Abraham BJ,Namiki Y,Mansour M,Abdelfattah NS,Molodtsov A,Alexe G,Toiber D,de Waard M,Jain E,Boukhali M,Lion M,Bhere D,Shah K,Gutierrez A,Stegmaier K,Silverman LB,Sadreyev RI,Asara JM,Oettinger MA,Haas W,Look AT,Young RA,Mostoslavsky R,Dellaire G,Langenau DM

TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese.
Scientific reports745203(2017 03)
Li S,Xu C,Tian Y,Wang X,Jiang R,Zhang M,Wang L,Yang G,Gao Y,Song C,He Y,Zhang Y,Li J,Li WD

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TOX cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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