ADAMTS3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAMTS3
Entrez Gene ID	9508
Full Name	ADAM metallopeptidase with thrombospondin type 1 motif 3
Synonyms	ADAMTS-4
General protein information	Preferred Names ADAM metallopeptidase with thrombospondin type 1 motif 3 Names A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAM-TS 3 ADAM-TS3 ADAMTS-3 PC II-NP a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3 procollagen II N-proteinase procollagen II amino propeptide-processing enzyme zinc metalloendopeptidase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q13.3
Summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016].
Disorder MIM:	605011

mRNA and Protein(s)

mRNA	Protein	Name
XM_011532421.2	XP_011530723.1	A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X1
XM_011532422.2	XP_011530724.1	A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X2
NM_014243.2	NP_055058.2	A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein
NM_014243.3	NP_055058.2	A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein
XM_011532422.3	XP_011530724.1	A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ADAMTS3	XP_517240.2
Macaca mulatta (Rhesus monkey)	ADAMTS3	XP_001104686.2
Canis lupus familiaris (dog)	ADAMTS3	XP_539311.3
Homo sapiens (human)	ADAMTS3	NP_055058.2
Danio rerio (zebrafish)	LOC568788	XP_005165504.1
Mus musculus (house mouse)	Adamts3	NP_808540.2
Rattus norvegicus (Norway rat)	Adamts3	NP_001100682.1
Xenopus tropicalis (tropical clawed frog)	adamts3	XP_002940398.2
Bos taurus (cattle)	ADAMTS3	NP_001179726.1
Gallus gallus (chicken)	ADAMTS3	XP_426316.4

Gene Ontology
Bibliography

Related articles in PubMed

An additional case of Hennekam lymphangiectasia-lymphedema syndrome caused by loss-of-function mutation in ADAMTS3.
Scheuerle AE, Sweed NT, Timmons CF, Smith ED, Alcaraz WA, Shinde DN
American journal of medical genetics. Part A176(12)2858-2861(2018 12)

SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models.
Aydemir AT, Alper M, Kockar F
Gene6591-10(2018 Jun)

Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
Xu Y, Wang Y, Liu H, Shi Q, Zhu D, Amos CI, Fang S, Lee JE, Hyslop T, Li X, Han J, Wei Q
Molecular carcinogenesis57(1)22-31(2018 Jan)

Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.
Brouillard P, Dupont L, Helaers R, Coulie R, Tiller GE, Peeden J, Colige A, Vikkula M
Human molecular genetics26(21)4095-4104(2017 11)

ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.
Pekcan MK, Sarıkaya E, Tokmak A, Alışık M, Alkan A, Özakşit G, Erel Ö
The Kaohsiung journal of medical sciences33(1)30-35(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ADAMTS3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAMTS3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu62898	XM_011532421.2 Latest version!	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00
OHu62899	XM_011532422.3 Latest version!	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00
OHu55645	NM_014243.3 Latest version!	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$384.30 $549.00
View Old Accession Versions >>
OHu55645	NM_014243.2	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$384.30 $549.00
OHu62899	XM_011532422.2	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$643.30 $919.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAMTS3 ( XM_011532421.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530723.1 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X1, mRNA.

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CloneID	OHu62898
Clone ID Related Accession (Same CDS sequence)	XM_011532421.2
Accession Version	XM_011532421.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532421.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGACTTT GGGCTGGTAA TGAAGAAATG GTGCAAATAG ATTTACCAAT AAAGAGATAT 
AGAGAGTATG AGCTGGTGAC TCCAGTCAGC ACAAATCTAG AAGGACGCTA TCTCTCCCAT 
ACTCTTTCTG CGAGTCACAA AAAGAGGTCA GCGAGGGACG TGTCTTCCAA CCCTGAGCAG 
TTGTTCTTTA ACATCACGGC ATTTGGAAAA GATTTTCATC TGCGACTAAA GCCCAACACT 
CAACTAGTAG CTCCTGGGGC TGTTGTGGAG TGGCATGAGA CATCTCTGGT GCCTGGGAAT 
ATAACCGATC CCATTAACAA CCATCAACCA GGAAGTGCTA CGTATAGAAT CCGGAGAACA 
GAGCCTTTGC AGACTAACTG TGCTTATGTT GGTGACATCG TGGACATTCC AGGAACCTCT 
GTTGCCATCA GCAACTGTGA TGGTCTGGCT GGAATGATAA AAAGTGATAA TGAAGAGTAT 
TTCATTGAAC CCTTGGAAAG AGGTAAACAG ATGGAGGAAG AAAAAGGAAG GATTCATGTT 
GTCTACAAGA GATCAGCTGT AGAACAGGCT CCCATAGACA TGTCCAAAGA CTTCCACTAC 
AGAGAGTCGG ACCTGGAAGG CCTTGATGAT CTAGGTACTG TTTATGGCAA CATCCACCAG 
CAGCTGAATG AAACAATGAG ACGCCGCAGA CACGCGGGAG AAAACGATTA CAATATCGAG 
GTACTGCTGG GAGTGGATGA CTCTGTGGTC CGTTTCCATG GCAAAGAGCA CGTCCAAAAC 
TACCTCCTGA CCCTAATGAA CATTGTGAAT GAAATTTACC ATGATGAGTC CCTCGGAGTG 
CATATAAATG TGGTCCTGGT GCGCATGATA ATGCTGGGAT ATGCAAAGTC CATCAGCCTC 
ATAGAAAGGG GAAACCCATC CAGAAGCTTG GAGAATGTGT GTCGCTGGGC GTCCCAACAG 
CAAAGATCTG ATCTCAACCA CTCTGAACAC CATGACCATG CAATTTTTTT AACCAGGCAA 
GACTTTGGAC CTGCTGGAAT GCAAGGATAT GCTCCAGTCA CCGGCATGTG TCATCCAGTG 
AGAAGTTGTA CCCTGAATCA TGAGGATGGT TTTTCATCTG CTTTTGTAGT AGCCCATGAA 
ACGGGCCATG TGTTGGGAAT GGAGCATGAT GGACAAGGCA ACAGGTGTGG TGATGAGACT 
GCTATGGGAA GTGTCATGGC TCCCTTGGTA CAAGCAGCAT TCCATCGTTA CCACTGGTCC 
CGATGCAGTG GTCAAGAACT GAAAAGATAT ATCCATTCCT ATGACTGTCT CCTTGATGAC 
CCTTTTGATC ATGATTGGCC TAAACTCCCA GAACTTCCTG GAATCAATTA TTCTATGGAT 
GAGCAATGTC GTTTTGATTT TGGTGTTGGC TATAAAATGT GCACCGCGTT CCGAACCTTT 
GACCCATGTA AACAGCTGTG GTGTAGCCAT CCTGATAATC CCTACTTTTG TAAGACTAAA 
AAGGGACCTC CACTTGATGG GACTGAATGT GCTGCTGGAA AATGGTGCTA TAAGGGTCAT 
TGCATGTGGA AGAATGCTAA TCAGCAAAAA CAAGATGGCA ATTGGGGGTC ATGGACTAAA 
TTTGGCTCCT GTTCTCGGAC ATGTGGAACT GGTGTTCGTT TCAGAACACG CCAGTGCAAT 
AATCCCATGC CCATCAATGG TGGTCAGGAT TGTCCTGGTG TTAATTTTGA GTACCAGCTT 
TGTAACACAG AAGAATGCCA AAAACACTTT GAGGACTTCA GAGCACAGCA GTGTCAGCAG 
CGAAACTCCC ACTTTGAATA CCAGAATACC AAACACCACT GGTTGCCATA TGAACATCCT 
GACCCCAAGA AAAGATGCCA CCTTTACTGT CAGTCCAAGG AGACTGGAGA TGTTGCTTAC 
ATGAAACAAC TGGTGCATGA TGGAACGCAC TGTTCTTACA AAGATCCATA TAGCATATGT 
GTGCGAGGAG AGTGTGTGAA AGTGGGCTGT GATAAAGAAA TTGGTTCTAA TAAGGTTGAG 
GATAAGTGTG GTGTCTGTGG AGGAGATAAT TCCCACTGCC GAACCGTGAA GGGGACATTT 
ACCAGAACTC CCAGGAAGCT TGGGTACCTT AAGATGTTTG ATATACCCCC TGGGGCTAGA 
CATGTGTTAA TCCAAGAAGA CGAGGCTTCT CCTCATATTC TTGCTATTAA GAACCAGGCT 
ACAGGCCATT ATATTTTAAA TGGCAAAGGG GAGGAAGCCA AGTCGCGGAC CTTCATAGAT 
CTTGGTGTGG AGTGGGATTA TAACATTGAA GATGACATTG AAAGTCTTCA CACCGATGGA 
CCTTTACATG ATCCTGTTAT TGTTTTGATT ATACCTCAAG AAAATGATAC CCGCTCTAGC 
CTGACATATA AGTACATCAT CCATGAAGAC TCTGTACCTA CAATCAACAG CAACAATGTC 
ATCCAGGAAG AATTAGATAC TTTTGAGTGG GCTTTGAAGA GCTGGTCTCA GTGTTCCAAA 
CCCTGTGGTG GAGGTTTCCA GTACACTAAA TATGGATGCC GTAGGAAAAG TGATAATAAA 
ATGGTCCATC GCAGCTTCTG TGAGGCCAAC AAAAAGCCGA AACCTATTAG ACGAATGTGC 
AATATTCAAG AGTGTACACA TCCACTCTGG GTAGCAGAAG AATGGGAACA CTGCACCAAA 
ACCTGTGGAA GTTCTGGCTA TCAGCTTCGC ACTGTACGCT GCCTTCAGCC ACTCCTTGAT 
GGCACCAACC GCTCTGTGCA CAGCAAATAC TGCATGGGTG ACCGTCCCGA GAGCCGCCGG 
CCCTGTAACA GAGTGCCCTG CCCTGCACAG TGGAAAACAG GACCCTGGAG TGAGTGTTCA 
GTGACCTGCG GTGAAGGAAC GGAGGTGAGG CAGGTCCTCT GCAGGGCTGG GGACCACTGT 
GATGGTGAAA AGCCTGAGTC GGTCAGAGCC TGTCAACTGC CTCCTTGTAA TGATGAACCA 
TGTTTGGGAG ACAAGTCCAT ATTCTGTCAA ATGGAAGTGT TGGCACGATA CTGCTCCATA 
CCAGGTTATA ACAAGTTATG TTGTGAGTCC TGCAGCAAGC GCAGTAGCAC CCTGCCACCA 
CCATACCTTC TAGAAGCTGC TGAAACTCAT GATGATGTCA TCTCTAACCC TAGTGACCTC 
CCTAGATCTC TAGTGATGCC TACATCTTTG GTTCCTTATC ATTCAGAGAC CCCTGCAAAG 
AAGATGTCTT TGAGTAGCAT CTCTTCAGTG GGAGGTCCAA ATGCATATGC TGCTTTCAGG 
CCAAACAGTA AACCTGATGG TGCTAATTTA CGCCAGAGGA GTGCTCAGCA AGCAGGAAGT 
AAGACTGTGA GACTGGTCAC CGTACCATCC TCCCCACCCA CCAAGAGGGT CCACCTCAGT 
TCAGCTTCAC AAATGGCTGC TGCTTCCTTC TTTGCAGCCA GTGATTCAAT AGGTGCTTCT 
TCTCAGGCAA GAACCTCAAA GAAAGATGGA AAGATCATTG ACAACAGACG TCCGACAAGA 
TCATCCACCT TAGAAAGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530723.1
CDS	127..3687
Translation	MGLWAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER

Target ORF information:

RefSeq Version	XM_011532421.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532421.2

ORF Insert Sequence:

ATGGGACTTT GGGCTGGTAA TGAAGAAATG GTGCAAATAG ATTTACCAAT AAAGAGATAT 
AGAGAGTATG AGCTGGTGAC TCCAGTCAGC ACAAATCTAG AAGGACGCTA TCTCTCCCAT 
ACTCTTTCTG CGAGTCACAA AAAGAGGTCA GCGAGGGACG TGTCTTCCAA CCCTGAGCAG 
TTGTTCTTTA ACATCACGGC ATTTGGAAAA GATTTTCATC TGCGACTAAA GCCCAACACT 
CAACTAGTAG CTCCTGGGGC TGTTGTGGAG TGGCATGAGA CATCTCTGGT GCCTGGGAAT 
ATAACCGATC CCATTAACAA CCATCAACCA GGAAGTGCTA CGTATAGAAT CCGGAGAACA 
GAGCCTTTGC AGACTAACTG TGCTTATGTT GGTGACATCG TGGACATTCC AGGAACCTCT 
GTTGCCATCA GCAACTGTGA TGGTCTGGCT GGAATGATAA AAAGTGATAA TGAAGAGTAT 
TTCATTGAAC CCTTGGAAAG AGGTAAACAG ATGGAGGAAG AAAAAGGAAG GATTCATGTT 
GTCTACAAGA GATCAGCTGT AGAACAGGCT CCCATAGACA TGTCCAAAGA CTTCCACTAC 
AGAGAGTCGG ACCTGGAAGG CCTTGATGAT CTAGGTACTG TTTATGGCAA CATCCACCAG 
CAGCTGAATG AAACAATGAG ACGCCGCAGA CACGCGGGAG AAAACGATTA CAATATCGAG 
GTACTGCTGG GAGTGGATGA CTCTGTGGTC CGTTTCCATG GCAAAGAGCA CGTCCAAAAC 
TACCTCCTGA CCCTAATGAA CATTGTGAAT GAAATTTACC ATGATGAGTC CCTCGGAGTG 
CATATAAATG TGGTCCTGGT GCGCATGATA ATGCTGGGAT ATGCAAAGTC CATCAGCCTC 
ATAGAAAGGG GAAACCCATC CAGAAGCTTG GAGAATGTGT GTCGCTGGGC GTCCCAACAG 
CAAAGATCTG ATCTCAACCA CTCTGAACAC CATGACCATG CAATTTTTTT AACCAGGCAA 
GACTTTGGAC CTGCTGGAAT GCAAGGATAT GCTCCAGTCA CCGGCATGTG TCATCCAGTG 
AGAAGTTGTA CCCTGAATCA TGAGGATGGT TTTTCATCTG CTTTTGTAGT AGCCCATGAA 
ACGGGCCATG TGTTGGGAAT GGAGCATGAT GGACAAGGCA ACAGGTGTGG TGATGAGACT 
GCTATGGGAA GTGTCATGGC TCCCTTGGTA CAAGCAGCAT TCCATCGTTA CCACTGGTCC 
CGATGCAGTG GTCAAGAACT GAAAAGATAT ATCCATTCCT ATGACTGTCT CCTTGATGAC 
CCTTTTGATC ATGATTGGCC TAAACTCCCA GAACTTCCTG GAATCAATTA TTCTATGGAT 
GAGCAATGTC GTTTTGATTT TGGTGTTGGC TATAAAATGT GCACCGCGTT CCGAACCTTT 
GACCCATGTA AACAGCTGTG GTGTAGCCAT CCTGATAATC CCTACTTTTG TAAGACTAAA 
AAGGGACCTC CACTTGATGG GACTGAATGT GCTGCTGGAA AATGGTGCTA TAAGGGTCAT 
TGCATGTGGA AGAATGCTAA TCAGCAAAAA CAAGATGGCA ATTGGGGGTC ATGGACTAAA 
TTTGGCTCCT GTTCTCGGAC ATGTGGAACT GGTGTTCGTT TCAGAACACG CCAGTGCAAT 
AATCCCATGC CCATCAATGG TGGTCAGGAT TGTCCTGGTG TTAATTTTGA GTACCAGCTT 
TGTAACACAG AAGAATGCCA AAAACACTTT GAGGACTTCA GAGCACAGCA GTGTCAGCAG 
CGAAACTCCC ACTTTGAATA CCAGAATACC AAACACCACT GGTTGCCATA TGAACATCCT 
GACCCCAAGA AAAGATGCCA CCTTTACTGT CAGTCCAAGG AGACTGGAGA TGTTGCTTAC 
ATGAAACAAC TGGTGCATGA TGGAACGCAC TGTTCTTACA AAGATCCATA TAGCATATGT 
GTGCGAGGAG AGTGTGTGAA AGTGGGCTGT GATAAAGAAA TTGGTTCTAA TAAGGTTGAG 
GATAAGTGTG GTGTCTGTGG AGGAGATAAT TCCCACTGCC GAACCGTGAA GGGGACATTT 
ACCAGAACTC CCAGGAAGCT TGGGTACCTT AAGATGTTTG ATATACCCCC TGGGGCTAGA 
CATGTGTTAA TCCAAGAAGA CGAGGCTTCT CCTCATATTC TTGCTATTAA GAACCAGGCT 
ACAGGCCATT ATATTTTAAA TGGCAAAGGG GAGGAAGCCA AGTCGCGGAC CTTCATAGAT 
CTTGGTGTGG AGTGGGATTA TAACATTGAA GATGACATTG AAAGTCTTCA CACCGATGGA 
CCTTTACATG ATCCTGTTAT TGTTTTGATT ATACCTCAAG AAAATGATAC CCGCTCTAGC 
CTGACATATA AGTACATCAT CCATGAAGAC TCTGTACCTA CAATCAACAG CAACAATGTC 
ATCCAGGAAG AATTAGATAC TTTTGAGTGG GCTTTGAAGA GCTGGTCTCA GTGTTCCAAA 
CCCTGTGGTG GAGGTTTCCA GTACACTAAA TATGGATGCC GTAGGAAAAG TGATAATAAA 
ATGGTCCATC GCAGCTTCTG TGAGGCCAAC AAAAAGCCGA AACCTATTAG ACGAATGTGC 
AATATTCAAG AGTGTACACA TCCACTCTGG GTAGCAGAAG AATGGGAACA CTGCACCAAA 
ACCTGTGGAA GTTCTGGCTA TCAGCTTCGC ACTGTACGCT GCCTTCAGCC ACTCCTTGAT 
GGCACCAACC GCTCTGTGCA CAGCAAATAC TGCATGGGTG ACCGTCCCGA GAGCCGCCGG 
CCCTGTAACA GAGTGCCCTG CCCTGCACAG TGGAAAACAG GACCCTGGAG TGAGTGTTCA 
GTGACCTGCG GTGAAGGAAC GGAGGTGAGG CAGGTCCTCT GCAGGGCTGG GGACCACTGT 
GATGGTGAAA AGCCTGAGTC GGTCAGAGCC TGTCAACTGC CTCCTTGTAA TGATGAACCA 
TGTTTGGGAG ACAAGTCCAT ATTCTGTCAA ATGGAAGTGT TGGCACGATA CTGCTCCATA 
CCAGGTTATA ACAAGTTATG TTGTGAGTCC TGCAGCAAGC GCAGTAGCAC CCTGCCACCA 
CCATACCTTC TAGAAGCTGC TGAAACTCAT GATGATGTCA TCTCTAACCC TAGTGACCTC 
CCTAGATCTC TAGTGATGCC TACATCTTTG GTTCCTTATC ATTCAGAGAC CCCTGCAAAG 
AAGATGTCTT TGAGTAGCAT CTCTTCAGTG GGAGGTCCAA ATGCATATGC TGCTTTCAGG 
CCAAACAGTA AACCTGATGG TGCTAATTTA CGCCAGAGGA GTGCTCAGCA AGCAGGAAGT 
AAGACTGTGA GACTGGTCAC CGTACCATCC TCCCCACCCA CCAAGAGGGT CCACCTCAGT 
TCAGCTTCAC AAATGGCTGC TGCTTCCTTC TTTGCAGCCA GTGATTCAAT AGGTGCTTCT 
TCTCAGGCAA GAACCTCAAA GAAAGATGGA AAGATCATTG ACAACAGACG TCCGACAAGA 
TCATCCACCT TAGAAAGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS3 ( XM_011532422.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530724.1 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu62899
Clone ID Related Accession (Same CDS sequence)	XM_011532422.2 , XM_011532422.3
Accession Version	XM_011532422.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1465056000000
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532422.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCAAA TAGATTTACC AATAAAGAGA TATAGAGAGT ATGAGCTGGT GACTCCAGTC 
AGCACAAATC TAGAAGGACG CTATCTCTCC CATACTCTTT CTGCGAGTCA CAAAAAGAGG 
TCAGCGAGGG ACGTGTCTTC CAACCCTGAG CAGTTGTTCT TTAACATCAC GGCATTTGGA 
AAAGATTTTC ATCTGCGACT AAAGCCCAAC ACTCAACTAG TAGCTCCTGG GGCTGTTGTG 
GAGTGGCATG AGACATCTCT GGTGCCTGGG AATATAACCG ATCCCATTAA CAACCATCAA 
CCAGGAAGTG CTACGTATAG AATCCGGAGA ACAGAGCCTT TGCAGACTAA CTGTGCTTAT 
GTTGGTGACA TCGTGGACAT TCCAGGAACC TCTGTTGCCA TCAGCAACTG TGATGGTCTG 
GCTGGAATGA TAAAAAGTGA TAATGAAGAG TATTTCATTG AACCCTTGGA AAGAGGTAAA 
CAGATGGAGG AAGAAAAAGG AAGGATTCAT GTTGTCTACA AGAGATCAGC TGTAGAACAG 
GCTCCCATAG ACATGTCCAA AGACTTCCAC TACAGAGAGT CGGACCTGGA AGGCCTTGAT 
GATCTAGGTA CTGTTTATGG CAACATCCAC CAGCAGCTGA ATGAAACAAT GAGACGCCGC 
AGACACGCGG GAGAAAACGA TTACAATATC GAGGTACTGC TGGGAGTGGA TGACTCTGTG 
GTCCGTTTCC ATGGCAAAGA GCACGTCCAA AACTACCTCC TGACCCTAAT GAACATTGTG 
AATGAAATTT ACCATGATGA GTCCCTCGGA GTGCATATAA ATGTGGTCCT GGTGCGCATG 
ATAATGCTGG GATATGCAAA GTCCATCAGC CTCATAGAAA GGGGAAACCC ATCCAGAAGC 
TTGGAGAATG TGTGTCGCTG GGCGTCCCAA CAGCAAAGAT CTGATCTCAA CCACTCTGAA 
CACCATGACC ATGCAATTTT TTTAACCAGG CAAGACTTTG GACCTGCTGG AATGCAAGGA 
TATGCTCCAG TCACCGGCAT GTGTCATCCA GTGAGAAGTT GTACCCTGAA TCATGAGGAT 
GGTTTTTCAT CTGCTTTTGT AGTAGCCCAT GAAACGGGCC ATGTGTTGGG AATGGAGCAT 
GATGGACAAG GCAACAGGTG TGGTGATGAG ACTGCTATGG GAAGTGTCAT GGCTCCCTTG 
GTACAAGCAG CATTCCATCG TTACCACTGG TCCCGATGCA GTGGTCAAGA ACTGAAAAGA 
TATATCCATT CCTATGACTG TCTCCTTGAT GACCCTTTTG ATCATGATTG GCCTAAACTC 
CCAGAACTTC CTGGAATCAA TTATTCTATG GATGAGCAAT GTCGTTTTGA TTTTGGTGTT 
GGCTATAAAA TGTGCACCGC GTTCCGAACC TTTGACCCAT GTAAACAGCT GTGGTGTAGC 
CATCCTGATA ATCCCTACTT TTGTAAGACT AAAAAGGGAC CTCCACTTGA TGGGACTGAA 
TGTGCTGCTG GAAAATGGTG CTATAAGGGT CATTGCATGT GGAAGAATGC TAATCAGCAA 
AAACAAGATG GCAATTGGGG GTCATGGACT AAATTTGGCT CCTGTTCTCG GACATGTGGA 
ACTGGTGTTC GTTTCAGAAC ACGCCAGTGC AATAATCCCA TGCCCATCAA TGGTGGTCAG 
GATTGTCCTG GTGTTAATTT TGAGTACCAG CTTTGTAACA CAGAAGAATG CCAAAAACAC 
TTTGAGGACT TCAGAGCACA GCAGTGTCAG CAGCGAAACT CCCACTTTGA ATACCAGAAT 
ACCAAACACC ACTGGTTGCC ATATGAACAT CCTGACCCCA AGAAAAGATG CCACCTTTAC 
TGTCAGTCCA AGGAGACTGG AGATGTTGCT TACATGAAAC AACTGGTGCA TGATGGAACG 
CACTGTTCTT ACAAAGATCC ATATAGCATA TGTGTGCGAG GAGAGTGTGT GAAAGTGGGC 
TGTGATAAAG AAATTGGTTC TAATAAGGTT GAGGATAAGT GTGGTGTCTG TGGAGGAGAT 
AATTCCCACT GCCGAACCGT GAAGGGGACA TTTACCAGAA CTCCCAGGAA GCTTGGGTAC 
CTTAAGATGT TTGATATACC CCCTGGGGCT AGACATGTGT TAATCCAAGA AGACGAGGCT 
TCTCCTCATA TTCTTGCTAT TAAGAACCAG GCTACAGGCC ATTATATTTT AAATGGCAAA 
GGGGAGGAAG CCAAGTCGCG GACCTTCATA GATCTTGGTG TGGAGTGGGA TTATAACATT 
GAAGATGACA TTGAAAGTCT TCACACCGAT GGACCTTTAC ATGATCCTGT TATTGTTTTG 
ATTATACCTC AAGAAAATGA TACCCGCTCT AGCCTGACAT ATAAGTACAT CATCCATGAA 
GACTCTGTAC CTACAATCAA CAGCAACAAT GTCATCCAGG AAGAATTAGA TACTTTTGAG 
TGGGCTTTGA AGAGCTGGTC TCAGTGTTCC AAACCCTGTG GTGGAGGTTT CCAGTACACT 
AAATATGGAT GCCGTAGGAA AAGTGATAAT AAAATGGTCC ATCGCAGCTT CTGTGAGGCC 
AACAAAAAGC CGAAACCTAT TAGACGAATG TGCAATATTC AAGAGTGTAC ACATCCACTC 
TGGGTAGCAG AAGAATGGGA ACACTGCACC AAAACCTGTG GAAGTTCTGG CTATCAGCTT 
CGCACTGTAC GCTGCCTTCA GCCACTCCTT GATGGCACCA ACCGCTCTGT GCACAGCAAA 
TACTGCATGG GTGACCGTCC CGAGAGCCGC CGGCCCTGTA ACAGAGTGCC CTGCCCTGCA 
CAGTGGAAAA CAGGACCCTG GAGTGAGTGT TCAGTGACCT GCGGTGAAGG AACGGAGGTG 
AGGCAGGTCC TCTGCAGGGC TGGGGACCAC TGTGATGGTG AAAAGCCTGA GTCGGTCAGA 
GCCTGTCAAC TGCCTCCTTG TAATGATGAA CCATGTTTGG GAGACAAGTC CATATTCTGT 
CAAATGGAAG TGTTGGCACG ATACTGCTCC ATACCAGGTT ATAACAAGTT ATGTTGTGAG 
TCCTGCAGCA AGCGCAGTAG CACCCTGCCA CCACCATACC TTCTAGAAGC TGCTGAAACT 
CATGATGATG TCATCTCTAA CCCTAGTGAC CTCCCTAGAT CTCTAGTGAT GCCTACATCT 
TTGGTTCCTT ATCATTCAGA GACCCCTGCA AAGAAGATGT CTTTGAGTAG CATCTCTTCA 
GTGGGAGGTC CAAATGCATA TGCTGCTTTC AGGCCAAACA GTAAACCTGA TGGTGCTAAT 
TTACGCCAGA GGAGTGCTCA GCAAGCAGGA AGTAAGACTG TGAGACTGGT CACCGTACCA 
TCCTCCCCAC CCACCAAGAG GGTCCACCTC AGTTCAGCTT CACAAATGGC TGCTGCTTCC 
TTCTTTGCAG CCAGTGATTC AATAGGTGCT TCTTCTCAGG CAAGAACCTC AAAGAAAGAT 
GGAAAGATCA TTGACAACAG ACGTCCGACA AGATCATCCA CCTTAGAAAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530724.1
CDS	653..4186
Translation	MVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER

Target ORF information:

RefSeq Version	XM_011532422.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532422.2

ORF Insert Sequence:

ATGGTGCAAA TAGATTTACC AATAAAGAGA TATAGAGAGT ATGAGCTGGT GACTCCAGTC 
AGCACAAATC TAGAAGGACG CTATCTCTCC CATACTCTTT CTGCGAGTCA CAAAAAGAGG 
TCAGCGAGGG ACGTGTCTTC CAACCCTGAG CAGTTGTTCT TTAACATCAC GGCATTTGGA 
AAAGATTTTC ATCTGCGACT AAAGCCCAAC ACTCAACTAG TAGCTCCTGG GGCTGTTGTG 
GAGTGGCATG AGACATCTCT GGTGCCTGGG AATATAACCG ATCCCATTAA CAACCATCAA 
CCAGGAAGTG CTACGTATAG AATCCGGAGA ACAGAGCCTT TGCAGACTAA CTGTGCTTAT 
GTTGGTGACA TCGTGGACAT TCCAGGAACC TCTGTTGCCA TCAGCAACTG TGATGGTCTG 
GCTGGAATGA TAAAAAGTGA TAATGAAGAG TATTTCATTG AACCCTTGGA AAGAGGTAAA 
CAGATGGAGG AAGAAAAAGG AAGGATTCAT GTTGTCTACA AGAGATCAGC TGTAGAACAG 
GCTCCCATAG ACATGTCCAA AGACTTCCAC TACAGAGAGT CGGACCTGGA AGGCCTTGAT 
GATCTAGGTA CTGTTTATGG CAACATCCAC CAGCAGCTGA ATGAAACAAT GAGACGCCGC 
AGACACGCGG GAGAAAACGA TTACAATATC GAGGTACTGC TGGGAGTGGA TGACTCTGTG 
GTCCGTTTCC ATGGCAAAGA GCACGTCCAA AACTACCTCC TGACCCTAAT GAACATTGTG 
AATGAAATTT ACCATGATGA GTCCCTCGGA GTGCATATAA ATGTGGTCCT GGTGCGCATG 
ATAATGCTGG GATATGCAAA GTCCATCAGC CTCATAGAAA GGGGAAACCC ATCCAGAAGC 
TTGGAGAATG TGTGTCGCTG GGCGTCCCAA CAGCAAAGAT CTGATCTCAA CCACTCTGAA 
CACCATGACC ATGCAATTTT TTTAACCAGG CAAGACTTTG GACCTGCTGG AATGCAAGGA 
TATGCTCCAG TCACCGGCAT GTGTCATCCA GTGAGAAGTT GTACCCTGAA TCATGAGGAT 
GGTTTTTCAT CTGCTTTTGT AGTAGCCCAT GAAACGGGCC ATGTGTTGGG AATGGAGCAT 
GATGGACAAG GCAACAGGTG TGGTGATGAG ACTGCTATGG GAAGTGTCAT GGCTCCCTTG 
GTACAAGCAG CATTCCATCG TTACCACTGG TCCCGATGCA GTGGTCAAGA ACTGAAAAGA 
TATATCCATT CCTATGACTG TCTCCTTGAT GACCCTTTTG ATCATGATTG GCCTAAACTC 
CCAGAACTTC CTGGAATCAA TTATTCTATG GATGAGCAAT GTCGTTTTGA TTTTGGTGTT 
GGCTATAAAA TGTGCACCGC GTTCCGAACC TTTGACCCAT GTAAACAGCT GTGGTGTAGC 
CATCCTGATA ATCCCTACTT TTGTAAGACT AAAAAGGGAC CTCCACTTGA TGGGACTGAA 
TGTGCTGCTG GAAAATGGTG CTATAAGGGT CATTGCATGT GGAAGAATGC TAATCAGCAA 
AAACAAGATG GCAATTGGGG GTCATGGACT AAATTTGGCT CCTGTTCTCG GACATGTGGA 
ACTGGTGTTC GTTTCAGAAC ACGCCAGTGC AATAATCCCA TGCCCATCAA TGGTGGTCAG 
GATTGTCCTG GTGTTAATTT TGAGTACCAG CTTTGTAACA CAGAAGAATG CCAAAAACAC 
TTTGAGGACT TCAGAGCACA GCAGTGTCAG CAGCGAAACT CCCACTTTGA ATACCAGAAT 
ACCAAACACC ACTGGTTGCC ATATGAACAT CCTGACCCCA AGAAAAGATG CCACCTTTAC 
TGTCAGTCCA AGGAGACTGG AGATGTTGCT TACATGAAAC AACTGGTGCA TGATGGAACG 
CACTGTTCTT ACAAAGATCC ATATAGCATA TGTGTGCGAG GAGAGTGTGT GAAAGTGGGC 
TGTGATAAAG AAATTGGTTC TAATAAGGTT GAGGATAAGT GTGGTGTCTG TGGAGGAGAT 
AATTCCCACT GCCGAACCGT GAAGGGGACA TTTACCAGAA CTCCCAGGAA GCTTGGGTAC 
CTTAAGATGT TTGATATACC CCCTGGGGCT AGACATGTGT TAATCCAAGA AGACGAGGCT 
TCTCCTCATA TTCTTGCTAT TAAGAACCAG GCTACAGGCC ATTATATTTT AAATGGCAAA 
GGGGAGGAAG CCAAGTCGCG GACCTTCATA GATCTTGGTG TGGAGTGGGA TTATAACATT 
GAAGATGACA TTGAAAGTCT TCACACCGAT GGACCTTTAC ATGATCCTGT TATTGTTTTG 
ATTATACCTC AAGAAAATGA TACCCGCTCT AGCCTGACAT ATAAGTACAT CATCCATGAA 
GACTCTGTAC CTACAATCAA CAGCAACAAT GTCATCCAGG AAGAATTAGA TACTTTTGAG 
TGGGCTTTGA AGAGCTGGTC TCAGTGTTCC AAACCCTGTG GTGGAGGTTT CCAGTACACT 
AAATATGGAT GCCGTAGGAA AAGTGATAAT AAAATGGTCC ATCGCAGCTT CTGTGAGGCC 
AACAAAAAGC CGAAACCTAT TAGACGAATG TGCAATATTC AAGAGTGTAC ACATCCACTC 
TGGGTAGCAG AAGAATGGGA ACACTGCACC AAAACCTGTG GAAGTTCTGG CTATCAGCTT 
CGCACTGTAC GCTGCCTTCA GCCACTCCTT GATGGCACCA ACCGCTCTGT GCACAGCAAA 
TACTGCATGG GTGACCGTCC CGAGAGCCGC CGGCCCTGTA ACAGAGTGCC CTGCCCTGCA 
CAGTGGAAAA CAGGACCCTG GAGTGAGTGT TCAGTGACCT GCGGTGAAGG AACGGAGGTG 
AGGCAGGTCC TCTGCAGGGC TGGGGACCAC TGTGATGGTG AAAAGCCTGA GTCGGTCAGA 
GCCTGTCAAC TGCCTCCTTG TAATGATGAA CCATGTTTGG GAGACAAGTC CATATTCTGT 
CAAATGGAAG TGTTGGCACG ATACTGCTCC ATACCAGGTT ATAACAAGTT ATGTTGTGAG 
TCCTGCAGCA AGCGCAGTAG CACCCTGCCA CCACCATACC TTCTAGAAGC TGCTGAAACT 
CATGATGATG TCATCTCTAA CCCTAGTGAC CTCCCTAGAT CTCTAGTGAT GCCTACATCT 
TTGGTTCCTT ATCATTCAGA GACCCCTGCA AAGAAGATGT CTTTGAGTAG CATCTCTTCA 
GTGGGAGGTC CAAATGCATA TGCTGCTTTC AGGCCAAACA GTAAACCTGA TGGTGCTAAT 
TTACGCCAGA GGAGTGCTCA GCAAGCAGGA AGTAAGACTG TGAGACTGGT CACCGTACCA 
TCCTCCCCAC CCACCAAGAG GGTCCACCTC AGTTCAGCTT CACAAATGGC TGCTGCTTCC 
TTCTTTGCAG CCAGTGATTC AATAGGTGCT TCTTCTCAGG CAAGAACCTC AAAGAAAGAT 
GGAAAGATCA TTGACAACAG ACGTCCGACA AGATCATCCA CCTTAGAAAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS3 ( XM_011532422.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011530724.1 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X2, mRNA.

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CloneID	OHu62899
Clone ID Related Accession (Same CDS sequence)	XM_011532422.2 , XM_011532422.3
Accession Version	XM_011532422.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3534bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011532422.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGCAAA TAGATTTACC AATAAAGAGA TATAGAGAGT ATGAGCTGGT GACTCCAGTC 
AGCACAAATC TAGAAGGACG CTATCTCTCC CATACTCTTT CTGCGAGTCA CAAAAAGAGG 
TCAGCGAGGG ACGTGTCTTC CAACCCTGAG CAGTTGTTCT TTAACATCAC GGCATTTGGA 
AAAGATTTTC ATCTGCGACT AAAGCCCAAC ACTCAACTAG TAGCTCCTGG GGCTGTTGTG 
GAGTGGCATG AGACATCTCT GGTGCCTGGG AATATAACCG ATCCCATTAA CAACCATCAA 
CCAGGAAGTG CTACGTATAG AATCCGGAGA ACAGAGCCTT TGCAGACTAA CTGTGCTTAT 
GTTGGTGACA TCGTGGACAT TCCAGGAACC TCTGTTGCCA TCAGCAACTG TGATGGTCTG 
GCTGGAATGA TAAAAAGTGA TAATGAAGAG TATTTCATTG AACCCTTGGA AAGAGGTAAA 
CAGATGGAGG AAGAAAAAGG AAGGATTCAT GTTGTCTACA AGAGATCAGC TGTAGAACAG 
GCTCCCATAG ACATGTCCAA AGACTTCCAC TACAGAGAGT CGGACCTGGA AGGCCTTGAT 
GATCTAGGTA CTGTTTATGG CAACATCCAC CAGCAGCTGA ATGAAACAAT GAGACGCCGC 
AGACACGCGG GAGAAAACGA TTACAATATC GAGGTACTGC TGGGAGTGGA TGACTCTGTG 
GTCCGTTTCC ATGGCAAAGA GCACGTCCAA AACTACCTCC TGACCCTAAT GAACATTGTG 
AATGAAATTT ACCATGATGA GTCCCTCGGA GTGCATATAA ATGTGGTCCT GGTGCGCATG 
ATAATGCTGG GATATGCAAA GTCCATCAGC CTCATAGAAA GGGGAAACCC ATCCAGAAGC 
TTGGAGAATG TGTGTCGCTG GGCGTCCCAA CAGCAAAGAT CTGATCTCAA CCACTCTGAA 
CACCATGACC ATGCAATTTT TTTAACCAGG CAAGACTTTG GACCTGCTGG AATGCAAGGA 
TATGCTCCAG TCACCGGCAT GTGTCATCCA GTGAGAAGTT GTACCCTGAA TCATGAGGAT 
GGTTTTTCAT CTGCTTTTGT AGTAGCCCAT GAAACGGGCC ATGTGTTGGG AATGGAGCAT 
GATGGACAAG GCAACAGGTG TGGTGATGAG ACTGCTATGG GAAGTGTCAT GGCTCCCTTG 
GTACAAGCAG CATTCCATCG TTACCACTGG TCCCGATGCA GTGGTCAAGA ACTGAAAAGA 
TATATCCATT CCTATGACTG TCTCCTTGAT GACCCTTTTG ATCATGATTG GCCTAAACTC 
CCAGAACTTC CTGGAATCAA TTATTCTATG GATGAGCAAT GTCGTTTTGA TTTTGGTGTT 
GGCTATAAAA TGTGCACCGC GTTCCGAACC TTTGACCCAT GTAAACAGCT GTGGTGTAGC 
CATCCTGATA ATCCCTACTT TTGTAAGACT AAAAAGGGAC CTCCACTTGA TGGGACTGAA 
TGTGCTGCTG GAAAATGGTG CTATAAGGGT CATTGCATGT GGAAGAATGC TAATCAGCAA 
AAACAAGATG GCAATTGGGG GTCATGGACT AAATTTGGCT CCTGTTCTCG GACATGTGGA 
ACTGGTGTTC GTTTCAGAAC ACGCCAGTGC AATAATCCCA TGCCCATCAA TGGTGGTCAG 
GATTGTCCTG GTGTTAATTT TGAGTACCAG CTTTGTAACA CAGAAGAATG CCAAAAACAC 
TTTGAGGACT TCAGAGCACA GCAGTGTCAG CAGCGAAACT CCCACTTTGA ATACCAGAAT 
ACCAAACACC ACTGGTTGCC ATATGAACAT CCTGACCCCA AGAAAAGATG CCACCTTTAC 
TGTCAGTCCA AGGAGACTGG AGATGTTGCT TACATGAAAC AACTGGTGCA TGATGGAACG 
CACTGTTCTT ACAAAGATCC ATATAGCATA TGTGTGCGAG GAGAGTGTGT GAAAGTGGGC 
TGTGATAAAG AAATTGGTTC TAATAAGGTT GAGGATAAGT GTGGTGTCTG TGGAGGAGAT 
AATTCCCACT GCCGAACCGT GAAGGGGACA TTTACCAGAA CTCCCAGGAA GCTTGGGTAC 
CTTAAGATGT TTGATATACC CCCTGGGGCT AGACATGTGT TAATCCAAGA AGACGAGGCT 
TCTCCTCATA TTCTTGCTAT TAAGAACCAG GCTACAGGCC ATTATATTTT AAATGGCAAA 
GGGGAGGAAG CCAAGTCGCG GACCTTCATA GATCTTGGTG TGGAGTGGGA TTATAACATT 
GAAGATGACA TTGAAAGTCT TCACACCGAT GGACCTTTAC ATGATCCTGT TATTGTTTTG 
ATTATACCTC AAGAAAATGA TACCCGCTCT AGCCTGACAT ATAAGTACAT CATCCATGAA 
GACTCTGTAC CTACAATCAA CAGCAACAAT GTCATCCAGG AAGAATTAGA TACTTTTGAG 
TGGGCTTTGA AGAGCTGGTC TCAGTGTTCC AAACCCTGTG GTGGAGGTTT CCAGTACACT 
AAATATGGAT GCCGTAGGAA AAGTGATAAT AAAATGGTCC ATCGCAGCTT CTGTGAGGCC 
AACAAAAAGC CGAAACCTAT TAGACGAATG TGCAATATTC AAGAGTGTAC ACATCCACTC 
TGGGTAGCAG AAGAATGGGA ACACTGCACC AAAACCTGTG GAAGTTCTGG CTATCAGCTT 
CGCACTGTAC GCTGCCTTCA GCCACTCCTT GATGGCACCA ACCGCTCTGT GCACAGCAAA 
TACTGCATGG GTGACCGTCC CGAGAGCCGC CGGCCCTGTA ACAGAGTGCC CTGCCCTGCA 
CAGTGGAAAA CAGGACCCTG GAGTGAGTGT TCAGTGACCT GCGGTGAAGG AACGGAGGTG 
AGGCAGGTCC TCTGCAGGGC TGGGGACCAC TGTGATGGTG AAAAGCCTGA GTCGGTCAGA 
GCCTGTCAAC TGCCTCCTTG TAATGATGAA CCATGTTTGG GAGACAAGTC CATATTCTGT 
CAAATGGAAG TGTTGGCACG ATACTGCTCC ATACCAGGTT ATAACAAGTT ATGTTGTGAG 
TCCTGCAGCA AGCGCAGTAG CACCCTGCCA CCACCATACC TTCTAGAAGC TGCTGAAACT 
CATGATGATG TCATCTCTAA CCCTAGTGAC CTCCCTAGAT CTCTAGTGAT GCCTACATCT 
TTGGTTCCTT ATCATTCAGA GACCCCTGCA AAGAAGATGT CTTTGAGTAG CATCTCTTCA 
GTGGGAGGTC CAAATGCATA TGCTGCTTTC AGGCCAAACA GTAAACCTGA TGGTGCTAAT 
TTACGCCAGA GGAGTGCTCA GCAAGCAGGA AGTAAGACTG TGAGACTGGT CACCGTACCA 
TCCTCCCCAC CCACCAAGAG GGTCCACCTC AGTTCAGCTT CACAAATGGC TGCTGCTTCC 
TTCTTTGCAG CCAGTGATTC AATAGGTGCT TCTTCTCAGG CAAGAACCTC AAAGAAAGAT 
GGAAAGATCA TTGACAACAG ACGTCCGACA AGATCATCCA CCTTAGAAAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011530724.1
CDS	654..4187
Translation	MVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER

Target ORF information:

RefSeq Version	XM_011532422.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011532422.3

ORF Insert Sequence:

ATGGTGCAAA TAGATTTACC AATAAAGAGA TATAGAGAGT ATGAGCTGGT GACTCCAGTC 
AGCACAAATC TAGAAGGACG CTATCTCTCC CATACTCTTT CTGCGAGTCA CAAAAAGAGG 
TCAGCGAGGG ACGTGTCTTC CAACCCTGAG CAGTTGTTCT TTAACATCAC GGCATTTGGA 
AAAGATTTTC ATCTGCGACT AAAGCCCAAC ACTCAACTAG TAGCTCCTGG GGCTGTTGTG 
GAGTGGCATG AGACATCTCT GGTGCCTGGG AATATAACCG ATCCCATTAA CAACCATCAA 
CCAGGAAGTG CTACGTATAG AATCCGGAGA ACAGAGCCTT TGCAGACTAA CTGTGCTTAT 
GTTGGTGACA TCGTGGACAT TCCAGGAACC TCTGTTGCCA TCAGCAACTG TGATGGTCTG 
GCTGGAATGA TAAAAAGTGA TAATGAAGAG TATTTCATTG AACCCTTGGA AAGAGGTAAA 
CAGATGGAGG AAGAAAAAGG AAGGATTCAT GTTGTCTACA AGAGATCAGC TGTAGAACAG 
GCTCCCATAG ACATGTCCAA AGACTTCCAC TACAGAGAGT CGGACCTGGA AGGCCTTGAT 
GATCTAGGTA CTGTTTATGG CAACATCCAC CAGCAGCTGA ATGAAACAAT GAGACGCCGC 
AGACACGCGG GAGAAAACGA TTACAATATC GAGGTACTGC TGGGAGTGGA TGACTCTGTG 
GTCCGTTTCC ATGGCAAAGA GCACGTCCAA AACTACCTCC TGACCCTAAT GAACATTGTG 
AATGAAATTT ACCATGATGA GTCCCTCGGA GTGCATATAA ATGTGGTCCT GGTGCGCATG 
ATAATGCTGG GATATGCAAA GTCCATCAGC CTCATAGAAA GGGGAAACCC ATCCAGAAGC 
TTGGAGAATG TGTGTCGCTG GGCGTCCCAA CAGCAAAGAT CTGATCTCAA CCACTCTGAA 
CACCATGACC ATGCAATTTT TTTAACCAGG CAAGACTTTG GACCTGCTGG AATGCAAGGA 
TATGCTCCAG TCACCGGCAT GTGTCATCCA GTGAGAAGTT GTACCCTGAA TCATGAGGAT 
GGTTTTTCAT CTGCTTTTGT AGTAGCCCAT GAAACGGGCC ATGTGTTGGG AATGGAGCAT 
GATGGACAAG GCAACAGGTG TGGTGATGAG ACTGCTATGG GAAGTGTCAT GGCTCCCTTG 
GTACAAGCAG CATTCCATCG TTACCACTGG TCCCGATGCA GTGGTCAAGA ACTGAAAAGA 
TATATCCATT CCTATGACTG TCTCCTTGAT GACCCTTTTG ATCATGATTG GCCTAAACTC 
CCAGAACTTC CTGGAATCAA TTATTCTATG GATGAGCAAT GTCGTTTTGA TTTTGGTGTT 
GGCTATAAAA TGTGCACCGC GTTCCGAACC TTTGACCCAT GTAAACAGCT GTGGTGTAGC 
CATCCTGATA ATCCCTACTT TTGTAAGACT AAAAAGGGAC CTCCACTTGA TGGGACTGAA 
TGTGCTGCTG GAAAATGGTG CTATAAGGGT CATTGCATGT GGAAGAATGC TAATCAGCAA 
AAACAAGATG GCAATTGGGG GTCATGGACT AAATTTGGCT CCTGTTCTCG GACATGTGGA 
ACTGGTGTTC GTTTCAGAAC ACGCCAGTGC AATAATCCCA TGCCCATCAA TGGTGGTCAG 
GATTGTCCTG GTGTTAATTT TGAGTACCAG CTTTGTAACA CAGAAGAATG CCAAAAACAC 
TTTGAGGACT TCAGAGCACA GCAGTGTCAG CAGCGAAACT CCCACTTTGA ATACCAGAAT 
ACCAAACACC ACTGGTTGCC ATATGAACAT CCTGACCCCA AGAAAAGATG CCACCTTTAC 
TGTCAGTCCA AGGAGACTGG AGATGTTGCT TACATGAAAC AACTGGTGCA TGATGGAACG 
CACTGTTCTT ACAAAGATCC ATATAGCATA TGTGTGCGAG GAGAGTGTGT GAAAGTGGGC 
TGTGATAAAG AAATTGGTTC TAATAAGGTT GAGGATAAGT GTGGTGTCTG TGGAGGAGAT 
AATTCCCACT GCCGAACCGT GAAGGGGACA TTTACCAGAA CTCCCAGGAA GCTTGGGTAC 
CTTAAGATGT TTGATATACC CCCTGGGGCT AGACATGTGT TAATCCAAGA AGACGAGGCT 
TCTCCTCATA TTCTTGCTAT TAAGAACCAG GCTACAGGCC ATTATATTTT AAATGGCAAA 
GGGGAGGAAG CCAAGTCGCG GACCTTCATA GATCTTGGTG TGGAGTGGGA TTATAACATT 
GAAGATGACA TTGAAAGTCT TCACACCGAT GGACCTTTAC ATGATCCTGT TATTGTTTTG 
ATTATACCTC AAGAAAATGA TACCCGCTCT AGCCTGACAT ATAAGTACAT CATCCATGAA 
GACTCTGTAC CTACAATCAA CAGCAACAAT GTCATCCAGG AAGAATTAGA TACTTTTGAG 
TGGGCTTTGA AGAGCTGGTC TCAGTGTTCC AAACCCTGTG GTGGAGGTTT CCAGTACACT 
AAATATGGAT GCCGTAGGAA AAGTGATAAT AAAATGGTCC ATCGCAGCTT CTGTGAGGCC 
AACAAAAAGC CGAAACCTAT TAGACGAATG TGCAATATTC AAGAGTGTAC ACATCCACTC 
TGGGTAGCAG AAGAATGGGA ACACTGCACC AAAACCTGTG GAAGTTCTGG CTATCAGCTT 
CGCACTGTAC GCTGCCTTCA GCCACTCCTT GATGGCACCA ACCGCTCTGT GCACAGCAAA 
TACTGCATGG GTGACCGTCC CGAGAGCCGC CGGCCCTGTA ACAGAGTGCC CTGCCCTGCA 
CAGTGGAAAA CAGGACCCTG GAGTGAGTGT TCAGTGACCT GCGGTGAAGG AACGGAGGTG 
AGGCAGGTCC TCTGCAGGGC TGGGGACCAC TGTGATGGTG AAAAGCCTGA GTCGGTCAGA 
GCCTGTCAAC TGCCTCCTTG TAATGATGAA CCATGTTTGG GAGACAAGTC CATATTCTGT 
CAAATGGAAG TGTTGGCACG ATACTGCTCC ATACCAGGTT ATAACAAGTT ATGTTGTGAG 
TCCTGCAGCA AGCGCAGTAG CACCCTGCCA CCACCATACC TTCTAGAAGC TGCTGAAACT 
CATGATGATG TCATCTCTAA CCCTAGTGAC CTCCCTAGAT CTCTAGTGAT GCCTACATCT 
TTGGTTCCTT ATCATTCAGA GACCCCTGCA AAGAAGATGT CTTTGAGTAG CATCTCTTCA 
GTGGGAGGTC CAAATGCATA TGCTGCTTTC AGGCCAAACA GTAAACCTGA TGGTGCTAAT 
TTACGCCAGA GGAGTGCTCA GCAAGCAGGA AGTAAGACTG TGAGACTGGT CACCGTACCA 
TCCTCCCCAC CCACCAAGAG GGTCCACCTC AGTTCAGCTT CACAAATGGC TGCTGCTTCC 
TTCTTTGCAG CCAGTGATTC AATAGGTGCT TCTTCTCAGG CAAGAACCTC AAAGAAAGAT 
GGAAAGATCA TTGACAACAG ACGTCCGACA AGATCATCCA CCTTAGAAAG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS3 ( NM_014243.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_055058.2 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), mRNA.

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CloneID	OHu55645
Clone ID Related Accession (Same CDS sequence)	NM_014243.2 , NM_014243.3
Accession Version	NM_014243.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514390400000
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF247668.1, AK295131.1, BC130287.1, AB002364.1 and BC016451.1. This sequence is a reference standard in the RefSeqGene project. On May 18, 2011 this sequence version replaced NM_014243.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB002364.1, BC130287.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTTCTCC TGTCACTTTG GTTGATAGCA GCCGCTCTGG TAGAGGTTAG GACTTCAGCT 
GATGGACAAG CTGGTAATGA AGAAATGGTG CAAATAGATT TACCAATAAA GAGATATAGA 
GAGTATGAGC TGGTGACTCC AGTCAGCACA AATCTAGAAG GACGCTATCT CTCCCATACT 
CTTTCTGCGA GTCACAAAAA GAGGTCAGCG AGGGACGTGT CTTCCAACCC TGAGCAGTTG 
TTCTTTAACA TCACGGCATT TGGAAAAGAT TTTCATCTGC GACTAAAGCC CAACACTCAA 
CTAGTAGCTC CTGGGGCTGT TGTGGAGTGG CATGAGACAT CTCTGGTGCC TGGGAATATA 
ACCGATCCCA TTAACAACCA TCAACCAGGA AGTGCTACGT ATAGAATCCG GAGAACAGAG 
CCTTTGCAGA CTAACTGTGC TTATGTTGGT GACATCGTGG ACATTCCAGG AACCTCTGTT 
GCCATCAGCA ACTGTGATGG TCTGGCTGGA ATGATAAAAA GTGATAATGA AGAGTATTTC 
ATTGAACCCT TGGAAAGAGG TAAACAGATG GAGGAAGAAA AAGGAAGGAT TCATGTTGTC 
TACAAGAGAT CAGCTGTAGA ACAGGCTCCC ATAGACATGT CCAAAGACTT CCACTACAGA 
GAGTCGGACC TGGAAGGCCT TGATGATCTA GGTACTGTTT ATGGCAACAT CCACCAGCAG 
CTGAATGAAA CAATGAGACG CCGCAGACAC GCGGGAGAAA ACGATTACAA TATCGAGGTA 
CTGCTGGGAG TGGATGACTC TGTGGTCCGT TTCCATGGCA AAGAGCACGT CCAAAACTAC 
CTCCTGACCC TAATGAACAT TGTGAATGAA ATTTACCATG ATGAGTCCCT CGGAGTGCAT 
ATAAATGTGG TCCTGGTGCG CATGATAATG CTGGGATATG CAAAGTCCAT CAGCCTCATA 
GAAAGGGGAA ACCCATCCAG AAGCTTGGAG AATGTGTGTC GCTGGGCGTC CCAACAGCAA 
AGATCTGATC TCAACCACTC TGAACACCAT GACCATGCAA TTTTTTTAAC CAGGCAAGAC 
TTTGGACCTG CTGGAATGCA AGGATATGCT CCAGTCACCG GCATGTGTCA TCCAGTGAGA 
AGTTGTACCC TGAATCATGA GGATGGTTTT TCATCTGCTT TTGTAGTAGC CCATGAAACG 
GGCCATGTGT TGGGAATGGA GCATGATGGA CAAGGCAACA GGTGTGGTGA TGAGACTGCT 
ATGGGAAGTG TCATGGCTCC CTTGGTACAA GCAGCATTCC ATCGTTACCA CTGGTCCCGA 
TGCAGTGGTC AAGAACTGAA AAGATATATC CATTCCTATG ACTGTCTCCT TGATGACCCT 
TTTGATCATG ATTGGCCTAA ACTCCCAGAA CTTCCTGGAA TCAATTATTC TATGGATGAG 
CAATGTCGTT TTGATTTTGG TGTTGGCTAT AAAATGTGCA CCGCGTTCCG AACCTTTGAC 
CCATGTAAAC AGCTGTGGTG TAGCCATCCT GATAATCCCT ACTTTTGTAA GACTAAAAAG 
GGACCTCCAC TTGATGGGAC TGAATGTGCT GCTGGAAAAT GGTGCTATAA GGGTCATTGC 
ATGTGGAAGA ATGCTAATCA GCAAAAACAA GATGGCAATT GGGGGTCATG GACTAAATTT 
GGCTCCTGTT CTCGGACATG TGGAACTGGT GTTCGTTTCA GAACACGCCA GTGCAATAAT 
CCCATGCCCA TCAATGGTGG TCAGGATTGT CCTGGTGTTA ATTTTGAGTA CCAGCTTTGT 
AACACAGAAG AATGCCAAAA ACACTTTGAG GACTTCAGAG CACAGCAGTG TCAGCAGCGA 
AACTCCCACT TTGAATACCA GAATACCAAA CACCACTGGT TGCCATATGA ACATCCTGAC 
CCCAAGAAAA GATGCCACCT TTACTGTCAG TCCAAGGAGA CTGGAGATGT TGCTTACATG 
AAACAACTGG TGCATGATGG AACGCACTGT TCTTACAAAG ATCCATATAG CATATGTGTG 
CGAGGAGAGT GTGTGAAAGT GGGCTGTGAT AAAGAAATTG GTTCTAATAA GGTTGAGGAT 
AAGTGTGGTG TCTGTGGAGG AGATAATTCC CACTGCCGAA CCGTGAAGGG GACATTTACC 
AGAACTCCCA GGAAGCTTGG GTACCTTAAG ATGTTTGATA TACCCCCTGG GGCTAGACAT 
GTGTTAATCC AAGAAGACGA GGCTTCTCCT CATATTCTTG CTATTAAGAA CCAGGCTACA 
GGCCATTATA TTTTAAATGG CAAAGGGGAG GAAGCCAAGT CGCGGACCTT CATAGATCTT 
GGTGTGGAGT GGGATTATAA CATTGAAGAT GACATTGAAA GTCTTCACAC CGATGGACCT 
TTACATGATC CTGTTATTGT TTTGATTATA CCTCAAGAAA ATGATACCCG CTCTAGCCTG 
ACATATAAGT ACATCATCCA TGAAGACTCT GTACCTACAA TCAACAGCAA CAATGTCATC 
CAGGAAGAAT TAGATACTTT TGAGTGGGCT TTGAAGAGCT GGTCTCAGTG TTCCAAACCC 
TGTGGTGGAG GTTTCCAGTA CACTAAATAT GGATGCCGTA GGAAAAGTGA TAATAAAATG 
GTCCATCGCA GCTTCTGTGA GGCCAACAAA AAGCCGAAAC CTATTAGACG AATGTGCAAT 
ATTCAAGAGT GTACACATCC ACTCTGGGTA GCAGAAGAAT GGGAACACTG CACCAAAACC 
TGTGGAAGTT CTGGCTATCA GCTTCGCACT GTACGCTGCC TTCAGCCACT CCTTGATGGC 
ACCAACCGCT CTGTGCACAG CAAATACTGC ATGGGTGACC GTCCCGAGAG CCGCCGGCCC 
TGTAACAGAG TGCCCTGCCC TGCACAGTGG AAAACAGGAC CCTGGAGTGA GTGTTCAGTG 
ACCTGCGGTG AAGGAACGGA GGTGAGGCAG GTCCTCTGCA GGGCTGGGGA CCACTGTGAT 
GGTGAAAAGC CTGAGTCGGT CAGAGCCTGT CAACTGCCTC CTTGTAATGA TGAACCATGT 
TTGGGAGACA AGTCCATATT CTGTCAAATG GAAGTGTTGG CACGATACTG CTCCATACCA 
GGTTATAACA AGTTATGTTG TGAGTCCTGC AGCAAGCGCA GTAGCACCCT GCCACCACCA 
TACCTTCTAG AAGCTGCTGA AACTCATGAT GATGTCATCT CTAACCCTAG TGACCTCCCT 
AGATCTCTAG TGATGCCTAC ATCTTTGGTT CCTTATCATT CAGAGACCCC TGCAAAGAAG 
ATGTCTTTGA GTAGCATCTC TTCAGTGGGA GGTCCAAATG CATATGCTGC TTTCAGGCCA 
AACAGTAAAC CTGATGGTGC TAATTTACGC CAGAGGAGTG CTCAGCAAGC AGGAAGTAAG 
ACTGTGAGAC TGGTCACCGT ACCATCCTCC CCACCCACCA AGAGGGTCCA CCTCAGTTCA 
GCTTCACAAA TGGCTGCTGC TTCCTTCTTT GCAGCCAGTG ATTCAATAGG TGCTTCTTCT 
CAGGCAAGAA CCTCAAAGAA AGATGGAAAG ATCATTGACA ACAGACGTCC GACAAGATCA 
TCCACCTTAG AAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055058.2
CDS	38..3655
Translation	MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER

Target ORF information:

RefSeq Version	NM_014243.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014243.2

ORF Insert Sequence:

ATGGTTCTCC TGTCACTTTG GTTGATAGCA GCCGCTCTGG TAGAGGTTAG GACTTCAGCT 
GATGGACAAG CTGGTAATGA AGAAATGGTG CAAATAGATT TACCAATAAA GAGATATAGA 
GAGTATGAGC TGGTGACTCC AGTCAGCACA AATCTAGAAG GACGCTATCT CTCCCATACT 
CTTTCTGCGA GTCACAAAAA GAGGTCAGCG AGGGACGTGT CTTCCAACCC TGAGCAGTTG 
TTCTTTAACA TCACGGCATT TGGAAAAGAT TTTCATCTGC GACTAAAGCC CAACACTCAA 
CTAGTAGCTC CTGGGGCTGT TGTGGAGTGG CATGAGACAT CTCTGGTGCC TGGGAATATA 
ACCGATCCCA TTAACAACCA TCAACCAGGA AGTGCTACGT ATAGAATCCG GAGAACAGAG 
CCTTTGCAGA CTAACTGTGC TTATGTTGGT GACATCGTGG ACATTCCAGG AACCTCTGTT 
GCCATCAGCA ACTGTGATGG TCTGGCTGGA ATGATAAAAA GTGATAATGA AGAGTATTTC 
ATTGAACCCT TGGAAAGAGG TAAACAGATG GAGGAAGAAA AAGGAAGGAT TCATGTTGTC 
TACAAGAGAT CAGCTGTAGA ACAGGCTCCC ATAGACATGT CCAAAGACTT CCACTACAGA 
GAGTCGGACC TGGAAGGCCT TGATGATCTA GGTACTGTTT ATGGCAACAT CCACCAGCAG 
CTGAATGAAA CAATGAGACG CCGCAGACAC GCGGGAGAAA ACGATTACAA TATCGAGGTA 
CTGCTGGGAG TGGATGACTC TGTGGTCCGT TTCCATGGCA AAGAGCACGT CCAAAACTAC 
CTCCTGACCC TAATGAACAT TGTGAATGAA ATTTACCATG ATGAGTCCCT CGGAGTGCAT 
ATAAATGTGG TCCTGGTGCG CATGATAATG CTGGGATATG CAAAGTCCAT CAGCCTCATA 
GAAAGGGGAA ACCCATCCAG AAGCTTGGAG AATGTGTGTC GCTGGGCGTC CCAACAGCAA 
AGATCTGATC TCAACCACTC TGAACACCAT GACCATGCAA TTTTTTTAAC CAGGCAAGAC 
TTTGGACCTG CTGGAATGCA AGGATATGCT CCAGTCACCG GCATGTGTCA TCCAGTGAGA 
AGTTGTACCC TGAATCATGA GGATGGTTTT TCATCTGCTT TTGTAGTAGC CCATGAAACG 
GGCCATGTGT TGGGAATGGA GCATGATGGA CAAGGCAACA GGTGTGGTGA TGAGACTGCT 
ATGGGAAGTG TCATGGCTCC CTTGGTACAA GCAGCATTCC ATCGTTACCA CTGGTCCCGA 
TGCAGTGGTC AAGAACTGAA AAGATATATC CATTCCTATG ACTGTCTCCT TGATGACCCT 
TTTGATCATG ATTGGCCTAA ACTCCCAGAA CTTCCTGGAA TCAATTATTC TATGGATGAG 
CAATGTCGTT TTGATTTTGG TGTTGGCTAT AAAATGTGCA CCGCGTTCCG AACCTTTGAC 
CCATGTAAAC AGCTGTGGTG TAGCCATCCT GATAATCCCT ACTTTTGTAA GACTAAAAAG 
GGACCTCCAC TTGATGGGAC TGAATGTGCT GCTGGAAAAT GGTGCTATAA GGGTCATTGC 
ATGTGGAAGA ATGCTAATCA GCAAAAACAA GATGGCAATT GGGGGTCATG GACTAAATTT 
GGCTCCTGTT CTCGGACATG TGGAACTGGT GTTCGTTTCA GAACACGCCA GTGCAATAAT 
CCCATGCCCA TCAATGGTGG TCAGGATTGT CCTGGTGTTA ATTTTGAGTA CCAGCTTTGT 
AACACAGAAG AATGCCAAAA ACACTTTGAG GACTTCAGAG CACAGCAGTG TCAGCAGCGA 
AACTCCCACT TTGAATACCA GAATACCAAA CACCACTGGT TGCCATATGA ACATCCTGAC 
CCCAAGAAAA GATGCCACCT TTACTGTCAG TCCAAGGAGA CTGGAGATGT TGCTTACATG 
AAACAACTGG TGCATGATGG AACGCACTGT TCTTACAAAG ATCCATATAG CATATGTGTG 
CGAGGAGAGT GTGTGAAAGT GGGCTGTGAT AAAGAAATTG GTTCTAATAA GGTTGAGGAT 
AAGTGTGGTG TCTGTGGAGG AGATAATTCC CACTGCCGAA CCGTGAAGGG GACATTTACC 
AGAACTCCCA GGAAGCTTGG GTACCTTAAG ATGTTTGATA TACCCCCTGG GGCTAGACAT 
GTGTTAATCC AAGAAGACGA GGCTTCTCCT CATATTCTTG CTATTAAGAA CCAGGCTACA 
GGCCATTATA TTTTAAATGG CAAAGGGGAG GAAGCCAAGT CGCGGACCTT CATAGATCTT 
GGTGTGGAGT GGGATTATAA CATTGAAGAT GACATTGAAA GTCTTCACAC CGATGGACCT 
TTACATGATC CTGTTATTGT TTTGATTATA CCTCAAGAAA ATGATACCCG CTCTAGCCTG 
ACATATAAGT ACATCATCCA TGAAGACTCT GTACCTACAA TCAACAGCAA CAATGTCATC 
CAGGAAGAAT TAGATACTTT TGAGTGGGCT TTGAAGAGCT GGTCTCAGTG TTCCAAACCC 
TGTGGTGGAG GTTTCCAGTA CACTAAATAT GGATGCCGTA GGAAAAGTGA TAATAAAATG 
GTCCATCGCA GCTTCTGTGA GGCCAACAAA AAGCCGAAAC CTATTAGACG AATGTGCAAT 
ATTCAAGAGT GTACACATCC ACTCTGGGTA GCAGAAGAAT GGGAACACTG CACCAAAACC 
TGTGGAAGTT CTGGCTATCA GCTTCGCACT GTACGCTGCC TTCAGCCACT CCTTGATGGC 
ACCAACCGCT CTGTGCACAG CAAATACTGC ATGGGTGACC GTCCCGAGAG CCGCCGGCCC 
TGTAACAGAG TGCCCTGCCC TGCACAGTGG AAAACAGGAC CCTGGAGTGA GTGTTCAGTG 
ACCTGCGGTG AAGGAACGGA GGTGAGGCAG GTCCTCTGCA GGGCTGGGGA CCACTGTGAT 
GGTGAAAAGC CTGAGTCGGT CAGAGCCTGT CAACTGCCTC CTTGTAATGA TGAACCATGT 
TTGGGAGACA AGTCCATATT CTGTCAAATG GAAGTGTTGG CACGATACTG CTCCATACCA 
GGTTATAACA AGTTATGTTG TGAGTCCTGC AGCAAGCGCA GTAGCACCCT GCCACCACCA 
TACCTTCTAG AAGCTGCTGA AACTCATGAT GATGTCATCT CTAACCCTAG TGACCTCCCT 
AGATCTCTAG TGATGCCTAC ATCTTTGGTT CCTTATCATT CAGAGACCCC TGCAAAGAAG 
ATGTCTTTGA GTAGCATCTC TTCAGTGGGA GGTCCAAATG CATATGCTGC TTTCAGGCCA 
AACAGTAAAC CTGATGGTGC TAATTTACGC CAGAGGAGTG CTCAGCAAGC AGGAAGTAAG 
ACTGTGAGAC TGGTCACCGT ACCATCCTCC CCACCCACCA AGAGGGTCCA CCTCAGTTCA 
GCTTCACAAA TGGCTGCTGC TTCCTTCTTT GCAGCCAGTG ATTCAATAGG TGCTTCTTCT 
CAGGCAAGAA CCTCAAAGAA AGATGGAAAG ATCATTGACA ACAGACGTCC GACAAGATCA 
TCCACCTTAG AAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS3 ( NM_014243.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055058.2 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), mRNA.

Price & Availability↑

CloneID	OHu55645
Clone ID Related Accession (Same CDS sequence)	NM_014243.2 , NM_014243.3
Accession Version	NM_014243.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3618bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572796800000
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104814.5, AF247668.1, AK295131.1, BC130287.1, AB002364.1 and BC016451.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_014243.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB002364.1, BC130287.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000286657.10/ ENSP00000286657.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTTCTCC TGTCACTTTG GTTGATAGCA GCCGCTCTGG TAGAGGTTAG GACTTCAGCT 
GATGGACAAG CTGGTAATGA AGAAATGGTG CAAATAGATT TACCAATAAA GAGATATAGA 
GAGTATGAGC TGGTGACTCC AGTCAGCACA AATCTAGAAG GACGCTATCT CTCCCATACT 
CTTTCTGCGA GTCACAAAAA GAGGTCAGCG AGGGACGTGT CTTCCAACCC TGAGCAGTTG 
TTCTTTAACA TCACGGCATT TGGAAAAGAT TTTCATCTGC GACTAAAGCC CAACACTCAA 
CTAGTAGCTC CTGGGGCTGT TGTGGAGTGG CATGAGACAT CTCTGGTGCC TGGGAATATA 
ACCGATCCCA TTAACAACCA TCAACCAGGA AGTGCTACGT ATAGAATCCG GAGAACAGAG 
CCTTTGCAGA CTAACTGTGC TTATGTTGGT GACATCGTGG ACATTCCAGG AACCTCTGTT 
GCCATCAGCA ACTGTGATGG TCTGGCTGGA ATGATAAAAA GTGATAATGA AGAGTATTTC 
ATTGAACCCT TGGAAAGAGG TAAACAGATG GAGGAAGAAA AAGGAAGGAT TCATGTTGTC 
TACAAGAGAT CAGCTGTAGA ACAGGCTCCC ATAGACATGT CCAAAGACTT CCACTACAGA 
GAGTCGGACC TGGAAGGCCT TGATGATCTA GGTACTGTTT ATGGCAACAT CCACCAGCAG 
CTGAATGAAA CAATGAGACG CCGCAGACAC GCGGGAGAAA ACGATTACAA TATCGAGGTA 
CTGCTGGGAG TGGATGACTC TGTGGTCCGT TTCCATGGCA AAGAGCACGT CCAAAACTAC 
CTCCTGACCC TAATGAACAT TGTGAATGAA ATTTACCATG ATGAGTCCCT CGGAGTGCAT 
ATAAATGTGG TCCTGGTGCG CATGATAATG CTGGGATATG CAAAGTCCAT CAGCCTCATA 
GAAAGGGGAA ACCCATCCAG AAGCTTGGAG AATGTGTGTC GCTGGGCGTC CCAACAGCAA 
AGATCTGATC TCAACCACTC TGAACACCAT GACCATGCAA TTTTTTTAAC CAGGCAAGAC 
TTTGGACCTG CTGGAATGCA AGGATATGCT CCAGTCACCG GCATGTGTCA TCCAGTGAGA 
AGTTGTACCC TGAATCATGA GGATGGTTTT TCATCTGCTT TTGTAGTAGC CCATGAAACG 
GGCCATGTGT TGGGAATGGA GCATGATGGA CAAGGCAACA GGTGTGGTGA TGAGACTGCT 
ATGGGAAGTG TCATGGCTCC CTTGGTACAA GCAGCATTCC ATCGTTACCA CTGGTCCCGA 
TGCAGTGGTC AAGAACTGAA AAGATATATC CATTCCTATG ACTGTCTCCT TGATGACCCT 
TTTGATCATG ATTGGCCTAA ACTCCCAGAA CTTCCTGGAA TCAATTATTC TATGGATGAG 
CAATGTCGTT TTGATTTTGG TGTTGGCTAT AAAATGTGCA CCGCGTTCCG AACCTTTGAC 
CCATGTAAAC AGCTGTGGTG TAGCCATCCT GATAATCCCT ACTTTTGTAA GACTAAAAAG 
GGACCTCCAC TTGATGGGAC TGAATGTGCT GCTGGAAAAT GGTGCTATAA GGGTCATTGC 
ATGTGGAAGA ATGCTAATCA GCAAAAACAA GATGGCAATT GGGGGTCATG GACTAAATTT 
GGCTCCTGTT CTCGGACATG TGGAACTGGT GTTCGTTTCA GAACACGCCA GTGCAATAAT 
CCCATGCCCA TCAATGGTGG TCAGGATTGT CCTGGTGTTA ATTTTGAGTA CCAGCTTTGT 
AACACAGAAG AATGCCAAAA ACACTTTGAG GACTTCAGAG CACAGCAGTG TCAGCAGCGA 
AACTCCCACT TTGAATACCA GAATACCAAA CACCACTGGT TGCCATATGA ACATCCTGAC 
CCCAAGAAAA GATGCCACCT TTACTGTCAG TCCAAGGAGA CTGGAGATGT TGCTTACATG 
AAACAACTGG TGCATGATGG AACGCACTGT TCTTACAAAG ATCCATATAG CATATGTGTG 
CGAGGAGAGT GTGTGAAAGT GGGCTGTGAT AAAGAAATTG GTTCTAATAA GGTTGAGGAT 
AAGTGTGGTG TCTGTGGAGG AGATAATTCC CACTGCCGAA CCGTGAAGGG GACATTTACC 
AGAACTCCCA GGAAGCTTGG GTACCTTAAG ATGTTTGATA TACCCCCTGG GGCTAGACAT 
GTGTTAATCC AAGAAGACGA GGCTTCTCCT CATATTCTTG CTATTAAGAA CCAGGCTACA 
GGCCATTATA TTTTAAATGG CAAAGGGGAG GAAGCCAAGT CGCGGACCTT CATAGATCTT 
GGTGTGGAGT GGGATTATAA CATTGAAGAT GACATTGAAA GTCTTCACAC CGATGGACCT 
TTACATGATC CTGTTATTGT TTTGATTATA CCTCAAGAAA ATGATACCCG CTCTAGCCTG 
ACATATAAGT ACATCATCCA TGAAGACTCT GTACCTACAA TCAACAGCAA CAATGTCATC 
CAGGAAGAAT TAGATACTTT TGAGTGGGCT TTGAAGAGCT GGTCTCAGTG TTCCAAACCC 
TGTGGTGGAG GTTTCCAGTA CACTAAATAT GGATGCCGTA GGAAAAGTGA TAATAAAATG 
GTCCATCGCA GCTTCTGTGA GGCCAACAAA AAGCCGAAAC CTATTAGACG AATGTGCAAT 
ATTCAAGAGT GTACACATCC ACTCTGGGTA GCAGAAGAAT GGGAACACTG CACCAAAACC 
TGTGGAAGTT CTGGCTATCA GCTTCGCACT GTACGCTGCC TTCAGCCACT CCTTGATGGC 
ACCAACCGCT CTGTGCACAG CAAATACTGC ATGGGTGACC GTCCCGAGAG CCGCCGGCCC 
TGTAACAGAG TGCCCTGCCC TGCACAGTGG AAAACAGGAC CCTGGAGTGA GTGTTCAGTG 
ACCTGCGGTG AAGGAACGGA GGTGAGGCAG GTCCTCTGCA GGGCTGGGGA CCACTGTGAT 
GGTGAAAAGC CTGAGTCGGT CAGAGCCTGT CAACTGCCTC CTTGTAATGA TGAACCATGT 
TTGGGAGACA AGTCCATATT CTGTCAAATG GAAGTGTTGG CACGATACTG CTCCATACCA 
GGTTATAACA AGTTATGTTG TGAGTCCTGC AGCAAGCGCA GTAGCACCCT GCCACCACCA 
TACCTTCTAG AAGCTGCTGA AACTCATGAT GATGTCATCT CTAACCCTAG TGACCTCCCT 
AGATCTCTAG TGATGCCTAC ATCTTTGGTT CCTTATCATT CAGAGACCCC TGCAAAGAAG 
ATGTCTTTGA GTAGCATCTC TTCAGTGGGA GGTCCAAATG CATATGCTGC TTTCAGGCCA 
AACAGTAAAC CTGATGGTGC TAATTTACGC CAGAGGAGTG CTCAGCAAGC AGGAAGTAAG 
ACTGTGAGAC TGGTCACCGT ACCATCCTCC CCACCCACCA AGAGGGTCCA CCTCAGTTCA 
GCTTCACAAA TGGCTGCTGC TTCCTTCTTT GCAGCCAGTG ATTCAATAGG TGCTTCTTCT 
CAGGCAAGAA CCTCAAAGAA AGATGGAAAG ATCATTGACA ACAGACGTCC GACAAGATCA 
TCCACCTTAG AAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055058.2
CDS	460..4077
Translation	MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRSSTLER

Target ORF information:

RefSeq Version	NM_014243.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 3 (ADAMTS3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014243.3

ORF Insert Sequence:

ATGGTTCTCC TGTCACTTTG GTTGATAGCA GCCGCTCTGG TAGAGGTTAG GACTTCAGCT 
GATGGACAAG CTGGTAATGA AGAAATGGTG CAAATAGATT TACCAATAAA GAGATATAGA 
GAGTATGAGC TGGTGACTCC AGTCAGCACA AATCTAGAAG GACGCTATCT CTCCCATACT 
CTTTCTGCGA GTCACAAAAA GAGGTCAGCG AGGGACGTGT CTTCCAACCC TGAGCAGTTG 
TTCTTTAACA TCACGGCATT TGGAAAAGAT TTTCATCTGC GACTAAAGCC CAACACTCAA 
CTAGTAGCTC CTGGGGCTGT TGTGGAGTGG CATGAGACAT CTCTGGTGCC TGGGAATATA 
ACCGATCCCA TTAACAACCA TCAACCAGGA AGTGCTACGT ATAGAATCCG GAGAACAGAG 
CCTTTGCAGA CTAACTGTGC TTATGTTGGT GACATCGTGG ACATTCCAGG AACCTCTGTT 
GCCATCAGCA ACTGTGATGG TCTGGCTGGA ATGATAAAAA GTGATAATGA AGAGTATTTC 
ATTGAACCCT TGGAAAGAGG TAAACAGATG GAGGAAGAAA AAGGAAGGAT TCATGTTGTC 
TACAAGAGAT CAGCTGTAGA ACAGGCTCCC ATAGACATGT CCAAAGACTT CCACTACAGA 
GAGTCGGACC TGGAAGGCCT TGATGATCTA GGTACTGTTT ATGGCAACAT CCACCAGCAG 
CTGAATGAAA CAATGAGACG CCGCAGACAC GCGGGAGAAA ACGATTACAA TATCGAGGTA 
CTGCTGGGAG TGGATGACTC TGTGGTCCGT TTCCATGGCA AAGAGCACGT CCAAAACTAC 
CTCCTGACCC TAATGAACAT TGTGAATGAA ATTTACCATG ATGAGTCCCT CGGAGTGCAT 
ATAAATGTGG TCCTGGTGCG CATGATAATG CTGGGATATG CAAAGTCCAT CAGCCTCATA 
GAAAGGGGAA ACCCATCCAG AAGCTTGGAG AATGTGTGTC GCTGGGCGTC CCAACAGCAA 
AGATCTGATC TCAACCACTC TGAACACCAT GACCATGCAA TTTTTTTAAC CAGGCAAGAC 
TTTGGACCTG CTGGAATGCA AGGATATGCT CCAGTCACCG GCATGTGTCA TCCAGTGAGA 
AGTTGTACCC TGAATCATGA GGATGGTTTT TCATCTGCTT TTGTAGTAGC CCATGAAACG 
GGCCATGTGT TGGGAATGGA GCATGATGGA CAAGGCAACA GGTGTGGTGA TGAGACTGCT 
ATGGGAAGTG TCATGGCTCC CTTGGTACAA GCAGCATTCC ATCGTTACCA CTGGTCCCGA 
TGCAGTGGTC AAGAACTGAA AAGATATATC CATTCCTATG ACTGTCTCCT TGATGACCCT 
TTTGATCATG ATTGGCCTAA ACTCCCAGAA CTTCCTGGAA TCAATTATTC TATGGATGAG 
CAATGTCGTT TTGATTTTGG TGTTGGCTAT AAAATGTGCA CCGCGTTCCG AACCTTTGAC 
CCATGTAAAC AGCTGTGGTG TAGCCATCCT GATAATCCCT ACTTTTGTAA GACTAAAAAG 
GGACCTCCAC TTGATGGGAC TGAATGTGCT GCTGGAAAAT GGTGCTATAA GGGTCATTGC 
ATGTGGAAGA ATGCTAATCA GCAAAAACAA GATGGCAATT GGGGGTCATG GACTAAATTT 
GGCTCCTGTT CTCGGACATG TGGAACTGGT GTTCGTTTCA GAACACGCCA GTGCAATAAT 
CCCATGCCCA TCAATGGTGG TCAGGATTGT CCTGGTGTTA ATTTTGAGTA CCAGCTTTGT 
AACACAGAAG AATGCCAAAA ACACTTTGAG GACTTCAGAG CACAGCAGTG TCAGCAGCGA 
AACTCCCACT TTGAATACCA GAATACCAAA CACCACTGGT TGCCATATGA ACATCCTGAC 
CCCAAGAAAA GATGCCACCT TTACTGTCAG TCCAAGGAGA CTGGAGATGT TGCTTACATG 
AAACAACTGG TGCATGATGG AACGCACTGT TCTTACAAAG ATCCATATAG CATATGTGTG 
CGAGGAGAGT GTGTGAAAGT GGGCTGTGAT AAAGAAATTG GTTCTAATAA GGTTGAGGAT 
AAGTGTGGTG TCTGTGGAGG AGATAATTCC CACTGCCGAA CCGTGAAGGG GACATTTACC 
AGAACTCCCA GGAAGCTTGG GTACCTTAAG ATGTTTGATA TACCCCCTGG GGCTAGACAT 
GTGTTAATCC AAGAAGACGA GGCTTCTCCT CATATTCTTG CTATTAAGAA CCAGGCTACA 
GGCCATTATA TTTTAAATGG CAAAGGGGAG GAAGCCAAGT CGCGGACCTT CATAGATCTT 
GGTGTGGAGT GGGATTATAA CATTGAAGAT GACATTGAAA GTCTTCACAC CGATGGACCT 
TTACATGATC CTGTTATTGT TTTGATTATA CCTCAAGAAA ATGATACCCG CTCTAGCCTG 
ACATATAAGT ACATCATCCA TGAAGACTCT GTACCTACAA TCAACAGCAA CAATGTCATC 
CAGGAAGAAT TAGATACTTT TGAGTGGGCT TTGAAGAGCT GGTCTCAGTG TTCCAAACCC 
TGTGGTGGAG GTTTCCAGTA CACTAAATAT GGATGCCGTA GGAAAAGTGA TAATAAAATG 
GTCCATCGCA GCTTCTGTGA GGCCAACAAA AAGCCGAAAC CTATTAGACG AATGTGCAAT 
ATTCAAGAGT GTACACATCC ACTCTGGGTA GCAGAAGAAT GGGAACACTG CACCAAAACC 
TGTGGAAGTT CTGGCTATCA GCTTCGCACT GTACGCTGCC TTCAGCCACT CCTTGATGGC 
ACCAACCGCT CTGTGCACAG CAAATACTGC ATGGGTGACC GTCCCGAGAG CCGCCGGCCC 
TGTAACAGAG TGCCCTGCCC TGCACAGTGG AAAACAGGAC CCTGGAGTGA GTGTTCAGTG 
ACCTGCGGTG AAGGAACGGA GGTGAGGCAG GTCCTCTGCA GGGCTGGGGA CCACTGTGAT 
GGTGAAAAGC CTGAGTCGGT CAGAGCCTGT CAACTGCCTC CTTGTAATGA TGAACCATGT 
TTGGGAGACA AGTCCATATT CTGTCAAATG GAAGTGTTGG CACGATACTG CTCCATACCA 
GGTTATAACA AGTTATGTTG TGAGTCCTGC AGCAAGCGCA GTAGCACCCT GCCACCACCA 
TACCTTCTAG AAGCTGCTGA AACTCATGAT GATGTCATCT CTAACCCTAG TGACCTCCCT 
AGATCTCTAG TGATGCCTAC ATCTTTGGTT CCTTATCATT CAGAGACCCC TGCAAAGAAG 
ATGTCTTTGA GTAGCATCTC TTCAGTGGGA GGTCCAAATG CATATGCTGC TTTCAGGCCA 
AACAGTAAAC CTGATGGTGC TAATTTACGC CAGAGGAGTG CTCAGCAAGC AGGAAGTAAG 
ACTGTGAGAC TGGTCACCGT ACCATCCTCC CCACCCACCA AGAGGGTCCA CCTCAGTTCA 
GCTTCACAAA TGGCTGCTGC TTCCTTCTTT GCAGCCAGTG ATTCAATAGG TGCTTCTTCT 
CAGGCAAGAA CCTCAAAGAA AGATGGAAAG ATCATTGACA ACAGACGTCC GACAAGATCA 
TCCACCTTAG AAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

An additional case of Hennekam lymphangiectasia-lymphedema syndrome caused by loss-of-function mutation in ADAMTS3.
American journal of medical genetics. Part A176(12)2858-2861(2018 12)
Scheuerle AE,Sweed NT,Timmons CF,Smith ED,Alcaraz WA,Shinde DN

SP1-mediated downregulation of ADAMTS3 gene expression in osteosarcoma models.
Gene6591-10(2018 Jun)
Aydemir AT,Alper M,Kockar F

Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival.
Molecular carcinogenesis57(1)22-31(2018 Jan)
Xu Y,Wang Y,Liu H,Shi Q,Zhu D,Amos CI,Fang S,Lee JE,Hyslop T,Li X,Han J,Wei Q

Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.
Human molecular genetics26(21)4095-4104(2017 11)
Brouillard P,Dupont L,Helaers R,Coulie R,Tiller GE,Peeden J,Colige A,Vikkula M

ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.
The Kaohsiung journal of medical sciences33(1)30-35(2017 Jan)
Pekcan MK,Sarıkaya E,Tokmak A,Alışık M,Alkan A,Özakşit G,Erel Ö

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ADAMTS3 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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