| Gene Symbol | ARHGEF6 |
| Entrez Gene ID | 9459 |
| Full Name | Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Synonyms | COOL2,Cool-2,MRX46,PIXA,alpha-PIX,alphaPIX |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Mental retardation, X-linked 46, 300436 (3) |

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