AIM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AIM2
Entrez Gene ID	9447
Full Name	absent in melanoma 2
Synonyms	PYHIN4
General protein information	Preferred Names absent in melanoma 2 Names interferon-inducible protein AIM2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.1-q23.2
Summary	AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008].
Disorder MIM:	604578

mRNA and Protein(s)

mRNA	Protein	Name
NM_004833.2	NP_004824.1	interferon-inducible protein AIM2 isoform 1
NM_004833.1	NP_004824.1	interferon-inducible protein AIM2
NM_001348247.1	NP_001335176.1	interferon-inducible protein AIM2 isoform 2
XM_017002848.1	XP_016858337.1	interferon-inducible protein AIM2 isoform X1
NM_004833.3	NP_004824.1	interferon-inducible protein AIM2 isoform 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Aim2	NP_001013801.2
Pan troglodytes (chimpanzee)	AIM2	XP_513914.2
Macaca mulatta (Rhesus monkey)	AIM2	XP_001117183.1
Homo sapiens (human)	AIM2	NP_004824.1
Rattus norvegicus (Norway rat)	Aim2	XP_006250399.1

Gene Ontology
Bibliography

Related articles in PubMed

Low expression of AIM2 combined with high expression of p‑STAT3 is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.
Li Z, Shi X, Li H, Wang W, Li X
Oncology reports41(4)2396-2408(2019 Apr)

AIM2 levels and DNA-triggered inflammasome response are increased in peripheral leukocytes of patients with abdominal aortic aneurysm.
Wortmann M, Xiao X, Wabnitz G, Samstag Y, Hakimi M, Böckler D, Dihlmann S
Inflammation research : official journal of the European Histamine Research Society ... [et al.]68(4)337-345(2019 Apr)

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome.
Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, Streblow DN, Fruh KJ, DeFilippis VR
mBio10(1)(2019 02)

Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.
Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K
Biochemical and biophysical research communications509(1)82-88(2019 01)

Differential Activation of NLRP3, AIM2, and IFI16 Inflammasomes in Humans with Acute and Chronic Hepatitis B.
Chen H, He G, Chen Y, Zhang X, Wu S
Viral immunology31(9)639-645(2018 11)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following AIM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AIM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu34825	NM_001348247.1 Latest version!	Homo sapiens absent in melanoma 2 (AIM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu24772	NM_004833.3 Latest version!	Homo sapiens absent in melanoma 2 (AIM2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
OHu24772	XM_017002848.1 Latest version!	Homo sapiens absent in melanoma 2 (AIM2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu24772	NM_004833.1	Homo sapiens absent in melanoma 2 (AIM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
OHu24772	NM_004833.2	Homo sapiens absent in melanoma 2 (AIM2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AIM2 ( NM_001348247.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335176.1 Homo sapiens absent in melanoma 2 (AIM2), transcript variant 2, mRNA.

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CloneID	OHu34825
Clone ID Related Accession (Same CDS sequence)	NM_001348247.1
Accession Version	NM_001348247.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 717bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577548800000
Organism	Homo sapiens(human)
Product	interferon-inducible protein AIM2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL359753.9. On Jan 25, 2017 this sequence version replaced XM_005245616.4. Transcript Variant: This variant (2) lacks an exon in the 5' coding region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.2764.1, SRR1163658.414427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTCCTG CTGCATCTGC AGCCATCAGA AATGATGTCG CAAAGCAACG TGCTGCACCA 
AAAGTCTCTC CTCATGTTAA GCCTGAACAG AAACAGATGG TGGCCCAGCA GGAATCTATC 
AGAGAAGGGT TTCAGAAGCG CTGTTTGCCA GTTATGGTAC TGAAAGCAAA GAAGCCCTTC 
ACGTTTGAGA CCCAAGAAGG CAAGCAGGAG ATGTTTCATG CTACAGTGGC TACAGAAAAG 
GAATTCTTCT TTGTAAAAGT TTTTAATACA CTGCTGAAAG ATAAATTCAT TCCAAAGAGA 
ATAATTATAA TAGCAAGATA TTATCGGCAC AGTGGTTTCT TAGAGGTAAA TAGCGCCTCA 
CGTGTGTTAG ATGCTGAATC TGACCAAAAG GTTAATGTCC CGCTGAACAT TATCAGAAAA 
GCTGGTGAAA CCCCGAAGAT CAACACGCTT CAAACTCAGC CCCTTGGAAC AATTGTGAAT 
GGTTTGTTTG TAGTCCAGAA GGTAACAGAA AAGAAGAAAA ACATATTATT TGACCTAAGT 
GACAACACTG GGAAAATGGA AGTACTGGGG GTTAGAAACG AGGACACAAT GAAATGTAAG 
GAAGGAGATA AGGTTCGACT TACATTCTTC ACACTGTCAA AAAATGGAGA AAAACTACAG 
CTGACATCTG GAGTTCATAG CACCATAAAG GTTATTAAGG CCAAAAAAAA AACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335176.1
CDS	323..1039
Translation	MSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

Target ORF information:

RefSeq Version	NM_001348247.1
Organism	Homo sapiens(human)
Definition	Homo sapiens absent in melanoma 2 (AIM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348247.1

ORF Insert Sequence:

ATGAGTCCTG CTGCATCTGC AGCCATCAGA AATGATGTCG CAAAGCAACG TGCTGCACCA 
AAAGTCTCTC CTCATGTTAA GCCTGAACAG AAACAGATGG TGGCCCAGCA GGAATCTATC 
AGAGAAGGGT TTCAGAAGCG CTGTTTGCCA GTTATGGTAC TGAAAGCAAA GAAGCCCTTC 
ACGTTTGAGA CCCAAGAAGG CAAGCAGGAG ATGTTTCATG CTACAGTGGC TACAGAAAAG 
GAATTCTTCT TTGTAAAAGT TTTTAATACA CTGCTGAAAG ATAAATTCAT TCCAAAGAGA 
ATAATTATAA TAGCAAGATA TTATCGGCAC AGTGGTTTCT TAGAGGTAAA TAGCGCCTCA 
CGTGTGTTAG ATGCTGAATC TGACCAAAAG GTTAATGTCC CGCTGAACAT TATCAGAAAA 
GCTGGTGAAA CCCCGAAGAT CAACACGCTT CAAACTCAGC CCCTTGGAAC AATTGTGAAT 
GGTTTGTTTG TAGTCCAGAA GGTAACAGAA AAGAAGAAAA ACATATTATT TGACCTAAGT 
GACAACACTG GGAAAATGGA AGTACTGGGG GTTAGAAACG AGGACACAAT GAAATGTAAG 
GAAGGAGATA AGGTTCGACT TACATTCTTC ACACTGTCAA AAAATGGAGA AAAACTACAG 
CTGACATCTG GAGTTCATAG CACCATAAAG GTTATTAAGG CCAAAAAAAA AACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AIM2 ( NM_004833.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004824.1 Homo sapiens absent in melanoma 2 (AIM2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24772
Clone ID Related Accession (Same CDS sequence)	NM_004833.2 , NM_004833.1 , XM_017002848.1 , NM_004833.3
Accession Version	NM_004833.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1514649600000
Organism	Homo sapiens(human)
Product	interferon-inducible protein AIM2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB151016.1, AF024714.1 and BC010940.1. On Jan 25, 2017 this sequence version replaced NM_004833.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010940.1, AF024714.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2151358 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004824.1
CDS	290..1321
Translation	MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

Target ORF information:

RefSeq Version	NM_004833.2
Organism	Homo sapiens(human)
Definition	Homo sapiens absent in melanoma 2 (AIM2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004833.2

ORF Insert Sequence:

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AIM2 ( NM_004833.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_004824.1 Homo sapiens absent in melanoma 2 (AIM2), mRNA.

Price & Availability↑

CloneID	OHu24772
Clone ID Related Accession (Same CDS sequence)	NM_004833.2 , NM_004833.1 , XM_017002848.1 , NM_004833.3
Accession Version	NM_004833.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	interferon-inducible protein AIM2
Comment

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004824.1
Translation	MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

Target ORF information:

RefSeq Version	NM_004833.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens absent in melanoma 2 (AIM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004833.1

ORF Insert Sequence:

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AIM2 ( NM_004833.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004824.1 Homo sapiens absent in melanoma 2 (AIM2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24772
Clone ID Related Accession (Same CDS sequence)	NM_004833.2 , NM_004833.1 , XM_017002848.1 , NM_004833.3
Accession Version	NM_004833.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577635200000
Organism	Homo sapiens(human)
Product	interferon-inducible protein AIM2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF024714.1 and BC010940.1. On Nov 23, 2018 this sequence version replaced NM_004833.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC010940.1, AK292042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146236, SAMEA2151358 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368130.9/ ENSP00000357112.4 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004824.1
CDS	155..1186
Translation	MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

Target ORF information:

RefSeq Version	NM_004833.3
Organism	Homo sapiens(human)
Definition	Homo sapiens absent in melanoma 2 (AIM2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004833.3

ORF Insert Sequence:

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AIM2 ( XM_017002848.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016858337.1 Homo sapiens absent in melanoma 2 (AIM2), transcript variant X4, mRNA.

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CloneID	OHu24772
Clone ID Related Accession (Same CDS sequence)	NM_004833.2 , NM_004833.1 , XM_017002848.1 , NM_004833.3
Accession Version	XM_017002848.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1032bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	interferon-inducible protein AIM2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016858337.1
CDS	1473..2504
Translation	MESKYKEILLLTGLDNITDEELDRFKFFLSDEFNIATGKLHTANRIQVATLMIQNAGAVSAVMKTIRIFQKLNYMLLAKRLQEEKEKVDKQYKSVTKPKPLSQAEMSPAASAAIRNDVAKQRAAPKVSPHVKPEQKQMVAQQESIREGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTLLKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKAGETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGVRNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAKKKT

Target ORF information:

RefSeq Version	XM_017002848.1
Organism	Homo sapiens(human)
Definition	Homo sapiens absent in melanoma 2 (AIM2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017002848.1

ORF Insert Sequence:

ATGGAGAGTA AATACAAGGA GATACTCTTG CTAACAGGCC TGGATAACAT CACTGATGAG 
GAACTGGATA GGTTTAAGTT CTTTCTTTCA GACGAGTTTA ATATTGCCAC AGGCAAACTA 
CATACTGCAA ACAGAATACA AGTAGCTACC TTGATGATTC AAAATGCTGG GGCGGTGTCT 
GCAGTGATGA AGACCATTCG TATTTTTCAG AAGTTGAATT ATATGCTTTT GGCAAAACGT 
CTTCAGGAGG AGAAGGAGAA AGTTGATAAG CAATACAAAT CGGTAACAAA ACCAAAGCCA 
CTAAGTCAAG CTGAAATGAG TCCTGCTGCA TCTGCAGCCA TCAGAAATGA TGTCGCAAAG 
CAACGTGCTG CACCAAAAGT CTCTCCTCAT GTTAAGCCTG AACAGAAACA GATGGTGGCC 
CAGCAGGAAT CTATCAGAGA AGGGTTTCAG AAGCGCTGTT TGCCAGTTAT GGTACTGAAA 
GCAAAGAAGC CCTTCACGTT TGAGACCCAA GAAGGCAAGC AGGAGATGTT TCATGCTACA 
GTGGCTACAG AAAAGGAATT CTTCTTTGTA AAAGTTTTTA ATACACTGCT GAAAGATAAA 
TTCATTCCAA AGAGAATAAT TATAATAGCA AGATATTATC GGCACAGTGG TTTCTTAGAG 
GTAAATAGCG CCTCACGTGT GTTAGATGCT GAATCTGACC AAAAGGTTAA TGTCCCGCTG 
AACATTATCA GAAAAGCTGG TGAAACCCCG AAGATCAACA CGCTTCAAAC TCAGCCCCTT 
GGAACAATTG TGAATGGTTT GTTTGTAGTC CAGAAGGTAA CAGAAAAGAA GAAAAACATA 
TTATTTGACC TAAGTGACAA CACTGGGAAA ATGGAAGTAC TGGGGGTTAG AAACGAGGAC 
ACAATGAAAT GTAAGGAAGG AGATAAGGTT CGACTTACAT TCTTCACACT GTCAAAAAAT 
GGAGAAAAAC TACAGCTGAC ATCTGGAGTT CATAGCACCA TAAAGGTTAT TAAGGCCAAA 
AAAAAAACAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Low expression of AIM2 combined with high expression of p‑STAT3 is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.
Oncology reports41(4)2396-2408(2019 Apr)
Li Z,Shi X,Li H,Wang W,Li X

AIM2 levels and DNA-triggered inflammasome response are increased in peripheral leukocytes of patients with abdominal aortic aneurysm.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]68(4)337-345(2019 Apr)
Wortmann M,Xiao X,Wabnitz G,Samstag Y,Hakimi M,Böckler D,Dihlmann S

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome.
mBio10(1)(2019 02)
Botto S,Abraham J,Mizuno N,Pryke K,Gall B,Landais I,Streblow DN,Fruh KJ,DeFilippis VR

Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.
Biochemical and biophysical research communications509(1)82-88(2019 01)
Nakamura Y,Nakahata S,Kondo Y,Izumi A,Yamamoto K,Ichikawa T,Tamura T,Noumi K,Yamashita Y,Morishita K

Differential Activation of NLRP3, AIM2, and IFI16 Inflammasomes in Humans with Acute and Chronic Hepatitis B.
Viral immunology31(9)639-645(2018 11)
Chen H,He G,Chen Y,Zhang X,Wu S

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AIM2 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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