| Gene Symbol | COX5A |
| Entrez Gene ID | 9377 |
| Full Name | cytochrome c oxidase subunit 5A |
| Synonyms | COX,COX-VA,VA |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
- REAGENT SERVICES Hot!
-
PRODUCTS
-
Most Popular Reagents
-
Instruments
-
Antibodies
-
ELISA Kits
-
Protein Electrophoresis and Blotting
-
Protein and Antibody Purification
-
Recombinant Proteins
-
Molecular Biology
-
Stable Cell Lines
-
Cell Isolation and Activation
-
IVD Raw Materials
-
Therapy Applications
-
Resources
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Anti-Camelid VHH]()
MonoRab™ Anti-VHH Antibodies
-
![ELISA Kits]()
ELISA Kits
-
![Precast Gels]()
SurePAGE™ Precast Gels
-
![Quatro ProAb Automated Protein and Antibody Purification System]()
AmMag™ Quatro ProAb Automated Protein and Antibody Purification System
-
![Target Proteins]()
Target Proteins
-
![AmMag™ Quatro Automated Plasmid Purification]()
AmMag™ Quatro automated plasmid purification
-
![Stable Cell Lines]()
Stable Cell Lines
-
![Cell Isolation and Activation]()
Cell Isolation and Activation
-
![Quick
Order]()
Quick Order
-
![Quick
Order]()
Quick Order
- APPLICATIONS
- RESOURCES
- ABOUT US
COX5A cDNA ORF clone, Homo sapiens(human)
-
Gene
-
Clones
gRNAs
The following COX5A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX5A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
-
Reference Sequences (Refseq)
CloneID OHu09156 Clone ID Related Accession (Same CDS sequence) NM_004255.3 , NM_004255.4 Accession Version NM_004255.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 453bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1514217600000 Organism Homo sapiens(human) Product cytochrome c oxidase subunit 5A, mitochondrial precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI815421.1 and AK026623.1. On Jun 20, 2008 this sequence version replaced NM_004255.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.85208.1, BC024240.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_004246.2 CDS 141..593 Translation 
Target ORF information:
RefSeq Version NM_004255.3 Organism Homo sapiens(human) Definition Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_004255.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu09156 Clone ID Related Accession (Same CDS sequence) NM_004255.3 , NM_004255.4 Accession Version NM_004255.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 453bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1577635200000 Organism Homo sapiens(human) Product cytochrome c oxidase subunit 5A, mitochondrial precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI815421.1, AK026623.1 and AC125435.8. On Nov 22, 2018 this sequence version replaced NM_004255.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.40972.1, SRR1163655.347096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000322347.11/ ENSP00000317780.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_004246.2 CDS 60..512 Translation
Target ORF information:
RefSeq Version NM_004255.4 Organism Homo sapiens(human) Definition Homo sapiens cytochrome c oxidase subunit 5A (COX5A), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_004255.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421ATGCTGGGCG CCGCTCTCCG CCGCTGCGCT GTGGCCGCAA CCACCCGGGC CGACCCTCGA
GGCCTCCTGC ACTCCGCCCG GACCCCCGGC CCCGCCGTGG CTATCCAGTC AGTTCGCTGC
TATTCCCATG GGTCACAGGA GACAGATGAG GAGTTTGATG CTCGCTGGGT AACATACTTC
AACAAGCCAG ATATAGATGC CTGGGAATTG CGTAAAGGGA TAAACACACT TGTTACCTAT
GATATGGTTC CAGAGCCCAA AATCATTGAT GCTGCTTTGC GGGCATGCAG ACGGTTAAAT
GATTTTGCTA GTACAGTTCG TATCCTAGAG GTTGTTAAGG ACAAAGCAGG ACCTCATAAG
GAAATCTACC CCTATGTCAT CCAGGAACTT AGACCAACTT TAAATGAACT GGGAATCTCC
ACTCCGGAGG AACTGGGCCT TGACAAAGTG TAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
-
PubMed
Mutation in mitochondrial complex IV subunit COX5A causes pulmonary arterial hypertension, lactic acidemia, and failure to thrive.
Human mutation38(6)692-703(2017 06)
Baertling F,Al-Murshedi F,Sánchez-Caballero L,Al-Senaidi K,Joshi NP,Venselaar H,van den Brand MA,Nijtmans LG,Rodenburg RJ
The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.
The Biochemical journal473(6)797-804(2016 Mar)
Cesnekova J,Rodinova M,Hansikova H,Houstek J,Zeman J,Stiburek L
The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis.
BMC cancer12273(2012 Jun)
Chen WL,Kuo KT,Chou TY,Chen CL,Wang CH,Wei YH,Wang LS
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
PLoS genetics7(4)e1002033(2011 Apr)
Cornelis MC,Monda KL,Yu K,Paynter N,Azzato EM,Bennett SN,Berndt SI,Boerwinkle E,Chanock S,Chatterjee N,Couper D,Curhan G,Heiss G,Hu FB,Hunter DJ,Jacobs K,Jensen MK,Kraft P,Landi MT,Nettleton JA,Purdue MP,Rajaraman P,Rimm EB,Rose LM,Rothman N,Silverman D,Stolzenberg-Solomon R,Subar A,Yeager M,Chasman DI,van Dam RM,Caporaso NE
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ
-
-
Most Popular Services
-
Services & Products
-
News & Blogs
- Novel Approach for Improved Knock-In Efficiency in Primary Cells
- Genetic Variants in Serotonin Signaling Cascade Linked to Obsessive Compulsive Disorder
- Gene Therapy for AADC: Targeting Neurons with AAV Vectors
- New Study Shows the pros and cons to drinking coffee
- Molecular chainsaw massacre of cancer cells
- Advances Supporting IVT mRNA Medicines
- Delivering CRISPR/Cas9: Advances and Challenges
- From Bispecific to Trispecific Antibodies in Cancer Immunotherapy
-
-
-
PubMed
-
