F2RL3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	F2RL3
Entrez Gene ID	9002
Full Name	F2R like thrombin or trypsin receptor 3
Synonyms	PAR4
General protein information	Preferred Names F2R like thrombin or trypsin receptor 3 Names proteinase-activated receptor 4 F2R like thrombin/trypsin receptor 3 PAR-4 coagulation factor II (thrombin) receptor-like 3 protease-activated receptor-4 thrombin receptor-like 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016].
Disorder MIM:	602779

mRNA and Protein(s)

mRNA	Protein	Name
NM_003950.3	NP_003941.2	proteinase-activated receptor 4 preproprotein
NM_003950.2	NP_003941.2	proteinase-activated receptor 4 precursor
NM_003950.4	NP_003941.2	proteinase-activated receptor 4 preproprotein
XM_005260139.2	XP_005260196.1	proteinase-activated receptor 4 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	F2RL3	NP_003941.2
Macaca mulatta (Rhesus monkey)	F2RL3	XP_001112955.1
Bos taurus (cattle)	F2RL3	NP_001069606.1
Rattus norvegicus (Norway rat)	F2rl3	NP_446260.1
Pan troglodytes (chimpanzee)	F2RL3	XP_512484.2
Canis lupus familiaris (dog)	F2RL3	XP_541962.2
Mus musculus (house mouse)	F2rl3	NP_032001.2

Gene Ontology
Bibliography

Related articles in PubMed

Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes.
Posthuma JJ, Posma JJN, Schep G, Bender MMH, van Oerle R, van der Wal AC, Ten Cate H, Spronk HMH
Journal of vascular surgery69(4)1243-1250(2019 04)

Correlation of hypertension and F2RL3 gene methylation with Prognosis of coronary heart disease.
Gao BF, Shen ZC, Bian WS, Wu SX, Kang ZX, Gao Y
Journal of biological regulators and homeostatic agents32(6)1539-1544(2018 Nov-Dec)

Frequency of PAR4 Ala120Thr variant associated with platelet reactivity significantly varies across sub-Saharan African populations.
Heenkenda MK, Lindahl TL, Osman A
Blood132(19)2103-2106(2018 11)

Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.
Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF
Blood cells, molecules & diseases7237-43(2018 09)

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.
Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M
Arteriosclerosis, thrombosis, and vascular biology38(7)1632-1643(2018 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following F2RL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F2RL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu51883	XM_005260139.2 Latest version!	Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OHu19025	NM_003950.4 Latest version!	Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
View Old Accession Versions >>
OHu19025	NM_003950.2	Homo sapiens coagulation factor II (thrombin) receptor-like 3 (F2RL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
OHu19025	NM_003950.3	Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F2RL3 ( XM_005260139.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005260196.1 Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), transcript variant X1, mRNA.

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CloneID	OHu51883
Clone ID Related Accession (Same CDS sequence)	XM_005260139.2
Accession Version	XM_005260139.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1575475200000
Organism	Homo sapiens(human)
Product	proteinase-activated receptor 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005260139.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGCTGA TGAACCTCGC GGCTGCTGAC CTCCTGCTGG CCCTGGCGCT GCCCCCGCGG 
ATCGCCTACC ACCTGCGTGG CCAGCGCTGG CCCTTCGGGG AGGCCGCCTG CCGCCTGGCC 
ACGGCCGCAC TCTATGGTCA CATGTATGGC TCAGTGCTGC TGCTGGCCGC CGTCAGCCTG 
GATCGCTACC TGGCCCTGGT GCACCCGCTG CGGGCCCGCG CCCTGCGTGG CCGGCGCCTG 
GCCCTTGGAC TCTGCATGGC TGCTTGGCTC ATGGCGGCCG CCCTGGCACT GCCCCTGACA 
CTGCAGCGGC AGACCTTCCG GCTGGCGCGC TCCGATCGCG TGCTCTGCCA TGACGCGCTG 
CCCCTGGACG CACAGGCCTC CCACTGGCAA CCGGCCTTCA CCTGCCTGGC GCTGTTGGGC 
TGTTTCCTGC CCCTGCTGGC CATGCTGCTG TGCTACGGGG CCACCCTGCA CACGCTGGCG 
GCCAGCGGCC GGCGCTACGG CCACGCGCTG AGGCTGACCG CAGTGGTGCT GGCCTCCGCC 
GTGGCCTTCT TCGTGCCCAG CAACCTGCTG CTGCTGCTGC ATTACTCGGA CCCGAGCCCC 
AGCGCCTGGG GCAACCTCTA TGGTGCCTAC GTGCCCAGCC TGGCGCTGAG CACCCTCAAC 
AGCTGCGTGG ATCCCTTCAT CTACTACTAC GTGTCGGCCG AGTTCAGGGA CAAGGTGCGG 
GCAGGGCTCT TCCAACGGTC GCCGGGGGAC ACCGTGGCCT CCAAGGCCTC TGCGGAAGGG 
GGCAGCCGGG GCATGGGCAC CCACTCCTCT TTGCTCCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005260196.1
CDS	333..1154
Translation	MLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ

Target ORF information:

RefSeq Version	XM_005260139.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005260139.2

ORF Insert Sequence:

ATGCTGCTGA TGAACCTCGC GGCTGCTGAC CTCCTGCTGG CCCTGGCGCT GCCCCCGCGG 
ATCGCCTACC ACCTGCGTGG CCAGCGCTGG CCCTTCGGGG AGGCCGCCTG CCGCCTGGCC 
ACGGCCGCAC TCTATGGTCA CATGTATGGC TCAGTGCTGC TGCTGGCCGC CGTCAGCCTG 
GATCGCTACC TGGCCCTGGT GCACCCGCTG CGGGCCCGCG CCCTGCGTGG CCGGCGCCTG 
GCCCTTGGAC TCTGCATGGC TGCTTGGCTC ATGGCGGCCG CCCTGGCACT GCCCCTGACA 
CTGCAGCGGC AGACCTTCCG GCTGGCGCGC TCCGATCGCG TGCTCTGCCA TGACGCGCTG 
CCCCTGGACG CACAGGCCTC CCACTGGCAA CCGGCCTTCA CCTGCCTGGC GCTGTTGGGC 
TGTTTCCTGC CCCTGCTGGC CATGCTGCTG TGCTACGGGG CCACCCTGCA CACGCTGGCG 
GCCAGCGGCC GGCGCTACGG CCACGCGCTG AGGCTGACCG CAGTGGTGCT GGCCTCCGCC 
GTGGCCTTCT TCGTGCCCAG CAACCTGCTG CTGCTGCTGC ATTACTCGGA CCCGAGCCCC 
AGCGCCTGGG GCAACCTCTA TGGTGCCTAC GTGCCCAGCC TGGCGCTGAG CACCCTCAAC 
AGCTGCGTGG ATCCCTTCAT CTACTACTAC GTGTCGGCCG AGTTCAGGGA CAAGGTGCGG 
GCAGGGCTCT TCCAACGGTC GCCGGGGGAC ACCGTGGCCT CCAAGGCCTC TGCGGAAGGG 
GGCAGCCGGG GCATGGGCAC CCACTCCTCT TTGCTCCAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F2RL3 ( NM_003950.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003941.2 Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA.

Price & Availability↑

CloneID	OHu19025
Clone ID Related Accession (Same CDS sequence)	NM_003950.3 , NM_003950.2 , NM_003950.4
Accession Version	NM_003950.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1549641600000
Organism	Homo sapiens(human)
Product	proteinase-activated receptor 4 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP281855.1, AC008737.11, BQ269855.1 and AF055917.1. On Sep 22, 2016 this sequence version replaced NM_003950.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP281855.1, ERR279860.1560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGGGGC GACTGCTCCT GTGGCCCCTG GTGCTGGGGT TCAGCCTGTC TGGCGGCACC 
CAGACCCCCA GCGTCTACGA CGAGAGCGGG AGCACCGGAG GTGGTGATGA CAGCACGCCC 
TCAATCCTGC CTGCCCCCCG CGGCTACCCA GGCCAAGTCT GTGCCAATGA CAGTGACACC 
CTGGAGCTCC CGGACAGCTC ACGGGCACTG CTTCTGGGCT GGGTGCCCAC CAGGCTGGTG 
CCCGCCCTCT ATGGGCTGGT CCTGGTGGTG GGGCTGCCGG CCAATGGGCT GGCGCTGTGG 
GTGCTGGCCA CGCAGGCACC TCGGCTGCCC TCCACCATGC TGCTGATGAA CCTCGCGGCT 
GCTGACCTCC TGCTGGCCCT GGCGCTGCCC CCGCGGATCG CCTACCACCT GCGTGGCCAG 
CGCTGGCCCT TCGGGGAGGC CGCCTGCCGC CTGGCCACGG CCGCACTCTA TGGTCACATG 
TATGGCTCAG TGCTGCTGCT GGCCGCCGTC AGCCTGGATC GCTACCTGGC CCTGGTGCAC 
CCGCTGCGGG CCCGCGCCCT GCGTGGCCGG CGCCTGGCCC TTGGACTCTG CATGGCTGCT 
TGGCTCATGG CGGCCGCCCT GGCACTGCCC CTGACACTGC AGCGGCAGAC CTTCCGGCTG 
GCGCGCTCCG ATCGCGTGCT CTGCCATGAC GCGCTGCCCC TGGACGCACA GGCCTCCCAC 
TGGCAACCGG CCTTCACCTG CCTGGCGCTG TTGGGCTGTT TCCTGCCCCT GCTGGCCATG 
CTGCTGTGCT ACGGGGCCAC CCTGCACACG CTGGCGGCCA GCGGCCGGCG CTACGGCCAC 
GCGCTGAGGC TGACCGCAGT GGTGCTGGCC TCCGCCGTGG CCTTCTTCGT GCCCAGCAAC 
CTGCTGCTGC TGCTGCATTA CTCGGACCCG AGCCCCAGCG CCTGGGGCAA CCTCTATGGT 
GCCTACGTGC CCAGCCTGGC GCTGAGCACC CTCAACAGCT GCGTGGATCC CTTCATCTAC 
TACTACGTGT CGGCCGAGTT CAGGGACAAG GTGCGGGCAG GGCTCTTCCA ACGGTCGCCG 
GGGGACACCG TGGCCTCCAA GGCCTCTGCG GAAGGGGGCA GCCGGGGCAT GGGCACCCAC 
TCCTCTTTGC TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003941.2
CDS	331..1488
Translation	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ

Target ORF information:

RefSeq Version	NM_003950.3
Organism	Homo sapiens(human)
Definition	Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003950.3

ORF Insert Sequence:

ATGTGGGGGC GACTGCTCCT GTGGCCCCTG GTGCTGGGGT TCAGCCTGTC TGGCGGCACC 
CAGACCCCCA GCGTCTACGA CGAGAGCGGG AGCACCGGAG GTGGTGATGA CAGCACGCCC 
TCAATCCTGC CTGCCCCCCG CGGCTACCCA GGCCAAGTCT GTGCCAATGA CAGTGACACC 
CTGGAGCTCC CGGACAGCTC ACGGGCACTG CTTCTGGGCT GGGTGCCCAC CAGGCTGGTG 
CCCGCCCTCT ATGGGCTGGT CCTGGTGGTG GGGCTGCCGG CCAATGGGCT GGCGCTGTGG 
GTGCTGGCCA CGCAGGCACC TCGGCTGCCC TCCACCATGC TGCTGATGAA CCTCGCGGCT 
GCTGACCTCC TGCTGGCCCT GGCGCTGCCC CCGCGGATCG CCTACCACCT GCGTGGCCAG 
CGCTGGCCCT TCGGGGAGGC CGCCTGCCGC CTGGCCACGG CCGCACTCTA TGGTCACATG 
TATGGCTCAG TGCTGCTGCT GGCCGCCGTC AGCCTGGATC GCTACCTGGC CCTGGTGCAC 
CCGCTGCGGG CCCGCGCCCT GCGTGGCCGG CGCCTGGCCC TTGGACTCTG CATGGCTGCT 
TGGCTCATGG CGGCCGCCCT GGCACTGCCC CTGACACTGC AGCGGCAGAC CTTCCGGCTG 
GCGCGCTCCG ATCGCGTGCT CTGCCATGAC GCGCTGCCCC TGGACGCACA GGCCTCCCAC 
TGGCAACCGG CCTTCACCTG CCTGGCGCTG TTGGGCTGTT TCCTGCCCCT GCTGGCCATG 
CTGCTGTGCT ACGGGGCCAC CCTGCACACG CTGGCGGCCA GCGGCCGGCG CTACGGCCAC 
GCGCTGAGGC TGACCGCAGT GGTGCTGGCC TCCGCCGTGG CCTTCTTCGT GCCCAGCAAC 
CTGCTGCTGC TGCTGCATTA CTCGGACCCG AGCCCCAGCG CCTGGGGCAA CCTCTATGGT 
GCCTACGTGC CCAGCCTGGC GCTGAGCACC CTCAACAGCT GCGTGGATCC CTTCATCTAC 
TACTACGTGT CGGCCGAGTT CAGGGACAAG GTGCGGGCAG GGCTCTTCCA ACGGTCGCCG 
GGGGACACCG TGGCCTCCAA GGCCTCTGCG GAAGGGGGCA GCCGGGGCAT GGGCACCCAC 
TCCTCTTTGC TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F2RL3 ( NM_003950.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003941.2 Homo sapiens coagulation factor II (thrombin) receptor-like 3 (F2RL3), mRNA.

Price & Availability↑

CloneID	OHu19025
Clone ID Related Accession (Same CDS sequence)	NM_003950.3 , NM_003950.2 , NM_003950.4
Accession Version	NM_003950.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1426262400000
Organism	Homo sapiens(Human)
Product	proteinase-activated receptor 4 precursor
Comment

ATGTGGGGGC GACTGCTCCT GTGGCCCCTG GTGCTGGGGT TCAGCCTGTC TGGCGGCACC 
CAGACCCCCA GCGTCTACGA CGAGAGCGGG AGCACCGGAG GTGGTGATGA CAGCACGCCC 
TCAATCCTGC CTGCCCCCCG CGGCTACCCA GGCCAAGTCT GTGCCAATGA CAGTGACACC 
CTGGAGCTCC CGGACAGCTC ACGGGCACTG CTTCTGGGCT GGGTGCCCAC CAGGCTGGTG 
CCCGCCCTCT ATGGGCTGGT CCTGGTGGTG GGGCTGCCGG CCAATGGGCT GGCGCTGTGG 
GTGCTGGCCA CGCAGGCACC TCGGCTGCCC TCCACCATGC TGCTGATGAA CCTCGCGGCT 
GCTGACCTCC TGCTGGCCCT GGCGCTGCCC CCGCGGATCG CCTACCACCT GCGTGGCCAG 
CGCTGGCCCT TCGGGGAGGC CGCCTGCCGC CTGGCCACGG CCGCACTCTA TGGTCACATG 
TATGGCTCAG TGCTGCTGCT GGCCGCCGTC AGCCTGGATC GCTACCTGGC CCTGGTGCAC 
CCGCTGCGGG CCCGCGCCCT GCGTGGCCGG CGCCTGGCCC TTGGACTCTG CATGGCTGCT 
TGGCTCATGG CGGCCGCCCT GGCACTGCCC CTGACACTGC AGCGGCAGAC CTTCCGGCTG 
GCGCGCTCCG ATCGCGTGCT CTGCCATGAC GCGCTGCCCC TGGACGCACA GGCCTCCCAC 
TGGCAACCGG CCTTCACCTG CCTGGCGCTG TTGGGCTGTT TCCTGCCCCT GCTGGCCATG 
CTGCTGTGCT ACGGGGCCAC CCTGCACACG CTGGCGGCCA GCGGCCGGCG CTACGGCCAC 
GCGCTGAGGC TGACCGCAGT GGTGCTGGCC TCCGCCGTGG CCTTCTTCGT GCCCAGCAAC 
CTGCTGCTGC TGCTGCATTA CTCGGACCCG AGCCCCAGCG CCTGGGGCAA CCTCTATGGT 
GCCTACGTGC CCAGCCTGGC GCTGAGCACC CTCAACAGCT GCGTGGATCC CTTCATCTAC 
TACTACGTGT CGGCCGAGTT CAGGGACAAG GTGCGGGCAG GGCTCTTCCA ACGGTCGCCG 
GGGGACACCG TGGCCTCCAA GGCCTCTGCG GAAGGGGGCA GCCGGGGCAT GGGCACCCAC 
TCCTCTTTGC TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003941.2
Translation	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ

Target ORF information:

RefSeq Version	NM_003950.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens coagulation factor II (thrombin) receptor-like 3 (F2RL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003950.2

ORF Insert Sequence:

ATGTGGGGGC GACTGCTCCT GTGGCCCCTG GTGCTGGGGT TCAGCCTGTC TGGCGGCACC 
CAGACCCCCA GCGTCTACGA CGAGAGCGGG AGCACCGGAG GTGGTGATGA CAGCACGCCC 
TCAATCCTGC CTGCCCCCCG CGGCTACCCA GGCCAAGTCT GTGCCAATGA CAGTGACACC 
CTGGAGCTCC CGGACAGCTC ACGGGCACTG CTTCTGGGCT GGGTGCCCAC CAGGCTGGTG 
CCCGCCCTCT ATGGGCTGGT CCTGGTGGTG GGGCTGCCGG CCAATGGGCT GGCGCTGTGG 
GTGCTGGCCA CGCAGGCACC TCGGCTGCCC TCCACCATGC TGCTGATGAA CCTCGCGGCT 
GCTGACCTCC TGCTGGCCCT GGCGCTGCCC CCGCGGATCG CCTACCACCT GCGTGGCCAG 
CGCTGGCCCT TCGGGGAGGC CGCCTGCCGC CTGGCCACGG CCGCACTCTA TGGTCACATG 
TATGGCTCAG TGCTGCTGCT GGCCGCCGTC AGCCTGGATC GCTACCTGGC CCTGGTGCAC 
CCGCTGCGGG CCCGCGCCCT GCGTGGCCGG CGCCTGGCCC TTGGACTCTG CATGGCTGCT 
TGGCTCATGG CGGCCGCCCT GGCACTGCCC CTGACACTGC AGCGGCAGAC CTTCCGGCTG 
GCGCGCTCCG ATCGCGTGCT CTGCCATGAC GCGCTGCCCC TGGACGCACA GGCCTCCCAC 
TGGCAACCGG CCTTCACCTG CCTGGCGCTG TTGGGCTGTT TCCTGCCCCT GCTGGCCATG 
CTGCTGTGCT ACGGGGCCAC CCTGCACACG CTGGCGGCCA GCGGCCGGCG CTACGGCCAC 
GCGCTGAGGC TGACCGCAGT GGTGCTGGCC TCCGCCGTGG CCTTCTTCGT GCCCAGCAAC 
CTGCTGCTGC TGCTGCATTA CTCGGACCCG AGCCCCAGCG CCTGGGGCAA CCTCTATGGT 
GCCTACGTGC CCAGCCTGGC GCTGAGCACC CTCAACAGCT GCGTGGATCC CTTCATCTAC 
TACTACGTGT CGGCCGAGTT CAGGGACAAG GTGCGGGCAG GGCTCTTCCA ACGGTCGCCG 
GGGGACACCG TGGCCTCCAA GGCCTCTGCG GAAGGGGGCA GCCGGGGCAT GGGCACCCAC 
TCCTCTTTGC TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F2RL3 ( NM_003950.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003941.2 Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA.

Price & Availability↑

CloneID	OHu19025
Clone ID Related Accession (Same CDS sequence)	NM_003950.3 , NM_003950.2 , NM_003950.4
Accession Version	NM_003950.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577808000000
Organism	Homo sapiens(human)
Product	proteinase-activated receptor 4 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP281855.1, AC008737.11, BQ269855.1 and AF055917.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_003950.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138516.858413.1, AF080214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000248076.4/ ENSP00000248076.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGGGGC GACTGCTCCT GTGGCCCCTG GTGCTGGGGT TCAGCCTGTC TGGCGGCACC 
CAGACCCCCA GCGTCTACGA CGAGAGCGGG AGCACCGGAG GTGGTGATGA CAGCACGCCC 
TCAATCCTGC CTGCCCCCCG CGGCTACCCA GGCCAAGTCT GTGCCAATGA CAGTGACACC 
CTGGAGCTCC CGGACAGCTC ACGGGCACTG CTTCTGGGCT GGGTGCCCAC CAGGCTGGTG 
CCCGCCCTCT ATGGGCTGGT CCTGGTGGTG GGGCTGCCGG CCAATGGGCT GGCGCTGTGG 
GTGCTGGCCA CGCAGGCACC TCGGCTGCCC TCCACCATGC TGCTGATGAA CCTCGCGGCT 
GCTGACCTCC TGCTGGCCCT GGCGCTGCCC CCGCGGATCG CCTACCACCT GCGTGGCCAG 
CGCTGGCCCT TCGGGGAGGC CGCCTGCCGC CTGGCCACGG CCGCACTCTA TGGTCACATG 
TATGGCTCAG TGCTGCTGCT GGCCGCCGTC AGCCTGGATC GCTACCTGGC CCTGGTGCAC 
CCGCTGCGGG CCCGCGCCCT GCGTGGCCGG CGCCTGGCCC TTGGACTCTG CATGGCTGCT 
TGGCTCATGG CGGCCGCCCT GGCACTGCCC CTGACACTGC AGCGGCAGAC CTTCCGGCTG 
GCGCGCTCCG ATCGCGTGCT CTGCCATGAC GCGCTGCCCC TGGACGCACA GGCCTCCCAC 
TGGCAACCGG CCTTCACCTG CCTGGCGCTG TTGGGCTGTT TCCTGCCCCT GCTGGCCATG 
CTGCTGTGCT ACGGGGCCAC CCTGCACACG CTGGCGGCCA GCGGCCGGCG CTACGGCCAC 
GCGCTGAGGC TGACCGCAGT GGTGCTGGCC TCCGCCGTGG CCTTCTTCGT GCCCAGCAAC 
CTGCTGCTGC TGCTGCATTA CTCGGACCCG AGCCCCAGCG CCTGGGGCAA CCTCTATGGT 
GCCTACGTGC CCAGCCTGGC GCTGAGCACC CTCAACAGCT GCGTGGATCC CTTCATCTAC 
TACTACGTGT CGGCCGAGTT CAGGGACAAG GTGCGGGCAG GGCTCTTCCA ACGGTCGCCG 
GGGGACACCG TGGCCTCCAA GGCCTCTGCG GAAGGGGGCA GCCGGGGCAT GGGCACCCAC 
TCCTCTTTGC TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003941.2
CDS	192..1349
Translation	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ

Target ORF information:

RefSeq Version	NM_003950.4
Organism	Homo sapiens(human)
Definition	Homo sapiens F2R like thrombin or trypsin receptor 3 (F2RL3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003950.4

ORF Insert Sequence:

ATGTGGGGGC GACTGCTCCT GTGGCCCCTG GTGCTGGGGT TCAGCCTGTC TGGCGGCACC 
CAGACCCCCA GCGTCTACGA CGAGAGCGGG AGCACCGGAG GTGGTGATGA CAGCACGCCC 
TCAATCCTGC CTGCCCCCCG CGGCTACCCA GGCCAAGTCT GTGCCAATGA CAGTGACACC 
CTGGAGCTCC CGGACAGCTC ACGGGCACTG CTTCTGGGCT GGGTGCCCAC CAGGCTGGTG 
CCCGCCCTCT ATGGGCTGGT CCTGGTGGTG GGGCTGCCGG CCAATGGGCT GGCGCTGTGG 
GTGCTGGCCA CGCAGGCACC TCGGCTGCCC TCCACCATGC TGCTGATGAA CCTCGCGGCT 
GCTGACCTCC TGCTGGCCCT GGCGCTGCCC CCGCGGATCG CCTACCACCT GCGTGGCCAG 
CGCTGGCCCT TCGGGGAGGC CGCCTGCCGC CTGGCCACGG CCGCACTCTA TGGTCACATG 
TATGGCTCAG TGCTGCTGCT GGCCGCCGTC AGCCTGGATC GCTACCTGGC CCTGGTGCAC 
CCGCTGCGGG CCCGCGCCCT GCGTGGCCGG CGCCTGGCCC TTGGACTCTG CATGGCTGCT 
TGGCTCATGG CGGCCGCCCT GGCACTGCCC CTGACACTGC AGCGGCAGAC CTTCCGGCTG 
GCGCGCTCCG ATCGCGTGCT CTGCCATGAC GCGCTGCCCC TGGACGCACA GGCCTCCCAC 
TGGCAACCGG CCTTCACCTG CCTGGCGCTG TTGGGCTGTT TCCTGCCCCT GCTGGCCATG 
CTGCTGTGCT ACGGGGCCAC CCTGCACACG CTGGCGGCCA GCGGCCGGCG CTACGGCCAC 
GCGCTGAGGC TGACCGCAGT GGTGCTGGCC TCCGCCGTGG CCTTCTTCGT GCCCAGCAAC 
CTGCTGCTGC TGCTGCATTA CTCGGACCCG AGCCCCAGCG CCTGGGGCAA CCTCTATGGT 
GCCTACGTGC CCAGCCTGGC GCTGAGCACC CTCAACAGCT GCGTGGATCC CTTCATCTAC 
TACTACGTGT CGGCCGAGTT CAGGGACAAG GTGCGGGCAG GGCTCTTCCA ACGGTCGCCG 
GGGGACACCG TGGCCTCCAA GGCCTCTGCG GAAGGGGGCA GCCGGGGCAT GGGCACCCAC 
TCCTCTTTGC TCCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes.
Journal of vascular surgery69(4)1243-1250(2019 04)
Posthuma JJ,Posma JJN,Schep G,Bender MMH,van Oerle R,van der Wal AC,Ten Cate H,Spronk HMH

Correlation of hypertension and F2RL3 gene methylation with Prognosis of coronary heart disease.
Journal of biological regulators and homeostatic agents32(6)1539-1544(2018 Nov-Dec)
Gao BF,Shen ZC,Bian WS,Wu SX,Kang ZX,Gao Y

Frequency of PAR4 Ala120Thr variant associated with platelet reactivity significantly varies across sub-Saharan African populations.
Blood132(19)2103-2106(2018 11)
Heenkenda MK,Lindahl TL,Osman A

Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.
Blood cells, molecules & diseases7237-43(2018 09)
Tricoci P,Neely M,Whitley MJ,Edelstein LC,Simon LM,Shaw C,Fortina P,Moliterno DJ,Armstrong PW,Aylward P,White H,Van de Werf F,Jennings LK,Wallentin L,Held C,Harrington RA,Mahaffey KW,Bray PF

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.
Arteriosclerosis, thrombosis, and vascular biology38(7)1632-1643(2018 07)
Tourdot BE,Stoveken H,Trumbo D,Yeung J,Kanthi Y,Edelstein LC,Bray PF,Tall GG,Holinstat M

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F2RL3 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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