SNX3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SNX3
Entrez Gene ID	8724
Full Name	sorting nexin 3
Synonyms	Grd19,MCOPS8,SDP3
General protein information	Preferred Names sorting nexin 3 Names sorting nexin-3 sorting nexin 3A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q21
Summary	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Disorder MIM:	605930

mRNA and Protein(s)

mRNA	Protein	Name
NM_152827.3	NP_690040.1	sorting nexin-3 isoform b
NM_001300929.1	NP_001287858.1	sorting nexin-3 isoform d
NM_003795.5	NP_003786.1	sorting nexin-3 isoform a
NM_001300929.2	NP_001287858.1	sorting nexin-3 isoform d
NM_003795.6	NP_003786.1	sorting nexin-3 isoform a
NM_152827.4	NP_690040.1	sorting nexin-3 isoform b
NM_001300928.1	NP_001287857.1	sorting nexin-3 isoform c
NM_001300928.2	NP_001287857.1	sorting nexin-3 isoform c

Pathways from BioSystems

Homologies

Kluyveromyces lactis	KLLA0A03718g	XP_451164.1
Neurospora crassa	NCU01914	XP_965545.1
Schizosaccharomyces pombe (fission yeast)	snx3	NP_596480.1
Canis lupus familiaris (dog)	SNX3	XP_855006.2
Rattus norvegicus (Norway rat)	Snx3	NP_001037748.1
Gallus gallus (chicken)	SNX3	NP_001006408.1
Danio rerio (zebrafish)	snx3	NP_001032183.1
Pan troglodytes (chimpanzee)	SNX3	XP_001149032.1
Bos taurus (cattle)	SNX3	NP_001073246.1
Eremothecium gossypii	AGOS_ADR390C	NP_984486.2
Magnaporthe oryzae (rice blast fungus)	MGG_02948	XP_003720759.1
Mus musculus (house mouse)	Snx3	NP_059500.2
Homo sapiens (human)	SNX3	NP_003786.1
Macaca mulatta (Rhesus monkey)	SNX3	XP_001094537.1
Saccharomyces cerevisiae (baker's yeast)	SNX3	NP_015002.3
Xenopus tropicalis (tropical clawed frog)	snx3	NP_989030.1

Gene Ontology
Bibliography

Related articles in PubMed

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.
McGough IJ, de Groot REA, Jellett AP, Betist MC, Varandas KC, Danson CM, Heesom KJ, Korswagen HC, Cullen PJ
Nature communications9(1)3737(2018 09)

Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein.
Xu S, Nigam SM, Brodin L
Neuro-degenerative diseases18(1)26-37(2018)

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex.
Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L, Ong ACM
Journal of the American Society of Nephrology : JASN28(10)2973-2984(2017 Oct)

Structural Mechanism for Cargo Recognition by the Retromer Complex.
Lucas M, Gershlick DC, Vidaurrazaga A, Rojas AL, Bonifacino JS, Hierro A
Cell167(6)1623-1635.e14(2016 Dec)

[The morphological changes of SW620 cells induced by over-expression of human sorting nexin 3].
Yang W, Pan B, Zhang T, Wang Z, Zhang L, Guo Y
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(8)1057-61(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following SNX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SNX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26404	NM_152827.4 Latest version!	Homo sapiens sorting nexin 3 (SNX3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu40998	NM_001300929.2 Latest version!	Homo sapiens sorting nexin 3 (SNX3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu62142	NM_001300928.2 Latest version!	Homo sapiens sorting nexin 3 (SNX3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu26200	NM_003795.6 Latest version!	Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu40998	NM_001300929.1	Homo sapiens sorting nexin 3 (SNX3), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu26200	NM_003795.5	Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
OHu26404	NM_152827.3	Homo sapiens sorting nexin 3 (SNX3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu62142	NM_001300928.1	Homo sapiens sorting nexin 3 (SNX3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SNX3 ( NM_152827.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_690040.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26404
Clone ID Related Accession (Same CDS sequence)	NM_152827.3 , NM_152827.4
Accession Version	NM_152827.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023148.1, AB047360.1, BQ432490.1 and CA442762.1. On Jul 16, 2014 this sequence version replaced NM_152827.2. Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. It encodes isoform b, also known as SNX3A, which is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB047360.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGGTCGTAGT TCCCCCGCTC 
CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT TTTAGAGGAG ATGATGGAAT ATTTGATGAC 
AATTTTATTG AGGAAAGAAA ACAAGGGCTG GAGCAGTTTA TAAACAAGGT CGCTGGTCAT 
CCTCTGGCAC AGAACGAACG TTGTCTTCAC ATGTTTTTAC AAGATGAAAT AATAGATAAA 
AGCTATACTC CATCTAAAAT AAGACATGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690040.1
CDS	340..732
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Target ORF information:

RefSeq Version	NM_152827.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152827.3

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGGTCGTAGT TCCCCCGCTC 
CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT TTTAGAGGAG ATGATGGAAT ATTTGATGAC 
AATTTTATTG AGGAAAGAAA ACAAGGGCTG GAGCAGTTTA TAAACAAGGT CGCTGGTCAT 
CCTCTGGCAC AGAACGAACG TTGTCTTCAC ATGTTTTTAC AAGATGAAAT AATAGATAAA 
AGCTATACTC CATCTAAAAT AAGACATGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX3 ( NM_152827.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_690040.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26404
Clone ID Related Accession (Same CDS sequence)	NM_152827.3 , NM_152827.4
Accession Version	NM_152827.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1559232000000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023148.1, AB047360.1, BQ432490.1 and CA442762.1. On Jun 1, 2019 this sequence version replaced NM_152827.3. Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. It encodes isoform b, also known as SNX3A, which is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB047360.1, SRR7410570.265410.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGGTCGTAGT TCCCCCGCTC 
CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT TTTAGAGGAG ATGATGGAAT ATTTGATGAC 
AATTTTATTG AGGAAAGAAA ACAAGGGCTG GAGCAGTTTA TAAACAAGGT CGCTGGTCAT 
CCTCTGGCAC AGAACGAACG TTGTCTTCAC ATGTTTTTAC AAGATGAAAT AATAGATAAA 
AGCTATACTC CATCTAAAAT AAGACATGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_690040.1
CDS	120..512
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Target ORF information:

RefSeq Version	NM_152827.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_152827.4

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGGTCGTAGT TCCCCCGCTC 
CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT TTTAGAGGAG ATGATGGAAT ATTTGATGAC 
AATTTTATTG AGGAAAGAAA ACAAGGGCTG GAGCAGTTTA TAAACAAGGT CGCTGGTCAT 
CCTCTGGCAC AGAACGAACG TTGTCTTCAC ATGTTTTTAC AAGATGAAAT AATAGATAAA 
AGCTATACTC CATCTAAAAT AAGACATGCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX3 ( NM_001300929.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287858.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu40998
Clone ID Related Accession (Same CDS sequence)	NM_001300929.1 , NM_001300929.2
Accession Version	NM_001300929.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1547222400000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023148.1, CN422502.1, AI921483.1, BQ432490.1 and CA442762.1. On Jul 16, 2014 this sequence version replaced XM_005267192.1. Transcript Variant: This variant (4) lacks an in-frame portion of the first coding exon, compared to variant 1. It encodes isoform d, which is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.468652.1, SRR1163655.444195.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATACAA ATCTTCCTAT TTTCAAGCTG 
AAAGAATCTA CTGTTAGAAG AAGATACAGT GACTTTGAAT GGCTGCGAAG TGAATTAGAA 
AGAGAGAGCA AGGTCGTAGT TCCCCCGCTC CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT 
TTTAGAGGAG ATGATGGAAT ATTTGATGAC AATTTTATTG AGGAAAGAAA ACAAGGGCTG 
GAGCAGTTTA TAAACAAGGT CGCTGGTCAT CCTCTGGCAC AGAACGAACG TTGTCTTCAC 
ATGTTTTTAC AAGATGAAAT AATAGATAAA AGCTATACTC CATCTAAAAT AAGACATGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287858.1
CDS	340..762
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Target ORF information:

RefSeq Version	NM_001300929.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300929.1

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATACAA ATCTTCCTAT TTTCAAGCTG 
AAAGAATCTA CTGTTAGAAG AAGATACAGT GACTTTGAAT GGCTGCGAAG TGAATTAGAA 
AGAGAGAGCA AGGTCGTAGT TCCCCCGCTC CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT 
TTTAGAGGAG ATGATGGAAT ATTTGATGAC AATTTTATTG AGGAAAGAAA ACAAGGGCTG 
GAGCAGTTTA TAAACAAGGT CGCTGGTCAT CCTCTGGCAC AGAACGAACG TTGTCTTCAC 
ATGTTTTTAC AAGATGAAAT AATAGATAAA AGCTATACTC CATCTAAAAT AAGACATGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX3 ( NM_001300929.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287858.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu40998
Clone ID Related Accession (Same CDS sequence)	NM_001300929.1 , NM_001300929.2
Accession Version	NM_001300929.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1559145600000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform d
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023148.1, CN422502.1, AI921483.1, BQ432490.1 and CA442762.1. On May 31, 2019 this sequence version replaced NM_001300929.1. Transcript Variant: This variant (4) lacks an in-frame portion of the first coding exon, compared to variant 1. It encodes isoform d, which is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.997548.1, SRR5189658.76575.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATACAA ATCTTCCTAT TTTCAAGCTG 
AAAGAATCTA CTGTTAGAAG AAGATACAGT GACTTTGAAT GGCTGCGAAG TGAATTAGAA 
AGAGAGAGCA AGGTCGTAGT TCCCCCGCTC CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT 
TTTAGAGGAG ATGATGGAAT ATTTGATGAC AATTTTATTG AGGAAAGAAA ACAAGGGCTG 
GAGCAGTTTA TAAACAAGGT CGCTGGTCAT CCTCTGGCAC AGAACGAACG TTGTCTTCAC 
ATGTTTTTAC AAGATGAAAT AATAGATAAA AGCTATACTC CATCTAAAAT AAGACATGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287858.1
CDS	120..542
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Target ORF information:

RefSeq Version	NM_001300929.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300929.2

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATACAA ATCTTCCTAT TTTCAAGCTG 
AAAGAATCTA CTGTTAGAAG AAGATACAGT GACTTTGAAT GGCTGCGAAG TGAATTAGAA 
AGAGAGAGCA AGGTCGTAGT TCCCCCGCTC CCTGGGAAAG CGTTTTTGCG TCAGCTTCCT 
TTTAGAGGAG ATGATGGAAT ATTTGATGAC AATTTTATTG AGGAAAGAAA ACAAGGGCTG 
GAGCAGTTTA TAAACAAGGT CGCTGGTCAT CCTCTGGCAC AGAACGAACG TTGTCTTCAC 
ATGTTTTTAC AAGATGAAAT AATAGATAAA AGCTATACTC CATCTAAAAT AAGACATGCC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX3 ( NM_001300928.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287857.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu62142
Clone ID Related Accession (Same CDS sequence)	NM_001300928.1 , NM_001300928.2
Accession Version	NM_001300928.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550851200000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023148.1, HY156437.1, CN422502.1, AI921483.1, BQ432490.1 and CA442762.1. Transcript Variant: This variant (3) lacks an exon in the 3' coding region, compared to variant 1, which results in a frameshift and a protein (isoform c) with a shorter and distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279856.776.1, BU181300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGG TCGCTGGTCA TCCTCTGGCA CAGAACGAAC GTTGTCTTCA 
CATGTTTTTA CAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287857.1
CDS	340..657
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKGRWSSSGTERTLSSHVFTR

Target ORF information:

RefSeq Version	NM_001300928.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300928.1

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGG TCGCTGGTCA TCCTCTGGCA CAGAACGAAC GTTGTCTTCA 
CATGTTTTTA CAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX3 ( NM_001300928.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287857.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 3, mRNA.

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CloneID	OHu62142
Clone ID Related Accession (Same CDS sequence)	NM_001300928.1 , NM_001300928.2
Accession Version	NM_001300928.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 318bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1559145600000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY156437.1, CN422502.1, AI921483.1, BQ432490.1 and CA442762.1. On May 31, 2019 this sequence version replaced NM_001300928.1. Transcript Variant: This variant (3) lacks an exon in the 3' coding region, compared to variant 1, which results in a frameshift and a protein (isoform c) with a shorter and distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.731568.1, SRR3476690.544550.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGG TCGCTGGTCA TCCTCTGGCA CAGAACGAAC GTTGTCTTCA 
CATGTTTTTA CAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287857.1
CDS	120..437
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKGRWSSSGTERTLSSHVFTR

Target ORF information:

RefSeq Version	NM_001300928.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300928.2

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGG TCGCTGGTCA TCCTCTGGCA CAGAACGAAC GTTGTCTTCA 
CATGTTTTTA CAAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX3 ( NM_003795.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003786.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26200
Clone ID Related Accession (Same CDS sequence)	NM_003795.5 , NM_003795.6
Accession Version	NM_003795.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1508688000000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023148.1, AF034546.1, BQ432490.1 and CA442762.1. This sequence is a reference standard in the RefSeqGene project. On Jul 17, 2014 this sequence version replaced NM_003795.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279834.4102.1, SRR1660809.163934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGT CGTAGTTCCC CCGCTCCCTG GGAAAGCGTT TTTGCGTCAG 
CTTCCTTTTA GAGGAGATGA TGGAATATTT GATGACAATT TTATTGAGGA AAGAAAACAA 
GGGCTGGAGC AGTTTATAAA CAAGGTCGCT GGTCATCCTC TGGCACAGAA CGAACGTTGT 
CTTCACATGT TTTTACAAGA TGAAATAATA GATAAAAGCT ATACTCCATC TAAAATAAGA 
CATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003786.1
CDS	340..828
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Target ORF information:

RefSeq Version	NM_003795.5
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003795.5

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGT CGTAGTTCCC CCGCTCCCTG GGAAAGCGTT TTTGCGTCAG 
CTTCCTTTTA GAGGAGATGA TGGAATATTT GATGACAATT TTATTGAGGA AAGAAAACAA 
GGGCTGGAGC AGTTTATAAA CAAGGTCGCT GGTCATCCTC TGGCACAGAA CGAACGTTGT 
CTTCACATGT TTTTACAAGA TGAAATAATA GATAAAAGCT ATACTCCATC TAAAATAAGA 
CATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SNX3 ( NM_003795.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_003786.1 Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu26200
Clone ID Related Accession (Same CDS sequence)	NM_003795.5 , NM_003795.6
Accession Version	NM_003795.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566316800000
Organism	Homo sapiens(human)
Product	sorting nexin-3 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY023148.1, AF034546.1, BQ432490.1 and CA442762.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003795.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.156253.1, SRR3476690.827852.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000230085.13/ ENSP00000230085.8 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGT CGTAGTTCCC CCGCTCCCTG GGAAAGCGTT TTTGCGTCAG 
CTTCCTTTTA GAGGAGATGA TGGAATATTT GATGACAATT TTATTGAGGA AAGAAAACAA 
GGGCTGGAGC AGTTTATAAA CAAGGTCGCT GGTCATCCTC TGGCACAGAA CGAACGTTGT 
CTTCACATGT TTTTACAAGA TGAAATAATA GATAAAAGCT ATACTCCATC TAAAATAAGA 
CATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003786.1
CDS	120..608
Translation	MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA

Target ORF information:

RefSeq Version	NM_003795.6
Organism	Homo sapiens(human)
Definition	Homo sapiens sorting nexin 3 (SNX3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003795.6

ORF Insert Sequence:

ATGGCGGAGA CCGTGGCTGA CACCCGGCGG CTGATCACCA AGCCGCAGAA CCTGAATGAC 
GCCTACGGAC CCCCCAGCAA CTTCCTCGAG ATCGATGTGA GCAACCCGCA AACGGTGGGG 
GTCGGCCGGG GCCGCTTCAC CACTTACGAA ATCAGGGTCA AGACAAATCT TCCTATTTTC 
AAGCTGAAAG AATCTACTGT TAGAAGAAGA TACAGTGACT TTGAATGGCT GCGAAGTGAA 
TTAGAAAGAG AGAGCAAGGT CGTAGTTCCC CCGCTCCCTG GGAAAGCGTT TTTGCGTCAG 
CTTCCTTTTA GAGGAGATGA TGGAATATTT GATGACAATT TTATTGAGGA AAGAAAACAA 
GGGCTGGAGC AGTTTATAAA CAAGGTCGCT GGTCATCCTC TGGCACAGAA CGAACGTTGT 
CTTCACATGT TTTTACAAGA TGAAATAATA GATAAAAGCT ATACTCCATC TAAAATAAGA 
CATGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.
Nature communications9(1)3737(2018 09)
McGough IJ,de Groot REA,Jellett AP,Betist MC,Varandas KC,Danson CM,Heesom KJ,Korswagen HC,Cullen PJ

Overexpression of SNX3 Decreases Amyloid-β Peptide Production by Reducing Internalization of Amyloid Precursor Protein.
Neuro-degenerative diseases18(1)26-37(2018)
Xu S,Nigam SM,Brodin L

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex.
Journal of the American Society of Nephrology : JASN28(10)2973-2984(2017 Oct)
Feng S,Streets AJ,Nesin V,Tran U,Nie H,Onopiuk M,Wessely O,Tsiokas L,Ong ACM

Structural Mechanism for Cargo Recognition by the Retromer Complex.
Cell167(6)1623-1635.e14(2016 Dec)
Lucas M,Gershlick DC,Vidaurrazaga A,Rojas AL,Bonifacino JS,Hierro A

[The morphological changes of SW620 cells induced by over-expression of human sorting nexin 3].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(8)1057-61(2015 Aug)
Yang W,Pan B,Zhang T,Wang Z,Zhang L,Guo Y

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SNX3 cDNA ORF clone, Homo sapiens(human)

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