| Gene Symbol | MCEE |
| Entrez Gene ID | 84693 |
| Full Name | methylmalonyl-CoA epimerase |
| Synonyms | GLOD2 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Methylmalonyl-CoA epimerase deficiency, 251120 (3) |
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MCEE cDNA ORF clone, Homo sapiens(human)
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Gene
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Clones
gRNAs
The following MCEE gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCEE cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID OHu26303 
Clone ID Related Accession (Same CDS sequence) NM_032601.3 , NM_032601.4 Accession Version NM_032601.3 Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 531bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1514217600000 Organism Homo sapiens(human) Product methylmalonyl-CoA epimerase, mitochondrial precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM271757.1, AF364547.1, BC020825.1 and AI033764.1. This sequence is a reference standard in the RefSeqGene project. On May 14, 2008 this sequence version replaced NM_032601.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.120940.1, SRR1163655.692786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.
1
61
121
181
241
301
361
421
481ATGGCGCGGG TGCTGAAGGC TGCAGCCGCG AATGCCGTAG GGCTTTTTTC CAGACTTCAA
GCTCCCATTC CAACAGTAAG AGCTTCTTCC ACATCACAGC CCTTGGATCA AGTGACAGGT
TCTGTGTGGA ACCTGGGTCG ACTCAACCAT GTAGCCATAG CAGTGCCAGA TTTGGAAAAG
GCTGCAGCAT TTTATAAGAA TATTCTGGGG GCCCAGGTAA GTGAAGCGGT CCCTCTTCCT
GAACATGGAG TATCTGTTGT TTTTGTCAAC CTGGGAAATA CCAAGATGGA ACTGCTTCAT
CCATTGGGAC GTGACAGTCC AATTGCAGGT TTTCTGCAGA AAAACAAGGC TGGAGGAATG
CATCACATCT GCATCGAGGT GGATAATATT AATGCAGCTG TGATGGATTT GAAAAAAAAG
AAGATCCGCA GTCTAAGTGA AGAGGTCAAA ATAGGAGCAC ATGGAAAACC AGTGATTTTT
CTCCATCCTA AAGACTGTGG TGGAGTCCTT GTGGAACTGG AGCAAGCTTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_115990.3 CDS 46..576 Translation 
Target ORF information:
RefSeq Version NM_032601.3 Organism Homo sapiens(human) Definition Homo sapiens methylmalonyl-CoA epimerase (MCEE), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_032601.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGGCGCGGG TGCTGAAGGC TGCAGCCGCG AATGCCGTAG GGCTTTTTTC CAGACTTCAA
GCTCCCATTC CAACAGTAAG AGCTTCTTCC ACATCACAGC CCTTGGATCA AGTGACAGGT
TCTGTGTGGA ACCTGGGTCG ACTCAACCAT GTAGCCATAG CAGTGCCAGA TTTGGAAAAG
GCTGCAGCAT TTTATAAGAA TATTCTGGGG GCCCAGGTAA GTGAAGCGGT CCCTCTTCCT
GAACATGGAG TATCTGTTGT TTTTGTCAAC CTGGGAAATA CCAAGATGGA ACTGCTTCAT
CCATTGGGAC GTGACAGTCC AATTGCAGGT TTTCTGCAGA AAAACAAGGC TGGAGGAATG
CATCACATCT GCATCGAGGT GGATAATATT AATGCAGCTG TGATGGATTT GAAAAAAAAG
AAGATCCGCA GTCTAAGTGA AGAGGTCAAA ATAGGAGCAC ATGGAAAACC AGTGATTTTT
CTCCATCCTA AAGACTGTGG TGGAGTCCTT GTGGAACTGG AGCAAGCTTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu35637 Clone ID Related Accession (Same CDS sequence) XM_005264613.2 Accession Version XM_005264613.2 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 369bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1575475200000 Organism Homo sapiens(human) Product methylmalonyl-CoA epimerase, mitochondrial isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005264613.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361ATGGCGCGGG TGCTGAAGGC TGCAGCCGCG AATGCCGTAG GGCTTTTTTC CAGACTTCAA
GCTCCCATTC CAACAGTAAG AGCTTCTTCC ACATCACAGC CCTTGGATCA AGTGACAGGT
TCTGTGTGGA ACCTGGGTCG ACTCAACCAT GTAGCCATAG CAGTGCCAGA TTTGGAAAAG
GCTGCAGCAT TTTATAAGAA TATTCTGGGG GCCCAGGTGG ATAATATTAA TGCAGCTGTG
ATGGATTTGA AAAAAAAGAA GATCCGCAGT CTAAGTGAAG AGGTCAAAAT AGGAGCACAT
GGAAAACCAG TGATTTTTCT CCATCCTAAA GACTGTGGTG GAGTCCTTGT GGAACTGGAG
CAAGCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_005264670.1 CDS 70..438 Translation
Target ORF information:
RefSeq Version XM_005264613.2 Organism Homo sapiens(human) Definition Homo sapiens methylmalonyl-CoA epimerase (MCEE), transcript variant X2, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_005264613.2
ORF Insert Sequence:
1
61
121
181
241
301
361ATGGCGCGGG TGCTGAAGGC TGCAGCCGCG AATGCCGTAG GGCTTTTTTC CAGACTTCAA
GCTCCCATTC CAACAGTAAG AGCTTCTTCC ACATCACAGC CCTTGGATCA AGTGACAGGT
TCTGTGTGGA ACCTGGGTCG ACTCAACCAT GTAGCCATAG CAGTGCCAGA TTTGGAAAAG
GCTGCAGCAT TTTATAAGAA TATTCTGGGG GCCCAGGTGG ATAATATTAA TGCAGCTGTG
ATGGATTTGA AAAAAAAGAA GATCCGCAGT CTAAGTGAAG AGGTCAAAAT AGGAGCACAT
GGAAAACCAG TGATTTTTCT CCATCCTAAA GACTGTGGTG GAGTCCTTGT GGAACTGGAG
CAAGCTTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID OHu26303 Clone ID Related Accession (Same CDS sequence) NM_032601.3 , NM_032601.4 Accession Version NM_032601.4 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 531bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1566316800000 Organism Homo sapiens(human) Product methylmalonyl-CoA epimerase, mitochondrial precursor Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF364547.1, BC020825.1 and AI033764.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_032601.3. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.63614.1, SRR5189661.77625.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000244217.6/ ENSP00000244217.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.
1
61
121
181
241
301
361
421
481ATGGCGCGGG TGCTGAAGGC TGCAGCCGCG AATGCCGTAG GGCTTTTTTC CAGACTTCAA
GCTCCCATTC CAACAGTAAG AGCTTCTTCC ACATCACAGC CCTTGGATCA AGTGACAGGT
TCTGTGTGGA ACCTGGGTCG ACTCAACCAT GTAGCCATAG CAGTGCCAGA TTTGGAAAAG
GCTGCAGCAT TTTATAAGAA TATTCTGGGG GCCCAGGTAA GTGAAGCGGT CCCTCTTCCT
GAACATGGAG TATCTGTTGT TTTTGTCAAC CTGGGAAATA CCAAGATGGA ACTGCTTCAT
CCATTGGGAC GTGACAGTCC AATTGCAGGT TTTCTGCAGA AAAACAAGGC TGGAGGAATG
CATCACATCT GCATCGAGGT GGATAATATT AATGCAGCTG TGATGGATTT GAAAAAAAAG
AAGATCCGCA GTCTAAGTGA AGAGGTCAAA ATAGGAGCAC ATGGAAAACC AGTGATTTTT
CTCCATCCTA AAGACTGTGG TGGAGTCCTT GTGGAACTGG AGCAAGCTTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_115990.3 CDS 11..541 Translation
Target ORF information:
RefSeq Version NM_032601.4 Organism Homo sapiens(human) Definition Homo sapiens methylmalonyl-CoA epimerase (MCEE), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK NM_032601.4
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGGCGCGGG TGCTGAAGGC TGCAGCCGCG AATGCCGTAG GGCTTTTTTC CAGACTTCAA
GCTCCCATTC CAACAGTAAG AGCTTCTTCC ACATCACAGC CCTTGGATCA AGTGACAGGT
TCTGTGTGGA ACCTGGGTCG ACTCAACCAT GTAGCCATAG CAGTGCCAGA TTTGGAAAAG
GCTGCAGCAT TTTATAAGAA TATTCTGGGG GCCCAGGTAA GTGAAGCGGT CCCTCTTCCT
GAACATGGAG TATCTGTTGT TTTTGTCAAC CTGGGAAATA CCAAGATGGA ACTGCTTCAT
CCATTGGGAC GTGACAGTCC AATTGCAGGT TTTCTGCAGA AAAACAAGGC TGGAGGAATG
CATCACATCT GCATCGAGGT GGATAATATT AATGCAGCTG TGATGGATTT GAAAAAAAAG
AAGATCCGCA GTCTAAGTGA AGAGGTCAAA ATAGGAGCAC ATGGAAAACC AGTGATTTTT
CTCCATCCTA AAGACTGTGG TGGAGTCCTT GTGGAACTGG AGCAAGCTTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kovács IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barabási AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ
Atypical methylmalonic aciduria: frequency of mutations in the methylmalonyl CoA epimerase gene (MCEE).
Human mutation28(10)1045(2007 Oct)
Gradinger AB,Bélair C,Worgan LC,Li CD,Lavallée J,Roquis D,Watkins D,Rosenblatt DS
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